ZA200404525B - Platinum derivative Pharmaceutical formulations. - Google Patents
Platinum derivative Pharmaceutical formulations. Download PDFInfo
- Publication number
- ZA200404525B ZA200404525B ZA200404525A ZA200404525A ZA200404525B ZA 200404525 B ZA200404525 B ZA 200404525B ZA 200404525 A ZA200404525 A ZA 200404525A ZA 200404525 A ZA200404525 A ZA 200404525A ZA 200404525 B ZA200404525 B ZA 200404525B
- Authority
- ZA
- South Africa
- Prior art keywords
- formulation
- oxaliplatin
- lactic acid
- pharmaceutically acceptable
- ranges
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title description 6
- 150000003057 platinum Chemical class 0.000 title description 3
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims description 79
- 229960001756 oxaliplatin Drugs 0.000 claims description 79
- 239000000203 mixture Substances 0.000 claims description 72
- 238000009472 formulation Methods 0.000 claims description 69
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 54
- 239000004310 lactic acid Substances 0.000 claims description 27
- 235000014655 lactic acid Nutrition 0.000 claims description 27
- 230000000087 stabilizing effect Effects 0.000 claims description 26
- -1 alkali metal salt Chemical class 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 claims description 16
- 239000003937 drug carrier Substances 0.000 claims description 14
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- 206010028980 Neoplasm Diseases 0.000 claims description 9
- 230000003287 optical effect Effects 0.000 claims description 8
- 229910052783 alkali metal Inorganic materials 0.000 claims description 6
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- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000001540 sodium lactate Substances 0.000 claims description 4
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- 239000003814 drug Substances 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 22
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/010,122 US6476068B1 (en) | 2001-12-06 | 2001-12-06 | Platinum derivative pharmaceutical formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200404525B true ZA200404525B (en) | 2005-08-15 |
Family
ID=21744006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200404525A ZA200404525B (en) | 2001-12-06 | 2004-06-08 | Platinum derivative Pharmaceutical formulations. |
Country Status (42)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040186172A1 (en) * | 2001-07-02 | 2004-09-23 | Houssam Ibrahim | Oxaliplatin active substance with a very low content of oxalic acid |
| CA2388352A1 (fr) * | 2002-05-31 | 2003-11-30 | Voiceage Corporation | Methode et dispositif pour l'amelioration selective en frequence de la hauteur de la parole synthetisee |
| US20040022842A1 (en) * | 2002-06-03 | 2004-02-05 | Mebiopharm Co., Ltd. | Liposome preparations containing oxaliplatin |
| DE10314377A1 (de) * | 2003-03-28 | 2004-10-07 | Stada Arzneimittel Ag | Gebrauchsfertige Oxaliplatin-Lösungen |
| EP1680103A4 (fr) * | 2003-08-28 | 2009-03-25 | Mayne Pharma Ltd | Formulations d'oxaliplatine contenant de l'acide |
| GB2441445B (en) * | 2003-08-28 | 2008-04-23 | Mayne Pharma Ltd | Acid containing oxaliplatin formulation |
| JP4724665B2 (ja) * | 2003-11-07 | 2011-07-13 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | キノリノン化合物を合成する方法 |
| US7795205B2 (en) * | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
| MXPA06014477A (es) * | 2004-06-09 | 2007-03-21 | Taiho Pharmaceutical Co Ltd | Agente antitumor, fortificador de efecto antitumor y metodo de terapia para cancer. |
| TW200617014A (en) * | 2004-07-12 | 2006-06-01 | Sicor Inc | Cis-diiodo-(trans-l-1,2-cyclohexanediamine) platinum (Ⅱ) complex and processes for preparing high purity oxaliplatin |
| US20060063833A1 (en) * | 2004-09-22 | 2006-03-23 | Edgar Schridde | Ready-to-use oxaliplatin solutions |
| US20060063720A1 (en) * | 2004-09-22 | 2006-03-23 | Edgar Schridde | Oxaliplatin solution concentrate |
| DE102004052877B4 (de) * | 2004-11-02 | 2008-06-19 | Ebewe Pharma Ges.M.B.H. Nfg.Kg | Stabile wässrige Formulierungen eines Platin-Derivats |
| CN1311818C (zh) * | 2004-11-22 | 2007-04-25 | 山东蓝金生物工程有限公司 | 一种抗实体肿瘤的药物组合物 |
| DE102004063764A1 (de) * | 2004-12-29 | 2006-07-13 | Hexal Ag | Kunststoff-Flasche für Oxaliplatin |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| AU2005329764B2 (en) * | 2005-03-28 | 2010-08-12 | Dabur Pharma Ltd. | Stable pharmaceutical compositions of platinum (II) antitumour agents |
| WO2006124413A2 (fr) * | 2005-05-13 | 2006-11-23 | Novartis Ag | Procedes pour traiter un cancer pharmacoresistant |
| DE102005038347A1 (de) * | 2005-08-11 | 2007-02-15 | Hexal Ag | Herstellung einer Oxaliplatin-Lösung und Behälter sowie Behälter-Set mit der Lösung |
| WO2007029268A2 (fr) * | 2005-09-05 | 2007-03-15 | Dabur Pharma Limited | Formulation stable d'oxaliplatine |
| MY148529A (en) * | 2005-11-29 | 2013-04-30 | Novartis Ag | Formulations of quinolinones |
| US20090076139A1 (en) * | 2007-09-19 | 2009-03-19 | Protia, Llc | Deuterium-enriched oxalplatin |
| EP2152239A1 (fr) | 2007-11-12 | 2010-02-17 | Intas Pharmaceuticals Limited | Composition d'oxaliplatine stable pour une administration parentérale |
| EP2259776A4 (fr) * | 2008-02-29 | 2011-03-16 | Eagle Pharmaceuticals Inc | Solutions de topotécan prêtes à l'emploi |
| TW201021855A (en) * | 2008-11-13 | 2010-06-16 | Taigen Biotechnology Co Ltd | Lyophilization formulation |
| RU2563997C2 (ru) * | 2009-09-21 | 2015-09-27 | Джей ДаблЮ ФАРМАСЬЮТИКАЛ КОРПОРЭЙШН | Наночастицы оксалиплатина и способ их получения |
| WO2012006101A2 (fr) | 2010-06-28 | 2012-01-12 | The General Hospital Corporation | Substituts sanguins et utilisations associées |
| CN102274171A (zh) * | 2011-08-04 | 2011-12-14 | 上海希迪制药有限公司 | 一种奥沙利铂注射剂 |
| MX363455B (es) | 2012-07-18 | 2019-03-25 | Onyx Therapeutics Inc | Composiciones liposómicas de inhibidores de proteasoma basadas en epoxicetona. |
| JP5929607B2 (ja) * | 2012-08-06 | 2016-06-08 | ニプロ株式会社 | オキサリプラチン製剤 |
| CN102885765B (zh) * | 2012-10-25 | 2013-11-06 | 哈药集团生物工程有限公司 | 一种盐酸伊立替康注射液及其制备方法 |
| US10098813B2 (en) | 2014-09-03 | 2018-10-16 | Sun Pharmaceutical Industries Limited | Perfusion dosage form |
| KR101683635B1 (ko) * | 2014-12-29 | 2016-12-09 | 가천대학교 산학협력단 | 락테이트 금속염을 포함하는 암 치료용 약학 조성물 |
| KR102293907B1 (ko) | 2015-06-30 | 2021-08-26 | 한미약품 주식회사 | 이리노테칸 함유 경구용 고형제제 및 그 제조방법 |
| US11554207B2 (en) | 2016-02-09 | 2023-01-17 | Sun Pharmaceutical Industries Ltd. | Perfusion system |
| JP2020500020A (ja) | 2016-11-14 | 2020-01-09 | ノバルティス アーゲー | 融合誘導性タンパク質ｍｉｎｉｏｎに関連する組成物、方法、および治療上の使用 |
| US10751365B2 (en) | 2018-01-12 | 2020-08-25 | Metimedi Pharmaceuticals Co., Ltd. | Methods of treating chronic inflammatory diseases |
| KR101998246B1 (ko) | 2018-08-22 | 2019-07-10 | 주식회사 메타파인즈 | 금속이온에 결합된 이온화합물을 포함하는 암 치료용 약학 조성물 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6041077B2 (ja) | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体 |
| US5041578A (en) * | 1988-11-22 | 1991-08-20 | Board Of Regents, The University Of Texas System | Water soluble 1,2-diaminocyclohexane platinum (IV) complexes as antitumor agents |
| CA2123321C (fr) | 1991-11-15 | 2003-09-30 | Randall Keith Johnson | Chimiotherapie d'association |
| JPH0776230B2 (ja) | 1992-01-13 | 1995-08-16 | 田中貴金属工業株式会社 | 白金化合物の製造方法 |
| JP2673331B2 (ja) | 1993-01-12 | 1997-11-05 | 田中貴金属工業 株式会社 | 光学的に高純度なシス―オキザラート（トランス―１―１，２―シクロヘキサンジアミン）白金（▲ｉｉ▼） |
| JPH06287021A (ja) | 1992-04-22 | 1994-10-11 | Tanaka Kikinzoku Kogyo Kk | 光学活性な白金錯化合物の光学的分割方法 |
| WO1994012193A1 (fr) | 1992-11-24 | 1994-06-09 | Debiopharm S.A. | Combinaison de cisplatine avec l'oxaliplatine |
| EP0835657B1 (fr) * | 1992-11-27 | 2004-08-25 | Mayne Pharma (USA) Inc. | Composition injectable stable de paclitaxel |
| JP3025602B2 (ja) | 1993-05-21 | 2000-03-27 | デビオファーム エス．アー． | 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法 |
| US5455270A (en) * | 1993-08-11 | 1995-10-03 | Bristol-Myers Squibb Co. | Stabilized solutions of platinum(II) antitumor agents |
| UA42779C2 (uk) | 1994-08-08 | 2001-11-15 | Дебіофарм С.А. | Фармацевтично стійкий препарат оксалату платини для парентерального застосування |
| ES2206478T3 (es) | 1994-11-11 | 2004-05-16 | Debiopharm S.A. | Composiciones carcinostaticas que contienen cis-oxaliplatino y otra u otras sustancias carcinostaticas compatibles. |
| US5919816A (en) | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| AU4842996A (en) * | 1995-02-28 | 1996-09-18 | Yoshinori Kidani | Novel platinum (iv) complexes, process for producing the same, and carcinostatic agents containing the same |
| US5776959A (en) | 1995-06-05 | 1998-07-07 | Washington University | Anticonvulsant and anxiolytic lactam and thiolactam derivatives |
| WO1997033894A1 (fr) * | 1996-03-11 | 1997-09-18 | Debiopharm Sa | Complexes de platine dinucleaires, procede pour leur preparation et compositions pharmaceutiques en contenant |
| JP3154399B2 (ja) | 1996-07-04 | 2001-04-09 | デビオファーム エス．アー． | 白金化合物の製造方法 |
| ES2208946T3 (es) | 1996-08-23 | 2004-06-16 | Sequus Pharmaceuticals, Inc. | Liposomas que contienen un compuesto de cisplatino. |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| CA2279279C (fr) | 1997-02-05 | 2008-10-14 | Pharmacia & Upjohn Company | Complexes de lipides et liposomes a base de complexes de platine fortement insolubles |
| DK1014990T3 (da) | 1997-03-07 | 2006-12-11 | Sanofi Aventis Us Llc | Antitumorkombination af 3 amino-1,2,4 benzotriazin-1,4 dioxid/paclitaxel/platin |
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| GB9804013D0 (en) * | 1998-02-25 | 1998-04-22 | Sanofi Sa | Formulations |
| MXPA01003799A (es) | 1998-10-14 | 2003-06-09 | Debiopharm Sa | Empaque para preparacion de oxaliplatino. |
| WO2001015691A1 (fr) | 1999-08-30 | 2001-03-08 | Debiopharm S.A. | Preparation pharmaceutique stable d'oxaliplatine pour administration par voie parenterale |
| WO2001066102A2 (fr) | 2000-03-08 | 2001-09-13 | Bristol-Myers Squibb Company | Forme posologique orale d'administration de la combinaison de tegafur, uracile, acide folique et oxaliplatine et procede d'utilisation correspondant |
| SE0003026D0 (sv) * | 2000-08-25 | 2000-08-25 | Kerstin Sunnerheim | Use for conifer sapling protection |
-
2001
- 2001-12-06 US US10/010,122 patent/US6476068B1/en not_active Expired - Fee Related
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2002
- 2002-08-22 US US10/225,607 patent/US6673805B2/en not_active Expired - Fee Related
- 2002-11-15 US US10/295,799 patent/US20030109515A1/en not_active Abandoned
- 2002-11-22 JP JP2003548842A patent/JP2005515202A/ja not_active Withdrawn
- 2002-11-22 ES ES02787779T patent/ES2258661T3/es not_active Expired - Lifetime
- 2002-11-22 DK DK02787779T patent/DK1453517T3/da active
- 2002-11-22 KR KR1020047008709A patent/KR100941210B1/ko not_active IP Right Cessation
- 2002-11-22 CA CA002468916A patent/CA2468916C/fr not_active Expired - Fee Related
- 2002-11-22 PT PT02787779T patent/PT1453517E/pt unknown
- 2002-11-22 OA OA1200400165A patent/OA12739A/en unknown
- 2002-11-22 WO PCT/EP2002/013146 patent/WO2003047587A1/fr active IP Right Grant
- 2002-11-22 AU AU2002352105A patent/AU2002352105B2/en not_active Ceased
- 2002-11-22 EA EA200400777A patent/EA008090B1/ru not_active IP Right Cessation
- 2002-11-22 AP APAP/P/2004/003055A patent/AP1760A/en active
- 2002-11-22 MX MXPA04005423A patent/MXPA04005423A/es active IP Right Grant
- 2002-11-22 UA UA20040705324A patent/UA77728C2/uk unknown
- 2002-11-22 ME MEP-104/08A patent/MEP10408A/xx unknown
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- 2002-11-22 CN CNB028268431A patent/CN100540006C/zh not_active Expired - Fee Related
- 2002-11-22 IL IL16234802A patent/IL162348A0/xx unknown
- 2002-11-22 HU HU0402217A patent/HUP0402217A3/hu unknown
- 2002-11-22 GE GE5607A patent/GEP20063895B/en unknown
- 2002-11-22 EP EP02787779A patent/EP1453517B1/fr not_active Expired - Lifetime
- 2002-11-22 AT AT02787779T patent/ATE317260T1/de active
- 2002-11-22 PL PL370254A patent/PL206755B1/pl not_active IP Right Cessation
- 2002-11-22 NZ NZ533383A patent/NZ533383A/en not_active IP Right Cessation
- 2002-11-22 SI SI200220035A patent/SI21493A/sl not_active IP Right Cessation
- 2002-11-22 BR BR0214757-2A patent/BR0214757A/pt not_active IP Right Cessation
- 2002-11-22 DE DE60209145T patent/DE60209145T2/de not_active Expired - Lifetime
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- 2002-12-04 MY MYPI20024553A patent/MY134422A/en unknown
- 2002-12-04 AR ARP020104679A patent/AR037629A1/es unknown
- 2002-12-05 TW TW091135278A patent/TW200409640A/zh unknown
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2004
- 2004-06-03 IL IL162348A patent/IL162348A/en not_active IP Right Cessation
- 2004-06-03 IS IS7298A patent/IS2580B/is unknown
- 2004-06-04 CR CR7362A patent/CR7362A/es not_active Application Discontinuation
- 2004-06-04 MA MA27715A patent/MA27153A1/fr unknown
- 2004-06-04 TN TNP2004000104A patent/TNSN04104A1/fr unknown
- 2004-06-04 EC EC2004005140A patent/ECSP045140A/es unknown
- 2004-06-07 CO CO04053199A patent/CO5580776A2/es not_active Application Discontinuation
- 2004-06-07 HR HR20040514A patent/HRP20040514A2/hr not_active Application Discontinuation
- 2004-06-08 ZA ZA200404525A patent/ZA200404525B/en unknown
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