ZA200306731B - Metalloproteinase inhibitors. - Google Patents

Metalloproteinase inhibitors. Download PDF

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Publication number
ZA200306731B
ZA200306731B ZA200306731A ZA200306731A ZA200306731B ZA 200306731 B ZA200306731 B ZA 200306731B ZA 200306731 A ZA200306731 A ZA 200306731A ZA 200306731 A ZA200306731 A ZA 200306731A ZA 200306731 B ZA200306731 B ZA 200306731B
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ZA
South Africa
Prior art keywords
alkyl
ring
heteroaryl
aryl
compound
Prior art date
Application number
ZA200306731A
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English (en)
Inventor
Anders Eriksson
Michael Lundkvist
Pavol Zlatoidsky
Matti Lepistoe
Magnus Munck Af Rosenschoeld
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA200306731B publication Critical patent/ZA200306731B/en

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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ZA200306731A 2001-03-15 2003-08-28 Metalloproteinase inhibitors. ZA200306731B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0100902A SE0100902D0 (sv) 2001-03-15 2001-03-15 Compounds

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ZA200306731A ZA200306731B (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors.
ZA200306732A ZA200306732B (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors.
ZA200306737A ZA200306737B (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors.
ZA200306734A ZA200306734B (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors.

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ZA200306732A ZA200306732B (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors.
ZA200306737A ZA200306737B (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors.
ZA200306734A ZA200306734B (en) 2001-03-15 2003-08-28 Metalloproteinase inhibitors.

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US (8) US7368465B2 (fr)
EP (4) EP1370534A1 (fr)
JP (4) JP2004527515A (fr)
KR (4) KR100879905B1 (fr)
CN (5) CN1962641B (fr)
AR (2) AR035695A1 (fr)
AT (3) ATE333454T1 (fr)
AU (2) AU2002237626B2 (fr)
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DE (3) DE60238794D1 (fr)
DK (1) DK1370556T3 (fr)
EE (3) EE05431B1 (fr)
ES (3) ES2357138T3 (fr)
HK (3) HK1059932A1 (fr)
HU (3) HUP0400327A3 (fr)
IL (5) IL157652A0 (fr)
IS (3) IS6943A (fr)
MX (3) MXPA03008191A (fr)
MY (2) MY136141A (fr)
NO (3) NO326087B1 (fr)
NZ (3) NZ528107A (fr)
PL (3) PL364707A1 (fr)
PT (1) PT1370556E (fr)
RU (3) RU2293729C2 (fr)
SE (1) SE0100902D0 (fr)
SI (1) SI1370556T1 (fr)
SK (3) SK287834B6 (fr)
UA (3) UA78502C2 (fr)
WO (3) WO2002074751A1 (fr)
ZA (4) ZA200306731B (fr)

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SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0100903D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
DE60234028D1 (de) 2001-05-25 2009-11-26 Bristol Myers Squibb Co Hydantion-derivate als hemmer von matrix-metalloproteinasen
SE0103710D0 (sv) * 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
DE10221018A1 (de) * 2002-05-11 2003-11-27 Boehringer Ingelheim Pharma Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie
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MY136789A (en) 2008-11-28
CN1509272A (zh) 2004-06-30
NO326087B1 (no) 2008-09-15
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PT1370556E (pt) 2006-11-30
UA78502C2 (en) 2007-04-10
CY1107525T1 (el) 2013-03-13
HUP0400202A2 (hu) 2004-08-30
CA2440473A1 (fr) 2002-09-26
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EE200300449A (et) 2003-12-15
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IL157652A (en) 2010-11-30
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US7427631B2 (en) 2008-09-23
EP1370534A1 (fr) 2003-12-17
EP1676846A3 (fr) 2006-07-26
KR20030082989A (ko) 2003-10-23
EP1370556B1 (fr) 2006-07-19
NZ528140A (en) 2005-02-25
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SK287766B6 (sk) 2011-09-05
UA77667C2 (en) 2007-01-15
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CZ20032499A3 (cs) 2004-03-17
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CZ20032497A3 (cs) 2004-02-18
JP2004527515A (ja) 2004-09-09
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CA2440630C (fr) 2011-09-27
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EP1370556A1 (fr) 2003-12-17

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