CA2356689A1 - Derives de 1-carboxymethyl-2-oxo-azepan utilises comme inhibiteurs selectifs de mmp-12 - Google Patents

Derives de 1-carboxymethyl-2-oxo-azepan utilises comme inhibiteurs selectifs de mmp-12 Download PDF

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Publication number
CA2356689A1
CA2356689A1 CA002356689A CA2356689A CA2356689A1 CA 2356689 A1 CA2356689 A1 CA 2356689A1 CA 002356689 A CA002356689 A CA 002356689A CA 2356689 A CA2356689 A CA 2356689A CA 2356689 A1 CA2356689 A1 CA 2356689A1
Authority
CA
Canada
Prior art keywords
group
alkyl
compound
hydrogen
mmp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002356689A
Other languages
English (en)
Inventor
Michael J. Janusz
Alan M. Warshawsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2356689A1 publication Critical patent/CA2356689A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2

Abstract

Cette invention a trait à certains nouveaux dérivés de 1-carboxyméthyl-2-oxo-azepan, correspondant à la formule (1), utilisés comme inhibiteurs de métalloprotéinases matricielles (MMP). Elle porte également sur des compositions pharmaceutiques renfermant ces composés ainsi que sur des méthodes de traitement de divers états pathologiques réagissant à l'inhibition de la métalloprotéinase matricielle.
CA002356689A 1998-12-31 1999-11-12 Derives de 1-carboxymethyl-2-oxo-azepan utilises comme inhibiteurs selectifs de mmp-12 Abandoned CA2356689A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22445798A 1998-12-31 1998-12-31
US09/224,457 1998-12-31
PCT/US1999/026748 WO2000040577A1 (fr) 1998-12-31 1999-11-12 Derives de 1-carboxymethyl-2-oxo-azepan utilises comme inhibiteurs selectifs de mmp-12

Publications (1)

Publication Number Publication Date
CA2356689A1 true CA2356689A1 (fr) 2000-07-13

Family

ID=22840777

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002356689A Abandoned CA2356689A1 (fr) 1998-12-31 1999-11-12 Derives de 1-carboxymethyl-2-oxo-azepan utilises comme inhibiteurs selectifs de mmp-12

Country Status (4)

Country Link
EP (1) EP1150975A1 (fr)
AU (1) AU1817700A (fr)
CA (1) CA2356689A1 (fr)
WO (1) WO2000040577A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
BR0208105A (pt) * 2001-03-15 2004-03-09 Astrazeneca Ab Inibidores de metaloproteinase
SE0100903D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0103710D0 (sv) 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SI1789036T1 (sl) 2004-08-19 2011-09-30 Quest Pharmaceutical Services 5-(3-(4-benziloksifeniltio)-fur-2-il)-imidazolidin-2, 4-dion in analogi kot inhibitorji elastaze makrofaga
SE0403086D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
US10851089B2 (en) 2018-05-15 2020-12-01 Foresee Pharmaceuticals Co., Ltd. Matrix metalloproteinase (MMP) inhibitors and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL129035A0 (en) * 1996-09-19 2000-02-17 Hoechst Marion Roussel Inc 3-Mercaptoacetylamino-1,5-substituted-2-oxo- azepan derivatives useful as inhibitors of matrix metalloproteinase

Also Published As

Publication number Publication date
WO2000040577A1 (fr) 2000-07-13
EP1150975A1 (fr) 2001-11-07
AU1817700A (en) 2000-07-24

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued