ZA200207030B - O-aryl glucoside SGLT2 inhibitors and method. - Google Patents
O-aryl glucoside SGLT2 inhibitors and method. Download PDFInfo
- Publication number
- ZA200207030B ZA200207030B ZA200207030A ZA200207030A ZA200207030B ZA 200207030 B ZA200207030 B ZA 200207030B ZA 200207030 A ZA200207030 A ZA 200207030A ZA 200207030 A ZA200207030 A ZA 200207030A ZA 200207030 B ZA200207030 B ZA 200207030B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- inhibitor
- alkyl
- combination
- composition
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 20
- 229940123518 Sodium/glucose cotransporter 2 inhibitor Drugs 0.000 title claims description 11
- 229930182478 glucoside Natural products 0.000 title description 6
- 150000001875 compounds Chemical class 0.000 claims description 95
- -1 CFs Chemical group 0.000 claims description 53
- 125000000217 alkyl group Chemical group 0.000 claims description 43
- 125000003118 aryl group Chemical group 0.000 claims description 35
- 229910052739 hydrogen Inorganic materials 0.000 claims description 28
- 239000001257 hydrogen Substances 0.000 claims description 23
- 206010012601 diabetes mellitus Diseases 0.000 claims description 19
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 18
- 125000001072 heteroaryl group Chemical group 0.000 claims description 18
- 239000003112 inhibitor Substances 0.000 claims description 15
- 125000005842 heteroatom Chemical group 0.000 claims description 14
- 150000002431 hydrogen Chemical class 0.000 claims description 14
- 239000003472 antidiabetic agent Substances 0.000 claims description 13
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 13
- 229910052736 halogen Inorganic materials 0.000 claims description 13
- 150000002367 halogens Chemical class 0.000 claims description 13
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 10
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- BOVGTQGAOIONJV-BETUJISGSA-N 1-[(3ar,6as)-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-2-yl]-3-(4-methylphenyl)sulfonylurea Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1C[C@H]2CCC[C@H]2C1 BOVGTQGAOIONJV-BETUJISGSA-N 0.000 claims 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19309400P | 2000-03-30 | 2000-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200207030B true ZA200207030B (en) | 2003-12-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200207030A ZA200207030B (en) | 2000-03-30 | 2002-09-02 | O-aryl glucoside SGLT2 inhibitors and method. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6683056B2 (zh) |
| EP (1) | EP1268502B1 (zh) |
| JP (1) | JP4986202B2 (zh) |
| KR (1) | KR100798203B1 (zh) |
| CN (1) | CN1275977C (zh) |
| AT (1) | ATE316976T1 (zh) |
| AU (2) | AU4959801A (zh) |
| BR (1) | BR0109326A (zh) |
| CA (1) | CA2404373A1 (zh) |
| DE (1) | DE60117012T2 (zh) |
| ES (1) | ES2258079T3 (zh) |
| HK (1) | HK1049168A1 (zh) |
| HU (1) | HUP0301513A3 (zh) |
| IL (1) | IL151473A0 (zh) |
| MX (1) | MXPA02009522A (zh) |
| NO (1) | NO20024642L (zh) |
| NZ (1) | NZ520822A (zh) |
| PL (1) | PL365176A1 (zh) |
| RU (1) | RU2269540C2 (zh) |
| WO (1) | WO2001074834A1 (zh) |
| ZA (1) | ZA200207030B (zh) |
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| JPS61233621A (ja) * | 1985-04-10 | 1986-10-17 | Agency Of Ind Science & Technol | 肥満細胞脱顆粒抑制剤 |
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| JP3065235B2 (ja) | 1995-11-07 | 2000-07-17 | 田辺製薬株式会社 | プロピオフェノン誘導体およびその製法 |
| JP3006513B2 (ja) | 1995-11-07 | 2000-02-07 | 田辺製薬株式会社 | 医薬組成物 |
| JP3034192B2 (ja) | 1995-11-07 | 2000-04-17 | 田辺製薬株式会社 | プロピオフェノン誘導体およびその製法 |
| DE19615576A1 (de) * | 1996-04-19 | 1997-10-23 | Beiersdorf Ag | Verfahren zur Herstellung von Mono- und/oder Diglucosiden des Glabridins und deren Verwendung als antiirritativer Wirkstoff in kosmetischen und topischen dermatologischen Zubereitungen |
| PT850948E (pt) | 1996-12-26 | 2002-08-30 | Tanabe Seiyaku Co | Derivados propiofenona e processo para a preparacao dos mesmos |
| WO1998031697A1 (en) | 1997-01-15 | 1998-07-23 | Sankyo Company, Limited | Aryl c-glycoside compounds and sulfated esters thereof |
| JPH10245391A (ja) | 1997-03-03 | 1998-09-14 | Dainippon Ink & Chem Inc | ７−グリコシロキシベンゾピラン誘導体を有効成分とする糖尿病治療剤 |
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| NZ521369A (en) * | 2000-03-17 | 2004-07-30 | Kissei Pharmaceutical | Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives |
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- 2001-03-29 EP EP01922840A patent/EP1268502B1/en not_active Expired - Lifetime
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- 2001-03-29 CA CA002404373A patent/CA2404373A1/en not_active Abandoned
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| CN1275977C (zh) | 2006-09-20 |
| CA2404373A1 (en) | 2001-10-11 |
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| CN1437608A (zh) | 2003-08-20 |
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| HUP0301513A3 (en) | 2007-05-29 |
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| AU2001249598B2 (en) | 2006-09-07 |
| JP4986202B2 (ja) | 2012-07-25 |
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| HUP0301513A2 (hu) | 2003-09-29 |
| ATE316976T1 (de) | 2006-02-15 |
| US20020111315A1 (en) | 2002-08-15 |
| BR0109326A (pt) | 2004-03-30 |
| DE60117012T2 (de) | 2006-08-31 |
| ES2258079T3 (es) | 2006-08-16 |
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