ZA200203204B - Substituted indoles for modulating NFKB activity. - Google Patents
Substituted indoles for modulating NFKB activity. Download PDFInfo
- Publication number
- ZA200203204B ZA200203204B ZA200203204A ZA200203204A ZA200203204B ZA 200203204 B ZA200203204 B ZA 200203204B ZA 200203204 A ZA200203204 A ZA 200203204A ZA 200203204 A ZA200203204 A ZA 200203204A ZA 200203204 B ZA200203204 B ZA 200203204B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- unsubstituted
- formula
- heteroaryl
- heterocycle
- Prior art date
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- 230000000694 effects Effects 0.000 title claims 2
- 150000002475 indoles Chemical class 0.000 title description 4
- -1 phenyiglycine Chemical compound 0.000 claims description 92
- 125000000623 heterocyclic group Chemical group 0.000 claims description 60
- 125000001072 heteroaryl group Chemical group 0.000 claims description 48
- 150000003254 radicals Chemical group 0.000 claims description 48
- 125000003118 aryl group Chemical group 0.000 claims description 45
- 229910052736 halogen Inorganic materials 0.000 claims description 35
- 150000002367 halogens Chemical class 0.000 claims description 34
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 29
- 229910052739 hydrogen Inorganic materials 0.000 claims description 28
- 239000001257 hydrogen Substances 0.000 claims description 28
- 229910052757 nitrogen Inorganic materials 0.000 claims description 28
- 229910052717 sulfur Inorganic materials 0.000 claims description 28
- 150000001875 compounds Chemical class 0.000 claims description 27
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 27
- 125000000217 alkyl group Chemical group 0.000 claims description 23
- 125000001424 substituent group Chemical group 0.000 claims description 23
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- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 21
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 20
- 125000004434 sulfur atom Chemical group 0.000 claims description 20
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Natural products C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims description 18
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 18
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 18
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 17
- 125000004432 carbon atom Chemical group C* 0.000 claims description 17
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 17
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 17
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 15
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 14
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 14
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims description 14
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 11
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- 125000004122 cyclic group Chemical group 0.000 claims description 8
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- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 5
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- 238000002560 therapeutic procedure Methods 0.000 claims description 5
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- 238000011275 oncology therapy Methods 0.000 description 1
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- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
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- 108060006633 protein kinase Proteins 0.000 description 1
- 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 description 1
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- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 description 1
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Classifications
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19951360A DE19951360A1 (de) | 1999-10-26 | 1999-10-26 | Substituierte Indole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200203204B true ZA200203204B (en) | 2002-10-23 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| ZA200203204A ZA200203204B (en) | 1999-10-26 | 2002-04-23 | Substituted indoles for modulating NFKB activity. |
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| US (3) | US20030119820A1 (ja) |
| EP (1) | EP1261601B1 (ja) |
| JP (1) | JP3843012B2 (ja) |
| KR (1) | KR100795709B1 (ja) |
| CN (1) | CN1172929C (ja) |
| AT (1) | ATE437867T1 (ja) |
| AU (1) | AU781553B2 (ja) |
| BR (1) | BR0015026B1 (ja) |
| CA (1) | CA2389165C (ja) |
| CY (1) | CY1110521T1 (ja) |
| CZ (1) | CZ304885B6 (ja) |
| DE (2) | DE19951360A1 (ja) |
| DK (1) | DK1261601T3 (ja) |
| EE (1) | EE05036B1 (ja) |
| ES (1) | ES2329871T3 (ja) |
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| HR (1) | HRP20020357B1 (ja) |
| HU (1) | HU229215B1 (ja) |
| IL (2) | IL149272A0 (ja) |
| ME (1) | ME00434B (ja) |
| MX (1) | MXPA02003998A (ja) |
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| NZ (1) | NZ518587A (ja) |
| PL (1) | PL200115B1 (ja) |
| PT (1) | PT1261601E (ja) |
| RS (1) | RS50424B (ja) |
| RU (1) | RU2255087C2 (ja) |
| SI (1) | SI1261601T1 (ja) |
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| WO (1) | WO2001030774A1 (ja) |
| ZA (1) | ZA200203204B (ja) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2699568C (en) | 1999-12-24 | 2013-03-12 | Aventis Pharma Limited | Azaindoles |
| CA2427284A1 (en) * | 2000-10-26 | 2002-05-30 | Tularik Inc. | Antiinflammation agents |
| GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| EP1417200B1 (en) * | 2001-08-13 | 2010-06-02 | E.I. Du Pont De Nemours And Company | Substituted 1h-dihydropyrazoles, their preparation and use |
| WO2003039545A2 (en) * | 2001-11-07 | 2003-05-15 | Millennium Pharmaceuticals, Inc. | Carboline derivatives as inhibitors of ikb in the treatment of multiple myeloma and others cancers |
| US7176314B2 (en) | 2001-12-05 | 2007-02-13 | Amgen, Inc. | Inflammation modulators |
| MXPA04006614A (es) | 2002-01-07 | 2004-10-04 | Eisai Co Ltd | Deazapurinas y usos de las mismas. |
| ME00355B (me) | 2002-06-06 | 2010-06-30 | Ptp Group Ltd | Kristalisan polietilen tereftalat, koji sadrži silicijum, i postupak za njegovo dobijanje |
| US6974870B2 (en) | 2002-06-06 | 2005-12-13 | Boehringer Ingelheim Phamaceuticals, Inc. | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
| DE10237723A1 (de) * | 2002-08-17 | 2004-07-08 | Aventis Pharma Deutschland Gmbh | Verwendung von IKappaB-Kinase Inhibitoren in der Schmerztherapie |
| US7462638B2 (en) * | 2002-08-17 | 2008-12-09 | Sanofi-Aventis Deutschland Gmbh | Use of IκB-kinase inhibitors in pain therapy |
| DE10237722A1 (de) | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| CA2502429A1 (en) | 2002-10-31 | 2004-05-21 | Amgen Inc. | Antiinflammation agents |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| EP1462105A1 (en) * | 2003-03-28 | 2004-09-29 | Procorde GmbH | Activation specific inhibitors of NF-kB and method of treating inflammatory processes in cardio-vascular diseases |
| MXPA05010793A (es) * | 2003-04-09 | 2005-12-05 | Millennium Pharm Inc | Beta-carbolinas utiles para tratar enfermedades inflamatorias. |
| US20050004164A1 (en) * | 2003-04-30 | 2005-01-06 | Caggiano Thomas J. | 2-Cyanopropanoic acid amide and ester derivatives and methods of their use |
| DK1718608T3 (da) | 2004-02-20 | 2013-10-14 | Boehringer Ingelheim Int | Virale polymeraseinhibitorer |
| US7951801B2 (en) | 2004-04-09 | 2011-05-31 | Millennium Pharmaceuticals, Inc. | Beta-carbolines useful for treating inflammatory disease |
| US7425580B2 (en) | 2004-05-19 | 2008-09-16 | Wyeth | (Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands |
| PE20060373A1 (es) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
| PE20060748A1 (es) | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
| DE102005025225A1 (de) | 2005-06-01 | 2006-12-07 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von 2-(2-Amino-pyrimidin-4-yl)-1H-indol-5-carbonsäure-derivaten |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| UA99699C2 (ru) | 2005-06-30 | 2012-09-25 | Смитклайн Бичам Корпорейшн | Производные индолкарбоксамида и фармацевтическая композиция, которая их содержит |
| US8076365B2 (en) | 2005-08-12 | 2011-12-13 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| JP2009001495A (ja) * | 2005-10-13 | 2009-01-08 | Taisho Pharmaceutical Co Ltd | ２−アリール−ベンゾイミダゾール−５−カルボキサミド誘導体 |
| US7592353B2 (en) | 2006-06-06 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
| WO2008017381A1 (de) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| DK2119703T3 (da) * | 2007-01-15 | 2013-01-14 | Santen Pharmaceutical Co Ltd | Nyt indolderivat med inhiberende virkning på I-B-kinase. |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| CA2721927C (en) | 2008-04-21 | 2014-01-28 | Otonomy, Inc. | Auris formulations for treating otic diseases and conditions |
| EP2310372B1 (en) | 2008-07-09 | 2012-05-23 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| EP2314575B1 (en) * | 2008-07-14 | 2013-06-19 | Santen Pharmaceutical Co., Ltd | Novel indole derivative having carbamoyl group, ureido group and substituted oxy group |
| MD4009C2 (ro) * | 2008-07-15 | 2010-08-31 | Институт Химии Академии Наук Молдовы | Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos |
| WO2010038465A1 (ja) | 2008-10-02 | 2010-04-08 | 旭化成ファーマ株式会社 | ８位置換イソキノリン誘導体及びその用途 |
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| CN102584842A (zh) * | 2011-01-17 | 2012-07-18 | 北京大学 | 取代吲哚并内酰胺衍生物的制备及作为抗疟疾剂的用途 |
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| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
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| ATE188379T1 (de) * | 1992-10-14 | 2000-01-15 | Merck & Co Inc | Fibrinogenrezeptor-antagonisten |
| GB9225141D0 (en) * | 1992-12-01 | 1993-01-20 | Smithkline Beecham Corp | Chemical compounds |
| JP3213426B2 (ja) * | 1993-02-19 | 2001-10-02 | エーザイ株式会社 | ６，７−ジヒドロ−５Ｈ−シクロペンタ〔ｄ〕ピリミジン誘導体 |
| IT1271352B (it) * | 1993-04-08 | 1997-05-27 | Boehringer Ingelheim Italia | Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale |
| GB9605065D0 (en) * | 1996-03-11 | 1996-05-08 | Merck Sharp & Dohme | Therapeutic agents |
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| ATE264318T1 (de) * | 1996-11-19 | 2004-04-15 | Amgen Inc | Aryl und heteroaryl substituierte kondensierte pyrrole als entzündunghemmende mittel |
| RU2212407C2 (ru) * | 1997-11-10 | 2003-09-20 | Бристол-Маерс Сквибб Компани | Бензотиазольные ингибиторы протеинтирозинкиназ |
| CA2322162A1 (en) | 1998-02-25 | 1999-09-02 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| BR0012450B1 (pt) * | 1999-06-23 | 2011-08-23 | benzimidazóis substituìdos. | |
| DE10237722A1 (de) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| US7462638B2 (en) * | 2002-08-17 | 2008-12-09 | Sanofi-Aventis Deutschland Gmbh | Use of IκB-kinase inhibitors in pain therapy |
| RU2006143758A (ru) | 2004-05-12 | 2008-06-27 | Авентис Фармасьютикалз Инк. (Us) | По существу чистая 2-{[2-(2-метиламинопиримидин-4-ил)-1н-индол-5-карбонил]-амино}-3-(фенилпиридин-2-иламино)-пропионовая кислота в качестве ингибитора 1кв киназы |
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1999
- 1999-10-26 DE DE19951360A patent/DE19951360A1/de not_active Withdrawn
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2000
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- 2000-10-17 DE DE50015700T patent/DE50015700D1/de not_active Expired - Lifetime
- 2000-10-17 JP JP2001533128A patent/JP3843012B2/ja not_active Expired - Fee Related
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- 2000-10-17 PL PL354528A patent/PL200115B1/pl unknown
- 2000-10-17 TR TR2002/01144T patent/TR200201144T2/xx unknown
- 2000-10-17 KR KR1020027005395A patent/KR100795709B1/ko not_active IP Right Cessation
- 2000-10-17 AU AU12728/01A patent/AU781553B2/en not_active Ceased
- 2000-10-17 SK SK543-2002A patent/SK287116B6/sk not_active IP Right Cessation
- 2000-10-17 EP EP00974405A patent/EP1261601B1/de not_active Expired - Lifetime
- 2000-10-17 DK DK00974405T patent/DK1261601T3/da active
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- 2000-10-17 RU RU2002113651/04A patent/RU2255087C2/ru not_active IP Right Cessation
- 2000-10-17 ES ES00974405T patent/ES2329871T3/es not_active Expired - Lifetime
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- 2000-10-17 MX MXPA02003998A patent/MXPA02003998A/es active IP Right Grant
- 2000-10-17 AT AT00974405T patent/ATE437867T1/de active
- 2000-10-17 CZ CZ2002-1413A patent/CZ304885B6/cs not_active IP Right Cessation
- 2000-10-17 WO PCT/EP2000/010210 patent/WO2001030774A1/de active IP Right Grant
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- 2002-10-04 US US10/263,691 patent/US20030119820A1/en not_active Abandoned
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