ZA200200823B - Beta-carboline pharmaceutical compositions. - Google Patents
Beta-carboline pharmaceutical compositions. Download PDFInfo
- Publication number
- ZA200200823B ZA200200823B ZA200200823A ZA200200823A ZA200200823B ZA 200200823 B ZA200200823 B ZA 200200823B ZA 200200823 A ZA200200823 A ZA 200200823A ZA 200200823 A ZA200200823 A ZA 200200823A ZA 200200823 B ZA200200823 B ZA 200200823B
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- ZA
- South Africa
- Prior art keywords
- formulation
- weight
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- present
- active compound
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 10
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical compound N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 title 2
- 239000000203 mixture Substances 0.000 claims description 74
- 238000009472 formulation Methods 0.000 claims description 57
- 150000001875 compounds Chemical class 0.000 claims description 38
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 22
- 239000002245 particle Substances 0.000 claims description 22
- 239000003085 diluting agent Substances 0.000 claims description 14
- 239000011230 binding agent Substances 0.000 claims description 13
- 239000002775 capsule Substances 0.000 claims description 13
- 239000000314 lubricant Substances 0.000 claims description 13
- -1 polyethylene Polymers 0.000 claims description 13
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 12
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 12
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 12
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 12
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 11
- 235000019359 magnesium stearate Nutrition 0.000 claims description 11
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 10
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- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
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- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
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- 238000005070 sampling Methods 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
- 229950004959 sorbitan oleate Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14692499P | 1999-08-03 | 1999-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200200823B true ZA200200823B (en) | 2003-04-30 |
Family
ID=22519593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200200823A ZA200200823B (en) | 1999-08-03 | 2002-01-30 | Beta-carboline pharmaceutical compositions. |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US7182958B1 (de) |
| EP (3) | EP2338491A3 (de) |
| JP (2) | JP2003505509A (de) |
| KR (2) | KR100738861B1 (de) |
| CN (1) | CN1213754C (de) |
| AT (1) | ATE399554T1 (de) |
| AU (2) | AU4491200A (de) |
| BR (1) | BR0012863A (de) |
| CA (1) | CA2379948C (de) |
| CZ (1) | CZ304624B6 (de) |
| DE (1) | DE60039357D1 (de) |
| DK (1) | DK1200090T3 (de) |
| DZ (1) | DZ3179A1 (de) |
| EA (1) | EA004872B1 (de) |
| ES (2) | ES2435816T3 (de) |
| HK (1) | HK1044277B (de) |
| HR (1) | HRP20020090B1 (de) |
| HU (1) | HU230660B1 (de) |
| IL (2) | IL147641A0 (de) |
| MX (1) | MXPA02001196A (de) |
| NO (1) | NO321649B1 (de) |
| NZ (1) | NZ516616A (de) |
| PL (1) | PL199137B1 (de) |
| PT (1) | PT1200090E (de) |
| SI (1) | SI1200090T1 (de) |
| SK (1) | SK287869B6 (de) |
| UA (1) | UA72922C2 (de) |
| WO (2) | WO2001008687A1 (de) |
| ZA (1) | ZA200200823B (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6821975B1 (en) | 1999-08-03 | 2004-11-23 | Lilly Icos Llc | Beta-carboline drug products |
| ES2435816T3 (es) * | 1999-08-03 | 2013-12-23 | Icos Corporation | Formulación farmacéutica que comprende una Beta-carbolina y su uso para el tratamiento de la disfunción sexual |
| US7115621B2 (en) | 2001-04-25 | 2006-10-03 | Lilly Icos Llc | Chemical compounds |
| EP1321142A1 (de) * | 2001-12-21 | 2003-06-25 | Novartis AG | Feste orale Zubereitung mit Tegaserod |
| DE10207160A1 (de) * | 2002-02-20 | 2003-12-18 | Altana Pharma Ag | Darreichungsform enthaltend PDE 4-Hemmer als Wirkstoff |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| GB0209265D0 (en) | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
| AR040588A1 (es) | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
| ME00524B (me) | 2003-03-10 | 2011-10-10 | Astrazeneca Ab | Novi postupak za dobijanje roflumilasta |
| KR100882156B1 (ko) | 2003-08-08 | 2009-02-06 | 아지노모토 가부시키가이샤 | 나테글리니드 함유 제제 |
| CA2601250C (en) * | 2005-03-16 | 2014-10-28 | Nycomed Gmbh | Taste masked dosage form containing roflumilast |
| KR20080047375A (ko) | 2005-07-29 | 2008-05-28 | 콘서트 파마슈티컬즈, 인크. | 약제 화합물 |
| FR2898492B1 (fr) * | 2006-03-15 | 2008-06-06 | Pierre Fabre Medicament Sa | Comprimes orodispersibles de domperidone |
| JP2009542648A (ja) * | 2006-07-07 | 2009-12-03 | テバ ファーマシューティカル インダストリーズ リミティド | タダラフィル及び少なくとも１種の担体を含んでなる固体組成物 |
| EP1923053A1 (de) | 2006-09-27 | 2008-05-21 | Novartis AG | Pharmazeutische Zusammensetzung umfassend Nilotinib oder dessen Salz |
| BRPI0810814A2 (pt) | 2007-04-25 | 2014-10-29 | Teva Pharma | Formas sólidas de dosagem incluindo tadalafil |
| DE102007028869A1 (de) * | 2007-06-22 | 2008-12-24 | Ratiopharm Gmbh | Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil |
| EP2042165A1 (de) * | 2007-09-28 | 2009-04-01 | Swiss Caps Rechte und Lizenzen AG | Hot-Melt-Befüllte Weichkapseln |
| US20090181975A1 (en) * | 2008-01-15 | 2009-07-16 | Forest Laboratories Holdings Limited | Nebivolol in the treatment of sexual dysfunction |
| DE102008047910A1 (de) | 2008-09-19 | 2010-03-25 | Molkerei Meggle Wasserburg Gmbh & Co. Kg | Tablettierhilfsstoff auf Laktose- und Cellulosebasis |
| WO2010099323A1 (en) | 2009-02-26 | 2010-09-02 | Thar Pharmaceuticals, Inc. | Crystalization of pharmaceutical compounds |
| DE102009033396A1 (de) | 2009-07-16 | 2011-01-20 | Ratiopharm Gmbh | Wässrige Lösung und gelatinierte Zusammensetzung umfassend einen Phosphodiesterase-5-Inhibitor sowie diesbezügliche Verfahren und Verwendung |
| DE102009035211A1 (de) | 2009-07-29 | 2011-02-17 | Ratiopharm Gmbh | Copräzipitate umfassend einen Phosphodiesterase-5-Inhibitor (PDE-5-Inhibitor) und einen pharmazeutisch verträglichen Trägerstoff, ihre Herstellung und Verwendung |
| WO2011030351A2 (en) | 2009-09-03 | 2011-03-17 | Rubicon Research Private Limited | Taste - masked pharmaceutical compositions |
| US20110136815A1 (en) * | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
| US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
| EP2517705B1 (de) | 2009-12-21 | 2016-10-19 | Acef S/A | Cubebin als vasodilatator bei der behandlung von erektiler dysfunktion |
| WO2012095151A1 (en) | 2010-12-23 | 2012-07-19 | Zaklady Farmaceutyczne Polpharma Sa | Solid pharmaceutical dosage forms comprising tadalafil and methods of preparation thereof |
| EP2672959A1 (de) | 2011-02-10 | 2013-12-18 | Synthon BV | Granulierte zusammensetzung mit tadalafil und einem sprengmittel |
| WO2012107092A1 (en) | 2011-02-10 | 2012-08-16 | Synthon Bv | Pharmaceutical composition comprising tadalafil and a cyclodextrin |
| WO2012107541A1 (en) | 2011-02-10 | 2012-08-16 | Synthon Bv | Pharmaceutical composition comprising tadalafil and a cyclodextrin |
| EP2535049A1 (de) | 2011-06-17 | 2012-12-19 | Proyecto de Biomedicina Cima, S.L. | Tadalafil zur Behandlung von Demenz |
| WO2014027979A2 (en) | 2012-08-17 | 2014-02-20 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Tablet formulations comprising tadalafil and dapoxetine |
| WO2014027975A2 (en) | 2012-08-17 | 2014-02-20 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Novel orally administered pharmaceutical formulations |
| US20150231092A1 (en) | 2012-08-17 | 2015-08-20 | Sanovell IIac Sanayi Ve Ticaret Anonim Sirketi | Novel effervescent sachet formulations of dapoxetine and a pde5 inhibitor |
| US20150320677A1 (en) | 2012-08-17 | 2015-11-12 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Effervescent tablet formulations of dapoxetine and a pde5 inhibitor |
| WO2014125343A1 (en) * | 2013-02-12 | 2014-08-21 | Alembic Pharmaceuticals Limited | Tadalafil tablet composition with reduced dose strength |
| CN105209025B (zh) | 2013-04-11 | 2019-06-18 | 西梯茜生命工学股份有限公司 | 包括聚乙二醇类聚合物和/或乙烯基吡咯烷酮类聚合物作为分散稳定剂的含他达拉非游离碱的膜剂形式 |
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| GB201402431D0 (en) | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
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| WO2015195812A1 (en) | 2014-06-17 | 2015-12-23 | The Research Foundation For The State University Of New York | Ship inhibition to induce activation of natural killer cells |
| EP2962684A1 (de) | 2014-06-30 | 2016-01-06 | Sanovel Ilac Sanayi ve Ticaret A.S. | Im mund zerfallende formulierungen von tadalafil |
| EP2962685B1 (de) | 2014-06-30 | 2020-01-08 | Montero Gida Sanayi Ve Ticaret A.S. | Im mund zerfallende formulierungen von tadalafil |
| KR101648051B1 (ko) | 2014-09-01 | 2016-08-12 | 주식회사 인트로팜텍 | 타다라필을 포함하는 휴대용 구강붕해정, 및 이의 제조방법 |
| KR101538985B1 (ko) | 2014-09-02 | 2015-07-24 | 주식회사 서울제약 | 타다라필 구강붕해필름 및 이의 제조방법 |
| CN104758941A (zh) * | 2015-04-27 | 2015-07-08 | 浙江永宁药业股份有限公司 | 一种利用羟丙基纤维素为粘合剂实现快速溶出的口服片剂 |
| GB201514758D0 (en) * | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Formulation |
| WO2017104862A1 (ko) * | 2015-12-16 | 2017-06-22 | 동국제약 주식회사 | 타달라필 및 두타스테라이드를 포함하는 복합제제 조성물 및 그 제조방법 |
| KR101716878B1 (ko) * | 2016-05-12 | 2017-03-15 | 주식회사 유유제약 | 글리세롤 지방산에스테르유도체 또는 프로필렌글리콜 지방산에스테르유도체를 함유한 두타스테리드와 타다라필의 복합 캡슐제제 조성물 및 이의 제조방법 |
| CA3046025A1 (en) | 2016-12-14 | 2018-06-21 | Respira Therapeutics, Inc. | Methods and compositions for treatment of pulmonary hypertension and other lung disorders |
| IT201700015145A1 (it) * | 2017-02-10 | 2018-08-10 | Altergon Sa | Capsule di gelatina molle ad elevata stabilità |
| CN106821991A (zh) * | 2017-03-21 | 2017-06-13 | 南京正科医药股份有限公司 | 一种微粒径他达拉非的制备方法 |
| KR102646431B1 (ko) | 2017-09-29 | 2024-03-12 | 한미약품 주식회사 | 생산성 및 균일성이 개선된 타다라필을 함유하는 고형제제 및 그 제조방법 |
| AU2018397436A1 (en) | 2017-12-26 | 2020-08-13 | Ftf Pharma Private Limited | Liquid oral formulations for PDE V inhibitors |
| LT3510997T (lt) | 2018-01-10 | 2021-01-11 | Gap S.A. | Minkšta želatinos kapsulė, apimanti tadalafilio suspensiją |
| US20210137919A1 (en) * | 2018-02-07 | 2021-05-13 | Smawa Gmbh | Pharmaceutical formulations, method for producing a pharmaceutical formulation, and medicament comprising same |
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| WO2023227185A1 (en) | 2022-05-27 | 2023-11-30 | Rontis Hellas S.A. | Improved pharmaceutical composition containing tadalafil and nanomilling process for the preparation thereof |
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| GB8328929D0 (en) | 1983-10-29 | 1983-11-30 | Sterwin Ag | Steroid compounds |
| US4721709A (en) * | 1984-07-26 | 1988-01-26 | Pyare Seth | Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions |
| JPH0347124A (ja) * | 1989-04-20 | 1991-02-28 | Fujisawa Pharmaceut Co Ltd | 経口吸収用製剤 |
| JPH0818985B2 (ja) * | 1989-05-30 | 1996-02-28 | 吉富製薬株式会社 | 溶出性の改良された製剤組成物 |
| US5294615A (en) * | 1993-04-29 | 1994-03-15 | Abbott Laboratories | Terazosin polymorph and pharmaceutical composition |
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-
2000
- 2000-04-26 ES ES00926368T patent/ES2435816T3/es not_active Expired - Lifetime
- 2000-04-26 SI SI200031076T patent/SI1200090T1/sl unknown
- 2000-04-26 PL PL353304A patent/PL199137B1/pl unknown
- 2000-04-26 PT PT926368T patent/PT1200090E/pt unknown
- 2000-04-26 KR KR1020027001406A patent/KR100738861B1/ko active IP Right Review Request
- 2000-04-26 US US10/031,464 patent/US7182958B1/en not_active Expired - Lifetime
- 2000-04-26 WO PCT/US2000/011136 patent/WO2001008687A1/en active Application Filing
- 2000-04-26 DE DE60039357T patent/DE60039357D1/de not_active Expired - Lifetime
- 2000-04-26 CN CNB008110360A patent/CN1213754C/zh not_active Expired - Lifetime
- 2000-04-26 BR BR0012863-5A patent/BR0012863A/pt not_active Application Discontinuation
- 2000-04-26 ES ES00926371T patent/ES2310166T3/es not_active Expired - Lifetime
- 2000-04-26 DZ DZ003179A patent/DZ3179A1/xx active
- 2000-04-26 AT AT00926371T patent/ATE399554T1/de not_active IP Right Cessation
- 2000-04-26 CZ CZ2002-386A patent/CZ304624B6/cs not_active IP Right Cessation
- 2000-04-26 DK DK00926368.2T patent/DK1200090T3/da active
- 2000-04-26 AU AU44912/00A patent/AU4491200A/en not_active Abandoned
- 2000-04-26 NZ NZ516616A patent/NZ516616A/en not_active IP Right Cessation
- 2000-04-26 WO PCT/US2000/011130 patent/WO2001008686A1/en active Search and Examination
- 2000-04-26 US US10/031,531 patent/US6841167B1/en not_active Expired - Lifetime
- 2000-04-26 HU HU0202513A patent/HU230660B1/hu unknown
- 2000-04-26 EP EP10012886A patent/EP2338491A3/de not_active Withdrawn
- 2000-04-26 EA EA200200118A patent/EA004872B1/ru not_active IP Right Cessation
- 2000-04-26 AU AU44909/00A patent/AU776722B2/en not_active Expired
- 2000-04-26 UA UA2002010772A patent/UA72922C2/uk unknown
- 2000-04-26 EP EP00926368.2A patent/EP1200090B1/de not_active Revoked
- 2000-04-26 JP JP2001513416A patent/JP2003505509A/ja active Pending
- 2000-04-26 EP EP00926371A patent/EP1200091B1/de not_active Expired - Lifetime
- 2000-04-26 KR KR1020067015696A patent/KR20060093355A/ko not_active Application Discontinuation
- 2000-04-26 SK SK173-2002A patent/SK287869B6/sk not_active IP Right Cessation
- 2000-04-26 CA CA002379948A patent/CA2379948C/en not_active Expired - Lifetime
- 2000-04-26 MX MXPA02001196A patent/MXPA02001196A/es active IP Right Grant
- 2000-04-26 IL IL14764100A patent/IL147641A0/xx unknown
-
2002
- 2002-01-15 IL IL147641A patent/IL147641A/en not_active IP Right Cessation
- 2002-01-29 HR HRP20020090AA patent/HRP20020090B1/hr not_active IP Right Cessation
- 2002-01-30 ZA ZA200200823A patent/ZA200200823B/en unknown
- 2002-02-01 NO NO20020532A patent/NO321649B1/no not_active IP Right Cessation
- 2002-06-19 HK HK02104539.8A patent/HK1044277B/zh not_active IP Right Cessation
-
2010
- 2010-05-06 JP JP2010106264A patent/JP2010163464A/ja active Pending
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