YU71495A - Selektivno acilovanje e-amino grupa - Google Patents

Selektivno acilovanje e-amino grupa

Info

Publication number
YU71495A
YU71495A YU71495A YU71495A YU71495A YU 71495 A YU71495 A YU 71495A YU 71495 A YU71495 A YU 71495A YU 71495 A YU71495 A YU 71495A YU 71495 A YU71495 A YU 71495A
Authority
YU
Yugoslavia
Prior art keywords
amino group
amino groups
selective acylation
sigma
fatty acid
Prior art date
Application number
YU71495A
Other languages
English (en)
Serbo-Croatian (sh)
Inventor
Jeffrey Clayton Baker
Victor John Chen
Aidas Vladas Kriauciunasm
Brian Alden Moser
Jose Michael Hanquier
Robert Theodore Shuman
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of YU71495A publication Critical patent/YU71495A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
YU71495A 1994-11-17 1995-11-14 Selektivno acilovanje e-amino grupa YU71495A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups

Publications (1)

Publication Number Publication Date
YU71495A true YU71495A (sh) 1998-09-18

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
YU71495A YU71495A (sh) 1994-11-17 1995-11-14 Selektivno acilovanje e-amino grupa

Country Status (27)

Country Link
US (2) US5646242A (en, 2012)
EP (2) EP1227107A1 (en, 2012)
JP (1) JP4312828B2 (en, 2012)
CN (1) CN1171742A (en, 2012)
AR (1) AR003915A1 (en, 2012)
AT (1) ATE328902T1 (en, 2012)
AU (2) AU691066B2 (en, 2012)
BR (1) BR9509652A (en, 2012)
CA (1) CA2205061A1 (en, 2012)
CO (1) CO4520285A1 (en, 2012)
CZ (1) CZ287731B6 (en, 2012)
DE (1) DE69535031T2 (en, 2012)
DK (1) DK0712862T3 (en, 2012)
ES (1) ES2264124T3 (en, 2012)
HU (2) HU217585B (en, 2012)
IL (1) IL115972A (en, 2012)
IN (1) IN179820B (en, 2012)
NO (1) NO972185L (en, 2012)
NZ (1) NZ297256A (en, 2012)
PL (1) PL320556A1 (en, 2012)
PT (1) PT712862E (en, 2012)
RU (1) RU2155773C2 (en, 2012)
SI (1) SI0712862T1 (en, 2012)
TR (1) TR199501421A2 (en, 2012)
WO (1) WO1996015803A1 (en, 2012)
YU (1) YU71495A (en, 2012)
ZA (1) ZA959680B (en, 2012)

Families Citing this family (76)

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US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
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CN1406131A (zh) * 2000-12-25 2003-03-26 株式会社资生堂 活化交感神经的香料组合物
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US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
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US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US20030082671A1 (en) 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
JP2005503141A (ja) * 2001-07-24 2005-02-03 ノボ　ノルディスク　アクティーゼルスカブ アシル化ポリペプチドを作出するための方法
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US7595172B2 (en) * 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
DE60234198D1 (de) 2001-09-07 2009-12-10 Biocon Ltd Verfahren zur synthese von insulinpolypeptid-oligomer-konjugaten und proinsulinpolypeptid-oligomer-konjugaten und verfahren zu deren synthese
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
AU2003236521A1 (en) 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
CN100586926C (zh) * 2002-09-25 2010-02-03 诺沃娜第克公司 制备酰化肽的方法
JP4463814B2 (ja) * 2003-08-05 2010-05-19 ノボ ノルディスク アクティーゼルスカブ 新規のインスリン誘導体
EP1687428A1 (en) 2003-11-14 2006-08-09 Novo Nordisk A/S Processes for making acylated insulin
DK1773878T3 (en) 2004-07-19 2015-05-11 Biocon Ltd Insulin-oligomerkonjugater, formulations and uses thereof
ATE513921T1 (de) 2005-08-16 2011-07-15 Novo Nordisk As Verfahren zur herstellung reifer insulinpolypeptide
JP4808785B2 (ja) * 2005-12-28 2011-11-02 ノボ・ノルデイスク・エー／エス インスリン組成物および組成物の製造方法
JP5202338B2 (ja) * 2006-02-27 2013-06-05 ノボ・ノルデイスク・エー／エス 新規インシュリン誘導体
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CN101573133B (zh) 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素
JP5864834B2 (ja) 2006-09-22 2016-02-17 ノボ・ノルデイスク・エー／エス プロテアーゼ耐性のインスリンアナログ
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AU2008313248B2 (en) 2007-10-16 2012-04-26 Biocon Limited An orally administerable solid pharmaceutical composition and a process thereof
JP5762001B2 (ja) 2008-03-14 2015-08-12 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化インスリンアナログ
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ES2561208T3 (es) 2008-09-12 2016-02-25 Novo Nordisk A/S Método de acilación de un péptido o una proteína
JP4959005B2 (ja) * 2008-10-30 2012-06-20 ノボ・ノルデイスク・エー／エス 毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療
AU2010216385B2 (en) * 2009-02-20 2013-06-20 Ipsen Pharma S.A.S. Analogues of neuropeptide Y having proline substitution at position 34
BR112012012945A2 (pt) 2009-11-25 2020-12-29 Arisgen Sa Composição de liberação mucosal, seu método de produção, complexo de peptídeo pré-formado, kit e uso de um agente ativo de peptídeo
RU2013123515A (ru) 2010-10-27 2014-12-10 Ново Нордиск А/С Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
MX2014012096A (es) 2012-04-11 2014-11-21 Novo Nordisk As Formulaciones de insulina.
EP2991672A1 (en) 2013-04-30 2016-03-09 Novo Nordisk A/S Novel administration regime
JP6499184B2 (ja) 2013-10-07 2019-04-10 ノヴォ ノルディスク アー／エス インスリン類似体の新規な誘導体
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
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Also Published As

Publication number Publication date
CN1171742A (zh) 1998-01-28
EP1227107A1 (en) 2002-07-31
HU217585B (hu) 2000-02-28
EP0712862B1 (en) 2006-06-07
DE69535031D1 (de) 2006-07-20
EP0712862A3 (en) 1998-03-04
WO1996015803A1 (en) 1996-05-30
NZ297256A (en) 2000-01-28
HU9903007D0 (en) 1999-11-29
USRE37971E1 (en) 2003-01-28
DK0712862T3 (da) 2006-09-25
TR199501421A2 (tr) 1996-06-21
ATE328902T1 (de) 2006-06-15
AU4237296A (en) 1996-06-17
BR9509652A (pt) 1997-09-16
EP0712862A2 (en) 1996-05-22
AU7885498A (en) 1998-11-05
CZ145697A3 (en) 1997-12-17
AR003915A1 (es) 1998-09-30
DE69535031T2 (de) 2006-12-28
NO972185D0 (no) 1997-05-13
NO972185L (no) 1997-05-13
CZ287731B6 (en) 2001-01-17
IN179820B (en, 2012) 1997-12-13
PL320556A1 (en) 1997-10-13
PT712862E (pt) 2006-08-31
US5646242A (en) 1997-07-08
ES2264124T3 (es) 2006-12-16
HK1014007A1 (en) 1999-09-17
IL115972A0 (en) 1996-01-31
JPH10509176A (ja) 1998-09-08
MX9703506A (es) 1997-07-31
CA2205061A1 (en) 1996-05-30
HUT77737A (hu) 1998-07-28
AU720820B2 (en) 2000-06-15
JP4312828B2 (ja) 2009-08-12
SI0712862T1 (sl) 2006-10-31
ZA959680B (en) 1997-05-14
RU2155773C2 (ru) 2000-09-10
CO4520285A1 (es) 1997-10-15
AU691066B2 (en) 1998-05-07
IL115972A (en) 2000-09-28

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