BR9509652A - Acilação seletiva de grupos epsílon-amino - Google Patents

Acilação seletiva de grupos epsílon-amino

Info

Publication number
BR9509652A
BR9509652A BR9509652A BR9509652A BR9509652A BR 9509652 A BR9509652 A BR 9509652A BR 9509652 A BR9509652 A BR 9509652A BR 9509652 A BR9509652 A BR 9509652A BR 9509652 A BR9509652 A BR 9509652A
Authority
BR
Brazil
Prior art keywords
epsilon
amino groups
selective acylation
acylation
selective
Prior art date
Application number
BR9509652A
Other languages
English (en)
Inventor
Jefrey Clayton Baker
Victor John Chen
Jose Michael Hanquier
Aidas Vladas Kriaciunas
Brian Allen Moser
Robert Theodore Shuman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9509652A publication Critical patent/BR9509652A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR9509652A 1994-11-17 1995-11-14 Acilação seletiva de grupos epsílon-amino BR9509652A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups
PCT/US1995/014872 WO1996015803A1 (en) 1994-11-17 1995-11-14 SELECTIVE ACYLATION OF ε-AMINO GROUPS

Publications (1)

Publication Number Publication Date
BR9509652A true BR9509652A (pt) 1997-09-16

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9509652A BR9509652A (pt) 1994-11-17 1995-11-14 Acilação seletiva de grupos epsílon-amino

Country Status (28)

Country Link
US (2) US5646242A (pt)
EP (2) EP1227107A1 (pt)
JP (1) JP4312828B2 (pt)
CN (1) CN1171742A (pt)
AR (1) AR003915A1 (pt)
AT (1) ATE328902T1 (pt)
AU (2) AU691066B2 (pt)
BR (1) BR9509652A (pt)
CA (1) CA2205061A1 (pt)
CO (1) CO4520285A1 (pt)
CZ (1) CZ287731B6 (pt)
DE (1) DE69535031T2 (pt)
DK (1) DK0712862T3 (pt)
ES (1) ES2264124T3 (pt)
HK (1) HK1014007A1 (pt)
HU (2) HU217585B (pt)
IL (1) IL115972A (pt)
IN (1) IN179820B (pt)
NO (1) NO972185L (pt)
NZ (1) NZ297256A (pt)
PL (1) PL320556A1 (pt)
PT (1) PT712862E (pt)
RU (1) RU2155773C2 (pt)
SI (1) SI0712862T1 (pt)
TR (1) TR199501421A2 (pt)
WO (1) WO1996015803A1 (pt)
YU (1) YU71495A (pt)
ZA (1) ZA959680B (pt)

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US6451970B1 (en) * 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
ES2230607T3 (es) * 1996-07-11 2005-05-01 Novo Nordisk A/S Metodo selectivo de acilacion.
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
HUP0004169A3 (en) * 1997-10-24 2001-06-28 Lilly Co Eli Insoluble insulin compositions and process for production thereof
US5985263A (en) * 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US5981709A (en) * 1997-12-19 1999-11-09 Enzon, Inc. α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
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AU4904800A (en) * 1999-05-27 2000-12-18 Robert Z-T. Luo Identification of compounds for modulating dimeric receptors
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
JP2003532691A (ja) * 2000-05-05 2003-11-05 ノボ ノルディスク アクティーゼルスカブ 重症疾患神経障害
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
EP1346726A4 (en) * 2000-12-25 2004-09-15 Shiseido Co Ltd FRAGRANCE COMPOSITION STIMULATING THE SYMPATHETIC SYSTEM
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US20030082671A1 (en) 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
JP2005503141A (ja) * 2001-07-24 2005-02-03 ノボ　ノルディスク　アクティーゼルスカブ アシル化ポリペプチドを作出するための方法
US7595172B2 (en) * 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
ATE411337T1 (de) * 2001-07-24 2008-10-15 Novo Nordisk As Verfahren zur herstellung acylierter polypeptide
MY127575A (en) 2001-09-07 2006-12-29 Biocon Ltd Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
MXPA05003002A (es) * 2002-09-25 2005-06-22 Novo Nordisk As Metodo para producir peptidos acilados.
EP1660531A2 (en) * 2003-08-05 2006-05-31 Novo Nordisk A/S Novel insulin derivatives
WO2005047508A1 (en) 2003-11-14 2005-05-26 Novo Nordisk A/S Processes for making acylated insulin
EP2626368B1 (en) 2004-07-19 2016-12-21 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
EP1917363B1 (en) 2005-08-16 2011-06-22 Novo Nordisk A/S Method for making mature insulin polypeptides
DK1969004T3 (da) * 2005-12-28 2011-11-28 Novo Nordisk As Insulinsammensætninger og metode til at lave en sammensætning
ES2387955T3 (es) * 2006-02-27 2012-10-04 Novo Nordisk A/S Derivados de insulina
WO2007121318A2 (en) * 2006-04-12 2007-10-25 Emisphere Technologies, Inc. Formulations for delivering insulin
EP2049149B1 (en) 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
PT2074141T (pt) 2006-09-22 2016-11-10 Novo Nordisk As Análogos de insulina resistentes a proteases
EP2069502B1 (en) 2006-09-27 2014-02-26 Novo Nordisk A/S Method for making maturated insulin polypeptides
US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US9034818B2 (en) 2007-06-13 2015-05-19 Novo Nordisk A/S Pharmaceutical formulations comprising an insulin derivative
BRPI0818004B8 (pt) 2007-10-16 2021-05-25 Biocon Ltd composição farmacêutica sólida administrável por via oral e o processo da mesma.
US9260502B2 (en) 2008-03-14 2016-02-16 Novo Nordisk A/S Protease-stabilized insulin analogues
PL2254906T3 (pl) 2008-03-18 2017-04-28 Novo Nordisk A/S Stabilizowane względem proteaz, acylowane analogi insuliny
US8637647B2 (en) 2008-09-12 2014-01-28 Novo Nordisk A/S Method of acylating a peptide or protein
CA2738615A1 (en) * 2008-10-30 2010-05-06 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
MX2011008775A (es) * 2009-02-20 2011-10-24 Ipsen Pharma Sas Analogos de neuropeptidos y con substitucion de prolina en la posicion 34.
EP2504019A2 (en) 2009-11-25 2012-10-03 ArisGen SA Mucosal delivery composition comprising a peptide complexed with a crown compound and/or a counter ion
BR112013010345A2 (pt) 2010-10-27 2017-07-25 Novo Nordisk As tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
MX2014012096A (es) 2012-04-11 2014-11-21 Novo Nordisk As Formulaciones de insulina.
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
CA2926701A1 (en) 2013-10-07 2015-04-16 Novo Nordisk A/S Novel derivative of an insulin analogue
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
EP3452587B1 (en) 2016-05-05 2021-09-08 Codexis, Inc. Penicillin-g acylases
MA46780A (fr) 2016-11-07 2019-09-11 Novo Nordisk As Esters à dchbs actif de composés peg et leur utilisation
EP3554534B1 (en) 2016-12-16 2021-06-23 Novo Nordisk A/S Insulin containing pharmaceutical compositions
CN107602437A (zh) * 2017-08-09 2018-01-19 上海昂德生物科技有限公司 活化酯的制备方法
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
CN116874585B (zh) * 2023-09-06 2023-12-15 杭州湃肽生化科技有限公司 一种地特胰岛素的合成方法

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Also Published As

Publication number Publication date
DE69535031T2 (de) 2006-12-28
EP0712862A3 (en) 1998-03-04
HK1014007A1 (en) 1999-09-17
CO4520285A1 (es) 1997-10-15
RU2155773C2 (ru) 2000-09-10
DE69535031D1 (de) 2006-07-20
DK0712862T3 (da) 2006-09-25
US5646242A (en) 1997-07-08
IL115972A0 (en) 1996-01-31
HU9903007D0 (en) 1999-11-29
WO1996015803A1 (en) 1996-05-30
JPH10509176A (ja) 1998-09-08
AU691066B2 (en) 1998-05-07
EP0712862A2 (en) 1996-05-22
PL320556A1 (en) 1997-10-13
YU71495A (sh) 1998-09-18
CN1171742A (zh) 1998-01-28
SI0712862T1 (sl) 2006-10-31
AU4237296A (en) 1996-06-17
NO972185D0 (no) 1997-05-13
IL115972A (en) 2000-09-28
USRE37971E1 (en) 2003-01-28
HU217585B (hu) 2000-02-28
CZ287731B6 (en) 2001-01-17
PT712862E (pt) 2006-08-31
MX9703506A (es) 1997-07-31
ES2264124T3 (es) 2006-12-16
JP4312828B2 (ja) 2009-08-12
ZA959680B (en) 1997-05-14
CZ145697A3 (en) 1997-12-17
AU7885498A (en) 1998-11-05
AU720820B2 (en) 2000-06-15
EP1227107A1 (en) 2002-07-31
AR003915A1 (es) 1998-09-30
IN179820B (pt) 1997-12-13
CA2205061A1 (en) 1996-05-30
NO972185L (no) 1997-05-13
NZ297256A (en) 2000-01-28
EP0712862B1 (en) 2006-06-07
HUT77737A (hu) 1998-07-28
TR199501421A2 (tr) 1996-06-21
ATE328902T1 (de) 2006-06-15

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal