AR003915A1 - Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre - Google Patents

Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre

Info

Publication number
AR003915A1
AR003915A1 ARP950100165A AR10016595A AR003915A1 AR 003915 A1 AR003915 A1 AR 003915A1 AR P950100165 A ARP950100165 A AR P950100165A AR 10016595 A AR10016595 A AR 10016595A AR 003915 A1 AR003915 A1 AR 003915A1
Authority
AR
Argentina
Prior art keywords
amino group
insulin
free
proinsulin
epsilon
Prior art date
Application number
ARP950100165A
Other languages
English (en)
Spanish (es)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR003915A1 publication Critical patent/AR003915A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ARP950100165A 1994-11-17 1995-11-14 Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre AR003915A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups

Publications (1)

Publication Number Publication Date
AR003915A1 true AR003915A1 (es) 1998-09-30

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP950100165A AR003915A1 (es) 1994-11-17 1995-11-14 Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre

Country Status (27)

Country Link
US (2) US5646242A (en, 2012)
EP (2) EP1227107A1 (en, 2012)
JP (1) JP4312828B2 (en, 2012)
CN (1) CN1171742A (en, 2012)
AR (1) AR003915A1 (en, 2012)
AT (1) ATE328902T1 (en, 2012)
AU (2) AU691066B2 (en, 2012)
BR (1) BR9509652A (en, 2012)
CA (1) CA2205061A1 (en, 2012)
CO (1) CO4520285A1 (en, 2012)
CZ (1) CZ287731B6 (en, 2012)
DE (1) DE69535031T2 (en, 2012)
DK (1) DK0712862T3 (en, 2012)
ES (1) ES2264124T3 (en, 2012)
HU (2) HU9903007D0 (en, 2012)
IL (1) IL115972A (en, 2012)
IN (1) IN179820B (en, 2012)
NO (1) NO972185D0 (en, 2012)
NZ (1) NZ297256A (en, 2012)
PL (1) PL320556A1 (en, 2012)
PT (1) PT712862E (en, 2012)
RU (1) RU2155773C2 (en, 2012)
SI (1) SI0712862T1 (en, 2012)
TR (1) TR199501421A2 (en, 2012)
WO (1) WO1996015803A1 (en, 2012)
YU (1) YU71495A (en, 2012)
ZA (1) ZA959680B (en, 2012)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9316895D0 (en) 1993-08-13 1993-09-29 Guy S And St Thomas Hospitals Hepatoselective insulin analogues
US6869930B1 (en) * 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
US5951974A (en) * 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
US6451970B1 (en) * 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
WO1998002460A1 (en) * 1996-07-11 1998-01-22 Novo Nordisk A/S Selective acylation method
ID24890A (id) * 1997-10-24 2000-08-31 Lilly Co Eli Komposisi-komposisi insulin yang tidak dapat larut
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
US5981709A (en) * 1997-12-19 1999-11-09 Enzon, Inc. α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
US5985263A (en) * 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US6451974B1 (en) 1999-03-17 2002-09-17 Novo Nordisk A/S Method of acylating peptides and novel acylating agents
US7181349B1 (en) 1999-05-27 2007-02-20 Cecil Yip Identification of compounds for modulating dimeric receptors
US7169889B1 (en) * 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
AU2001254621A1 (en) * 2000-05-05 2001-11-20 K.U. Leuven R And D Critical illness neuropathy
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US20030054015A1 (en) * 2000-12-25 2003-03-20 Shinichiro Haze Sympathetic-activating perfume composition
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US20030082671A1 (en) 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
AU2002355160A1 (en) * 2001-07-24 2003-02-17 Novo Nordisk A/S Method for making acylated polypeptides
US7595172B2 (en) * 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
CA2452735A1 (en) * 2001-07-24 2003-02-06 Ivan Diers Method for making acylated polypeptides
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
DK1430082T3 (da) 2001-09-07 2010-01-18 Biocon Ltd Fremgangsmåde til syntese af insulinpolypeptid-oligomer-konjugater og proinsulinpolypeptid-oligomerkonjugater samt fremgangsmåde til syntese deraf
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
WO2003105768A2 (en) 2002-06-13 2003-12-24 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
EP1546090B1 (en) * 2002-09-25 2009-06-24 Novo Nordisk A/S Method for producing acylated peptides
JP4463814B2 (ja) * 2003-08-05 2010-05-19 ノボ ノルディスク アクティーゼルスカブ 新規のインスリン誘導体
WO2005047508A1 (en) 2003-11-14 2005-05-26 Novo Nordisk A/S Processes for making acylated insulin
PL2626368T3 (pl) 2004-07-19 2017-06-30 Biocon Limited Koniugaty insulina-oligomer, ich formulacje i zastosowania
CN101243190B (zh) 2005-08-16 2015-05-13 诺沃-诺迪斯克有限公司 制备成熟胰岛素多肽的方法
ATE519780T1 (de) * 2005-12-28 2011-08-15 Novo Nordisk As Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
WO2007096431A1 (en) * 2006-02-27 2007-08-30 Novo Nordisk A/S Insulin derivatives
US8927015B2 (en) * 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
EP2049149B1 (en) 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
DK2074141T3 (en) 2006-09-22 2016-11-28 Novo Nordisk As The protease resistant insulin analogues.
US8518668B2 (en) 2006-09-27 2013-08-27 Novo Nordisk A/S Method for making maturated insulin polypeptides in a fungal cell
JP5496082B2 (ja) 2007-04-30 2014-05-21 ノボ・ノルデイスク・エー／エス タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
US9034818B2 (en) 2007-06-13 2015-05-19 Novo Nordisk A/S Pharmaceutical formulations comprising an insulin derivative
ES2664822T3 (es) 2007-10-16 2018-04-23 Biocon Limited Una composición farmacéutica sólida administrable por vía oral y un proceso de la misma
CN101970477B (zh) 2008-03-14 2014-12-31 诺沃-诺迪斯克有限公司 蛋白酶稳定的胰岛素类似物
EP2910569B1 (en) 2008-03-18 2016-10-05 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
WO2010029159A1 (en) 2008-09-12 2010-03-18 Novo Nordisk A/S Method of acylating a peptide or protein
EP2352513B1 (en) * 2008-10-30 2016-09-14 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
CA2751673A1 (en) * 2009-02-20 2010-08-26 Ipsen Pharma S.A.S Analogues of neuropeptide y having proline substitution at position 34
WO2011064316A2 (en) 2009-11-25 2011-06-03 Paolo Botti Mucosal delivery of peptides
RU2013123515A (ru) 2010-10-27 2014-12-10 Ново Нордиск А/С Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
BR112014025132A2 (pt) 2012-04-11 2017-07-11 Novo Nordisk As formulações de insulina
WO2014177623A1 (en) 2013-04-30 2014-11-06 Novo Nordisk A/S Novel administration regime
CA2926701A1 (en) 2013-10-07 2015-04-16 Novo Nordisk A/S Novel derivative of an insulin analogue
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
CA3021009A1 (en) * 2016-05-05 2017-11-09 Codexis, Inc. Penicillin-g acylases
US11787837B2 (en) 2016-11-07 2023-10-17 Novo Nordisk A/S DCHBS-active esters of PEG compounds and their use
SI3554534T1 (sl) 2016-12-16 2021-09-30 Novo Nordisk A/S Farmacevtski sestavki, ki vsebujejo inzulin
CN107602437A (zh) * 2017-08-09 2018-01-19 上海昂德生物科技有限公司 活化酯的制备方法
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
US12343383B2 (en) 2019-07-12 2025-07-01 Novo Nordisk A/S High concentration insulin formulation
CN116874585B (zh) * 2023-09-06 2023-12-15 杭州湃肽生化科技有限公司 一种地特胰岛素的合成方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1468831A (fr) * 1965-10-05 1967-02-10 Roussel Uclaf Procédé de préparation de nouveaux composés polypeptidiques et produits en résultant
DE1902865A1 (de) * 1968-02-01 1969-09-11 American Home Prod Substituierte Insulin-Derivate,Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen
US3591574A (en) * 1968-05-29 1971-07-06 American Home Prod Tri-n-phenylglycyl derivatives of insulin
US3528960A (en) * 1968-10-07 1970-09-15 Lilly Co Eli N-carboxyaroyl insulins
US3823125A (en) * 1969-10-14 1974-07-09 American Home Prod N-aminoacyl-substituted insulins
US3752798A (en) * 1969-12-02 1973-08-14 G Amird Tris-na1,nb1,nepsilonb29 - (3-x-3-oxo - 1-y-prop-1-en-1-yl)(ndelta-(4-z-6-r-pyrimidin - 2 - yl) ornithine b22)-insulins and their preparation
US3869437A (en) * 1970-05-08 1975-03-04 Nat Res Dev Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
US3950517A (en) * 1970-05-08 1976-04-13 National Research Development Corporation Insulin derivatives
GB1381274A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
GB1381273A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
US3864325A (en) * 1971-11-18 1975-02-04 Nat Res Dev (N{HU Al{b , N{HU Bl{b , N{HU B29{B , carbamoyl)-(O{HU A14{B , O{HU B16{B , O{HU B26{B aryl) insulin derivatives
BE791949A (fr) * 1971-11-27 1973-05-28 Schering Ag Derives d'insuline, leur preparation et leur utilisation
US3755569A (en) * 1972-07-25 1973-08-28 American Home Prod Acyl substituted insulins
DE2252157C3 (de) * 1972-10-25 1976-03-18 Hoechst Ag Zwischenprodukte zur herstellung von insulin, insulin-analogen und -derivaten und verfahren zur herstellung von insulin, insulin analogen und derivaten
NL7314766A (en, 2012) * 1972-10-31 1974-05-02
DE2253327A1 (de) * 1972-10-31 1974-05-09 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
DE2428412A1 (de) * 1974-06-12 1976-01-15 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
DE2439296A1 (de) * 1974-08-16 1976-02-26 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
GB1492997A (en) * 1976-07-21 1977-11-23 Nat Res Dev Insulin derivatives
US4218539A (en) * 1978-03-24 1980-08-19 Weltman Joel K Enzyme conjugates and method of preparation and use
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
JPH01254699A (ja) * 1988-04-05 1989-10-11 Kodama Kk インスリン誘導体及びその用途
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29
WO1992001476A1 (en) * 1990-07-26 1992-02-06 University Of Iowa Research Foundation Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule
US5304473A (en) * 1991-06-11 1994-04-19 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
EP1132404A3 (en) * 1993-09-17 2002-03-27 Novo Nordisk A/S Acylated insulin
DE4437604A1 (de) * 1994-10-21 1996-04-25 Basf Ag Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung
US5905140A (en) 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method

Also Published As

Publication number Publication date
AU4237296A (en) 1996-06-17
PL320556A1 (en) 1997-10-13
JP4312828B2 (ja) 2009-08-12
SI0712862T1 (sl) 2006-10-31
PT712862E (pt) 2006-08-31
CN1171742A (zh) 1998-01-28
DK0712862T3 (da) 2006-09-25
MX9703506A (es) 1997-07-31
DE69535031T2 (de) 2006-12-28
IL115972A (en) 2000-09-28
US5646242A (en) 1997-07-08
ATE328902T1 (de) 2006-06-15
AU691066B2 (en) 1998-05-07
EP1227107A1 (en) 2002-07-31
IN179820B (en, 2012) 1997-12-13
IL115972A0 (en) 1996-01-31
USRE37971E1 (en) 2003-01-28
CA2205061A1 (en) 1996-05-30
JPH10509176A (ja) 1998-09-08
EP0712862B1 (en) 2006-06-07
NO972185L (no) 1997-05-13
CZ287731B6 (en) 2001-01-17
WO1996015803A1 (en) 1996-05-30
NO972185D0 (no) 1997-05-13
TR199501421A2 (tr) 1996-06-21
EP0712862A2 (en) 1996-05-22
EP0712862A3 (en) 1998-03-04
HK1014007A1 (en) 1999-09-17
ES2264124T3 (es) 2006-12-16
ZA959680B (en) 1997-05-14
YU71495A (sh) 1998-09-18
HU9903007D0 (en) 1999-11-29
CO4520285A1 (es) 1997-10-15
HUT77737A (hu) 1998-07-28
HU217585B (hu) 2000-02-28
CZ145697A3 (en) 1997-12-17
AU720820B2 (en) 2000-06-15
BR9509652A (pt) 1997-09-16
NZ297256A (en) 2000-01-28
AU7885498A (en) 1998-11-05
DE69535031D1 (de) 2006-07-20
RU2155773C2 (ru) 2000-09-10

Similar Documents

Publication Publication Date Title
AR003915A1 (es) Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre
DE69629210D1 (de) Insulinabkömmlinge
AR023093A1 (es) Composiciones cosmeticas para la piel con contenido de dextrano y un acido carboxilico debil.
ES2175409T4 (es) Extraccion de esterol con un disolvente polar para dar un aceite microbiano bajo en esterol.
ES2168334T3 (es) Composicion para el tratamiento de la piel.
ES2166862T3 (es) Composiciones para el cuidado de la piel que contienen amidas de acidos grasos y retinol o esteres de retinilo.
ES2022610B3 (es) Compuestos para potenciar la permeabilidad de la piel que utilizan esteres de sacarosa.
KR910004199A (ko) 수성 이고제형 제약 조성물
ATE106867T1 (de) 13-trans-retinsäureester.
ES2123910T3 (es) Composiciones que contienen sales anfoteras de alfa-hidroxiacidos y monocaprilato de glicerol.
ES2117390T3 (es) Sales de un acido graso poliinsaturado y formulaciones farmaceuticas que las contienen.
DE68924036D1 (de) Mischung von Tallölfettsäuren für Kautschuk.
FI863976A0 (fi) Terapeutisk komposition.
ES2084150T3 (es) Aminoacidos, peptidos o sus derivados asociados a las grasas.
DE59504267D1 (de) Härten von ungesättigten fetten, fettsäuren oder fettsäureestern
UA42758C2 (uk) Спосіб екстракції барвників каротину з натуральної речовини
PE20050581A1 (es) Microparticulas que comprenden analogos de somatostatina
ES2052517T3 (es) Analogos de tuftsina parcialmente retroinversos, metodo de preparacion de los mismos y composiciones farmaceuticas que los contienen.
DK32684A (da) Fremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herfor
ES2052761T3 (es) Nuevos esteres del acido androstano 17-carboxilico, procedimiento para su preparacion y medicamento que los contiene.
AR013618A1 (es) Metodo y composiciones para la distribucion y expresion de acidos nucleicos de interferon
KR850001775A (ko) 인슐린 유도체의 제조방법
IS2279B (is) Notkun á hliðstæðum gamma-amínósmjörsýru (GABA) áborð við GABA-pentín til vinnslu lyfs til meðferðar á bólgusjúkdómum
DE3364838D1 (en) Process for the conversion of preproinsulin analogues into insulins
ES2027057T3 (es) Procedimiento para preparar 2-aza-4-(alcoxicarbonil)espiro(4,5)decan-3-onas.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal