YU47101B - Supstituisani piroli i postupak za njihovu proizvodnju - Google Patents
Supstituisani piroli i postupak za njihovu proizvodnjuInfo
- Publication number
- YU47101B YU47101B YU28489A YU28489A YU47101B YU 47101 B YU47101 B YU 47101B YU 28489 A YU28489 A YU 28489A YU 28489 A YU28489 A YU 28489A YU 47101 B YU47101 B YU 47101B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- denotes
- formula
- hydrogen
- compound
- production
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
SUPSTITUISANI PIROLI I POSTUPAK ZA NJIHOVU PROIZVODNJU, piroli opste formule u kojoj R1 oznacava vodonik, alkil, aril, aralkil, alkoksialkil, hidroksialkil, haloalkil, aminoalkil, monoalkilaminoalkil, aminoalkilaminoalkil, azidoalkil, acilaminoalkil, aciltioalkil, alkilsulfonilaminoalkil, aril-sulfonilaminoalkil, merkaptoalkil, alkiltioalkil, alkilsulfinialkil, alkilsulfonialkil, alkilkarboniloksialkil, cijanoalkil, amidiooalkil, isotiocijanatoalkil, glukopiranozil, karboksialkil, alkoksikar-bonilalkil, aminokarbonilalkil, hidroksialkiltioalkil, merkaptoalkil-tioalkil, ariltioalkil, ili karboksialkiltioalkil ili grupa formule U kojoj Het oznacava heterociklicnu grupu, W oznacava NH, S ili bezu, T oznacava NH ili S, V oznacava O,S,NH,NNO2 NCN ili CHNO2, Z oznacava alkiltio, amino, monoalkilamino, ili dialkilamino, Im oznacava 1-imidazolil, Ar oznacava aril i n stoji umesto 2-6; R2 oznacava vodonik, alkil, aralkil, alkoksialkil, hidroksialkil, haloalkil, aminoalkil, monoalkilaminoalkil, dialkilaminoalkil, acilaminoalkil, alkilsulfonilaminoalkil, arilsulfonilaminoalkil, merkaptoalkil, alkiltioalkil, karboksialkil, alkoksikarbonilalkil, aminokarbonilalkil, alkiltio ili alkilsulfinil grupu; R3 oznacava karbociklicnu i heterociklicnu aromaticnu grupu; R4, R5, R6 i R7 svaki nezavisno oznacava vodonik, halogen, alkil, hidroksi, alkoksi, ariloksi, haloalkil, nitro, amino, acilamino, monoalkilamino, dialkilamino, alkiltio, alkilsulfinil ili alkilsulfonil grupu, i 1 od X i Y oznacava O a drugi oznacava O, S, (H,OH) ili (H,H) pod pretpostavkom da R1 ima znacenje razlicito od vodonika kada R2 oznacava vodonik, R3 oznacava 3-indolil ili 6-hidroksi-3-indolil, R4, R5 i R7 svaki oznacava vodonik, R6 oznacava vodonik ili hidroksi grupu, a X i Y oba oznacavaju O i kada R2 oznacava vodonik, R3 oznacava 3-indolil, R4, R5, R6 i R7 svaki oznacava vodonik, X oznacava (H,H), a Y oznacava O; kao i farmaceutski prihvatljive soli kiselih jedinjenja formule I sa bazama i baznih jedinjenja formule 1 sa kiselinama. 11. Proces za proizvodnju pirola prema bilo kome od patentnih zahteva 1-10, naznacen time, sto obuhvata: a) za proizvodnju jedinjenja formule 1 u kojoj X i Y oba oznacavaju O, i reaguje jdinjenje opste formule u kojoj R1, R2, R3, R4, R5, R6 i R7 imaju znacenje dato u patentnom zahtevu 1, sa amonijakom pod pritiskom ili sa heksametildisilazanom i metanolom ili b) za proizvodnju jedinjenja formule 1 u kojoj R1 oznacava vodonik, a X i Y oba oznacavaju O, reaguje jedinjenje opste formule: u kojoj R2, R4, R5, R6 i R7 imaju znacenje dato u patentnom zahtevu 1, a Hal oznacava halogen. Sa jedinjenjem opste formule: u kojoj R8 ima isto znacenje kao R3 u patentnom zahtevu 1 ili prestavlja brom, ili c) za proizvodnju jedinjenja formule 1 u kojoj R3 oznacava 1-benzimidazolil, a X i Y oba oznacavaju O, reaguje jedinjenje opste formule: u kojoj R1, R2, R4, R5, R6 i R7 imaju znacenje dato u patentnom zahtevu 1, sa alkalometalnim derivatom benzimidazola ili d) za proizvodnju jedinj
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888803048A GB8803048D0 (en) | 1988-02-10 | 1988-02-10 | Substituted pyrroles |
GB888827565A GB8827565D0 (en) | 1988-02-10 | 1988-11-25 | Substituted pyrroles |
Publications (2)
Publication Number | Publication Date |
---|---|
YU28489A YU28489A (en) | 1991-06-30 |
YU47101B true YU47101B (sh) | 1994-12-28 |
Family
ID=26293462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU28489A YU47101B (sh) | 1988-02-10 | 1989-02-08 | Supstituisani piroli i postupak za njihovu proizvodnju |
Country Status (22)
Country | Link |
---|---|
US (1) | US5057614A (sh) |
EP (1) | EP0328026B1 (sh) |
JP (1) | JPH0730071B2 (sh) |
AU (1) | AU623630B2 (sh) |
CA (1) | CA1320194C (sh) |
CZ (1) | CZ280738B6 (sh) |
DE (1) | DE58904168D1 (sh) |
DK (1) | DK171891B1 (sh) |
DZ (1) | DZ1323A1 (sh) |
ES (1) | ES2054890T3 (sh) |
FI (1) | FI96861C (sh) |
HU (1) | HU201054B (sh) |
IE (1) | IE63489B1 (sh) |
IL (1) | IL89167A (sh) |
IS (1) | IS1941B (sh) |
MC (1) | MC2010A1 (sh) |
NO (1) | NO172540C (sh) |
NZ (1) | NZ227850A (sh) |
PH (1) | PH25185A (sh) |
PT (1) | PT89661B (sh) |
SK (1) | SK75289A3 (sh) |
YU (1) | YU47101B (sh) |
Families Citing this family (132)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MC2096A1 (fr) * | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
GB8904161D0 (en) * | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
DE3914764A1 (de) * | 1989-05-05 | 1990-11-08 | Goedecke Ag | Maleinimid-derivate und deren verwendung als arzneimittel |
US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
IL94274A0 (en) * | 1989-05-05 | 1991-03-10 | Goedecke Ag | Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same |
DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
DE4005970A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
WO1993018765A1 (en) * | 1992-03-20 | 1993-09-30 | The Wellcome Foundation Limited | Indole derivatives with antiviral activity |
US5290777A (en) * | 1993-02-24 | 1994-03-01 | Regents Of The Univ. Of California | Use for topsentin compounds and pharmaceutical compositions containing same |
AU678435B2 (en) * | 1993-05-10 | 1997-05-29 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
US5721230A (en) * | 1993-05-10 | 1998-02-24 | Hoffmann-La Roche Inc. | Substituted pyrroles |
US5405864A (en) * | 1993-10-15 | 1995-04-11 | Syntex (U.S.A.) Inc. | Chemotherapeutic maleimides |
TW270114B (sh) * | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
US5723456A (en) * | 1993-12-07 | 1998-03-03 | Eli Lilly & Company | Therapeutic treatment for cardiovascular diseases |
US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
UA44690C2 (uk) * | 1993-12-07 | 2002-03-15 | Елі Ліллі Енд Компані | Макроциклічна сполука іміду біс-індол-малеїнової кислоти, спосіб її одержання та фармацевтична композиція, макроциклічні сполуки іміду біс-індол-малеїнової кислоти та біс-індол-малеїнового ангідриду, спосіб одержання (варіанти) |
IL111851A (en) * | 1993-12-07 | 1998-09-24 | Lilly Co Eli | Improved synthesis of bisindolylsimilides and process for its preparation |
US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
US5843935A (en) * | 1993-12-07 | 1998-12-01 | Eli Lilly And Company | Protein kinase C inhibitors |
US5545636A (en) * | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
ES2236702T3 (es) * | 1993-12-23 | 2005-07-16 | Eli Lilly And Company | Inhibidores de la proteina quinasa c. |
AU2771395A (en) * | 1994-06-14 | 1996-01-05 | Sloan-Kettering Institute For Cancer Research | Ceramide-activated protein kinase and methods of use of effectors |
US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
US5481003A (en) * | 1994-06-22 | 1996-01-02 | Eli Lilly And Company | Protein kinase C inhibitors |
ATE172463T1 (de) * | 1994-08-04 | 1998-11-15 | Hoffmann La Roche | Pyrrolocarbazol |
US5591855A (en) * | 1994-10-14 | 1997-01-07 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US5594009A (en) * | 1994-10-14 | 1997-01-14 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US5475110A (en) * | 1994-10-14 | 1995-12-12 | Cephalon, Inc. | Fused Pyrrolocarbazoles |
US5705511A (en) * | 1994-10-14 | 1998-01-06 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
AU6836696A (en) * | 1995-09-05 | 1997-03-27 | Banyu Pharmaceutical Co., Ltd. | Antitumor indolopyrrolocarbazole derivatives |
BR9611724A (pt) * | 1995-11-20 | 1999-06-01 | Lilly Co Eli | Inibidor de quinase c de proteína |
US5616724A (en) * | 1996-02-21 | 1997-04-01 | Cephalon, Inc. | Fused pyrrolo[2,3-c]carbazole-6-ones |
BR9710648A (pt) * | 1996-03-20 | 1999-08-17 | Lilly Co Eli | S¡ntese de indolilmaleimidas |
US6232299B1 (en) | 1996-05-01 | 2001-05-15 | Eli Lilly And Company | Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy |
PL329851A1 (en) | 1996-05-01 | 1999-04-12 | Lilly Co Eli | Treatment of diseases associated with vegf |
UA54427C2 (uk) * | 1996-05-01 | 2003-03-17 | Елі Ліллі Енд Компані | Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту |
PE91698A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
PE91598A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
PE91498A1 (es) * | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | Pirroles sustituidos |
US6093709A (en) * | 1996-08-22 | 2000-07-25 | Eli Lilly And Company | Therapeutic treatment for sexual dysfunctions |
IL128376A0 (en) * | 1996-08-23 | 2000-01-31 | Lilly Co Eli | Synthesis of bisindolylmalimides |
US6107327A (en) * | 1996-08-30 | 2000-08-22 | Eli Lilly And Company | Therapeutic treatment for HIV infection |
US5962446A (en) * | 1996-08-30 | 1999-10-05 | Eli Lilly And Company | Therapetutic treatment for human T cell lymphotrophic virus type 1 infection |
SE9603284D0 (sv) * | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
SE9603283D0 (sv) * | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
TW472045B (en) | 1996-09-25 | 2002-01-11 | Astra Ab | Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation |
CA2268399C (en) * | 1996-10-31 | 2008-08-19 | Harbor Branch Oceanographic Institution, Inc. | Anti-neurogenic inflammatory compounds and compositions and methods of use thereof |
US5859261A (en) * | 1997-03-20 | 1999-01-12 | Eli Lilly And Company | Synthesis of indolylmaleimides |
US6093740A (en) * | 1997-04-30 | 2000-07-25 | Eli Lilly And Company | Therapeutic treatment for skin disorders |
US6133452A (en) * | 1997-08-22 | 2000-10-17 | Eli Lilly And Company | Synthesis of bisindolylmalimides |
AR017200A1 (es) | 1997-12-23 | 2001-08-22 | Astrazeneca Ab | Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos |
WO1999042100A1 (fr) * | 1998-02-23 | 1999-08-26 | Sagami Chemical Research Center | Inhibiteurs de la mort cellulaire |
US6291446B1 (en) | 1998-03-05 | 2001-09-18 | Eli Lilly And Company | Therapeutic treatment for cytomegalovirus infection |
US6225301B1 (en) | 1998-03-05 | 2001-05-01 | Eli Lilly And Company | Therapeutic treatment for renal dysfunction |
US6103713A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for autoimmune diseases |
US6103712A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for asthma |
SE9800835D0 (sv) | 1998-03-13 | 1998-03-13 | Astra Ab | New Compounds |
TR200002580T2 (tr) * | 1998-03-17 | 2000-11-21 | F.Hoffmann-La Roche Ag | Hücre çoğalmasının engellenmesinde kullanılan ikameli bisindolimaleimitler |
SE9802538D0 (sv) * | 1998-07-13 | 1998-07-13 | Astra Ab | New pharmaceutically active compounds |
US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
US6719520B2 (en) | 1998-10-08 | 2004-04-13 | Smithkline Beecham Corporation | Method and compounds |
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US6284783B1 (en) | 1999-06-09 | 2001-09-04 | The Uab Research Foundation | Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis |
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EP1224932A4 (en) * | 1999-08-20 | 2002-10-16 | Sagami Chem Res | DRUGS INHIBITING CELL DEATH |
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GB0008264D0 (en) * | 2000-04-04 | 2000-05-24 | Smithkline Beecham Plc | Novel method and compounds |
US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
US7129250B2 (en) * | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
US6353007B1 (en) * | 2000-07-13 | 2002-03-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents |
CA2417277A1 (en) * | 2000-07-27 | 2002-02-07 | F. Hoffmann-La Roche Ag | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3.beta. |
US6482847B2 (en) | 2000-10-03 | 2002-11-19 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
US6469179B1 (en) * | 2000-10-03 | 2002-10-22 | Hoffmann-La Roche Inc. | Amorphous form of cell cycle inhibitor having improved solubility and bioavailability |
KR100748386B1 (ko) * | 2000-11-07 | 2007-08-10 | 노파르티스 아게 | 단백질 키나제 c 억제제로서의 인돌릴말레이미드 유도체 |
US6645970B2 (en) * | 2000-11-07 | 2003-11-11 | Novartis Ag | Indolylmaleimide derivatives |
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- 1989-02-03 NZ NZ227850A patent/NZ227850A/xx unknown
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- 1989-02-06 CA CA000590178A patent/CA1320194C/en not_active Expired - Lifetime
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- 1989-02-06 EP EP89102025A patent/EP0328026B1/de not_active Expired - Lifetime
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