YU46697B - Postupak za dobijanje novih supstituisanih pirimidina - Google Patents

Postupak za dobijanje novih supstituisanih pirimidina

Info

Publication number
YU46697B
YU46697B YU144288A YU144288A YU46697B YU 46697 B YU46697 B YU 46697B YU 144288 A YU144288 A YU 144288A YU 144288 A YU144288 A YU 144288A YU 46697 B YU46697 B YU 46697B
Authority
YU
Yugoslavia
Prior art keywords
mono
4alkyl
substituted pyrimidines
formula
procedure
Prior art date
Application number
YU144288A
Other languages
English (en)
Other versions
YU144288A (en
Inventor
M.S. Daluge
P.M. Skonezny
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Priority to YU144288A priority Critical patent/YU46697B/sh
Publication of YU144288A publication Critical patent/YU144288A/xx
Publication of YU46697B publication Critical patent/YU46697B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVIH SUPSTITUISANIH PIRIMIDINA, opšte formule (I) ili njihovih soli, N-oksida ili acid derivata, u kojoj je (X) šestočlani prsten koji sadrži tri dvostruke veze, u kom slučaju je X -N= ili -C=, R1 i R2 su isti ili različiti i svaki je vodonik, C1-C4 alkil ili C1-C4alkoksi, R3 je vodonik, halogen. C2-4alkenil, hidroksi, C1-C4alkil ili C1-C4alkoksi, a R4 je C1-4alkoksi, mono-C1-C4alkilamino ili di-C1-4alkilamino, naznačen time, što obuhvata reakciju jedinjenja formule u kojoj je R4A hidroksi, amino ili mono-C1-4alkil amino a R1, R2 i R3 su definisani kao gore, sa sredstvom za alkilovanje koje služi za uvodjenje C1-4alkil grupe, kao što je C1-4alkil halogenid, poželjno jodid, ili C1-4 dialkilsulfat, u prisustvu baze kao što je alkoksid alkalnog metala sa 1-4 C-atoma, bikarbonat ili fosfat alkalnog metala, da bi se dobilo jedinjenje formule (I) u kojoj je R4 C1-4 alkoksi, C1-4mono-alkilamino ili C1-4 dialkilamino grupa.
YU144288A 1980-11-11 1988-07-26 Postupak za dobijanje novih supstituisanih pirimidina YU46697B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YU144288A YU46697B (sh) 1980-11-11 1988-07-26 Postupak za dobijanje novih supstituisanih pirimidina

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8036135 1980-11-11
YU1983/83A YU43551B (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines
YU144288A YU46697B (sh) 1980-11-11 1988-07-26 Postupak za dobijanje novih supstituisanih pirimidina

Publications (2)

Publication Number Publication Date
YU144288A YU144288A (en) 1990-04-30
YU46697B true YU46697B (sh) 1994-04-05

Family

ID=10517217

Family Applications (5)

Application Number Title Priority Date Filing Date
YU2663/81A YU42444B (en) 1980-11-11 1981-11-10 Process for obtaining new substituted pyrimidines
YU01982/83A YU198283A (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines
YU1983/83A YU43551B (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines
YU01981/83A YU198183A (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines
YU144288A YU46697B (sh) 1980-11-11 1988-07-26 Postupak za dobijanje novih supstituisanih pirimidina

Family Applications Before (4)

Application Number Title Priority Date Filing Date
YU2663/81A YU42444B (en) 1980-11-11 1981-11-10 Process for obtaining new substituted pyrimidines
YU01982/83A YU198283A (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines
YU1983/83A YU43551B (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines
YU01981/83A YU198183A (en) 1980-11-11 1983-10-03 Process for obtaining new substituted pyrimidines

Country Status (35)

Country Link
US (4) US4438267A (sh)
EP (1) EP0051879B1 (sh)
JP (1) JPS57114581A (sh)
KR (1) KR880001736B1 (sh)
AR (1) AR245447A1 (sh)
AU (1) AU549449B2 (sh)
CA (1) CA1186310A (sh)
CS (1) CS273153B2 (sh)
CY (1) CY1419A (sh)
DD (1) DD201896A5 (sh)
DE (1) DE3173752D1 (sh)
DK (1) DK172884B1 (sh)
EG (1) EG16107A (sh)
ES (5) ES506969A0 (sh)
FI (1) FI76333C (sh)
GB (1) GB2087881B (sh)
GR (1) GR81317B (sh)
HK (1) HK23388A (sh)
HU (1) HU188762B (sh)
IE (1) IE52128B1 (sh)
IL (1) IL64256A (sh)
IT (1) IT1210589B (sh)
MC (1) MC1418A1 (sh)
MY (1) MY8600678A (sh)
NO (2) NO160137C (sh)
NZ (1) NZ198932A (sh)
PH (2) PH25053A (sh)
PL (4) PL139827B1 (sh)
PT (1) PT73960B (sh)
RU (1) RU1819264C (sh)
SG (1) SG62686G (sh)
SU (4) SU1424732A3 (sh)
YU (5) YU42444B (sh)
ZA (1) ZA817780B (sh)
ZM (1) ZM9481A1 (sh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use
ZA833067B (en) * 1982-05-01 1984-12-24 Wellcome Found Antibacterial compounds
DK190983A (da) * 1982-05-01 1983-11-02 Wellcome Found 2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor
US4590271A (en) * 1982-05-01 1986-05-20 Burroughs Wellcome Co. 2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials
US4587341A (en) * 1982-05-07 1986-05-06 Burroughs Wellcome Co. 2,4-diamino-5-(1,2,3,4-tetrahydro-(substituted or unsubstituted)-6-quinolylmethyl)pyrimidines, useful as antimicrobials
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives
GB8603962D0 (en) * 1986-02-18 1986-03-26 Wellcome Found Chemical compositions
GB8603964D0 (en) * 1986-02-18 1986-03-26 Cooper Animal Health Ltd Compositions
LU86703A1 (fr) * 1986-12-08 1988-07-14 Oreal Composition cosmetique photostable contenant un filtre uv-a et un filtre uv-b,son utilisation pour la protection de la peau contre les rayons uv et procede de stabilisation du filtre uv-a par le filtre uv-b
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
GB8903978D0 (en) * 1989-02-22 1989-04-05 Coopers Animal Health Chemical compositions
GB9000241D0 (en) * 1990-01-05 1990-03-07 Coopers Animal Health Pharmaceutical use
RU95113597A (ru) * 1992-12-02 1997-06-10 ФМК Корпорейшн (US) Инсектицидная композиция, способы борьбы с насекомыми
US5707996A (en) * 1995-11-06 1998-01-13 Macleod Pharmaceuticals, Inc. Pharmaceutical solution and methods for preparation thereof
DK0866791T3 (da) * 1995-12-04 2002-04-22 Arpida Ag Diaminopyrimidiner, farmaceutiske præparater indeholdende disse og deres anvendelse som antibakterielle midler
WO2002010156A1 (en) * 2000-07-29 2002-02-07 Arpida Ag Benzofuran derivatives and their use as antibacterial agents
ATE343415T1 (de) 2001-06-29 2006-11-15 Ab Science Die verwendung von c-kit hemmer zur behandlung von entzündlichen darmerkrankungen
ATE330608T1 (de) * 2001-06-29 2006-07-15 Ab Science Die verwendung von n-phenyl-2-pyrimidine-amine derivaten zur behandlung von entzündlichen erkrankungen
PT1401413E (pt) * 2001-06-29 2007-02-28 Ab Science Uso de inibidores da tirosina cinase para tratar doenças alérgicas
JP2005500041A (ja) * 2001-06-29 2005-01-06 アブ サイエンス 強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤
CA2461181A1 (en) * 2001-09-20 2003-05-01 Ab Science Use of potent, selective and non-toxic c-kit inhibitors for treating bacterial infections
CA2461182A1 (en) * 2001-09-20 2003-05-01 Ab Science Use of tyrosine kinase inhibitors for promoting hair growth
JP2005511506A (ja) * 2001-09-20 2005-04-28 アブ サイエンス 間質性膀胱炎を治療するための強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤の使用方法
CN100443482C (zh) * 2003-07-11 2008-12-17 阿皮德公开股份有限公司 苯并呋喃衍生物及其在制备治疗由细菌引起的感染的药物中的用途
EE200700050A (et) * 2005-02-18 2007-12-17 Arpida Ag Meetod bensofuraani valmistamiseks ning vahehendid
CN101253159B (zh) * 2005-09-01 2011-12-07 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物
US20100029689A1 (en) * 2008-07-02 2010-02-04 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
JP5756096B2 (ja) * 2009-06-12 2015-07-29 ソックプラ−シアンセ エ ジェニー エス．ウ．セ． グアニンリボスイッチ結合化合物及び抗生物質としてのその使用
CN102649786B (zh) * 2011-02-28 2014-08-27 郑州福源动物药业有限公司 一种2，4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2，4-(1h，3h)嘧啶的制备方法
CN103755684B (zh) * 2014-02-10 2015-09-09 青岛蔚蓝生物股份有限公司 一种巴喹普林的制备方法
JP2022535852A (ja) * 2019-06-06 2022-08-10 ベイジン タイド ファーマシューティカル カンパニー リミテッド Ｐ２ｘ３及び／又はｐ２ｘ２／３受容体アンタゴニスト、それを含む医薬組成物及びその使用
CN110818694B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体及其应用
WO2022217295A1 (en) * 2021-04-09 2022-10-13 The Trustees Of The University Of Pennsylvania Control of protein expression with tmp-protac compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049544A (en) * 1962-08-14 Method for the preparation of
DE1303727B (de) 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-Arylidensubstituierte Propioni-Irile
US3956327A (en) * 1969-03-06 1976-05-11 Burroughs Wellcome Co. Method of preparing 2,4-diamino-5-benzyl pyrimidines
BE792096A (fr) * 1971-12-01 1973-05-30 Hoffmann La Roche Nouvelles benzylpyrimidines
GB1468374A (en) 1974-03-06 1977-03-23 Wellcome Found Process for preparing a pyrimidine derivative
US4039543A (en) 1974-12-24 1977-08-02 Hoffmann-La Roche Inc. Benzylpyrimidines
GB1582245A (en) * 1976-06-09 1981-01-07 Wellcome Found Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives
DE2730467A1 (de) * 1977-07-06 1979-01-18 Basf Ag Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use

Also Published As

Publication number Publication date
GB2087881B (en) 1985-05-15
YU144288A (en) 1990-04-30
IT1210589B (it) 1989-09-14
DD201896A5 (de) 1983-08-17
PL139427B1 (en) 1987-01-31
US4587342A (en) 1986-05-06
PH22654A (en) 1988-10-28
SG62686G (en) 1987-03-27
YU198283A (en) 1984-04-30
SU1535379A3 (ru) 1990-01-07
EP0051879B1 (en) 1986-02-05
HU188762B (en) 1986-05-28
PT73960B (en) 1983-11-23
NO160137B (no) 1988-12-05
PL239279A1 (en) 1983-08-01
SU1318148A3 (ru) 1987-06-15
SU1306473A3 (ru) 1987-04-23
EP0051879A2 (en) 1982-05-19
ES521204A0 (es) 1984-06-01
YU198183A (en) 1984-04-30
ES8405378A1 (es) 1984-06-01
PH25053A (en) 1991-01-28
PL233754A1 (en) 1983-08-01
ES8307759A1 (es) 1983-07-01
IE52128B1 (en) 1987-06-24
YU266381A (en) 1984-04-30
AU7733481A (en) 1982-05-20
CA1186310A (en) 1985-04-30
US4438267A (en) 1984-03-20
ES8405380A1 (es) 1984-06-01
HK23388A (en) 1988-04-08
FI813546L (fi) 1982-05-12
AU549449B2 (en) 1986-01-30
RU1819264C (ru) 1993-05-30
US4603136A (en) 1986-07-29
CY1419A (en) 1988-04-22
AR245447A1 (es) 1994-01-31
ZA817780B (en) 1983-06-29
SU1424732A3 (ru) 1988-09-15
ES506969A0 (es) 1983-07-01
PL139828B1 (en) 1987-02-28
IL64256A0 (en) 1982-02-28
PL239278A1 (en) 1983-08-01
EG16107A (en) 1987-10-30
JPS57114581A (en) 1982-07-16
PL139523B1 (en) 1987-01-31
DE3173752D1 (en) 1986-03-20
NO160137C (no) 1989-03-15
NO813804L (no) 1982-05-12
CS825781A2 (en) 1990-07-12
PL139827B1 (en) 1987-02-28
FI76333C (fi) 1988-10-10
FI76333B (fi) 1988-06-30
ES521203A0 (es) 1984-06-01
IE812631L (en) 1982-05-11
US4761475A (en) 1988-08-02
ES521201A0 (es) 1984-06-01
IT8149676A0 (it) 1981-11-10
PL239280A1 (en) 1983-08-01
ZM9481A1 (en) 1983-11-21
ES8405379A1 (es) 1984-06-01
YU43551B (en) 1989-08-31
YU42444B (en) 1988-08-31
GR81317B (sh) 1984-12-11
NZ198932A (en) 1985-05-31
PT73960A (en) 1981-12-01
NO1994029I1 (no) 1994-12-29
IL64256A (en) 1988-01-31
DK496681A (da) 1982-05-12
ES521202A0 (es) 1984-06-01
MY8600678A (en) 1986-12-31
YU198383A (en) 1984-04-30
DK172884B1 (da) 1999-09-06
ES8405377A1 (es) 1984-06-01
KR830007628A (ko) 1983-11-04
EP0051879A3 (en) 1982-08-04
GB2087881A (en) 1982-06-03
KR880001736B1 (ko) 1988-09-10
JPH0474351B2 (sh) 1992-11-26
CS273153B2 (en) 1991-03-12
MC1418A1 (fr) 1982-10-18

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