ES8405379A1 - Un procedimiento para preparar pirimidinas sustituidas. - Google Patents

Un procedimiento para preparar pirimidinas sustituidas.

Info

Publication number
ES8405379A1
ES8405379A1 ES521203A ES521203A ES8405379A1 ES 8405379 A1 ES8405379 A1 ES 8405379A1 ES 521203 A ES521203 A ES 521203A ES 521203 A ES521203 A ES 521203A ES 8405379 A1 ES8405379 A1 ES 8405379A1
Authority
ES
Spain
Prior art keywords
intermediates
medicine
synthesis
making
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521203A
Other languages
English (en)
Other versions
ES521203A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES8405379A1 publication Critical patent/ES8405379A1/es
Publication of ES521203A0 publication Critical patent/ES521203A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR PIRIMIDINAS SUSTITUIDAS.SE HACE REACCIONAR UN COMPUESTO (I) EN QUE R ES HIDROXI O AMINO, CON 2,4-DIAMINO-5-HIDROXIMETILPIRIMIDINA. SE OBTIENE EL COMPUESTO (II) O UNA DE SUS SALES N-OXIDOS O DERIVADOS ACILICOS. X ES UN ANILLO DE SEIS MIEMBROS QUE CONTIENE TRES DOBLES ENLACES EN CUYO CASO X ES NF O CHF; DOS DOBLES ENLACES EN CUYO CASO X ES -O-; -NF; -CHF; -CH2- O NR.
ES521203A 1980-11-11 1983-04-02 Un procedimiento para preparar pirimidinas sustituidas. Granted ES521203A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8036135 1980-11-11

Publications (2)

Publication Number Publication Date
ES8405379A1 true ES8405379A1 (es) 1984-06-01
ES521203A0 ES521203A0 (es) 1984-06-01

Family

ID=10517217

Family Applications (5)

Application Number Title Priority Date Filing Date
ES506969A Expired ES8307759A1 (es) 1980-11-11 1981-11-10 Un procedimiento para la preparacion de pirimidinas sustitu-idas.
ES521202A Granted ES521202A0 (es) 1980-11-11 1983-04-02 Un procedimiento para preparar pirimidinas sustituidas.
ES521201A Expired ES8405377A1 (es) 1980-11-11 1983-04-02 Un procedimiento para preparar pirimidinas sustituidas.
ES521203A Granted ES521203A0 (es) 1980-11-11 1983-04-02 Un procedimiento para preparar pirimidinas sustituidas.
ES521204A Expired ES8405380A1 (es) 1980-11-11 1983-04-02 Un procedimiento para preparar pirimidinas sustituidas.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES506969A Expired ES8307759A1 (es) 1980-11-11 1981-11-10 Un procedimiento para la preparacion de pirimidinas sustitu-idas.
ES521202A Granted ES521202A0 (es) 1980-11-11 1983-04-02 Un procedimiento para preparar pirimidinas sustituidas.
ES521201A Expired ES8405377A1 (es) 1980-11-11 1983-04-02 Un procedimiento para preparar pirimidinas sustituidas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES521204A Expired ES8405380A1 (es) 1980-11-11 1983-04-02 Un procedimiento para preparar pirimidinas sustituidas.

Country Status (35)

Country Link
US (4) US4438267A (es)
EP (1) EP0051879B1 (es)
JP (1) JPS57114581A (es)
KR (1) KR880001736B1 (es)
AR (1) AR245447A1 (es)
AU (1) AU549449B2 (es)
CA (1) CA1186310A (es)
CS (1) CS273153B2 (es)
CY (1) CY1419A (es)
DD (1) DD201896A5 (es)
DE (1) DE3173752D1 (es)
DK (1) DK172884B1 (es)
EG (1) EG16107A (es)
ES (5) ES8307759A1 (es)
FI (1) FI76333C (es)
GB (1) GB2087881B (es)
GR (1) GR81317B (es)
HK (1) HK23388A (es)
HU (1) HU188762B (es)
IE (1) IE52128B1 (es)
IL (1) IL64256A (es)
IT (1) IT1210589B (es)
MC (1) MC1418A1 (es)
MY (1) MY8600678A (es)
NO (2) NO160137C (es)
NZ (1) NZ198932A (es)
PH (2) PH25053A (es)
PL (4) PL139828B1 (es)
PT (1) PT73960B (es)
RU (1) RU1819264C (es)
SG (1) SG62686G (es)
SU (4) SU1424732A3 (es)
YU (5) YU42444B (es)
ZA (1) ZA817780B (es)
ZM (1) ZM9481A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use
DK190983A (da) * 1982-05-01 1983-11-02 Wellcome Found 2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor
ZA833067B (en) * 1982-05-01 1984-12-24 Wellcome Found Antibacterial compounds
US4590271A (en) * 1982-05-01 1986-05-20 Burroughs Wellcome Co. 2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials
US4587341A (en) * 1982-05-07 1986-05-06 Burroughs Wellcome Co. 2,4-diamino-5-(1,2,3,4-tetrahydro-(substituted or unsubstituted)-6-quinolylmethyl)pyrimidines, useful as antimicrobials
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives
GB8603962D0 (en) * 1986-02-18 1986-03-26 Wellcome Found Chemical compositions
GB8603964D0 (en) * 1986-02-18 1986-03-26 Cooper Animal Health Ltd Compositions
LU86703A1 (fr) * 1986-12-08 1988-07-14 Oreal Composition cosmetique photostable contenant un filtre uv-a et un filtre uv-b,son utilisation pour la protection de la peau contre les rayons uv et procede de stabilisation du filtre uv-a par le filtre uv-b
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
GB8903978D0 (en) * 1989-02-22 1989-04-05 Coopers Animal Health Chemical compositions
GB9000241D0 (en) * 1990-01-05 1990-03-07 Coopers Animal Health Pharmaceutical use
RU95113597A (ru) * 1992-12-02 1997-06-10 ФМК Корпорейшн (US) Инсектицидная композиция, способы борьбы с насекомыми
US5707996A (en) * 1995-11-06 1998-01-13 Macleod Pharmaceuticals, Inc. Pharmaceutical solution and methods for preparation thereof
ATE212629T1 (de) * 1995-12-04 2002-02-15 Arpida Ag Diaminopyrimidine, diese enthaltende pharmazeutische zusammensetzungen und ihre verwendung als antibakterielle mittel
WO2002010156A1 (en) * 2000-07-29 2002-02-07 Arpida Ag Benzofuran derivatives and their use as antibacterial agents
US7727731B2 (en) * 2001-06-29 2010-06-01 Ab Science Potent, selective and non toxic c-kit inhibitors
CA2452371A1 (en) * 2001-06-29 2003-01-09 Ab Science Use of tyrosine kinase inhibitors for treating allergic diseases
DK1401415T3 (da) * 2001-06-29 2006-10-16 Ab Science Anvendelse af N-phenyl-2-pyrimidinamin-derivater til behandling af inflammatoriske sygdomme
JP2004537542A (ja) 2001-06-29 2004-12-16 アブ サイエンス 炎症性腸疾患（ｉｂｄ）を治療するための、チロシンキナーゼ阻害剤の使用
JP2005507916A (ja) * 2001-09-20 2005-03-24 アブ サイエンス 細菌感染症を治療するための、強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤の使用方法
EP1461032B1 (en) * 2001-09-20 2008-07-16 AB Science Use of c-kit inhibitors for promoting hair growth
JP2005511506A (ja) * 2001-09-20 2005-04-28 アブ サイエンス 間質性膀胱炎を治療するための強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤の使用方法
MXPA05014081A (es) * 2003-07-11 2006-03-09 Arpida Ag Derivados de benzofurano y su uso en el tratamiento de infecciones microbianas.
MX2007009282A (es) * 2005-02-18 2008-02-19 Arpida Ag Nuevos procesos para la preparacion de un 2h-cromeno.
ES2601178T3 (es) * 2005-09-01 2017-02-14 F. Hoffmann-La Roche Ag Diaminopirimidinas como moduladores de P2X3 y P3X2/3
US20100029689A1 (en) * 2008-07-02 2010-02-04 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
US20120122819A1 (en) * 2009-06-12 2012-05-17 Socpra - Sciences Et Genie S.E.C. Guanine riboswitch binding compounds and their use as antibiotics
CN102649786B (zh) * 2011-02-28 2014-08-27 郑州福源动物药业有限公司 一种2，4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2，4-(1h，3h)嘧啶的制备方法
CN103755684B (zh) * 2014-02-10 2015-09-09 青岛蔚蓝生物股份有限公司 一种巴喹普林的制备方法
CN113924293B (zh) * 2019-06-06 2024-07-09 北京泰德制药股份有限公司 P2x3和/或p2x2/3受体拮抗剂、包含其的药物组合物及其用途
CN110818694B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体及其应用
WO2022217295A1 (en) * 2021-04-09 2022-10-13 The Trustees Of The University Of Pennsylvania Control of protein expression with tmp-protac compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049544A (en) * 1962-08-14 Method for the preparation of
DE1303727B (de) 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-Arylidensubstituierte Propioni-Irile
US3956327A (en) * 1969-03-06 1976-05-11 Burroughs Wellcome Co. Method of preparing 2,4-diamino-5-benzyl pyrimidines
BE792096A (fr) * 1971-12-01 1973-05-30 Hoffmann La Roche Nouvelles benzylpyrimidines
GB1468374A (en) 1974-03-06 1977-03-23 Wellcome Found Process for preparing a pyrimidine derivative
US4039543A (en) 1974-12-24 1977-08-02 Hoffmann-La Roche Inc. Benzylpyrimidines
GB1582245A (en) * 1976-06-09 1981-01-07 Wellcome Found Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives
DE2730467A1 (de) * 1977-07-06 1979-01-18 Basf Ag Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use

Also Published As

Publication number Publication date
AR245447A1 (es) 1994-01-31
DK496681A (da) 1982-05-12
EG16107A (en) 1987-10-30
US4603136A (en) 1986-07-29
PT73960B (en) 1983-11-23
YU266381A (en) 1984-04-30
YU46697B (sh) 1994-04-05
EP0051879A3 (en) 1982-08-04
SG62686G (en) 1987-03-27
IT1210589B (it) 1989-09-14
US4761475A (en) 1988-08-02
HK23388A (en) 1988-04-08
FI76333B (fi) 1988-06-30
SU1535379A3 (ru) 1990-01-07
FI813546L (fi) 1982-05-12
CY1419A (en) 1988-04-22
PL239278A1 (en) 1983-08-01
IL64256A (en) 1988-01-31
EP0051879B1 (en) 1986-02-05
US4438267A (en) 1984-03-20
EP0051879A2 (en) 1982-05-19
AU549449B2 (en) 1986-01-30
PL233754A1 (en) 1983-08-01
PL239279A1 (en) 1983-08-01
YU42444B (en) 1988-08-31
ES521203A0 (es) 1984-06-01
PL139427B1 (en) 1987-01-31
KR830007628A (ko) 1983-11-04
NZ198932A (en) 1985-05-31
DK172884B1 (da) 1999-09-06
ES506969A0 (es) 1983-07-01
ES521201A0 (es) 1984-06-01
PH22654A (en) 1988-10-28
PL139827B1 (en) 1987-02-28
ES8405378A1 (es) 1984-06-01
SU1306473A3 (ru) 1987-04-23
ES521202A0 (es) 1984-06-01
IT8149676A0 (it) 1981-11-10
NO160137B (no) 1988-12-05
DE3173752D1 (en) 1986-03-20
YU43551B (en) 1989-08-31
AU7733481A (en) 1982-05-20
CA1186310A (en) 1985-04-30
JPH0474351B2 (es) 1992-11-26
SU1318148A3 (ru) 1987-06-15
JPS57114581A (en) 1982-07-16
ES521204A0 (es) 1984-06-01
ES8405380A1 (es) 1984-06-01
RU1819264C (ru) 1993-05-30
PL139523B1 (en) 1987-01-31
ZM9481A1 (en) 1983-11-21
YU144288A (en) 1990-04-30
YU198283A (en) 1984-04-30
CS825781A2 (en) 1990-07-12
CS273153B2 (en) 1991-03-12
ES8405377A1 (es) 1984-06-01
NO1994029I1 (no) 1994-12-29
YU198383A (en) 1984-04-30
PT73960A (en) 1981-12-01
GR81317B (es) 1984-12-11
IE812631L (en) 1982-05-11
FI76333C (fi) 1988-10-10
GB2087881A (en) 1982-06-03
US4587342A (en) 1986-05-06
GB2087881B (en) 1985-05-15
PH25053A (en) 1991-01-28
IL64256A0 (en) 1982-02-28
NO813804L (no) 1982-05-12
PL239280A1 (en) 1983-08-01
NO160137C (no) 1989-03-15
ZA817780B (en) 1983-06-29
PL139828B1 (en) 1987-02-28
HU188762B (en) 1986-05-28
IE52128B1 (en) 1987-06-24
KR880001736B1 (ko) 1988-09-10
ES8307759A1 (es) 1983-07-01
YU198183A (en) 1984-04-30
MY8600678A (en) 1986-12-31
SU1424732A3 (ru) 1988-09-15
DD201896A5 (de) 1983-08-17
MC1418A1 (fr) 1982-10-18

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