ES475960A1 - Procedimiento para la preparacion de 3-di-n-propil-acetoxi- venzodiazepin-2-onas. - Google Patents
Procedimiento para la preparacion de 3-di-n-propil-acetoxi- venzodiazepin-2-onas.Info
- Publication number
- ES475960A1 ES475960A1 ES475960A ES475960A ES475960A1 ES 475960 A1 ES475960 A1 ES 475960A1 ES 475960 A ES475960 A ES 475960A ES 475960 A ES475960 A ES 475960A ES 475960 A1 ES475960 A1 ES 475960A1
- Authority
- ES
- Spain
- Prior art keywords
- benzodiazepine
- acetoxy
- propyl
- ones
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Procedimiento para la preparación de 3-di-n-propil-acetoxi-benzodiazepin-2-onas de la fórmula general: ***1 (Ver fórmula) en que R1 representa hidrógeno, un radical alcohilo inferior, un radical alcoxialcohilo, un radical aciloxialcohilo, un radical dialcohilaminoalcohilo o un radical N,N-dialcohilcarbamilalcohilo, y R2 y R3 pueden significar hidrógeno, halógeno, trifluorometilo o nitro, con la condición de que R1 y R2 no significan al mismo tiempo hidrógeno si R3 es un átomo de cloro en posición 7.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT893877A AT359509B (de) | 1977-12-14 | 1977-12-14 | Verfahren zur herstellung von neuen 3-di-n- -propylacetoxybenzodiazepin-2-onen |
| AT831278A AT358051B (de) | 1978-11-21 | 1978-11-21 | Verfahren zur herstellung von neuen 3-di-n- -propyl-acetoxy-benzodiazepin-2-onen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES475960A1 true ES475960A1 (es) | 1979-05-01 |
Family
ID=25604664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES475960A Expired ES475960A1 (es) | 1977-12-14 | 1978-12-13 | Procedimiento para la preparacion de 3-di-n-propil-acetoxi- venzodiazepin-2-onas. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4261987A (es) |
| JP (1) | JPS54138589A (es) |
| AU (1) | AU4255778A (es) |
| BG (2) | BG29285A3 (es) |
| DD (1) | DD139851A5 (es) |
| DE (1) | DE2852606A1 (es) |
| DK (1) | DK562478A (es) |
| ES (1) | ES475960A1 (es) |
| FI (1) | FI783743A (es) |
| FR (1) | FR2411836A1 (es) |
| GB (1) | GB2010267A (es) |
| GR (1) | GR65190B (es) |
| IT (1) | IT1104583B (es) |
| LU (1) | LU80632A1 (es) |
| NL (1) | NL7812144A (es) |
| NO (1) | NO784094L (es) |
| PL (1) | PL114759B1 (es) |
| RO (1) | RO79702A (es) |
| SE (1) | SE7812649L (es) |
| YU (1) | YU294378A (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1190133B (it) * | 1986-06-19 | 1988-02-10 | Chiesi Farma Spa | Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| US5030632A (en) * | 1986-09-23 | 1991-07-09 | Sandoz Pharm. Corp. | Low dose temazepam |
| US5629310A (en) * | 1986-09-23 | 1997-05-13 | Sterling; William R. | Low dose temazepam |
| US5211954A (en) * | 1986-09-23 | 1993-05-18 | Sandoz Ltd. | Low dose temazepam |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3176009A (en) * | 1965-03-30 | Hydrolysis of l-acylated-j-acyloxy benzodiazepines | ||
| BE621819A (es) * | 1961-08-29 | |||
| AT242706B (de) * | 1962-11-28 | 1965-10-11 | Hoffmann La Roche | Verfahren zur Herstellung von neuen Benzodiazepin-Derivaten |
| GB1051795A (es) * | 1964-02-11 | |||
| US3236838A (en) * | 1964-06-09 | 1966-02-22 | Hoffmann La Roche | Certain 1-substituted-benzodiazepin-2-one compounds |
| FR135F (es) * | 1964-08-13 | |||
| US3801568A (en) * | 1972-02-07 | 1974-04-02 | American Home Prod | Optically active 1,3-dihydro-3-substituted 5-phenyl-2h-1,4-benzodiazepin-2-ones and process for their separation |
| NL173269C (nl) * | 1974-04-30 | 1984-01-02 | Ferrer Int | Werkwijze voor de bereiding van een geneesmiddel met als werkzaam bestanddeel een 1,4-benzodiazepinederivaat, alsmede werkwijze voor de bereiding van het 1,4-benzodiazepinederivaat. |
-
1978
- 1978-12-05 FI FI783743A patent/FI783743A/fi unknown
- 1978-12-05 DE DE19782852606 patent/DE2852606A1/de not_active Withdrawn
- 1978-12-06 NO NO784094A patent/NO784094L/no unknown
- 1978-12-06 GR GR57804A patent/GR65190B/el unknown
- 1978-12-08 LU LU80632A patent/LU80632A1/de unknown
- 1978-12-08 SE SE7812649A patent/SE7812649L/xx unknown
- 1978-12-12 BG BG044352A patent/BG29285A3/xx unknown
- 1978-12-12 FR FR7834868A patent/FR2411836A1/fr not_active Withdrawn
- 1978-12-12 PL PL1978211668A patent/PL114759B1/pl unknown
- 1978-12-12 BG BG041705A patent/BG29284A3/xx unknown
- 1978-12-12 GB GB7848060A patent/GB2010267A/en not_active Withdrawn
- 1978-12-13 DD DD78209726A patent/DD139851A5/de unknown
- 1978-12-13 NL NL7812144A patent/NL7812144A/xx not_active Application Discontinuation
- 1978-12-13 IT IT7830778A patent/IT1104583B/it active
- 1978-12-13 ES ES475960A patent/ES475960A1/es not_active Expired
- 1978-12-14 RO RO78101144A patent/RO79702A/ro unknown
- 1978-12-14 JP JP15565978A patent/JPS54138589A/ja active Pending
- 1978-12-14 DK DK562478A patent/DK562478A/da unknown
- 1978-12-14 AU AU42557/78A patent/AU4255778A/en active Pending
- 1978-12-14 YU YU02943/78A patent/YU294378A/xx unknown
- 1978-12-14 US US05/970,057 patent/US4261987A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS54138589A (en) | 1979-10-27 |
| IT7830778A0 (it) | 1978-12-13 |
| GB2010267A (en) | 1979-06-27 |
| GR65190B (en) | 1980-07-29 |
| YU294378A (en) | 1983-06-30 |
| PL114759B1 (en) | 1981-02-28 |
| DK562478A (da) | 1979-06-15 |
| US4261987A (en) | 1981-04-14 |
| LU80632A1 (de) | 1979-04-09 |
| FI783743A (fi) | 1979-06-15 |
| BG29285A3 (en) | 1980-10-15 |
| BG29284A3 (en) | 1980-10-15 |
| FR2411836A1 (fr) | 1979-07-13 |
| NL7812144A (nl) | 1979-06-18 |
| RO79702A (ro) | 1982-08-17 |
| SE7812649L (sv) | 1979-06-15 |
| NO784094L (no) | 1979-06-15 |
| IT1104583B (it) | 1985-10-21 |
| DE2852606A1 (de) | 1979-06-21 |
| GB2010267B (es) | |
| DD139851A5 (de) | 1980-01-23 |
| AU4255778A (en) | 1979-06-21 |
| PL211668A1 (pl) | 1979-07-30 |
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