MC1418A1 - 2,4-diamino-pyrimidines,leur preparation et medicaments contenant ces substances - Google Patents
2,4-diamino-pyrimidines,leur preparation et medicaments contenant ces substancesInfo
- Publication number
- MC1418A1 MC1418A1 MC811560A MC1560A MC1418A1 MC 1418 A1 MC1418 A1 MC 1418A1 MC 811560 A MC811560 A MC 811560A MC 1560 A MC1560 A MC 1560A MC 1418 A1 MC1418 A1 MC 1418A1
- Authority
- MC
- Monaco
- Prior art keywords
- pyrimidines
- diamino
- substances
- preparation
- medicines containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8036135 | 1980-11-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
MC1418A1 true MC1418A1 (fr) | 1982-10-18 |
Family
ID=10517217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MC811560A MC1418A1 (fr) | 1980-11-11 | 1981-11-10 | 2,4-diamino-pyrimidines,leur preparation et medicaments contenant ces substances |
Country Status (35)
Country | Link |
---|---|
US (4) | US4438267A (fr) |
EP (1) | EP0051879B1 (fr) |
JP (1) | JPS57114581A (fr) |
KR (1) | KR880001736B1 (fr) |
AR (1) | AR245447A1 (fr) |
AU (1) | AU549449B2 (fr) |
CA (1) | CA1186310A (fr) |
CS (1) | CS273153B2 (fr) |
CY (1) | CY1419A (fr) |
DD (1) | DD201896A5 (fr) |
DE (1) | DE3173752D1 (fr) |
DK (1) | DK172884B1 (fr) |
EG (1) | EG16107A (fr) |
ES (5) | ES8307759A1 (fr) |
FI (1) | FI76333C (fr) |
GB (1) | GB2087881B (fr) |
GR (1) | GR81317B (fr) |
HK (1) | HK23388A (fr) |
HU (1) | HU188762B (fr) |
IE (1) | IE52128B1 (fr) |
IL (1) | IL64256A (fr) |
IT (1) | IT1210589B (fr) |
MC (1) | MC1418A1 (fr) |
MY (1) | MY8600678A (fr) |
NO (2) | NO160137C (fr) |
NZ (1) | NZ198932A (fr) |
PH (2) | PH25053A (fr) |
PL (4) | PL139827B1 (fr) |
PT (1) | PT73960B (fr) |
RU (1) | RU1819264C (fr) |
SG (1) | SG62686G (fr) |
SU (4) | SU1424732A3 (fr) |
YU (5) | YU42444B (fr) |
ZA (1) | ZA817780B (fr) |
ZM (1) | ZM9481A1 (fr) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4438267A (en) * | 1980-11-11 | 1984-03-20 | Daluge Susan M | Monoheteroring compounds and their use |
ZA833067B (en) * | 1982-05-01 | 1984-12-24 | Wellcome Found | Antibacterial compounds |
US4590271A (en) * | 1982-05-01 | 1986-05-20 | Burroughs Wellcome Co. | 2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials |
DK190983A (da) * | 1982-05-01 | 1983-11-02 | Wellcome Found | 2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor |
US4587341A (en) * | 1982-05-07 | 1986-05-06 | Burroughs Wellcome Co. | 2,4-diamino-5-(1,2,3,4-tetrahydro-(substituted or unsubstituted)-6-quinolylmethyl)pyrimidines, useful as antimicrobials |
CA1244028A (fr) * | 1983-04-14 | 1988-11-01 | Hans Maag | Derives de pyrimidine |
GB8603964D0 (en) * | 1986-02-18 | 1986-03-26 | Cooper Animal Health Ltd | Compositions |
GB8603962D0 (en) * | 1986-02-18 | 1986-03-26 | Wellcome Found | Chemical compositions |
LU86703A1 (fr) * | 1986-12-08 | 1988-07-14 | Oreal | Composition cosmetique photostable contenant un filtre uv-a et un filtre uv-b,son utilisation pour la protection de la peau contre les rayons uv et procede de stabilisation du filtre uv-a par le filtre uv-b |
FI895821A0 (fi) * | 1988-12-07 | 1989-12-05 | Wellcome Found | Farmaceutiskt aktiva cns foereningar. |
GB8903978D0 (en) * | 1989-02-22 | 1989-04-05 | Coopers Animal Health | Chemical compositions |
GB9000241D0 (en) * | 1990-01-05 | 1990-03-07 | Coopers Animal Health | Pharmaceutical use |
RU95113597A (ru) * | 1992-12-02 | 1997-06-10 | ФМК Корпорейшн (US) | Инсектицидная композиция, способы борьбы с насекомыми |
US5707996A (en) * | 1995-11-06 | 1998-01-13 | Macleod Pharmaceuticals, Inc. | Pharmaceutical solution and methods for preparation thereof |
ES2169272T3 (es) * | 1995-12-04 | 2002-07-01 | Arpida Ag | Diaminopirimidinas, composiciones farmaceuticas que las contienen y su utilizacion como agente antibacteriano. |
WO2002010156A1 (fr) * | 2000-07-29 | 2002-02-07 | Arpida Ag | Derives de benzofuranne et leur utilisation en tant qu'agents antibacteriens |
US7700610B2 (en) * | 2001-06-29 | 2010-04-20 | Ab Science | Use of tyrosine kinase inhibitors for treating allergic diseases |
EP1434991B1 (fr) * | 2001-06-29 | 2007-10-17 | AB Science | Nouveaux inhibiteurs selectifs puissants et non toxiques de c-kit |
PT1401415E (pt) * | 2001-06-29 | 2006-09-29 | Ab Science | Utilizacao de derivados de n-fenil-2-pirimidino-amina para o tratamento de doencas inflamatorias |
ATE343415T1 (de) | 2001-06-29 | 2006-11-15 | Ab Science | Die verwendung von c-kit hemmer zur behandlung von entzündlichen darmerkrankungen |
EP1427379B1 (fr) * | 2001-09-20 | 2008-08-13 | AB Science | Utilisation d'inhibiteurs c-kit puissants, selectifs et non toxiques pour le traitement de la cystopathie interstitielle |
EP1450775B1 (fr) * | 2001-09-20 | 2008-03-12 | AB Science | Inhibiteurs de c-kit pour traiter des infections bacteriennes |
DE60227701D1 (de) * | 2001-09-20 | 2008-08-28 | Ab Science | Die verwendung von c-kithemmern zur förderung des haarwuchses |
WO2005005418A1 (fr) * | 2003-07-11 | 2005-01-20 | Arpida Ag | Derives de benzofurane et leur utilisation dans le traitement d'infections microbiennes |
EE200700051A (et) * | 2005-02-18 | 2007-12-17 | Arpida Ag | Meetod 2H-kromeeni valmistamiseks ning vahehendid |
EP1924565B1 (fr) * | 2005-09-01 | 2016-09-14 | F.Hoffmann-La Roche Ag | Diaminopyrimidines en tant que modulateurs de p2x3 et p3x2/3 |
WO2010003084A2 (fr) * | 2008-07-02 | 2010-01-07 | Memory Pharmaceuticals Corporation | Inhibiteurs de la phosphodiestérase 4 |
EP2440533B1 (fr) * | 2009-06-12 | 2015-09-23 | Socpra-Sciences Et Génie S.E.C. | Composés se liant à un ribocommutateur guanine et leur utilisation en tant qu'antibiotiques |
CN102649786B (zh) * | 2011-02-28 | 2014-08-27 | 郑州福源动物药业有限公司 | 一种2,4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2,4-(1h,3h)嘧啶的制备方法 |
CN103755684B (zh) * | 2014-02-10 | 2015-09-09 | 青岛蔚蓝生物股份有限公司 | 一种巴喹普林的制备方法 |
CN113924293B (zh) * | 2019-06-06 | 2024-07-09 | 北京泰德制药股份有限公司 | P2x3和/或p2x2/3受体拮抗剂、包含其的药物组合物及其用途 |
CN110818694B (zh) * | 2019-11-18 | 2023-04-21 | 上海医药工业研究院有限公司 | 艾拉普林中间体及其应用 |
WO2022217295A1 (fr) * | 2021-04-09 | 2022-10-13 | The Trustees Of The University Of Pennsylvania | Régulation de l'expression protéique avec des composés de tmp-protac |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3049544A (en) * | 1962-08-14 | Method for the preparation of | ||
DE1303727B (de) | 1959-09-03 | 1976-02-05 | Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London | Alpha-Arylidensubstituierte Propioni-Irile |
US3956327A (en) * | 1969-03-06 | 1976-05-11 | Burroughs Wellcome Co. | Method of preparing 2,4-diamino-5-benzyl pyrimidines |
BE792096A (fr) * | 1971-12-01 | 1973-05-30 | Hoffmann La Roche | Nouvelles benzylpyrimidines |
GB1468374A (en) | 1974-03-06 | 1977-03-23 | Wellcome Found | Process for preparing a pyrimidine derivative |
US4039543A (en) | 1974-12-24 | 1977-08-02 | Hoffmann-La Roche Inc. | Benzylpyrimidines |
GB1582245A (en) * | 1976-06-09 | 1981-01-07 | Wellcome Found | Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives |
DE2730467A1 (de) * | 1977-07-06 | 1979-01-18 | Basf Ag | Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
US4258045A (en) * | 1979-11-30 | 1981-03-24 | Merck & Co., Inc. | Inhibitor of dihydrofolate reductase |
US4438267A (en) * | 1980-11-11 | 1984-03-20 | Daluge Susan M | Monoheteroring compounds and their use |
-
1981
- 1981-11-09 US US06/319,644 patent/US4438267A/en not_active Expired - Lifetime
- 1981-11-10 HU HU813359A patent/HU188762B/hu unknown
- 1981-11-10 JP JP56180271A patent/JPS57114581A/ja active Granted
- 1981-11-10 KR KR1019810004348A patent/KR880001736B1/ko active
- 1981-11-10 ES ES506969A patent/ES8307759A1/es not_active Expired
- 1981-11-10 MC MC811560A patent/MC1418A1/fr unknown
- 1981-11-10 NO NO813804A patent/NO160137C/no not_active IP Right Cessation
- 1981-11-10 IL IL64256A patent/IL64256A/xx not_active IP Right Cessation
- 1981-11-10 PL PL1981239278A patent/PL139827B1/pl unknown
- 1981-11-10 GR GR66482A patent/GR81317B/el unknown
- 1981-11-10 ZA ZA817780A patent/ZA817780B/xx unknown
- 1981-11-10 IE IE2631/81A patent/IE52128B1/en not_active IP Right Cessation
- 1981-11-10 DK DK198104966A patent/DK172884B1/da active Protection Beyond IP Right Term
- 1981-11-10 SU SU813358051A patent/SU1424732A3/ru active
- 1981-11-10 PL PL1981239280A patent/PL139828B1/pl unknown
- 1981-11-10 FI FI813546A patent/FI76333C/fi not_active IP Right Cessation
- 1981-11-10 DD DD81234745A patent/DD201896A5/de not_active IP Right Cessation
- 1981-11-10 CS CS825781A patent/CS273153B2/cs unknown
- 1981-11-10 PL PL1981239279A patent/PL139427B1/pl unknown
- 1981-11-10 PT PT73960A patent/PT73960B/pt unknown
- 1981-11-10 EG EG653/81A patent/EG16107A/xx active
- 1981-11-10 GB GB8133833A patent/GB2087881B/en not_active Expired
- 1981-11-10 AU AU77334/81A patent/AU549449B2/en not_active Expired
- 1981-11-10 PL PL1981233754A patent/PL139523B1/pl unknown
- 1981-11-10 CA CA000389807A patent/CA1186310A/fr not_active Expired
- 1981-11-10 NZ NZ198932A patent/NZ198932A/en unknown
- 1981-11-10 IT IT8149676A patent/IT1210589B/it active
- 1981-11-10 YU YU2663/81A patent/YU42444B/xx unknown
- 1981-11-11 CY CY141981A patent/CY1419A/xx unknown
- 1981-11-11 EP EP81109631A patent/EP0051879B1/fr not_active Expired
- 1981-11-11 ZM ZM94/81A patent/ZM9481A1/xx unknown
- 1981-11-11 DE DE8181109631T patent/DE3173752D1/de not_active Expired
-
1983
- 1983-01-27 SU SU833543245A patent/SU1318148A3/ru active
- 1983-01-31 SU SU833547444A patent/SU1306473A3/ru active
- 1983-04-02 ES ES521204A patent/ES8405380A1/es not_active Expired
- 1983-04-02 ES ES521203A patent/ES8405379A1/es not_active Expired
- 1983-04-02 ES ES521202A patent/ES521202A0/es active Granted
- 1983-04-02 ES ES521201A patent/ES521201A0/es active Granted
- 1983-09-07 PH PH29503A patent/PH25053A/en unknown
- 1983-09-07 PH PH29502A patent/PH22654A/en unknown
- 1983-10-03 YU YU01982/83A patent/YU198283A/xx unknown
- 1983-10-03 YU YU01981/83A patent/YU198183A/xx unknown
- 1983-10-03 YU YU1983/83A patent/YU43551B/xx unknown
- 1983-10-31 US US06/546,850 patent/US4587342A/en not_active Expired - Lifetime
- 1983-12-30 US US06/567,248 patent/US4603136A/en not_active Expired - Lifetime
-
1986
- 1986-02-02 RU SU863552053A patent/RU1819264C/ru active
- 1986-03-12 US US06/839,463 patent/US4761475A/en not_active Expired - Lifetime
- 1986-07-17 SG SG626/86A patent/SG62686G/en unknown
- 1986-12-30 MY MY678/86A patent/MY8600678A/xx unknown
-
1987
- 1987-01-14 SU SU874028793A patent/SU1535379A3/ru active
-
1988
- 1988-03-30 HK HK233/88A patent/HK23388A/xx not_active IP Right Cessation
- 1988-06-17 AR AR88311165A patent/AR245447A1/es active
- 1988-07-26 YU YU144288A patent/YU46697B/sh unknown
-
1994
- 1994-12-29 NO NO1994029C patent/NO1994029I1/no unknown
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Legal Events
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YP | Annual fee paid |