GB1468374A - Process for preparing a pyrimidine derivative - Google Patents

Process for preparing a pyrimidine derivative

Info

Publication number
GB1468374A
GB1468374A GB1010574A GB1010574A GB1468374A GB 1468374 A GB1468374 A GB 1468374A GB 1010574 A GB1010574 A GB 1010574A GB 1010574 A GB1010574 A GB 1010574A GB 1468374 A GB1468374 A GB 1468374A
Authority
GB
United Kingdom
Prior art keywords
resulting
pyrimidine
preparing
trimethoxybenzyl
diamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1010574A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB1010574A priority Critical patent/GB1468374A/en
Publication of GB1468374A publication Critical patent/GB1468374A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

1468374 Pyrimidines WELLCOME FOUNDATION Ltd 6 March 1974 10105/74 Heading C2C 2,4 - Diamino - 5 - (3,4,5 - trimethoxybenzyl)- pyrimidine is prepared by condensing 3,4,5-trimethoxybenzaldehyde with a dialkyl malonate, hydrogenating the resulting dialkyl 3,4,5-trimethoxybenzlidenemalonate, condensing the trimethoxybenzylmalonate obtained with urea to afford 3,4,5-trimethoxybenzylbarbituric acid, chlorinating the latter, subjecting the resulting 2,4,6 - trichloro - 5 - (3,4,5 - trimethoxybenzyl)- pyrimidine to selective amination and reducing the resulting 2,4-diamino-6-chloropyrimidine derivative to remove the remaining chlorine atom.
GB1010574A 1974-03-06 1974-03-06 Process for preparing a pyrimidine derivative Expired GB1468374A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1010574A GB1468374A (en) 1974-03-06 1974-03-06 Process for preparing a pyrimidine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1010574A GB1468374A (en) 1974-03-06 1974-03-06 Process for preparing a pyrimidine derivative

Publications (1)

Publication Number Publication Date
GB1468374A true GB1468374A (en) 1977-03-23

Family

ID=9961592

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1010574A Expired GB1468374A (en) 1974-03-06 1974-03-06 Process for preparing a pyrimidine derivative

Country Status (1)

Country Link
GB (1) GB1468374A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438267A (en) 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438267A (en) 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee