GB841239A - Process for the manufacture of 4-amino-2, 6-dichloro-pyrimidine - Google Patents

Process for the manufacture of 4-amino-2, 6-dichloro-pyrimidine

Info

Publication number
GB841239A
GB841239A GB3237059A GB3237059A GB841239A GB 841239 A GB841239 A GB 841239A GB 3237059 A GB3237059 A GB 3237059A GB 3237059 A GB3237059 A GB 3237059A GB 841239 A GB841239 A GB 841239A
Authority
GB
United Kingdom
Prior art keywords
amino
dichloro
pyrimidine
manufacture
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3237059A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB841239A publication Critical patent/GB841239A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

4 - Amino - 2:6 - dichloro - pyrimidine is made by heating 4 - amino - 2:6 - dihydroxypyrimidine with 4 to 12 (preferably 11) parts by weight of phosphorous oxychloride and 0.2 to 1.5 (preferably 0.3) parts of dimethylaniline at 70 DEG to 130 DEG C., preferably at 80 DEG to 100 DEG C. The product is worked up by removing the excess phosphorus oxychloride and treating with water.
GB3237059A 1957-03-26 1958-03-21 Process for the manufacture of 4-amino-2, 6-dichloro-pyrimidine Expired GB841239A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT197057 1957-03-26

Publications (1)

Publication Number Publication Date
GB841239A true GB841239A (en) 1960-07-13

Family

ID=3524986

Family Applications (2)

Application Number Title Priority Date Filing Date
GB3237059A Expired GB841239A (en) 1957-03-26 1958-03-21 Process for the manufacture of 4-amino-2, 6-dichloro-pyrimidine
GB908658A Expired GB841231A (en) 1957-03-26 1958-03-21 Process for the manufacture of 4-sulphanilamido-2, 6-dimethoxy-pyrimidine

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB908658A Expired GB841231A (en) 1957-03-26 1958-03-21 Process for the manufacture of 4-sulphanilamido-2, 6-dimethoxy-pyrimidine

Country Status (7)

Country Link
BE (1) BE565823A (en)
CH (1) CH369454A (en)
DE (1) DE1098516B (en)
FR (1) FR1203619A (en)
GB (2) GB841239A (en)
MY (2) MY6200012A (en)
NL (2) NL100261C (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB866842A (en) * 1958-12-08 1961-05-03 Ici Ltd Pyrimidines
DE1276040B (en) * 1959-11-18 1968-08-29 Hoffmann La Roche Process for the preparation of 2,6-dimethoxy-4-sulfanilamidopyrimidine
CN105646373B (en) * 2016-02-18 2018-05-29 滨海新东方医化有限公司 A kind of preparation method of 4- amino -2,6- dimethoxypyridins

Also Published As

Publication number Publication date
FR1203619A (en) 1960-01-20
GB841231A (en) 1960-07-13
NL100350C (en)
BE565823A (en)
MY6200012A (en) 1962-12-31
MY6200011A (en) 1962-12-31
NL100261C (en)
CH369454A (en) 1963-05-31
DE1098516B (en) 1961-02-02

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