GB1393863A - Process for producing n1-dihydroxyalkyl uracils - Google Patents

Process for producing n1-dihydroxyalkyl uracils

Info

Publication number
GB1393863A
GB1393863A GB2946573A GB2946573A GB1393863A GB 1393863 A GB1393863 A GB 1393863A GB 2946573 A GB2946573 A GB 2946573A GB 2946573 A GB2946573 A GB 2946573A GB 1393863 A GB1393863 A GB 1393863A
Authority
GB
United Kingdom
Prior art keywords
dihydroxypentyl
dihydroxybutyl
dihydroxyalkyl
uracils
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2946573A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
I ORCH SINTEZA AKADEMII NAUK L
Original Assignee
I ORCH SINTEZA AKADEMII NAUK L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I ORCH SINTEZA AKADEMII NAUK L filed Critical I ORCH SINTEZA AKADEMII NAUK L
Priority to GB2946573A priority Critical patent/GB1393863A/en
Publication of GB1393863A publication Critical patent/GB1393863A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1393863 N 1 -(Dihydroxyalkyl)-uracils ORDENA TRUDOVOGO KRASNOGO ZNAMENI INSTITUT ORGANICHESKOGO SINTEZA AKADEMII NAUK LATVIISKOI SSR 21 June 1973 29465/73 Heading C2C Compounds of Formula (I) wherein R 1 is -H, -CH 3 , trihalomethyl or halogen and R 2 is 1,4-dihydroxybutyl-2, 1,4- dihydroxypentyl-2, or 2,5-dihydroxypentyl-1, are obtained by reduction with an alkali metal boron hydride of the corresponding uracil wherein R 2 is The reaction is generally effected in aqueous or aqueous-alcoholic solution and at 15‹ to 50‹ C. The examples prepare N 1 -(1,4-dihydroxybutyl - 2) - uracil, N 1 - (1,4 - dihydroxybutyl - 2)- 5 - fluorouracil, N 1 - (1,4 - dihydroxypentyl - 2)- 5 - methyluracil and N 1 - (2,5 - dihydroxypentyl-1)-5-trifluoromethyluracil.
GB2946573A 1973-06-21 1973-06-21 Process for producing n1-dihydroxyalkyl uracils Expired GB1393863A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2946573A GB1393863A (en) 1973-06-21 1973-06-21 Process for producing n1-dihydroxyalkyl uracils

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2946573A GB1393863A (en) 1973-06-21 1973-06-21 Process for producing n1-dihydroxyalkyl uracils

Publications (1)

Publication Number Publication Date
GB1393863A true GB1393863A (en) 1975-05-14

Family

ID=10291979

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2946573A Expired GB1393863A (en) 1973-06-21 1973-06-21 Process for producing n1-dihydroxyalkyl uracils

Country Status (1)

Country Link
GB (1) GB1393863A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049144A1 (en) * 1980-10-01 1982-04-07 Beecham Group Plc 5-Fluoro uracil derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049144A1 (en) * 1980-10-01 1982-04-07 Beecham Group Plc 5-Fluoro uracil derivatives

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee