ES472284A1 - Procedimiento para la preparacion de 6-deoxineamina - Google Patents

Procedimiento para la preparacion de 6-deoxineamina

Info

Publication number
ES472284A1
ES472284A1 ES472284A ES472284A ES472284A1 ES 472284 A1 ES472284 A1 ES 472284A1 ES 472284 A ES472284 A ES 472284A ES 472284 A ES472284 A ES 472284A ES 472284 A1 ES472284 A1 ES 472284A1
Authority
ES
Spain
Prior art keywords
deoxyneamines
aminoglycoside compounds
deoxy
aminoglycoside
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES472284A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ES472284A1 publication Critical patent/ES472284A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedimiento para la preparación de 6-deoxineamina de la fórmula: ** (Ver fórmula III) ** o de una de sus sales farmacéuticamente acedptables, caracterizado porque comprende: (1) esterificar un compuesto de la fórmula: ** (Ver fórmula I) ** en la posición 6 con un compuesto de la fórmula Cl-SO2-R7 para formar un 6-sulfonil éster de la fórmula: ** (Ver fórmula II) ** y (2) desulfonando el 6-sulfonil éster de la fórmula II con una sal formadora de cetona, en que Q, Z'', E, A'', W'', R7 y G se definen en la memoria descriptiva.
ES472284A 1977-09-06 1978-08-02 Procedimiento para la preparacion de 6-deoxineamina Expired ES472284A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83068477A 1977-09-06 1977-09-06
US05/885,872 US4169197A (en) 1977-09-06 1978-03-13 6-Deoxyneamines aminoglycoside compounds

Publications (1)

Publication Number Publication Date
ES472284A1 true ES472284A1 (es) 1980-04-16

Family

ID=27125386

Family Applications (1)

Application Number Title Priority Date Filing Date
ES472284A Expired ES472284A1 (es) 1977-09-06 1978-08-02 Procedimiento para la preparacion de 6-deoxineamina

Country Status (12)

Country Link
US (1) US4169197A (es)
JP (1) JPS5448736A (es)
AU (1) AU521180B2 (es)
CA (1) CA1095031A (es)
CH (1) CH638225A5 (es)
DE (1) DE2836913A1 (es)
ES (1) ES472284A1 (es)
FR (3) FR2411842A1 (es)
GB (3) GB2024825A (es)
IL (1) IL55358A (es)
IT (1) IT7850981A0 (es)
NL (1) NL7809034A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5540621A (en) * 1978-09-14 1980-03-22 Shionogi & Co Ltd Novel aminoglycoside derivative
US4468513A (en) * 1980-09-22 1984-08-28 Eli Lilly And Company 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
US4424345A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
US4424344A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
US4468512A (en) * 1980-09-22 1984-08-28 Eli Lilly And Company 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
WO2016114339A1 (ja) 2015-01-14 2016-07-21 東洋紡株式会社 導電性布帛
HK1257935A1 (zh) 2015-09-02 2019-11-01 Eloxx Pharmaceuticals Ltd. 氨基糖苷衍生物及其在治疗遗传性病症中的应用
EP3344640A4 (en) 2015-09-02 2019-05-01 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
WO2017037718A1 (en) 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
WO2017118967A1 (en) * 2016-01-05 2017-07-13 Technion Research & Development Foundation Limited Aminoglycoside derivatives and uses thereof in treating microbial infections
WO2017122639A1 (ja) 2016-01-13 2017-07-20 東洋紡株式会社 伸縮性導体組成物、伸縮性導体形成用ペースト、伸縮性導体組成物からなる配線を有する衣服、およびその製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4063015A (en) * 1973-08-27 1977-12-13 Schering Corporation Garamine and derivatives thereof
FR2263747B1 (es) * 1974-03-12 1977-12-02 Roussel Uclaf
FR2290908A1 (fr) * 1974-11-13 1976-06-11 Roussel Uclaf Nouveau derive aminoglycosidique et ses sels, leur procede de preparation et leur application comme medicaments
JPS5913519B2 (ja) * 1975-08-15 1984-03-30 ザイダンホウジン ビセイブツカガクケンキユウカイ １−Ｎ−（α−置換−ω−アミノアシル）−３′−デオキシ−５−ｏ−ペントフラノシルネアミン誘導体の新規な製造法
US4038478A (en) * 1975-09-08 1977-07-26 The Upjohn Company O-glycoside ortho esters of neamine containing compounds
GB1537901A (en) * 1975-10-07 1979-01-10 Suami T Aminocyclitol derivatives and a process for producing the same

Also Published As

Publication number Publication date
NL7809034A (nl) 1979-03-08
FR2411843B1 (es) 1982-11-12
JPS5448736A (en) 1979-04-17
CH638225A5 (de) 1983-09-15
GB2005664A (en) 1979-04-25
GB2024825A (en) 1980-01-16
FR2411842B1 (es) 1981-12-11
IL55358A (en) 1983-09-30
IT7850981A0 (it) 1978-09-05
AU521180B2 (en) 1982-03-18
CA1095031A (en) 1981-02-03
FR2411843A1 (fr) 1979-07-13
FR2411842A1 (fr) 1979-07-13
GB2005664B (en) 1982-05-26
DE2836913A1 (de) 1979-03-15
IL55358A0 (en) 1978-10-31
US4169197A (en) 1979-09-25
FR2411844A1 (fr) 1979-07-13
GB2031894B (en) 1982-07-07
AU3887178A (en) 1980-02-21
GB2031894A (en) 1980-04-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000503