FR2411844A1 - Nouvelles 5-0-glucosyl-6-deoxyneamines et intermediaires necessaires a leur preparation - Google Patents

Nouvelles 5-0-glucosyl-6-deoxyneamines et intermediaires necessaires a leur preparation

Info

Publication number
FR2411844A1
FR2411844A1 FR7908623A FR7908623A FR2411844A1 FR 2411844 A1 FR2411844 A1 FR 2411844A1 FR 7908623 A FR7908623 A FR 7908623A FR 7908623 A FR7908623 A FR 7908623A FR 2411844 A1 FR2411844 A1 FR 2411844A1
Authority
FR
France
Prior art keywords
deoxyneamines
glucosyl
news
preparation
intermediaries
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7908623A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2411844A1 publication Critical patent/FR2411844A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'INVENTION SE SITUE DANS LE DOMAINE DES AGENTS ANTIBACTERIENS. ELLE CONCERNE PLUS PARTICULIEREMENT DES COMPOSES AYANT COMME FORMULE: (CF DESSIN DANS BOPI) (CF DESSIN DANS BOPI) (OU UN SEL ACCEPTABLE DU POINT DE VUE PHARMACEUTIQUE DE CE COMPOSE), FORMULE DANS LAQUELLE Q, Z, A, W, LE SIGNE , R, M ET L ONT LES DEFINITIONS DONNEES DANS LA REVENDICATION 1. L'INVENTION CONCERNE EGALEMENT DES INTERMEDIAIRES CHIMIQUES.
FR7908623A 1977-09-06 1979-04-05 Nouvelles 5-0-glucosyl-6-deoxyneamines et intermediaires necessaires a leur preparation Pending FR2411844A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83068477A 1977-09-06 1977-09-06
US05/885,872 US4169197A (en) 1977-09-06 1978-03-13 6-Deoxyneamines aminoglycoside compounds

Publications (1)

Publication Number Publication Date
FR2411844A1 true FR2411844A1 (fr) 1979-07-13

Family

ID=27125386

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7825492A Granted FR2411842A1 (fr) 1977-09-06 1978-09-05 Nouvelles 6-deoxy-5-oxoneamines, leur procede de preparation
FR7908623A Pending FR2411844A1 (fr) 1977-09-06 1979-04-05 Nouvelles 5-0-glucosyl-6-deoxyneamines et intermediaires necessaires a leur preparation
FR7908622A Granted FR2411843A1 (fr) 1977-09-06 1979-04-05 Nouvelles 6-deoxyneamines eventuellement 1-n-alkylees et intermediaires necessaires a leur preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7825492A Granted FR2411842A1 (fr) 1977-09-06 1978-09-05 Nouvelles 6-deoxy-5-oxoneamines, leur procede de preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7908622A Granted FR2411843A1 (fr) 1977-09-06 1979-04-05 Nouvelles 6-deoxyneamines eventuellement 1-n-alkylees et intermediaires necessaires a leur preparation

Country Status (12)

Country Link
US (1) US4169197A (fr)
JP (1) JPS5448736A (fr)
AU (1) AU521180B2 (fr)
CA (1) CA1095031A (fr)
CH (1) CH638225A5 (fr)
DE (1) DE2836913A1 (fr)
ES (1) ES472284A1 (fr)
FR (3) FR2411842A1 (fr)
GB (3) GB2031894B (fr)
IL (1) IL55358A (fr)
IT (1) IT7850981A0 (fr)
NL (1) NL7809034A (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5540621A (en) * 1978-09-14 1980-03-22 Shionogi & Co Ltd Novel aminoglycoside derivative
US4424345A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
US4468513A (en) * 1980-09-22 1984-08-28 Eli Lilly And Company 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
US4468512A (en) * 1980-09-22 1984-08-28 Eli Lilly And Company 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
US4424344A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
WO2016114339A1 (fr) 2015-01-14 2016-07-21 東洋紡株式会社 Tissu conducteur
US11306115B2 (en) 2015-09-02 2022-04-19 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
US10786520B2 (en) 2015-09-02 2020-09-29 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
CA2996763A1 (fr) 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Derives d'aminoglycosides et leurs utilisations dans le traitement de troubles genetiques
US20190016745A1 (en) * 2016-01-05 2019-01-17 Technion Research & Development Foundation Limited Aminoglycoside derivatives and uses thereof in treating microbial infections
JP6741026B2 (ja) 2016-01-13 2020-08-19 東洋紡株式会社 伸縮性導体組成物、伸縮性導体形成用ペースト、伸縮性導体組成物からなる配線を有する衣服、およびその製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4063015A (en) * 1973-08-27 1977-12-13 Schering Corporation Garamine and derivatives thereof
FR2263747B1 (fr) * 1974-03-12 1977-12-02 Roussel Uclaf
FR2290908A1 (fr) * 1974-11-13 1976-06-11 Roussel Uclaf Nouveau derive aminoglycosidique et ses sels, leur procede de preparation et leur application comme medicaments
JPS5913519B2 (ja) * 1975-08-15 1984-03-30 ザイダンホウジン ビセイブツカガクケンキユウカイ １−Ｎ−（α−置換−ω−アミノアシル）−３′−デオキシ−５−ｏ−ペントフラノシルネアミン誘導体の新規な製造法
US4038478A (en) * 1975-09-08 1977-07-26 The Upjohn Company O-glycoside ortho esters of neamine containing compounds
FR2327257A1 (fr) * 1975-10-07 1977-05-06 Suami T Derives de l'aminocyclitol et leur procede de preparation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL & PHARMACEUTICAL BULLETIN, volume 26, no. 6, juin 1978, JP, TERUO HAYASHI et al.: "Deoxysugar Synthesis.IV. Deoxygenation of Amono-glycoside Antibiotics through Reduction of Their Dithiocarbonates", pages 1786-1797 *
CHEMICAL ABSTRACTS, volume 81, no. 19, 11 novembre 1974, page 568, réf. 120 898t, COLUMBUS, OHIO, (US), & MEIJI SEIKA KENKYU NEMPO, 1973, no. 13, 1-20, INOUE et al.: "Chemical modification of antibiotic SF-733.II Synthesis of 6-deoxy derivatives of SF-733" & 9th Collective Index formulas, 81: 120898t *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, volume 98, no. 22, 27 octobre 1976, US, "A Chiral Synthesis of D-(+)-2,6-Dideoxystreptamine and Its Microbial Incorporation into Novel Antibiotics", pages 7710-7712 *
JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, no. 15, 2 août 1978, US, JEANINE CLEOPHAX et al.: "Synthesis of alpha-Linked 3'Deoxy-pseudo-di- and -tri-saccharides Related to Amino-cyclitol-glycoside Antibiotics", pages 773-774 *

Also Published As

Publication number Publication date
ES472284A1 (es) 1980-04-16
IT7850981A0 (it) 1978-09-05
CH638225A5 (de) 1983-09-15
FR2411842B1 (fr) 1981-12-11
DE2836913A1 (de) 1979-03-15
GB2005664A (en) 1979-04-25
IL55358A (en) 1983-09-30
FR2411843B1 (fr) 1982-11-12
AU521180B2 (en) 1982-03-18
NL7809034A (nl) 1979-03-08
FR2411842A1 (fr) 1979-07-13
IL55358A0 (en) 1978-10-31
CA1095031A (fr) 1981-02-03
JPS5448736A (en) 1979-04-17
AU3887178A (en) 1980-02-21
GB2031894A (en) 1980-04-30
GB2031894B (en) 1982-07-07
GB2005664B (en) 1982-05-26
GB2024825A (en) 1980-01-16
US4169197A (en) 1979-09-25
FR2411843A1 (fr) 1979-07-13

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