ES467189A1 - Un procedimiento para la preparacion de nuevas pirroloquino-xalinonas y pirrolobenzodiazepinonas - Google Patents

Un procedimiento para la preparacion de nuevas pirroloquino-xalinonas y pirrolobenzodiazepinonas

Info

Publication number
ES467189A1
ES467189A1 ES467189A ES467189A ES467189A1 ES 467189 A1 ES467189 A1 ES 467189A1 ES 467189 A ES467189 A ES 467189A ES 467189 A ES467189 A ES 467189A ES 467189 A1 ES467189 A1 ES 467189A1
Authority
ES
Spain
Prior art keywords
pyrroloquinoxalinones
diones
substituted
inflammatory
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES467189A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES467189A1 publication Critical patent/ES467189A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un procedimiento para la preparación de nuevas pirroloquinoxalinonas y pirrolobentodiazopinonas de fórmula: **(Fórmula)** donde R1 es hidrógeno o alquilo C1-C3; R2, tomado individualmente, es hidrógeno, alquilo C1-C3, alcoxi C1-C3, cloro, o flúor R3, tomado individualmente, es hidrógeno o bien R2 y R3 tomados junto con los átomos de carbono a los que están enlazados forman un anillo bencénico; R4 es hidrógeno, cloro o flúor; R5 es hidroxi, hidrógeno o fenilo; Y es oxígeno o dos átomos de hidrógeno; Z es -CH2-CH2- o -CHR6-, donde R6 es hidrógeno o alquilo C1- C3.
ES467189A 1977-02-25 1978-02-21 Un procedimiento para la preparacion de nuevas pirroloquino-xalinonas y pirrolobenzodiazepinonas Expired ES467189A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/772,154 US4075206A (en) 1977-02-25 1977-02-25 Substituted pyrroloquinoxalinones and diones

Publications (1)

Publication Number Publication Date
ES467189A1 true ES467189A1 (es) 1979-08-16

Family

ID=25094096

Family Applications (1)

Application Number Title Priority Date Filing Date
ES467189A Expired ES467189A1 (es) 1977-02-25 1978-02-21 Un procedimiento para la preparacion de nuevas pirroloquino-xalinonas y pirrolobenzodiazepinonas

Country Status (26)

Country Link
US (2) US4075206A (es)
JP (1) JPS53111095A (es)
AR (1) AR218056A1 (es)
AT (1) AT361489B (es)
AU (1) AU513391B2 (es)
BE (1) BE864105A (es)
BG (1) BG28565A3 (es)
CA (1) CA1097631A (es)
CS (1) CS203184B2 (es)
DD (1) DD134871A5 (es)
DE (1) DE2807145A1 (es)
DK (1) DK74578A (es)
ES (1) ES467189A1 (es)
FR (1) FR2381767A1 (es)
GB (1) GB1595745A (es)
GR (1) GR68942B (es)
IL (1) IL54086A0 (es)
IT (1) IT1094215B (es)
NL (1) NL7801927A (es)
NZ (1) NZ186512A (es)
PH (1) PH13147A (es)
PL (1) PL204796A1 (es)
PT (1) PT67678B (es)
SE (1) SE7802024L (es)
YU (1) YU39178A (es)
ZA (1) ZA78991B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4262123A (en) * 1978-09-11 1981-04-14 The Upjohn Company Quinoxalinones
US4242342A (en) * 1979-05-31 1980-12-30 The Upjohn Company Quinoxalinones useful for treating atopic eczema and urticaria
US4499270A (en) * 1981-04-16 1985-02-12 Riker Laboratories, Inc. Substituted pyridoquinoxaline-6-carboxylic acids and derivatives thereof
IL93136A (en) * 1989-02-23 1995-01-24 Janssen Pharmaceutica Nv History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them
NZ235137A (en) * 1989-09-13 1992-02-25 Janssen Pharmaceutica Nv Tetrahydroimidazo(1,4)benzodiazepine derivatives, preparation and pharmaceutical compositions thereof
JPH05117276A (ja) * 1991-10-23 1993-05-14 Sumitomo Pharmaceut Co Ltd 新規な３環性キノキサリンジオン誘導体
TW260660B (es) * 1993-04-22 1995-10-21 Sumitomo Pharma
CN114230528B (zh) * 2021-11-25 2024-02-06 桂林理工大学 一种制备喹喔啉酮衍生物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892746A (en) * 1969-06-09 1975-07-01 American Home Prod Pyrrolo{8 1,2,3-de{9 quinoxalin-2(3H)-ones and related compounds
US3813392A (en) * 1969-06-09 1974-05-28 J Sellstedt Pyrrolo(1,2,3-alpha epsilon)quinoxalin-2(3h)-ones and related compounds
US3642821A (en) * 1969-11-03 1972-02-15 Upjohn Co Tetrahydropyrrolobenzodiazepines
US3579503A (en) * 1969-11-03 1971-05-18 Upjohn Co Pyrrolo(3,2,1-jk)(1,4)benzodiazepinones

Also Published As

Publication number Publication date
CS203184B2 (en) 1981-02-27
US4087527A (en) 1978-05-02
PL204796A1 (pl) 1979-04-09
AU513391B2 (en) 1980-11-27
FR2381767A1 (fr) 1978-09-22
GR68942B (es) 1982-03-29
GB1595745A (en) 1981-08-19
SE7802024L (sv) 1978-08-26
IT1094215B (it) 1985-07-26
AT361489B (de) 1981-03-10
PT67678B (en) 1979-07-20
US4075206A (en) 1978-02-21
AU3343378A (en) 1979-08-30
CA1097631A (en) 1981-03-17
BG28565A3 (bg) 1980-05-15
IL54086A0 (en) 1978-04-30
BE864105A (fr) 1978-08-21
NL7801927A (nl) 1978-08-29
ZA78991B (en) 1979-10-31
AR218056A1 (es) 1980-05-15
DK74578A (da) 1978-08-26
DE2807145A1 (de) 1978-08-31
YU39178A (en) 1983-01-21
NZ186512A (en) 1981-03-16
DD134871A5 (de) 1979-03-28
IT7820417A0 (it) 1978-02-20
PH13147A (en) 1979-12-18
PT67678A (en) 1978-03-01
ATA131578A (de) 1980-08-15
JPS53111095A (en) 1978-09-28

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