MX171822B - Proceso quimico - Google Patents

Proceso quimico

Info

Publication number
MX171822B
MX171822B MX006890A MX689086A MX171822B MX 171822 B MX171822 B MX 171822B MX 006890 A MX006890 A MX 006890A MX 689086 A MX689086 A MX 689086A MX 171822 B MX171822 B MX 171822B
Authority
MX
Mexico
Prior art keywords
chemical process
formula
alkyl
compound
aryl
Prior art date
Application number
MX006890A
Other languages
English (en)
Inventor
Erol Ali Faruk
Roger Thomas Martin
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858520153A external-priority patent/GB8520153D0/en
Priority claimed from GB868612579A external-priority patent/GB8612579D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of MX171822B publication Critical patent/MX171822B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de un compuesto de fórmula (I): donde Ar es arilo, o arilo sustituído y R3 es hidrógeno, alquilo o aralquilo, que comprende reducir un compuesto de fórmula (II): donde Ar y R3 se definen como en la fórmula (I) y R4 es alquilo.
MX006890A 1985-08-10 1986-08-08 Proceso quimico MX171822B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858520153A GB8520153D0 (en) 1985-08-10 1985-08-10 Chemical process
GB868612579A GB8612579D0 (en) 1986-05-23 1986-05-23 Chemical process

Publications (1)

Publication Number Publication Date
MX171822B true MX171822B (es) 1993-11-17

Family

ID=26289644

Family Applications (1)

Application Number Title Priority Date Filing Date
MX006890A MX171822B (es) 1985-08-10 1986-08-08 Proceso quimico

Country Status (17)

Country Link
US (1) US4902801A (es)
EP (1) EP0223334B1 (es)
JP (2) JPH0696551B2 (es)
AU (1) AU582456B2 (es)
BG (1) BG61319B2 (es)
CA (1) CA1310649C (es)
CY (1) CY1708A (es)
DE (1) DE3680184D1 (es)
DK (1) DK169730B1 (es)
ES (2) ES2000603A6 (es)
GR (1) GR862102B (es)
HK (1) HK69793A (es)
IE (1) IE58831B1 (es)
MX (1) MX171822B (es)
NZ (1) NZ217141A (es)
PT (1) PT83179B (es)
SG (1) SG27793G (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8714707D0 (en) * 1987-06-23 1987-07-29 Beecham Group Plc Chemical process
DK588289D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Ny heterocyklisk kemi
JPH04288059A (ja) * 1991-03-14 1992-10-13 Nippon Paint Co Ltd 複素環化合物及びその製造法
GB9209687D0 (en) * 1992-05-06 1992-06-17 Smithkline Beecham Plc Novel process
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
GB9305175D0 (en) * 1993-03-13 1993-04-28 Smithkline Beecham Plc Novel process
GB9325644D0 (en) * 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation
US6444190B2 (en) 1995-08-03 2002-09-03 Fmc Corporation Reduction compositions and processes for making the same
WO1997005879A1 (en) * 1995-08-03 1997-02-20 Fmc Corporation Reductions using hydrides
ES2121685B1 (es) * 1996-04-10 1999-09-16 Vita Invest Sa Procedimiento para la obtencion de (+)-trans-4(4-fluoro-fenil)-3-hidroximetil-1-metilpiperidina.
JP3446468B2 (ja) 1996-04-15 2003-09-16 旭硝子株式会社 ピペリジンカルビノール類の製造方法
US5936090A (en) * 1996-05-24 1999-08-10 Fmc Corporation Processes for the reduction of imide ester functionality
EP1384711A1 (en) * 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Optical resolution of a piperidine derivative
US6638948B1 (en) 1996-09-09 2003-10-28 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
WO1998013319A1 (en) * 1996-09-24 1998-04-02 Fmc Corporation Novel reduction compositions and processes for making the same
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process
EP0975595B9 (en) * 1997-04-07 2009-09-16 Georgetown University Analogs of cocaine
GB9710004D0 (en) * 1997-05-17 1997-07-09 Knoll Ag Chemical process
JP2002514222A (ja) * 1997-05-29 2002-05-14 スミスクライン・ビーチャム・コーポレイション 新規方法
CA2293247C (en) * 1997-06-10 2005-04-12 Synthon B.V. 4-phenylpiperidine compounds
DE69910691T2 (de) * 1998-06-29 2004-07-08 Sumika Fine Chemical Co. Ltd. L-Tartrate von Trans-(-)-4-(4-Fluorphenyl)-3-Hydroxymethyl-Piperidin Verbindungen und Verfahren zu ihrer Herstellung
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
CZ20011465A3 (cs) * 1998-11-02 2001-08-15 Synthon B. V. Způsob přípravy 4-arylpiperidin-3-methanolů a příbuzných sloučenin
GB9915303D0 (en) * 1999-06-30 1999-09-01 Smithkline Beecham Plc Novel process
IT1313702B1 (it) * 1999-08-02 2002-09-09 Chemi Spa Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine.
GB9920147D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
WO2001029002A1 (en) * 1999-10-20 2001-04-26 Smithkline Beecham Plc Process for the preparation of 4-(fluorophenyl)piperidine esters
GB9924855D0 (en) * 1999-10-20 1999-12-22 Smithkline Beecham Plc Novel processes
GB9924882D0 (en) * 1999-10-20 1999-12-22 Smithkline Beecham Plc Novel process
GB9930577D0 (en) * 1999-12-23 2000-02-16 Smithkline Beecham Plc Novel process
WO2001085688A1 (en) * 2000-05-12 2001-11-15 Synthon B.V. TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS
US6833458B2 (en) 2000-06-05 2004-12-21 Development Center For Biotechnology Practical syntheses of chiral trans-3, 4-disubstituted piperidines and the intermediates
AU2001211337A1 (en) * 2000-10-06 2002-04-15 Smithkline Beecham Plc Process for the preparation of aryl-piperidine carbinols and intermediates thereof
EP1347960B1 (en) * 2001-01-04 2004-11-17 Ferrer Internacional, S.A. Process for preparing (+) trans-4-p-fluorophenyl-3-hydroxymethyl-1
US6777554B2 (en) 2001-02-05 2004-08-17 Teva Pharmaceutical Industries Ltd. Preparation of N-methylparoxetine and related intermediate compounds
EP1362032A2 (en) * 2001-02-24 2003-11-19 Spurcourt Limited Process of preparing paroxetine and intermediates for use therein
JP2006512278A (ja) 2001-06-13 2006-04-13 テバ ファーマシューティカル インダストリーズ リミティド アルコキシ不純物を実質的に含有しないパロキセチンの製造方法
KR100477048B1 (ko) * 2002-07-05 2005-03-17 임광민 피페리딘 화합물의 새로운 제조방법
WO2004043921A1 (en) * 2002-11-11 2004-05-27 Natco Pharma Limited Novel process for the preparation of 4-aryl-3-hydroxymethyl-1-methylpiperidines.
US20050266082A1 (en) * 2004-05-26 2005-12-01 Patel Satishkumar A Preparation of stable paroxetine HC1 ER tablets using a melt granulation process
CN101205211B (zh) * 2006-12-19 2011-12-14 北京德众万全药物技术开发有限公司 一种盐酸帕罗西汀重要中间体的制备方法
WO2015071831A1 (en) * 2013-11-18 2015-05-21 Piramal Enterprises Limited An improved process for minimising the formation of dehalogenated byproducts
CN104262255A (zh) * 2014-09-22 2015-01-07 四川大学 一种不对称催化合成γ-硝基吡唑酰胺化合物的方法
CN104402800A (zh) * 2014-12-02 2015-03-11 千辉药业（安徽）有限责任公司 一种反式-4-(4-氟苯基)-3-羟甲基-1-甲基哌啶的制备方法
WO2022269643A1 (en) * 2021-06-25 2022-12-29 Vihita Chem Private Limited An improved process for the preparation of intermediate for paroxetine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE625656A (es) * 1961-12-05
NL125654C (es) * 1963-12-17 1900-01-01
US3666746A (en) * 1969-06-25 1972-05-30 Gaf Corp Pyrrolidonylphenyl azo dyestuffs
US3681327A (en) * 1970-07-01 1972-08-01 Exxon Research Engineering Co N-methylenethiophosphate derivatives of 1,3-thiazines and 1,4-thiazanes
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US3947460A (en) * 1974-06-27 1976-03-30 Sandoz, Inc. 5-Hydroxy-5-substituted phenyl-pyrrolidones and piperidinones
EP0047516B1 (en) * 1980-09-04 1984-01-04 Toray Industries, Inc. Propylamine derivative and process of manufacturing the same
US4585777A (en) * 1984-02-07 1986-04-29 A/S Ferrosan (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT

Also Published As

Publication number Publication date
DK380986D0 (da) 1986-08-08
BG61319B2 (bg) 1997-05-30
EP0223334A1 (en) 1987-05-27
JPH0696551B2 (ja) 1994-11-30
IE862135L (en) 1987-02-10
JPS6239566A (ja) 1987-02-20
CA1310649C (en) 1992-11-24
PT83179A (en) 1986-09-01
AU6101286A (en) 1987-02-12
AU582456B2 (en) 1989-03-23
NZ217141A (en) 1989-06-28
HK69793A (en) 1993-07-30
IE58831B1 (en) 1993-11-17
DK169730B1 (da) 1995-01-30
JPH08809B2 (ja) 1996-01-10
PT83179B (pt) 1989-03-30
ES2000603A6 (es) 1988-03-01
ES2005745A6 (es) 1989-03-16
SG27793G (en) 1993-05-21
GR862102B (en) 1986-12-30
JPH07138228A (ja) 1995-05-30
DE3680184D1 (de) 1991-08-14
US4902801A (en) 1990-02-20
DK380986A (da) 1987-02-11
EP0223334B1 (en) 1991-07-10
CY1708A (en) 1994-01-14

Similar Documents

Publication Publication Date Title
MX171822B (es) Proceso quimico
PT88992A (pt) Processo para a preparacao de compostos contendo fosforo uteis como inibidores de colagenase
HUT45512A (en) Process for producing anticancer quinazoline derivatives and pharmaceutics comprising the same
ES2000910A6 (es) Procedimiento para preparar piridina-2,3-dicarboxilatos sustituidos y disustituidos
MX168599B (es) Procedimiento para la preparacion de compuestos cefemicos
MX173379B (es) Proceso quimico
SE8302694D0 (sv) Immunomodulating agent
ES2037665T3 (es) Procedimiento para la preparacion de compuestos heterociclicos que contienen n.
ES8101550A1 (es) Un procedimiento para la preparacion de nuevos derivados de 2-pirrolidin-metanol.
ATE50773T1 (de) Alkylresorcinolphosphite.
ES2054231T3 (es) Procedimiento para preparar oxido de estireno.
KR850002979A (ko) 1,2,3-트리티안화합물의 신규 제조방법
MY101645A (en) Phosphoric esters and process for preparing the same.
ATE51000T1 (de) Verfahren zur herstellung von alphaaminoalkylphosphon- und von alphaaminoalkylphosphins|uren.
ATE67201T1 (de) Verfahren zur herstellung von 9-(hydroxy-alkyl) hypoxanthinen.
LU88287I2 (fr) Cyproternacetate (Climen)
ATE25680T1 (de) Verfahren zur herstellung von 4-amino-5-dialkoxy- methylpyrimidinderivaten.
MX165848B (es) Un producto de reaccion, un compuesto y un procedimiento para obtener un compuesto
FI863897A (fi) Kemiskt foerfarande.
JO921B1 (en) Process to produce substituted basic alkyl theophylline
ES480278A1 (es) Metodo de preparar derivados condensados de purina.
DE68907978T2 (de) Verfahren zur Herstellung von N,N'-Bis-(2-hydroxyethyl)-piperazin.
ES8100293A1 (es) Un procedimiento para la preparacion de nuevos derivados triciclicos jaula.(como divisional de la patente numero 479.572)
ES480277A1 (es) Procedimiento de preparar derivados condensados de purina.
TH388EX (th) อนุพันธ์ของอะมิโนไธออล