DK169730B1 - Arylimidderivater samt fremgangsmåde til fremstilling af arylpiperidincarbinolderivater - Google Patents
Arylimidderivater samt fremgangsmåde til fremstilling af arylpiperidincarbinolderivater Download PDFInfo
- Publication number
- DK169730B1 DK169730B1 DK380986A DK380986A DK169730B1 DK 169730 B1 DK169730 B1 DK 169730B1 DK 380986 A DK380986 A DK 380986A DK 380986 A DK380986 A DK 380986A DK 169730 B1 DK169730 B1 DK 169730B1
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- alkyl
- trans
- phenyl
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK199400745A DK173902B1 (da) | 1985-08-10 | 1994-06-22 | Fremgangsmåde til fremstilling af paroxetin eller et farmaceutisk acceptabelt salt deraf |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858520153A GB8520153D0 (en) | 1985-08-10 | 1985-08-10 | Chemical process |
GB868612579A GB8612579D0 (en) | 1986-05-23 | 1986-05-23 | Chemical process |
GB8612579 | 1986-05-23 | ||
GB8520153 | 1986-05-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK380986D0 DK380986D0 (da) | 1986-08-08 |
DK380986A DK380986A (da) | 1987-02-11 |
DK169730B1 true DK169730B1 (da) | 1995-01-30 |
Family
ID=26289644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK380986A DK169730B1 (da) | 1985-08-10 | 1986-08-08 | Arylimidderivater samt fremgangsmåde til fremstilling af arylpiperidincarbinolderivater |
Country Status (17)
Country | Link |
---|---|
US (1) | US4902801A (es) |
EP (1) | EP0223334B1 (es) |
JP (2) | JPH0696551B2 (es) |
AU (1) | AU582456B2 (es) |
BG (1) | BG61319B2 (es) |
CA (1) | CA1310649C (es) |
CY (1) | CY1708A (es) |
DE (1) | DE3680184D1 (es) |
DK (1) | DK169730B1 (es) |
ES (2) | ES2000603A6 (es) |
GR (1) | GR862102B (es) |
HK (1) | HK69793A (es) |
IE (1) | IE58831B1 (es) |
MX (1) | MX171822B (es) |
NZ (1) | NZ217141A (es) |
PT (1) | PT83179B (es) |
SG (1) | SG27793G (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8714707D0 (en) * | 1987-06-23 | 1987-07-29 | Beecham Group Plc | Chemical process |
DK588289D0 (da) * | 1989-11-22 | 1989-11-22 | Ferrosan As | Ny heterocyklisk kemi |
JPH04288059A (ja) * | 1991-03-14 | 1992-10-13 | Nippon Paint Co Ltd | 複素環化合物及びその製造法 |
GB9209687D0 (en) * | 1992-05-06 | 1992-06-17 | Smithkline Beecham Plc | Novel process |
US5258517A (en) * | 1992-08-06 | 1993-11-02 | Sepracor, Inc. | Method of preparing optically pure precursors of paroxetine |
GB9305175D0 (en) * | 1993-03-13 | 1993-04-28 | Smithkline Beecham Plc | Novel process |
GB9325644D0 (en) * | 1993-12-15 | 1994-02-16 | Smithkline Beecham Plc | Novel formulation |
US6444190B2 (en) | 1995-08-03 | 2002-09-03 | Fmc Corporation | Reduction compositions and processes for making the same |
WO1997005879A1 (en) * | 1995-08-03 | 1997-02-20 | Fmc Corporation | Reductions using hydrides |
ES2121685B1 (es) * | 1996-04-10 | 1999-09-16 | Vita Invest Sa | Procedimiento para la obtencion de (+)-trans-4(4-fluoro-fenil)-3-hidroximetil-1-metilpiperidina. |
JP3446468B2 (ja) | 1996-04-15 | 2003-09-16 | 旭硝子株式会社 | ピペリジンカルビノール類の製造方法 |
US5936090A (en) * | 1996-05-24 | 1999-08-10 | Fmc Corporation | Processes for the reduction of imide ester functionality |
EP1384711A1 (en) | 1996-06-13 | 2004-01-28 | SUMIKA FINE CHEMICALS Co., Ltd. | Optical resolution of a piperidine derivative |
US6638948B1 (en) | 1996-09-09 | 2003-10-28 | Pentech Pharmaceuticals, Inc. | Amorphous paroxetine composition |
WO1998013319A1 (en) * | 1996-09-24 | 1998-04-02 | Fmc Corporation | Novel reduction compositions and processes for making the same |
GB9623359D0 (en) * | 1996-11-09 | 1997-01-08 | Smithkline Beecham Plc | Novel process |
DE69840909D1 (de) * | 1997-04-07 | 2009-07-30 | Univ Georgetown | Analoge von kokain |
GB9710004D0 (en) * | 1997-05-17 | 1997-07-09 | Knoll Ag | Chemical process |
HUP0003958A3 (en) | 1997-05-29 | 2001-06-28 | Smithkline Beecham Plc | Process for preparation of 4-aryl-piperidines and intermediates |
AU3108097A (en) * | 1997-06-10 | 1998-12-30 | Synthon B.V. | 4-phenylpiperidine compounds |
EP0969002B1 (en) | 1998-06-29 | 2003-08-27 | SUMIKA FINE CHEMICALS Co., Ltd. | L-tartrate of trans-(-)-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine compound and process for preparing the same |
CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
WO2000026187A1 (en) * | 1998-11-02 | 2000-05-11 | Synthon B.V. | Process for producing 4-arylpiperidine-3-carbinols and related compounds |
GB9915303D0 (en) * | 1999-06-30 | 1999-09-01 | Smithkline Beecham Plc | Novel process |
IT1313702B1 (it) * | 1999-08-02 | 2002-09-09 | Chemi Spa | Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine. |
GB9920147D0 (en) * | 1999-08-25 | 1999-10-27 | Smithkline Beecham Plc | Novel process |
AU1037701A (en) * | 1999-10-20 | 2001-04-30 | Smithkline Beecham Plc | Process for the preparation of 4-(fluorophenyl)piperidine esters |
GB9924855D0 (en) * | 1999-10-20 | 1999-12-22 | Smithkline Beecham Plc | Novel processes |
GB9924882D0 (en) * | 1999-10-20 | 1999-12-22 | Smithkline Beecham Plc | Novel process |
GB9930577D0 (en) * | 1999-12-23 | 2000-02-16 | Smithkline Beecham Plc | Novel process |
WO2001085688A1 (en) * | 2000-05-12 | 2001-11-15 | Synthon B.V. | TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS |
US6833458B2 (en) | 2000-06-05 | 2004-12-21 | Development Center For Biotechnology | Practical syntheses of chiral trans-3, 4-disubstituted piperidines and the intermediates |
WO2002028834A1 (en) * | 2000-10-06 | 2002-04-11 | Smithkline Beecham P.L.C. | Process for the preparation of aryl-piperidine carbinols and intermediates thereof |
WO2002053537A1 (en) * | 2001-01-04 | 2002-07-11 | Ferrer Internacional, S.A. | Process for preparing (±) trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine |
US6777554B2 (en) | 2001-02-05 | 2004-08-17 | Teva Pharmaceutical Industries Ltd. | Preparation of N-methylparoxetine and related intermediate compounds |
EP1362032A2 (en) * | 2001-02-24 | 2003-11-19 | Spurcourt Limited | Process of preparing paroxetine and intermediates for use therein |
EP1406624A4 (en) * | 2001-06-13 | 2005-03-30 | Teva Pharma | METHOD FOR PRODUCING PAROXETIN, WHICH IS ESPECIALLY FREE OF ALKOXY POLLUTION |
KR100477048B1 (ko) * | 2002-07-05 | 2005-03-17 | 임광민 | 피페리딘 화합물의 새로운 제조방법 |
WO2004043921A1 (en) * | 2002-11-11 | 2004-05-27 | Natco Pharma Limited | Novel process for the preparation of 4-aryl-3-hydroxymethyl-1-methylpiperidines. |
US20050266082A1 (en) * | 2004-05-26 | 2005-12-01 | Patel Satishkumar A | Preparation of stable paroxetine HC1 ER tablets using a melt granulation process |
CN101205211B (zh) * | 2006-12-19 | 2011-12-14 | 北京德众万全药物技术开发有限公司 | 一种盐酸帕罗西汀重要中间体的制备方法 |
IN2013MU03596A (es) * | 2013-11-18 | 2015-07-24 | Piramal Entpr Ltd | |
CN104262255A (zh) * | 2014-09-22 | 2015-01-07 | 四川大学 | 一种不对称催化合成γ-硝基吡唑酰胺化合物的方法 |
CN104402800A (zh) * | 2014-12-02 | 2015-03-11 | 千辉药业(安徽)有限责任公司 | 一种反式-4-(4-氟苯基)-3-羟甲基-1-甲基哌啶的制备方法 |
WO2022269643A1 (en) * | 2021-06-25 | 2022-12-29 | Vihita Chem Private Limited | An improved process for the preparation of intermediate for paroxetine |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE625656A (es) * | 1961-12-05 | |||
NL125654C (es) * | 1963-12-17 | 1900-01-01 | ||
US3666746A (en) * | 1969-06-25 | 1972-05-30 | Gaf Corp | Pyrrolidonylphenyl azo dyestuffs |
US3681327A (en) * | 1970-07-01 | 1972-08-01 | Exxon Research Engineering Co | N-methylenethiophosphate derivatives of 1,3-thiazines and 1,4-thiazanes |
GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
US3947460A (en) * | 1974-06-27 | 1976-03-30 | Sandoz, Inc. | 5-Hydroxy-5-substituted phenyl-pyrrolidones and piperidinones |
EP0047516B1 (en) * | 1980-09-04 | 1984-01-04 | Toray Industries, Inc. | Propylamine derivative and process of manufacturing the same |
US4585777A (en) * | 1984-02-07 | 1986-04-29 | A/S Ferrosan | (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT |
-
1986
- 1986-08-06 EP EP19860306070 patent/EP0223334B1/en not_active Expired - Lifetime
- 1986-08-06 DE DE8686306070T patent/DE3680184D1/de not_active Expired - Lifetime
- 1986-08-08 AU AU61012/86A patent/AU582456B2/en not_active Expired
- 1986-08-08 NZ NZ217141A patent/NZ217141A/xx unknown
- 1986-08-08 GR GR862102A patent/GR862102B/el unknown
- 1986-08-08 PT PT83179A patent/PT83179B/pt unknown
- 1986-08-08 JP JP61185429A patent/JPH0696551B2/ja not_active Expired - Lifetime
- 1986-08-08 MX MX006890A patent/MX171822B/es unknown
- 1986-08-08 ES ES8600960A patent/ES2000603A6/es not_active Expired
- 1986-08-08 US US06/894,695 patent/US4902801A/en not_active Expired - Lifetime
- 1986-08-08 IE IE213586A patent/IE58831B1/en not_active IP Right Cessation
- 1986-08-08 DK DK380986A patent/DK169730B1/da not_active IP Right Cessation
- 1986-08-08 CA CA000515598A patent/CA1310649C/en not_active Expired - Lifetime
-
1987
- 1987-12-30 ES ES8703767A patent/ES2005745A6/es not_active Expired
-
1993
- 1993-03-15 SG SG277/93A patent/SG27793G/en unknown
- 1993-07-22 HK HK697/93A patent/HK69793A/xx not_active IP Right Cessation
- 1993-12-29 BG BG98349A patent/BG61319B2/bg unknown
-
1994
- 1994-01-14 CY CY170894A patent/CY1708A/xx unknown
- 1994-05-25 JP JP6133871A patent/JPH08809B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH07138228A (ja) | 1995-05-30 |
GR862102B (en) | 1986-12-30 |
AU582456B2 (en) | 1989-03-23 |
JPH0696551B2 (ja) | 1994-11-30 |
IE58831B1 (en) | 1993-11-17 |
MX171822B (es) | 1993-11-17 |
DK380986A (da) | 1987-02-11 |
NZ217141A (en) | 1989-06-28 |
JPS6239566A (ja) | 1987-02-20 |
ES2005745A6 (es) | 1989-03-16 |
ES2000603A6 (es) | 1988-03-01 |
CA1310649C (en) | 1992-11-24 |
EP0223334A1 (en) | 1987-05-27 |
PT83179A (en) | 1986-09-01 |
BG61319B2 (bg) | 1997-05-30 |
HK69793A (en) | 1993-07-30 |
EP0223334B1 (en) | 1991-07-10 |
DE3680184D1 (de) | 1991-08-14 |
CY1708A (en) | 1994-01-14 |
PT83179B (pt) | 1989-03-30 |
DK380986D0 (da) | 1986-08-08 |
AU6101286A (en) | 1987-02-12 |
US4902801A (en) | 1990-02-20 |
IE862135L (en) | 1987-02-10 |
JPH08809B2 (ja) | 1996-01-10 |
SG27793G (en) | 1993-05-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |