YU46195B - Postupak za dobijanje antiaritmičkih agenasa - Google Patents
Postupak za dobijanje antiaritmičkih agenasaInfo
- Publication number
- YU46195B YU46195B YU78387A YU78387A YU46195B YU 46195 B YU46195 B YU 46195B YU 78387 A YU78387 A YU 78387A YU 78387 A YU78387 A YU 78387A YU 46195 B YU46195 B YU 46195B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- formula
- alkyl
- alk
- optionally substituted
- Prior art date
Links
- 239000003416 antiarrhythmic agent Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- -1 ethylene, trimethylene Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- NBNBICNWNFQDDD-UHFFFAOYSA-N sulfuryl dibromide Chemical compound BrS(Br)(=O)=O NBNBICNWNFQDDD-UHFFFAOYSA-N 0.000 abstract 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrrole Compounds (AREA)
- Lubricants (AREA)
- Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
- Polyamides (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fats And Perfumes (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BA980211A BA98211B1 (bs) | 1986-05-01 | 1998-03-30 | Postupak za dobijanje antiaritmickih agenasa |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868610668A GB8610668D0 (en) | 1986-05-01 | 1986-05-01 | Anti-arrhythmia agents |
| GB868630059A GB8630059D0 (en) | 1986-12-17 | 1986-12-17 | Antiarrhythmic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU78387A YU78387A (en) | 1988-08-31 |
| YU46195B true YU46195B (sh) | 1993-05-28 |
Family
ID=26290703
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU78387A YU46195B (sh) | 1986-05-01 | 1987-04-30 | Postupak za dobijanje antiaritmičkih agenasa |
| YU73588A YU46541B (sh) | 1986-05-01 | 1988-04-12 | Postupak za dobijanje antiaritmičkih agenasa |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU73588A YU46541B (sh) | 1986-05-01 | 1988-04-12 | Postupak za dobijanje antiaritmičkih agenasa |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US4959366A (enExample) |
| EP (1) | EP0245997B1 (enExample) |
| KR (2) | KR870011084A (enExample) |
| CN (1) | CN1019801B (enExample) |
| AT (1) | ATE74906T1 (enExample) |
| AU (1) | AU578557B2 (enExample) |
| BA (2) | BA98301A (enExample) |
| CA (1) | CA1289140C (enExample) |
| DE (2) | DE3778201D1 (enExample) |
| DK (1) | DK175096B1 (enExample) |
| EG (1) | EG18188A (enExample) |
| ES (1) | ES2033840T3 (enExample) |
| FI (1) | FI88291C (enExample) |
| GR (1) | GR3004457T3 (enExample) |
| HU (1) | HU196743B (enExample) |
| IE (1) | IE59366B1 (enExample) |
| IL (1) | IL82373A (enExample) |
| LU (1) | LU90519I2 (enExample) |
| LV (1) | LV5715B4 (enExample) |
| MY (1) | MY111142A (enExample) |
| NL (1) | NL300002I2 (enExample) |
| NO (2) | NO168527C (enExample) |
| NZ (1) | NZ220151A (enExample) |
| PH (1) | PH23425A (enExample) |
| PL (1) | PL149924B1 (enExample) |
| PT (1) | PT84782B (enExample) |
| YU (2) | YU46195B (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602174A (en) * | 1986-02-15 | 1997-02-11 | Beecham Wuefling Gmbh & Co. | Treatment |
| NL8700842A (enExample) * | 1987-04-10 | 1988-11-01 | Duphar Int Res | |
| SE8705150D0 (sv) * | 1987-12-23 | 1987-12-23 | Haessle Ab | Novel antiarrhythmic agents |
| US4906634A (en) * | 1988-03-08 | 1990-03-06 | Schering A.G. | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents |
| GB8809314D0 (en) * | 1988-04-20 | 1988-05-25 | Wellcome Found | Anti-hypertensive sulfonanilides |
| GB8819307D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Antiarrhythmic agents |
| US5166209A (en) * | 1989-04-21 | 1992-11-24 | Burroughs Wellcome Co. | Pharmacologically active compounds |
| HUT58270A (en) * | 1989-06-02 | 1992-02-28 | Wyeth John & Brother Ltd | Process for producing amine derivatives and pharmaceutical compositions containing them |
| US5084463A (en) * | 1989-12-11 | 1992-01-28 | American Home Products Corporation | N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity |
| MX9304626A (es) * | 1992-07-31 | 1994-02-28 | Syntex Inc | Derivados heterociclicos utiles en el tratamiento de enfermedades cardiovasculares. |
| US5451677A (en) * | 1993-02-09 | 1995-09-19 | Merck & Co., Inc. | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity |
| GB9404485D0 (en) * | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
| DE4422517A1 (de) * | 1994-06-28 | 1996-01-04 | Dresden Arzneimittel | Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP0775689B9 (en) * | 1994-08-04 | 2004-09-15 | C & C RESEARCH LABS. | Novel amine derivative, process for producing the same, and use thereof as antiarrhythmic |
| EP0697407B1 (en) | 1994-08-19 | 1997-06-25 | MITSUI TOATSU CHEMICALS, Inc. | Pyrimidinedione derivatives and antiarrhythmic compositions containing same |
| US5679706A (en) * | 1994-09-30 | 1997-10-21 | Bristol-Myers Squibb Company | Combination of a potassium channel activator and an antiarrhythmic agent |
| FR2726267B1 (fr) * | 1994-10-26 | 1998-01-02 | Smithkline Beecham Lab | Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer |
| CN1055682C (zh) * | 1995-12-06 | 2000-08-23 | 中国药科大学 | 甲磺酰胺基苯乙胺衍生物的新制备方法 |
| CN1055679C (zh) * | 1995-12-06 | 2000-08-23 | 中国药科大学 | 具有心血管活性的苯乙胺衍生物 |
| GB9722662D0 (en) * | 1997-10-27 | 1997-12-24 | Pfizer Ltd | Polymorphs |
| HUP9702411A2 (hu) * | 1997-12-11 | 2000-03-28 | Gyógyszerkutató Intézet Kft. | Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények |
| CA2440284A1 (en) * | 2001-03-08 | 2002-09-19 | Emory University | Ph-dependent nmda receptor antagonists |
| CN100358865C (zh) * | 2001-07-30 | 2008-01-02 | 中国科学院上海药物研究所 | 一类磺酰胺苯烷胺类化合物及其制备方法和用途 |
| DE10201550A1 (de) * | 2002-01-17 | 2003-07-31 | Merck Patent Gmbh | Phenoxy-Piperidine |
| AU2002357560A1 (en) * | 2002-04-26 | 2003-11-10 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Sulfamidophenylalkylamines and their production and use |
| MXPA05013364A (es) * | 2003-06-17 | 2006-03-17 | Arena Pharm Inc | Procedimiento para preparar 3-benzazepinas. |
| CN101274911B (zh) * | 2003-06-17 | 2011-01-26 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关病症的苯并氮杂卓衍生物 |
| DE102004025726B4 (de) * | 2004-05-26 | 2006-07-06 | Roder, Hanno, Dr. | Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit |
| ATE544455T1 (de) * | 2006-12-14 | 2012-02-15 | Tautatis Inc | Zusammensetzungen und verfahren für die krebsbehandlung |
| MX2009014216A (es) * | 2007-06-29 | 2010-07-05 | Univ Emory | Antagonistas del receptor nmda para neuroproteccion. |
| CN101372467B (zh) * | 2007-08-23 | 2011-09-14 | 明德国际仓储贸易(上海)有限公司 | 具有n,n-二烷氨基的桥基化合物及所应用的染料化合物 |
| US8822727B2 (en) | 2008-03-04 | 2014-09-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
| WO2010148207A2 (en) | 2009-06-18 | 2010-12-23 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
| US9045431B2 (en) | 2010-06-02 | 2015-06-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
| BR112013004707A2 (pt) | 2010-09-01 | 2016-05-10 | Arena Pharm Inc | administração de um composto antiobesidade a indivíduos com comprometimento renal |
| AU2011296033A1 (en) | 2010-09-01 | 2013-04-04 | Arena Pharmaceuticals, Inc. | Non-hygroscopic salts of 5-HT2C agonists |
| SG10201506870PA (en) | 2010-09-01 | 2015-10-29 | Arena Pharm Inc | Salts of lorcaserin with optically active acids |
| CN102531946A (zh) * | 2012-01-05 | 2012-07-04 | 山东大学 | 3-甲氧基苯甲酰胺衍生物及其制备方法与应用 |
| BR112015007779A2 (pt) | 2012-10-09 | 2017-07-04 | Arena Pharm Inc | célula de fluxo de permeabilidade e sistema de condutância hidráulica |
| FR3029113A1 (fr) | 2014-12-02 | 2016-06-03 | Univ Paris-Sud | Composes pour le traitement des maladies mitochondriales |
| CZ2017772A3 (cs) * | 2017-12-01 | 2019-05-29 | Farmak, A.S. | Způsob přípravy N-[4-(2-{[2-(4-methansulfonamidofenoxy)ethyl](methyl)amino}ethyl)fenyl]methansulfonamidu (Dofetilidu) |
| US10888524B2 (en) | 2018-02-05 | 2021-01-12 | Enaltec Pharma Research Pvt. Ltd. | Immediate release tablet of dofetilide |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR977261A (fr) * | 1948-11-04 | 1951-03-29 | équilibrage des masses dans les moteurs à combustion interne | |
| US3478149A (en) * | 1962-01-24 | 1969-11-11 | Mead Johnson & Co | Therapeutic compositions and methods employing sulfonamidophenethanolamines |
| FR148F (enExample) * | 1962-01-24 | |||
| US3852468A (en) * | 1967-02-27 | 1974-12-03 | Ici Ltd | Alkanolamine derivatives as {62 -adrenergic blocking agents |
| US3758692A (en) * | 1969-04-14 | 1973-09-11 | Mead Johnson & Co | Ylamines sympathomimetic process and compositions employing sulfonamidophenalk |
| US3574741A (en) * | 1969-04-14 | 1971-04-13 | Mead Johnson & Co | Sulfonamidophenalkylamines |
| GB1263987A (en) * | 1969-05-30 | 1972-02-16 | Allen & Hanburys Ltd | Phenethylamine derivatives |
| BE757005A (fr) * | 1969-10-02 | 1971-04-02 | Bristol Myers Co | Phenethanolamines substituees et procede pour leur preparation |
| GB1301134A (en) * | 1970-07-18 | 1972-12-29 | Pfizer Ltd | SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES |
| DE2965655D1 (en) * | 1978-06-28 | 1983-07-21 | Beecham Group Plc | Secondary amines, their preparation, pharmaceutical compositions containing them and their use |
| CA1120058A (en) * | 1978-07-03 | 1982-03-16 | Jack Mills | Phenethanolamines, formulations and potentiation of oncolytic drugs |
| ATE1899T1 (de) * | 1979-06-16 | 1982-12-15 | Beecham Group Plc | Sekundaere amine, ihre herstellung und verwendung in pharmazeutischen zusammensetzungen. |
| DD202692A5 (de) * | 1979-12-04 | 1983-09-28 | Ciba Geigy | Verfahren zur herstellung neuer derivate des 2-amino-aethanols |
| FR2541999B1 (fr) * | 1983-03-04 | 1986-09-19 | Bristol Myers Co | Phenethanolamines et leurs utilisations |
| DE3566886D1 (en) * | 1984-05-04 | 1989-01-26 | Upjohn Co | N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use |
| US4569801A (en) * | 1984-10-15 | 1986-02-11 | Eli Lilly And Company | Alkylsulfonamidophenylalkylamines |
-
1987
- 1987-04-19 EG EG230/87A patent/EG18188A/xx active
- 1987-04-24 PH PH35179A patent/PH23425A/en unknown
- 1987-04-27 MY MYPI87000548A patent/MY111142A/en unknown
- 1987-04-29 US US07/044,086 patent/US4959366A/en not_active Expired - Lifetime
- 1987-04-29 IL IL82373A patent/IL82373A/xx not_active IP Right Cessation
- 1987-04-29 CA CA000535897A patent/CA1289140C/en not_active Expired - Lifetime
- 1987-04-29 AT AT87303782T patent/ATE74906T1/de active
- 1987-04-29 PT PT84782A patent/PT84782B/pt unknown
- 1987-04-29 PL PL1987265418A patent/PL149924B1/pl unknown
- 1987-04-29 FI FI871898A patent/FI88291C/fi not_active IP Right Cessation
- 1987-04-29 EP EP87303782A patent/EP0245997B1/en not_active Expired - Lifetime
- 1987-04-29 ES ES198787303782T patent/ES2033840T3/es not_active Expired - Lifetime
- 1987-04-29 DE DE8787303782T patent/DE3778201D1/de not_active Expired - Lifetime
- 1987-04-29 DE DE2000175004 patent/DE10075004I2/de active Active
- 1987-04-30 NZ NZ220151A patent/NZ220151A/xx unknown
- 1987-04-30 HU HU871971A patent/HU196743B/hu unknown
- 1987-04-30 AU AU72260/87A patent/AU578557B2/en not_active Expired
- 1987-04-30 NO NO871820A patent/NO168527C/no not_active IP Right Cessation
- 1987-04-30 KR KR870004213A patent/KR870011084A/ko not_active Ceased
- 1987-04-30 DK DK198702202A patent/DK175096B1/da active Protection Beyond IP Right Term
- 1987-04-30 YU YU78387A patent/YU46195B/sh unknown
- 1987-05-01 CN CN87103300A patent/CN1019801B/zh not_active Expired
- 1987-05-11 IE IE116587A patent/IE59366B1/en not_active IP Right Cessation
-
1988
- 1988-04-12 YU YU73588A patent/YU46541B/sh unknown
-
1990
- 1990-06-20 US US07/541,232 patent/US5079248A/en not_active Expired - Lifetime
- 1990-12-07 KR KR1019900020068A patent/KR930001339B1/ko not_active Expired - Lifetime
-
1992
- 1992-04-29 GR GR920400823T patent/GR3004457T3/el unknown
-
1995
- 1995-03-15 LV LV950058A patent/LV5715B4/xx unknown
-
1998
- 1998-03-30 BA BA980301A patent/BA98301A/bs unknown
- 1998-03-30 BA BA980211A patent/BA98211B1/bs active
-
2000
- 2000-02-01 NL NL300002C patent/NL300002I2/nl unknown
- 2000-02-09 LU LU90519C patent/LU90519I2/fr unknown
-
2001
- 2001-06-26 NO NO2001011C patent/NO2001011I1/no unknown
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