WO2018118941A1 - Amino acid compositions and methods for the treatment of liver diseases - Google Patents

Amino acid compositions and methods for the treatment of liver diseases Download PDF

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Publication number
WO2018118941A1
WO2018118941A1 PCT/US2017/067345 US2017067345W WO2018118941A1 WO 2018118941 A1 WO2018118941 A1 WO 2018118941A1 US 2017067345 W US2017067345 W US 2017067345W WO 2018118941 A1 WO2018118941 A1 WO 2018118941A1
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WO
WIPO (PCT)
Prior art keywords
amino acid
composition
acid entity
entity
nac
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2017/067345
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English (en)
French (fr)
Inventor
Michael HAMILL
Raffi AFEYAN
Chung-Wei Lee
Harry LUITHARDT
David Berry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axcella Health Inc
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Axcella Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN201780078656.7A priority Critical patent/CN110087647B/zh
Priority to CA3046551A priority patent/CA3046551A1/en
Priority to KR1020197020657A priority patent/KR20190099242A/ko
Priority to CN202211400026.6A priority patent/CN115814053A/zh
Priority to EA201991502A priority patent/EA201991502A1/ru
Priority to MX2019007351A priority patent/MX2019007351A/es
Priority to CU2019000058A priority patent/CU20190058A7/es
Priority to JP2019533079A priority patent/JP2020504108A/ja
Priority to AU2017382170A priority patent/AU2017382170B2/en
Priority to IL296614A priority patent/IL296614A/en
Priority to EP17829105.0A priority patent/EP3554492A1/en
Application filed by Axcella Health Inc filed Critical Axcella Health Inc
Priority to BR112019012529-9A priority patent/BR112019012529A2/pt
Publication of WO2018118941A1 publication Critical patent/WO2018118941A1/en
Priority to ZA2019/03580A priority patent/ZA201903580B/en
Priority to CONC2019/0006291A priority patent/CO2019006291A2/es
Priority to IL267480A priority patent/IL267480B/en
Priority to PH12019501414A priority patent/PH12019501414A1/en
Anticipated expiration legal-status Critical
Priority to IL284371A priority patent/IL284371B2/en
Priority to JP2022193127A priority patent/JP2023029946A/ja
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/02—Acid
    • A23V2250/06—Amino acid
    • A23V2250/0634—N-Acetyl-Cysteine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Definitions

  • the wt. ratio of the L-amino acid entity, the R-amino acid entity, the L-glutamine or a salt thereof, and the NAC or salt thereof is about 0.5 to 3 : 0.5 to 4 : 1 to 4 : 0.1 to 2.5, e.g., the wt. ratio of the L-amino acid entity, the R- amino acid entity, the L-glutamine or a salt thereof, and the NAC or salt thereof is about 1 : 1.5 : 2 : 0.15 or about 1 : 1.5 : 2 : 0.3. In certain embodiments, the wt.
  • the branched-chain amino acid is leucine, isoleucine, and valine.
  • Another aspect of the invention features a dietary composition including the composition of any one of the foregoing aspects or embodiments, e.g., wherein the dietary composition is chosen from a medical food, a functional food, or a supplement.
  • the subject has pediatric NAFLD. In some embodiments, the patient has steatosis.
  • the subject has non-alcoholic steatohepatitis (NASH).
  • NASH non-alcoholic steatohepatitis
  • the subject has cirrhosis.
  • the subject has type 2 diabetes.
  • the subject has hepatocarcinoma, an increased risk of liver failure, or an increased risk of death.
  • administering the composition results in an improvement in one or more metabolic symptoms in the subject.
  • the improvement in one or more metabolic symptoms is selected from the following: increased free fatty acid and lipid metabolism, improved mitochondrial function, white adipose tissue (WAT) browning, decreased reactive oxygen species (ROS), increased levels of glutathione (GSH), decreased hepatic inflammation, decreased hepatocyte ballooning, improved gut barrier function, increased insulin secretion, or improved glucose tolerance.
  • (a) is a L- amino acid entity dipeptide or a salt thereof (e.g., a L-leucine dipeptide or a salt thereof).
  • (a) is a homodipeptide.
  • (a) is a heterodipeptide, e.g., Ala-Leu.
  • composition satisfies the properties of (gg)-(ii) defined above.
  • nn a combination of two or three of (kk)-(mm).
  • the composition satisfies the properties of (kk)-(mm) defined above. In certain embodiments, the composition satisfies the properties of at least 2, 3, or 4 of any of properties (kk)-(nn) defined above.
  • ratio of the R-amino acid entity to the S-amino acid entity or a salt thereof is greater than 1:4, greater than 1:3, about 1:2, or about 9:20, and not more than 1.5:2 or 1: 1, e.g., the ratio of the R-amino acid entity to the S-amino acid entity is about 1:2, or the ratio of the R-amino acid entity to the S-amino acid entity is about 9:20; or 22) a combination of two or three of (19)-(21).
  • the composition further comprises one or both of L-glycine and L-serine.
  • the composition comprises an L- amino acid entity, an I-amino acid entity, an V-amino acid entity, an R-amino acid entity, an L-glutamine or a salt thereof, an NAC or a salt thereof, and an L-glycine.
  • the composition comprises an L-amino acid entity, an I- amino acid entity, an V-amino acid entity, an R-amino acid entity, an L-glutamine or a salt thereof, an NAC or a salt thereof, and an L-serine.
  • the wt. ratio of the L-amino acid entity, the I-amino acid entity, the V-amino acid entity, the R-amino acid entity, the L-glutamine or salt thereof, and the NAC or salt thereof is about 1 : 0.5: 0.5: 1.5 : 2 : 0.15, about 1 : 0.5: 0.5: 1.5 : 2 : 0.225, about 1 : 0.5: 0.5: 1.5 : 2 : 0.3, or about 1 : 0.5: 0.5: 1.5 : 2 : 0.5.
  • the composition comprises about 4 g of the L-amino acid entity, about 2 g of the I- amino acid entity, about 1 g of V-amino acid entity, about 3 g of R-amino acid entity, about 4 g of L-glutamine or a salt thereof, about 0.9 g of NAC or a salt thereof, about 3 g of L-serine or a salt thereof, and about 3 g of L-glycine or a salt thereof.
  • L-Valine is provided as part of a dipeptide comprising L- Valine, or a salt thereof, or a tripeptide comprising L- Valine, or a salt thereof.
  • NAC is provided as a part of a dipeptide comprising NAC, or a salt thereof, or a tripeptide comprising NAC, or a salt thereof.
  • Another aspect of the invention features a method for treating fatty liver disease, wherein the method comprises administering to a subject in need thereof an effective amount of a composition comprising:
  • the subject has a disease or disorder selected from the group consisting of non-alcoholic fatty liver (NAFL), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic fatty liver disease (AFLD), and alcoholic steatohepatitis (ASH).
  • NAFL non-alcoholic fatty liver
  • NAFLD non-alcoholic fatty liver disease
  • NASH non-alcoholic steatohepatitis
  • AFLD alcoholic fatty liver disease
  • ASH alcoholic steatohepatitis
  • the subject has pediatric NAFLD.
  • the subject exhibits muscle atrophy or has a decreased ratio of muscle tissue to adipose tissue relative to a normal subject, e.g., without the one or more symptoms or without a fatty liver disease, e.g., the subject exhibits muscle atrophy without one or both of fibrosis or cirrhosis.
  • FIGS. 1A-1B are graphs showing the effect of treatment with an amino acid composition (Amino Acid Composition A-l) on the NAFLD activity score, ballooning, and fibrosis in the STAM mouse model (FIG. 1A) and in the FATZO mouse model (FIG. IB).
  • FIG. 2 is a schematic showing the metabolic symptoms of patients with non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and cirrhosis prior to administration of a composition comprising amino acid entities described herein (top) and the improvement in patients with NAFLD, NASH, and cirrhosis after administration of the composition (bottom).
  • NAFLD non-alcoholic fatty liver disease
  • NASH non-alcoholic steatohepatitis
  • FIGS. 1A-1B are graphs showing the effect of treatment with an amino acid composition (Amino Acid Composition A-l) on the NAFLD activity score, ballooning, and fibrosis in the STAM mouse model (FIG
  • the amino acid entity composition may be administered to the subject for a treatment period of, e.g., two weeks, three weeks, four weeks, five weeks, six weeks, seven weeks, eight weeks, nine weeks, 10 weeks, 11 weeks, 12 weeks, 13 weeks, 14 weeks, 15 weeks, 16 weeks, or longer at a dose of about 15 total grams per day to about 90 total grams per day (e.g., a total of about 48 g or a total of about 72 g per day).
  • NAFL NAFL
  • AFLD e.g., ASH
  • “About” and “approximately” shall generally mean an acceptable degree of error for the quantity measured given the nature or precision of the measurements. Exemplary degrees of error are within 20 percent (%), typically, within 10%, and more typically, within 5% of a given value or range of values.
  • a "pharmaceutical composition” described herein comprises at least one amino acid and a pharmaceutically acceptable carrier or excipient.
  • the pharmaceutical composition is used as a therapeutic, a nutraceutical, a medical food, or as a supplement.
  • compositions, formulation or product refers to amino acids, materials, excipients, compositions and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio.
  • a composition, formulation or product is "therapeutic” if it provides a beneficial clinical effect. A beneficial clinical effect can be shown by lessening the progression of a disease and/or alleviating one or more symptoms of the disease.
  • Amino acid entities include amino acids, precursors, metabolites, and derivatives of the compositions described herein.
  • the composition further comprises one or two additional branched-chain amino acid (BCAA)-entities, e.g., one or both of an isoleucine (I)-amino acid- entity and a valine (V)-amino acid-entity.
  • BCAA branched-chain amino acid
  • I isoleucine
  • V valine
  • both the I-amino acid-entity and the V-amino acid-entity are present.
  • the L-entity is present at a higher amount (% by weight) than one or both of the I-amino acid-entity and the V-amino acid- entity (e.g., the L-entity is present at an amount of at least 10 wt. %, at least 15 wt. %, at least 20 wt.
  • the composition comprises a combination of 2 to
  • the BCAA is leucine.
  • the BCAA is leucine, isoleucine, and valine.
  • the amino acids leucine, isoleucine, valine, arginine HCl, glutamine and N-acetylcysteine are present in a weight ratio of about 1 : 0.5 : 0.5 : 1.5 : 2 : 0.1 to 0.3. In some embodiments, the amino acids leucine, isoleucine, valine, arginine HCl, glutamine and N-acetylcysteine are present in a weight ratio of about 1 : 0.5 : 0.5 : 1.5 : 2 : 0.25.
  • a total weight (wt) of the amino acids is about 2 g to about 60 g.
  • the composition includes about 1 g of leucine, about 0.5 g of isoleucine, about 0.5 g of valine, about 1.5 g of arginine (or 1.81 g of arginine HCl), about 2 g of glutamine, and about 0.15 g of N-acetylcysteine.
  • Table 4 Exemplary amino acid components of the composition including Arginine.
  • An exemplary Amino Acid Composition includes leucine, isoleucine, valine, arginine, glutamine, and N-acetylcysteine as its amino acid entities in a wt. ratio of 1 : 0.5 : 0.5 : 0.75 : 2 : 0.15 (Table 6). Table 5. Exemplary amino acid components of the composition including Arginine HCl.
  • An exemplary Amino Acid Composition includes leucine, isoleucine, valine, arginine HCl, glutamine, N-acetylcysteine, and serine as its amino acid entities in a wt. ratio of 1 : 0.5 : 0.25 : 0.905 : 1 : 0.225 : 0.667 (Table 11).
  • An exemplary Amino Acid Composition includes leucine, isoleucine, valine, arginine, glutamine, N-acetylcysteine, and serine as its amino acid entities in a wt. ratio of 1 : 0.5 : 0.25 : 0.75 : 1 : 0.225 : 1.667 (Table 12).
  • the composition that decreases and/or prevents steatosis comprises one or more BCAAs, one or more CEAAs, and an antioxidant or ROS scavenger.
  • the composition comprises a coloring agent.
  • suitable color agents include food, drug and cosmetic colors (FD&C), drug and cosmetic colors (D&C), and external drug and cosmetic colors (Ext. D&C).
  • the coloring agents can be used as dyes or their corresponding lakes.
  • the composition reduces or inhibits liver fibrosis in a subject with NAFLD (e.g., a subject with pediatric NAFLD). In some embodiments, the composition reduces or inhibits liver fibrosis in a subject with NAFLD (e.g., a subject with pediatric NAFLD).
  • administration of the composition results in increased free fatty acid and lipid metabolism in a subject with NASH (e.g., a subject with NAFLD, fibrosis, and type 2 diabetes). In some embodiments, administration of the composition results in improved mitochondrial function in a subject with NASH. In some embodiments, administration of the composition results in white adipose tissue (WAT) browning in a subject with NASH (e.g., a subject with NAFLD, fibrosis, and type 2 diabetes).
  • WAT white adipose tissue
  • administration of the composition results in increased insulin secretion in a subject with cirrhosis (e.g., a subject with hepatocarcinoma, increased risk of liver failure, and increased risk of death). In some embodiments, administration of the composition results in improved glucose tolerance in a subject with cirrhosis (e.g., a subject with
  • the composition is administered at a dose of about 20 g to about 40 g total amino acids, e.g., once per day, twice per day, three times per day, four times per day, five times per day, or six times per day (e.g., three times per day).
  • the composition is administered at a dose of about 24 g total amino acids, e.g., once per day, twice per day, three times per day, four times per day, five times per day, or six times per day (e.g., three times per day).
  • the composition is administered at a dose of about 24 g total amino acids three times per day.
  • the composition includes at least 1 g of leucine, at least 0.5 g of isoleucine, at least 0.5 g of valine, at least 0.75 g of arginine (or 0.905 g of arginine HCl), at least 2 g of glutamine, and at least 0.15 g of N-acetylcysteine for administration three times per day (e.g., for a total of at least 18 g per day).
  • the composition includes about 1 g of leucine, about 0.5 g of isoleucine, about 0.25 g of valine, about 0.75 g of arginine (or 0.905 g of arginine HCl), about 1 g of glutamine, and about 0.225 g of N-acetylcysteine for administration three times per day (e.g., for a total of about 18 g per day).
  • administration of the dietary composition results in an
  • TIMP1 tissue inhibitor of metalloproteinase
  • TIMP2 tissue inhibitor of metalloproteinase
  • MMP matrix metalloproteinase
  • composition comprises L-leucine, a R-amino acid entity, a Q-amino acid entity, and homocysteine.
  • composition of embodiment 1-lD, 4, or 136, wherein the composition comprises HMB, a R-amino acid entity, a Q-amino acid entity, and serine.
  • composition of embodiment 1-lD, 4, or 136, wherein the composition comprises HMB, a R-amino acid entity, a Q-amino acid entity, and L-cysteine.
  • composition of embodiment 1-lD, 4, or 136 wherein the composition comprises HMB, a R-amino acid entity, glutamate, and serine.
  • composition of embodiment 1- lD, 4, or 136 wherein the composition comprises HMB, a R-amino acid entity, carbamoyl-P, and acetylserine.
  • composition of embodiment 1-lD, 4, or 136 wherein the composition comprises HMB, D-arginine, a Q-amino acid entity, and L-cysteine.
  • composition of embodiment 1-lD, 4, or 136 wherein the composition comprises HMB, N-acetyl-arginine, argininosuccinate, and cystine.
  • composition of embodiment 1-lD, 4, or 197 wherein the composition comprises isovaleryl-CoA, glutamate, a Q-amino acid entity, and an antioxidant or ROS scavenger, e.g., a NAC entity.
  • composition of embodiment 1-lD, 4, or 197, wherein the composition comprises isovaleryl-CoA, citrulline, D-glutamine, and an antioxidant or ROS scavenger, e.g., a NAC entity.
  • composition of embodiment 1-lD, 4, or 197, wherein the composition comprises isovaleryl-CoA, aspartate, N-acetyl-glutamine, and an antioxidant or ROS scavenger, e.g., a NAC entity.
  • composition of embodiment 1-lD, 4, or 197, wherein the composition comprises isovaleryl-CoA, creatine, D-glutamine and D-cysteine.
  • composition of embodiment 1-lD, 5, or 258, wherein the composition comprises D-leucine, a R-amino acid entity, L-glutamine, and L-cysteine. 308.
  • composition of embodiment 1-lD, 5, or 258, wherein the composition comprises D-leucine, a R-amino acid entity, a glutamate, and cystine.

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PCT/US2017/067345 2016-12-19 2017-12-19 Amino acid compositions and methods for the treatment of liver diseases Ceased WO2018118941A1 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
EP17829105.0A EP3554492A1 (en) 2016-12-19 2017-12-19 Amino acid compositions and methods for the treatment of liver diseases
KR1020197020657A KR20190099242A (ko) 2016-12-19 2017-12-19 아미노산 조성물 및 간 질환의 치료 방법
CN202211400026.6A CN115814053A (zh) 2016-12-19 2017-12-19 氨基酸组合物及肝疾病的治疗方法
EA201991502A EA201991502A1 (ru) 2017-10-24 2017-12-19 Композиции на основе аминокислот и способы лечения заболеваний печени
MX2019007351A MX2019007351A (es) 2016-12-19 2017-12-19 Composiciones de aminoacidos y metodos de tratamiento de enfermedades hepaticas.
CU2019000058A CU20190058A7 (es) 2016-12-19 2017-12-19 Composiciones de aminoácidos relacionadas con mejoras de la función hepática
JP2019533079A JP2020504108A (ja) 2016-12-19 2017-12-19 アミノ酸組成物および肝疾患の治療方法
AU2017382170A AU2017382170B2 (en) 2016-12-19 2017-12-19 Amino acid compositions and methods for the treatment of liver diseases
BR112019012529-9A BR112019012529A2 (pt) 2016-12-19 2017-12-19 composições de aminoácido e métodos para o tratamento de doenças hepáticas
CN201780078656.7A CN110087647B (zh) 2016-12-19 2017-12-19 氨基酸组合物及肝疾病的治疗方法
CA3046551A CA3046551A1 (en) 2016-12-19 2017-12-19 Amino acid compositions and methods for the treatment of liver diseases
IL296614A IL296614A (en) 2016-12-19 2017-12-19 Amino acid compounds and methods for treating liver diseases
ZA2019/03580A ZA201903580B (en) 2016-12-19 2019-06-04 Amino acid compositions and methods for the treatment of liver diseases
CONC2019/0006291A CO2019006291A2 (es) 2016-12-19 2019-06-17 Composiciones de aminoácidos y métodos de tratamiento de enfermedades hepáticas
IL267480A IL267480B (en) 2016-12-19 2019-06-18 Amino acid compounds and methods for treating liver diseases
PH12019501414A PH12019501414A1 (en) 2016-12-19 2019-06-19 Amino acid compositions and methods for the treatment of liver diseases
IL284371A IL284371B2 (en) 2016-12-19 2021-06-24 Amino acid compounds and methods for treating liver diseases
JP2022193127A JP2023029946A (ja) 2016-12-19 2022-12-01 アミノ酸組成物および肝疾患の治療方法

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201662436073P 2016-12-19 2016-12-19
US62/436,073 2016-12-19
US201762443205P 2017-01-06 2017-01-06
US62/443,205 2017-01-06
US201762491773P 2017-04-28 2017-04-28
US62/491,773 2017-04-28
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10201513B2 (en) 2016-12-19 2019-02-12 Axcella Health Inc. Amino acid compositions and methods for the treatment of liver diseases
WO2019036442A1 (en) * 2017-08-14 2019-02-21 Axcella Health Inc. AMINO ACIDS BRANCHED FOR THE TREATMENT OF NEURONAL INJURY
US10596136B2 (en) 2018-06-20 2020-03-24 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle
US10660870B2 (en) 2017-08-14 2020-05-26 Axcella Health Inc. Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
WO2021020923A1 (ko) * 2019-07-30 2021-02-04 주식회사 고바이오랩 간 손상 예방, 개선, 또는 치료용 조성물 및 간 손상 예방, 개선, 또는 치료방법
KR20210014609A (ko) * 2019-07-30 2021-02-09 주식회사 고바이오랩 비알코올성 지방간 질환의 예측 또는 진단용 키트, 및 진단방법
WO2022266480A1 (en) 2021-06-17 2022-12-22 Axcella Health Inc. Methods of predicting liver fat content and uses thereof
US11617731B2 (en) 2017-04-28 2023-04-04 Axcella Health, Inc. Amino acid compositions and their use for the treatment of traumatic brain injury
US20230203079A1 (en) * 2020-05-15 2023-06-29 Beijing Guanghe Original Technology Co., Ltd. Amino Acid Composition and Method for Catalytic Synthesis of Amino Acid by Means of Energy Radiation
RU2810601C2 (ru) * 2019-07-30 2023-12-27 Кобиолабс, Инк. Композиция и способ для предотвращения, снятия симптомов или терапевтического воздействия на поражение печени
WO2024026307A1 (en) 2022-07-25 2024-02-01 Axcella Health Inc. Biomarker for long covid and fatigue
WO2024030909A1 (en) 2022-08-01 2024-02-08 Axcella Health Inc. Biomarkers of amino acid composition treatment response in long covid

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3780973A4 (en) * 2018-04-18 2022-01-26 Ingenious Ingredients, LP COMPOSITIONS AND THEIR USE TO PROMOTE MUSCLE GROWTH AND FUNCTION
CN112823018A (zh) 2018-06-20 2021-05-18 胺细拉健康公司 制备氨基酸组合物的方法
CU20200106A7 (es) 2018-06-20 2021-08-06 Axcella Health Inc Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias
US11980645B2 (en) 2019-01-22 2024-05-14 The Regents Of The University Of California Bile acids and use in disease treatment
CN110037221A (zh) * 2019-05-28 2019-07-23 广州阿米乐生物技术有限公司 一种解酒固体饮料及其制备方法
US20230105984A1 (en) * 2019-12-23 2023-04-06 Svetlana Marukian Compositions and methods for the treatment of liver diseases and disorders
AU2020436820B2 (en) * 2020-03-16 2024-05-02 Wuhan Vast Conduct Science Foundation Co., Ltd. Copper clusters, composition, and method for treatment of liver cirrhosis
JP7553586B2 (ja) 2020-03-16 2024-09-18 武漢広行科学研究有限公司 肝硬変の治療のための金クラスター（ＡｕＣｓ）及び組成物
US11938152B2 (en) 2020-08-06 2024-03-26 Kedar N Prasad High-dose antioxidants in cancer treatment
CN112394178B (zh) * 2020-11-16 2022-08-05 首都医科大学附属北京朝阳医院 莫西沙星相关肝损伤的生物标志物、试剂盒及应用
WO2023009444A1 (en) * 2021-07-26 2023-02-02 Axcella Health Inc. Amino acid compositions and methods for use in the treatment of post-acute sequelae of covid-19
CN119343061A (zh) * 2022-04-25 2025-01-21 欧罗卡特基金会 含有氨基酸组合的药物组合物和保健食品组合物及其在以组织中脂质蓄积为特征的疾病中的用途
KR20250159205A (ko) * 2023-03-03 2025-11-10 그래즈 이노베이션 지방산의 강화된 대사성 산화를 위한 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001056402A2 (en) * 2000-02-01 2001-08-09 Muscletech Research And Development Inc. Alpha lipoic acid based food supplement to increase lean muscle mass and strength
EP1541141A1 (en) * 2002-08-30 2005-06-15 Ajinomoto Co., Inc. Therapeutic agent for hepatic disease
WO2005084323A2 (en) * 2004-03-02 2005-09-15 Technical Sourcing International, Inc. Compositions of bio-active compounds from fenugreek seed and methods for producing same
WO2011097273A1 (en) * 2010-02-02 2011-08-11 Martek Biosciences Corporation Methods and compositions for treating non-alcoholic fatty liver disease with docosahexaenoic acid and n-acetyl lcystenine
EP2792354A2 (en) * 2011-03-16 2014-10-22 Obshchestvo S Ogranichennoj Otvetstvennostju «Biotekhnologii Pyshchino» Composition of protectors of acute and chronic hepatic encephalopathy and method for treating acute and chronic hepatic encephalopathy

Family Cites Families (328)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US693094A (en) 1900-08-13 1902-02-11 Hall Signal Co Signal and signaling-circuit.
US2457820A (en) 1945-12-27 1949-01-04 Merck & Co Inc Amino acid solution and process for preparing the same
US3012924A (en) 1956-12-17 1961-12-12 Libbey Owens Ford Glass Co Electrically conducting unit
GB1034358A (en) 1963-05-01 1966-06-29 Chugai Pharmaceutical Co Ltd Body-protein-biosynthesis promoting composition
US3832465A (en) 1971-12-09 1974-08-27 H Ghadimi Injectable amino acid composition commensurate to the anabolic need of the body and method of using same
US3988466A (en) 1973-06-01 1976-10-26 Kyowa Hakko Kogyo Co., Ltd. Prevention of gastric lesions
US3950529A (en) 1975-02-03 1976-04-13 Massachusetts General Hospital Amino acid formulations for patients with liver disease and method of using same
JPS5535049A (en) 1978-09-04 1980-03-11 Otsuka Pharmaceut Factory Inc Amino acid transfusion for cancerous patient
DE2906034C2 (de) 1979-02-16 1985-03-28 Maggi AG, Kempttal Verfahren zur Gewinnung von L-Leucin, L-Phenylalanin, L-Tyrosin, L-Cystin und von Gemischen aus L-Leucin und L-Isoleucin
US4898879A (en) 1981-06-29 1990-02-06 Baxter International Inc. Nurtitional composition for management of hepatic failure
CA1184499A (en) 1981-06-29 1985-03-26 David C. Madsen Nutritional composition for management of hepatic failure
JPS58126767A (ja) 1982-01-22 1983-07-28 Ajinomoto Co Inc 肝臓病患者用栄養組成物
US5298493A (en) 1983-04-20 1994-03-29 Clintec Nutrition Co. Compound for use in dietetics, reanimation and therapeutics containing protein fractions based on three types of minipeptides
CH658165A5 (fr) 1984-01-04 1986-10-31 Nestle Sa Produit alimentaire efficace dans le traitement de la lepre.
US5034377A (en) 1984-11-19 1991-07-23 Montefiore Hospital Association Of Western Pennsylvania Aqueous nutrient compositions comprising oligopeptides
JPS61186320A (ja) * 1985-02-12 1986-08-20 Morishita Seiyaku Kk アミノ酸製剤
US4871550A (en) 1986-09-05 1989-10-03 Millman Phillip L Nutrient composition for athletes and method of making and using the same
FR2618331B1 (fr) 1987-07-23 1991-10-04 Synthelabo Compositions pharmaceutiques utiles pour le traitement de l'uremie
US5028622A (en) 1988-05-06 1991-07-02 Ajinomoto Company, Inc. Administration of amino acids as treatment for neurodegenerative disorders
US5576351A (en) 1989-12-29 1996-11-19 Mcgaw, Inc. Use of arginine as an immunostimulator
AU650293B2 (en) 1990-11-01 1994-06-16 Nestec S.A. High acid system nutritional formulations
US5106836A (en) 1991-02-22 1992-04-21 Clintec Nutrition Co. Enteral diet
US5977073A (en) 1991-06-06 1999-11-02 Life Sciences' Technologies, Inc. Nutrient composition for treatment of immune disorders
US5780039A (en) 1992-04-23 1998-07-14 Novartis Nutrition Ag Orally-ingestible nutrition compositions having improved palatability
US5229136A (en) 1992-05-21 1993-07-20 Clintec Nutrition Co. Low caloric density enteral formulation designed to reduce diarrhea in tube-fed patients
US5276018A (en) 1992-07-17 1994-01-04 Brigham And Women's Hospital Composition comprising amino acids and methods for decreasing muscle breakdown
DE4229166A1 (de) 1992-09-01 1994-03-03 Deutsches Krebsforsch Mittel zur Aufrechterhaltung und/oder Steigerung der Muskelleistung und Körperzellmasse
US5356873A (en) 1992-11-05 1994-10-18 Clintec Nutrition Co. Method for providing nutritional requirements to patients having a chronic inflammation reaction
US5348979A (en) * 1992-12-23 1994-09-20 Iowa State University Research Foundation Inc. Method of promoting nitrogen retention in humans
WO1994014458A1 (en) 1992-12-23 1994-07-07 Abbott Laboratories Medical foods for the nutritional support of infant/toddler metabolic diseases
US5571783A (en) 1993-03-09 1996-11-05 Clintec Nutrition Company Composition and method for treating patients with hepatic disease
US5891459A (en) 1993-06-11 1999-04-06 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of vascular function by modulation of endogenous nitric oxide production or activity
US5712309A (en) 1993-08-10 1998-01-27 Musashi Pty Ltd. Composition for treatment of hangovers
US5438042B1 (en) 1993-10-08 1997-08-26 Sandoz Nutrition Ltd Enteral nutritional composition having amino acid profile
AU682894B2 (en) 1993-10-28 1997-10-23 Institut National De La Recherche Agronomique Composition based on amino acids intended for the treatment of sepsis or of an attack bringing about an inflammatory reaction, in animals and man
US5378722A (en) 1993-12-03 1995-01-03 Clintec Nutrition Co. Nutritional compositions for management of nitrogen metabolism
US5714472A (en) 1993-12-23 1998-02-03 Nestec Ltd. Enternal formulation designed for optimized nutrient absorption and wound healing
US5723446A (en) 1993-12-23 1998-03-03 Nestec Ltd. Enteral formulation designed for optimized nutrient absorption and wound healing
GB9403935D0 (en) 1994-03-01 1994-04-20 Sandoz Nutrition Ltd Improvements in or relating to organic compounds
US5719133A (en) 1994-09-21 1998-02-17 Novartis Nutrition Ag Adolescent dietary composition
IT1275434B (it) 1995-05-19 1997-08-07 Farmila Farma Milano Composizioni farmaceutiche e/o dietetiche ad attivita' antiossidante
US5728678A (en) 1995-06-06 1998-03-17 Nestec Ltd. Method and composition for providing nutrition to a renal failure patient
JP4280310B2 (ja) 1995-08-10 2009-06-17 佐々木化学工業株式会社 アミノ酸組成剤
US5733884A (en) 1995-11-07 1998-03-31 Nestec Ltd. Enteral formulation designed for optimized wound healing
US6087398A (en) 1996-03-01 2000-07-11 South Alabama Medical Science Foundation Sickle cell anemia treatment
US5716926A (en) 1996-07-26 1998-02-10 Paxton K. Beale Composition of pyruvate and protein and method for increasing protein concentration in a mammal
US6096785A (en) 1996-07-30 2000-08-01 Novartis Nutrition Ag Amino acid compositions and use thereof in treating renal dysfunction
JPH1053521A (ja) 1996-08-12 1998-02-24 Kagaku Gijutsu Shinko Jigyodan 脳内グルタミン酸の活性抑制剤および活性増強剤
US6544260B1 (en) 1996-08-20 2003-04-08 Oratec Interventions, Inc. Method for treating tissue in arthroscopic environment using precooling and apparatus for same
IT1289754B1 (it) 1996-12-16 1998-10-16 Professional Dietetics Srl Composizioni a base di aminoacidi
US6013273A (en) 1997-01-27 2000-01-11 Novartis Nutrition Ag Treatment of endotoxic shock
US5817329A (en) 1997-02-28 1998-10-06 Gardiner; Paul T. Nutritional supplement for increased muscle size and strength for body builders
EP1123013A1 (en) 1997-06-02 2001-08-16 Société des Produits Nestlé S.A. Product and method for providing glutamine
US5849335A (en) 1997-06-02 1998-12-15 Nestec S.A. Composition and method for providing glutamine
US6281244B1 (en) 1997-06-05 2001-08-28 Novartis Nutrition Ag Therapeutic use for glycine
DE69823739T2 (de) 1997-06-05 2005-04-28 Novartis Nutrition Ag Glycin zur Vorbeugung oder Behandlung von Transplantatabstossungen
EP0891719A1 (en) 1997-07-14 1999-01-20 N.V. Nutricia Nutritional composition containing methionine
IT1294227B1 (it) 1997-08-01 1999-03-24 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o una alcanoil l-carnitina e alcoli alifatici a lunga catena utile per la prevenzione
TW473387B (en) 1997-09-30 2002-01-21 Chugai Pharmaceutical Co Ltd Pharmaceutical or food compositions for treating hepatic diseases or improving liver functions
US6288116B1 (en) 1998-05-13 2001-09-11 Novartis Nutrition Ag Method of administration of a nutritional product to a person having renal failure
US6203820B1 (en) 1998-05-28 2001-03-20 Brice E. Vickery Compositions and methods for enhancing protein anabolism and detoxification
US6103748A (en) 1998-06-19 2000-08-15 Bryan; Thomas B. Method of treating an autoimmune disorder
US6031000A (en) 1998-06-23 2000-02-29 Iowa State University Research Foundation, Inc. Composition comprising β-hydroxy-β-methylbutyric acid and at least one amino acid and methods of use
JP2000072669A (ja) 1998-08-24 2000-03-07 Inst Of Physical & Chemical Res アミノ酸・糖組成物
US6458338B1 (en) 1998-09-22 2002-10-01 Aeropharm Technology Incorporated Amino acid stabilized medicinal aerosol formulations
US20010041187A1 (en) 1998-10-20 2001-11-15 Carl W Hastings Performance-enhancing dietary supplement
EP1004302A3 (en) 1998-10-29 2003-06-04 Ajinomoto Co., Inc. Immunomodulator
US6051236A (en) 1998-11-12 2000-04-18 Pacifichealth Laboratories, Inc. Composition for optimizing muscle performance during exercise
US6143786A (en) 1999-02-02 2000-11-07 Novartis Nutrition Ag Oral arginine and insulin secretion
US6241996B1 (en) 1999-04-09 2001-06-05 Novartis Nutrition Ag Liquid soy nutritional products
WO2000064283A1 (en) 1999-04-27 2000-11-02 International Health Products And Services Ltd. Supplement for restoring growth hormone levels
WO2001026642A2 (en) 1999-10-08 2001-04-19 Joyce Corinne Bechthold Methods and compositions for treating neurobehavioral disorders
GB9929497D0 (en) 1999-12-14 2000-02-09 Vitaflo Limited Improved amino acid mixtures for the treatment and/or management of certain diseases
US6833350B2 (en) 2000-02-04 2004-12-21 Nestec S.A. Method for maintaining or improving the synthesis of mucins
US6521591B1 (en) 2000-02-10 2003-02-18 N.V. Nutricia Pharmaceutical composition for muscular anabolism
GB0009056D0 (en) 2000-04-12 2000-05-31 Nestle Sa Composition comprising free amino acids
AU5625001A (en) 2000-04-18 2001-10-30 Societe Des Produits Nestle S.A. Nutritional modules
US6391332B1 (en) 2000-04-20 2002-05-21 Baxter International, Inc. Therapeutic micronutrient composition for severe trauma, burns and critical illness
US20030187049A1 (en) 2000-07-04 2003-10-02 Dioguardi Francesco Saverio Compositions based on aminoacids, suitable for improving muscle performance
IT1320783B1 (it) 2000-07-04 2003-12-10 Professional Dietetics Srl Composizioni a base di aminoacidi, atte al miglioramento delleprestazioni muscolari.
IT1320782B1 (it) 2000-07-04 2003-12-10 Professional Dietetics Srl Composizioni a base di aminoacidi, atte al trattamentodell'insufficienza cardiaca.
US6417293B1 (en) 2000-12-04 2002-07-09 Dow Corning Corporation Thermoplastic silicone elastomers formed from polyester resins
DE10060819A1 (de) 2000-12-07 2002-06-13 Cognis Deutschland Gmbh Verwendung von Polyetheramin-Derivaten zur dauerhaften Verbesserung der Klebstoff- und/oder Beschichtungs-Kompatibilität von Polyethylen-basierten Formkörpern, Fasern und Folien
DE10060818A1 (de) 2000-12-07 2002-06-13 Cognis Deutschland Gmbh Verwendung von Polyetheraminen zur dauerhaften Verbesserung der Klebstoff- und/oder Beschichtungs-Kompatibilität von Polyethylen-basierten Formkörpern, Fasern und Folien
EP1372641A4 (en) 2001-03-05 2004-08-25 Stephen P Ernest ENTERAL FORMULATION
ATE441409T1 (de) 2001-03-15 2009-09-15 Riken Aminosäurezusammensetzungen zur linderung einer fehlfunktion der leber
US20020193342A1 (en) 2001-05-09 2002-12-19 Hamman John P. Modifying undesirable tastes
ITTO20010580A1 (it) 2001-06-15 2002-12-15 Professional Dietetics Srl Composizioni a base di aminoacidi per il miglioramento della funzioneventricolare miocardica in pazienti affetti da diabete.
US6864230B2 (en) 2001-07-31 2005-03-08 Novartis Nutrition Ag Glutamine rich dietary composition
EP1466602A4 (en) 2001-12-25 2006-03-01 Ajinomoto Kk ORGAN FIBROSIS INHIBITORS
EP1471903B1 (en) 2002-01-25 2019-11-20 SciMar Ltd. Use of glutathione synthesis stimulating compounds in reducing insulin resistance
JP2003238401A (ja) 2002-02-20 2003-08-27 Ajinomoto Co Inc 疾患の治療、改善又は予防用医薬品及び飲食品
US7338675B2 (en) 2002-05-10 2008-03-04 Tsi Health Sciences, Inc. Fenugreek seed bio-active compositions and methods for extracting same
US20050176827A1 (en) 2002-05-10 2005-08-11 Lee Steve S. Compositions and methods for glycogen synthesis
US8895059B2 (en) 2002-06-05 2014-11-25 Ivax Pharmaceuticals S.R.O. Reduction of cross-linking gelatin in gelatin capsules
US20040087490A1 (en) 2002-09-20 2004-05-06 Troup John P. Nutritional compositions
US20040057983A1 (en) 2002-09-25 2004-03-25 David Schmidt Biomolecular wearable apparatus
US7037522B2 (en) 2002-09-27 2006-05-02 Western Holdings, L.L.C. Nocturnal muscle enhancing composition and method
JP2004123564A (ja) 2002-09-30 2004-04-22 Inst Of Physical & Chemical Res 中枢機能改善用アミノ酸組成物
JP2004182705A (ja) 2002-10-11 2004-07-02 Yasutoshi Koga ミトコンドリア機能異常に起因する疾患における臨床症状発現の予防・治療用組成物
US7547450B2 (en) 2002-10-24 2009-06-16 Nestec Ltd. Senior feline food
US8093292B2 (en) 2002-11-22 2012-01-10 Bionexus, Ltd. Methods for the treatment of HIV-1 related fat maldistribution, fasting hyperlipidemia and modification of adipocyte physiology
US7288570B2 (en) 2002-12-20 2007-10-30 Nutricia N.V. Stimulation of in vivo production of proteins
US20040120983A1 (en) 2002-12-23 2004-06-24 Philip Connolly Nutritional supplement
JP4989836B2 (ja) 2002-12-26 2012-08-01 大塚製薬株式会社 経口栄養剤
EP1582207A4 (en) 2002-12-26 2008-03-05 Ajinomoto Kk HEMMER FOR OUTBREAKING AND PROGREDIENCE OF LIVER CANCER
JP2006520335A (ja) 2003-03-18 2006-09-07 ノバルティス アクチエンゲゼルシャフト 脂肪酸とアミノ酸を含有する組成物
US20040213838A1 (en) 2003-04-24 2004-10-28 Mazer Terrence B. Medical food tablets containing free amino acids
JP4528925B2 (ja) 2003-05-30 2010-08-25 独立行政法人理化学研究所 アミノ酸組成物及び補液
ES2391558T3 (es) 2003-06-23 2012-11-27 Nestec S.A. Suplemento de aminoácidos para un ecosistema microbiótico sano
JP2005027524A (ja) 2003-07-08 2005-02-03 Ajinomoto Co Inc 経口アミノ酸組成物
WO2005017094A2 (en) 2003-08-19 2005-02-24 Bioadvantex Pharma Inc. N-acetyl compositions as adjunct therapy for treatment and prevention of cysteine/glutathione deficiency
ITTO20030789A1 (it) 2003-10-07 2005-04-08 Professional Dietetics Srl Composizione a base di amino acidi per il trattamento
WO2005039318A1 (en) 2003-10-16 2005-05-06 Nestec S.A. Nutritional composition against side effects of chemotherapy of radiotherapy
EP1685833A1 (en) 2003-11-21 2006-08-02 Ajinomoto Co., Inc. Remedy for diabetes
EP1543735B1 (en) 2003-12-20 2015-10-07 Nestec S.A. Nutritional composition for wound healing
JPWO2005072721A1 (ja) 2004-01-28 2007-09-06 味の素株式会社 局所脳血流低下に伴う神経系障害の予防または治療のための医薬組成物
CA2558220C (en) 2004-02-27 2012-01-24 Incorporated Administrative Agency National Agriculture And Food Researc H Organization Food ingredient including enriched free amino acids and their production method
US20050215640A1 (en) 2004-03-26 2005-09-29 Baxter Jeffrey H HMB compositions and uses thereof
JP4815752B2 (ja) 2004-04-01 2011-11-16 味の素株式会社 アミノ酸含有飲食品
WO2005110124A1 (en) 2004-04-15 2005-11-24 Abbott Laboratories Composition and methods for nutritional management of patients with hepatic disease
CN1582912A (zh) 2004-06-10 2005-02-23 武汉启瑞科技发展有限公司 L－鸟氨酸和 l－门冬氨酸组合物
WO2006009975A2 (en) 2004-06-22 2006-01-26 Maxim Pharmaceuticals, Inc. Histamine to treat disorders affecting muscle function
RU2372900C2 (ru) 2004-07-14 2009-11-20 Адзиномото Ко., Инк. Ингибитор возникновения и развития рака печени для применения у пациентов-людей с циррозом печени, положительных по вирусу гепатита с
JP2008506771A (ja) 2004-07-19 2008-03-06 エヌ．ブイ．・ヌートリシア 血糖値を調節するためのアスパルテートを使用するための調製物
EP1637163A1 (en) 2004-09-21 2006-03-22 Andreas Kluge Indicator of therapeutic compliance
JP5177785B2 (ja) 2004-11-02 2013-04-10 味の素株式会社 周術期患者用薬剤
SG158073A1 (en) 2004-11-26 2010-01-29 Ucl Business Plc Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy
WO2006083381A2 (en) 2004-12-03 2006-08-10 University Of Maryland, Baltimore Composition for treating sulfur mustard toxicity and methods of using same
JPWO2006061992A1 (ja) 2004-12-10 2008-06-05 味の素株式会社 肝疾患予防・治療用組成物
US20080114067A1 (en) 2005-01-31 2008-05-15 Takanobu Yamamoto Composition for Recovery From or Prevention of Central Nervous System Fatigue
CN1679941A (zh) 2005-02-02 2005-10-12 北京阜康仁生物制药科技有限公司 一种由牛磺酸和治疗肝病的药物组成的复方制剂及其制备方法
US20060198899A1 (en) 2005-03-01 2006-09-07 Gardiner Paul T Supplemental dietary composition for supporting muscle growth, recovery and strength
CN101175995A (zh) 2005-03-15 2008-05-07 雀巢技术公司 用于调节维生素c生物利用率的营养组合物
ES2402935T3 (es) 2005-03-21 2013-05-10 Abbott Laboratories Composición de aminoácidos para mejorar la tolerancia a la glucosa
JP5545424B2 (ja) 2005-03-29 2014-07-09 味の素株式会社 高齢者の骨格筋量減少を防止又は改善するためのアミノ酸含有組成物
EP2243383A3 (en) 2005-04-06 2011-02-16 Nestec S.A. A method and composition for nutritionally improving glucose control and insulin action
US8993627B2 (en) 2005-04-21 2015-03-31 Sentient Lifesciences, Inc. N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress
US20090209647A1 (en) 2005-06-14 2009-08-20 Nestec S.A. Nutritional method
EP2184062A1 (en) 2005-06-22 2010-05-12 Ajinomoto Co., Inc. Use of glutamic acid and a nucleic acid as metabotropic glutamate receptor activators
US20100104548A1 (en) 2005-06-24 2010-04-29 Albert Einstein College Of Medicine Of Yeshiva University Modulation of amino acid metabolism in the hypothalamus
JPWO2007004613A1 (ja) 2005-07-01 2009-01-29 味の素株式会社 炎症性腸疾患治療薬及びＴＮＦ−α産生抑制剤
JP2007023921A (ja) * 2005-07-19 2007-02-01 Toyota Motor Corp 内燃機関の制御装置
JP5682990B2 (ja) 2005-08-04 2015-03-11 味の素株式会社 酸化型アルブミン低下剤
WO2007018278A1 (ja) 2005-08-05 2007-02-15 Ajinomoto Co., Inc. 肝癌発生・進展抑制剤
US8148356B2 (en) 2005-08-24 2012-04-03 Cumberland Pharmaceuticals, Inc. Acetylcysteine composition and uses therefor
EP1919304B1 (en) 2005-08-26 2011-05-25 Nestec S.A. Compositions and methods for improving functional vascular integrity, cellular survival and reducing apoptosis after an ischemic episode in the brain
EP1774973A1 (en) 2005-10-12 2007-04-18 Nutricia N.V. Leucine rich composition
CA2627566A1 (en) 2005-10-28 2007-05-10 Nestec S.A. Methods for the use of branched chain amino acids
WO2007056176A2 (en) 2005-11-03 2007-05-18 Southwest Immunology, Inc. Compositions for preventing and reducing delayed onset muscle soreness
US20070243211A1 (en) 2005-11-07 2007-10-18 Jaffe Russell M Compositions for regulating metabolic disorders and methods of use thereof
RU2414897C2 (ru) 2005-11-30 2011-03-27 Нестек С.А. Способы лечения потери мышечной массы
ES2548432T3 (es) 2005-12-19 2015-10-16 Abbott Laboratories Uso de beta-hidroxi-beta-metilbutirato para modular el desequilibrio en la producción de citoquinas de tipo 1 y tipo 2
RU2437655C2 (ru) 2006-01-09 2011-12-27 Нестек С.А. Лечение пациентов, подвергнутых стрессу
PL1983849T3 (pl) 2006-01-20 2013-09-30 Innova Food Ab Kompozycja spożywcza zawierająca aminokwasy
BRPI0706795A2 (pt) 2006-01-31 2011-04-05 Nestec Sa composição nutricional para bebês com baixo peso de nascimento
US20070270355A1 (en) 2006-05-11 2007-11-22 Garcia Ramon D Sport drink containing amino acids and carbohydrates
JP5100033B2 (ja) 2006-05-16 2012-12-19 大塚製薬株式会社 消化管及び腎臓の萎縮抑制剤
US20070286909A1 (en) 2006-06-07 2007-12-13 Daniel S. Smith Amino acid compositions
JP2008050277A (ja) 2006-08-22 2008-03-06 Ajinomoto Co Inc 鉄欠乏性貧血症治療用組成物
US9192593B2 (en) 2006-08-30 2015-11-24 Ajinomoto Co., Inc. Amino-acid containing composition for inhibiting accumulation of fat
MY146112A (en) 2006-10-19 2012-06-29 Nestec Sa Long-term feed - cancer patient
US20080102137A1 (en) 2006-10-31 2008-05-01 Guffey Manning V R Composition and method for etiological treatment and prevention of diseases and/or complications associated with chronic glucose metabolism destabilization
GB0624879D0 (en) 2006-12-14 2007-01-24 Shs Int Ltd Treatment of pervasive development disorders
EP1932437A1 (en) 2006-12-15 2008-06-18 Nestec S.A. Infant formula
CN100518815C (zh) 2007-02-15 2009-07-29 北京苏里曼医药科技有限公司 一种氨基酸组合物
US20080268038A1 (en) 2007-04-26 2008-10-30 Wolfe Robert R Compositions and Approaches for Increasing Diet Induced Thermogenesis, Inducing Weight Loss and Maintaining Muscle Mass and Strength
CN101332209B (zh) 2007-06-25 2010-12-08 三菱制药（广州）有限公司 治疗肝性脑病的复方氨基酸注射液
US7777074B2 (en) 2007-09-18 2010-08-17 Thermolife International, Llc Amino acid compounds
US8466187B2 (en) 2007-09-18 2013-06-18 Thermolife International, Llc Amino acid compositions
US8455531B2 (en) 2007-09-18 2013-06-04 Thermolife International, Llc Amino acid compositions
KR100970664B1 (ko) 2007-10-11 2010-07-15 한화제약주식회사 Ｌ-오르니틴-ｌ-아스파테이트를 함유한 겔제의 제조방법 및그 겔제
EP2057905A1 (en) 2007-11-12 2009-05-13 TIMA Foundation Composition for moderating Triglyceride and Cholesterol Levels
CA2706656A1 (en) 2007-11-26 2009-06-04 Nestec S.A. Compositions and methods for inhibiting the activation of dsrna-dependent protein kinase and tumor growth inhibition
CN101214050B (zh) 2007-12-28 2011-08-31 叶高山 一种具有提神、抗疲劳、醒酒功能的保健饮料
CA2994586C (en) 2008-01-04 2020-07-21 Nestec S.A. Compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and use thereof for enhancing cognitive and related functions
US7790688B2 (en) 2008-01-11 2010-09-07 Healthspan Solutions, Llc Compositions and methods for increasing muscle mass, strength, and functional performance in the elderly
US20090186098A1 (en) 2008-01-18 2009-07-23 Jose Briceno Sports drink composition
ATE523095T1 (de) 2008-01-25 2011-09-15 Cesar Gallia S R L Aminosäurenkonzentrat in wässrigem gel und mittels verdünnung besagten konzentrats mit wasser erhaltenes getränk zur bekämpfung von müdigkeit
US8716249B2 (en) 2008-01-31 2014-05-06 Energy Light Llc Compositions and methods for improving cardiovascular health
WO2009100241A2 (en) 2008-02-05 2009-08-13 Healthspan Solutions, Llc Systems for and methods of use of therapeutic nutrition for the management of age-associated and age-specific health conditions of the elderly.
AU2009210728B2 (en) 2008-02-07 2014-06-19 Société des Produits Nestlé S.A. Compositions and methods for influencing recovery from strenuous physical activity
EP2098126A1 (en) 2008-03-03 2009-09-09 Nestec S.A. Carbohydrate Bar
EP2098124A1 (en) 2008-03-03 2009-09-09 Nestec S.A. Carbohydrate gel
CN102316730A (zh) 2008-05-09 2012-01-11 天雅瑞药业有限公司 用于减轻全身性炎症和/或血管炎症的n-乙酰半胱氨酸(nac)的控释
US20090306209A1 (en) 2008-06-04 2009-12-10 Daugherty F Joseph Enteric-coated formulations of polyethylene glycol and one or more soluble amino acids for oral ingestion and enhanced uptake of same
US20100021573A1 (en) * 2008-07-22 2010-01-28 Michael J Gonzalez Compositions and methods for the prevention of cardiovascular disease
EP3011843A1 (en) 2008-09-19 2016-04-27 Nestec S.A. Nutritional support of the immune system during anti-cancer treatment
EP2165713B1 (en) 2008-09-19 2012-11-14 Nestec S.A. Whey and thymus function
WO2010050168A1 (ja) 2008-10-27 2010-05-06 味の素株式会社 バリン、イソロイシン、ロイシン固溶体およびその製造方法
US8362080B2 (en) 2008-12-18 2013-01-29 Baylor College Of Medicine Increasing glutathione levels for therapy
US9314444B2 (en) 2009-01-12 2016-04-19 Biokier, Inc. Composition and method for treatment of NASH
RS56054B1 (sr) 2009-01-12 2017-09-29 Biokier Inc Smeša i metod za lečenje dijabetesa
US20120178672A1 (en) 2009-03-18 2012-07-12 Wolfe Robert R Compositions and Methods for Sparing Muscle in Renal Insufficiency and During Hemodialysis
WO2010108542A1 (en) 2009-03-25 2010-09-30 Nestec S.A. A natural taste enhancing savoury base and a process for its preparation
CA2757373C (en) 2009-04-03 2018-05-08 Ocera Therapeutics, Inc. L-ornithine phenyl acetate and methods of making thereof
WO2010126353A1 (en) 2009-04-27 2010-11-04 N.V. Nutricia Pea-based protein mixture and use thereof in a liquid nutritional composition suitable for enteral feeding
US8703719B1 (en) 2009-05-18 2014-04-22 Bio-Engineered Supplements And Nutrition, Inc. Method and composition for improved muscle performance
EA201691430A1 (ru) 2009-06-08 2017-02-28 ЮСиЭл БИЗНЕС ПиЭлСи Лечение портальной гипертензии и восстановление функции печени с помощью l-орнитинфенилацетата
WO2010143939A1 (en) 2009-06-09 2010-12-16 N.V. Nutricia Nutrition for improving muscle strength in elderly
JP2012533627A (ja) 2009-07-20 2012-12-27 ネステク ソシエテ アノニム 機能状態の喪失を減弱する方法
WO2011030104A1 (en) 2009-09-09 2011-03-17 Rajiv Jalan Phenylacetate and/or phenylbutyrate (not ornithine) for reducing portal blood pressure
CN101664384B (zh) 2009-09-18 2011-09-14 杭州市第六人民医院 N-乙酰半胱氨酸盐木糖醇注射液及其制备方法和应用
CN102711800A (zh) 2009-09-23 2012-10-03 拜奥基尔公司 治疗糖尿病的组合物和方法
WO2011044230A2 (en) 2009-10-06 2011-04-14 Goldstein Glenn A N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions
WO2011043647A1 (en) 2009-10-09 2011-04-14 N.V. Nutricia Amino acid composition with improved dispersibility
EP2327316B1 (en) 2009-11-29 2016-11-16 Premier Nutrition Corporation Method of enhancing muscle protein synthesis
EP2327315B1 (en) 2009-11-29 2013-10-09 Nestec S.A. Dosing protocols for increasing protein synthesis in an active individual
JP2011132174A (ja) 2009-12-24 2011-07-07 Kirin Holdings Co Ltd 持久力向上剤
WO2011078654A1 (en) 2009-12-24 2011-06-30 N.V. Nutricia Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis
CA2792396C (en) 2010-03-12 2018-09-11 Nestec S.A. Compositions for masking the flavor of nutrients and methods for making same
WO2011119023A1 (en) 2010-03-26 2011-09-29 N.V. Nutricia Low protein infant formula with increased essential amino acids
US20130210715A1 (en) 2010-04-26 2013-08-15 Nestec S.A. Nutritional compositions and methods for weaning from parenteral nutrition to enteral nutrition
US8840950B2 (en) 2010-05-26 2014-09-23 Jacqueline M. Hibbert Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore
WO2012005568A1 (en) 2010-07-07 2012-01-12 N.V. Nutricia Nutritional composition for the stimulation of muscle protein synthesis
KR101213825B1 (ko) 2010-07-16 2012-12-18 서울대학교산학협력단 세린을 유효성분으로 함유하는 지방간 질환의 예방 및 치료용 조성물
MY173215A (en) 2010-07-21 2020-01-06 Cumberland Pharmaceuticals Inc Acetylcysteine compositions and methods of use thereof
US20120020947A1 (en) 2010-07-22 2012-01-26 Northern Innovations And Formulations Corp. Compositions and methods for increasing lean muscle mass after exercise
CN101912394B (zh) 2010-08-06 2013-11-06 岳茂兴 一种用于治疗凝血障碍出血的药物组合物及其用途
MX360062B (es) 2010-10-06 2018-10-22 Ocera Therapeutics Inc Metodos de elaboracion de fenilacetato de l-ornitina.
EP2444083A1 (en) 2010-10-21 2012-04-25 Nestec S.A. Cysteine and food intake
SG191315A1 (en) 2010-12-22 2013-07-31 Abbott Lab Nutritional products comprising calcium beta-hydroxy-beta methylbutyrate and conjugated linoleic acid
CA2821312A1 (en) 2010-12-27 2012-07-05 Abbott Laboratories Methods for facilitating muscle recovery after a period of disuse using beta-hydroxy-beta-methylbutyrate
WO2012097061A1 (en) 2011-01-13 2012-07-19 Abbott Laboratories Nutritional compositions and methods for improving skeletal muscle protein metabolism
RU2597793C2 (ru) 2011-01-25 2016-09-20 Нестек С.А. Способы и композиции для лечения, ослабления или предотвращения ухудшения зрительной системы животных
JP2014515011A (ja) 2011-03-18 2014-06-26 ネステク ソシエテ アノニム 加齢に伴う疾病を改善するのに有用な組成物及び方法
US11235008B2 (en) 2011-03-31 2022-02-01 Ganeden Biotech, Inc. Probiotic sports nutrition compositions
CN102327259A (zh) 2011-03-31 2012-01-25 姜国辉 具有显著化学性肝损伤保护功能的复合生物制剂
EP2696868A1 (en) 2011-04-12 2014-02-19 Nestec S.A. Nutritional compositions including branched chain fatty acids and methods of using same
CN103491804A (zh) 2011-04-18 2014-01-01 雀巢产品技术援助有限公司 具有α-HICA 和二十碳五烯酸的营养组合物
US20120270860A1 (en) 2011-04-19 2012-10-25 Gihyun Yoon Methods for treating or preventing alcohol-related disorders or craving-related disorders
JP2014513527A (ja) 2011-04-21 2014-06-05 ネステク ソシエテ アノニム パフォーマンス向上のための栄養組成物並びにその作製及び使用方法
US8828426B2 (en) 2011-06-07 2014-09-09 Zx Pharma, Llc Multiparticulate L-carnitine compositions and related methods
US20140135396A1 (en) 2011-07-05 2014-05-15 Beth Israel Deaconess Medical Center, Inc. Treatment of Acetaminophen-Induced Liver Damage by the Administration of Modulators of Nitric Oxide
BR112014002779A2 (pt) 2011-08-08 2017-02-21 Ajinomoto Kk composição contendo aminoácido para o melhoramento da recuperação a partir de fadiga muscular
HK1199378A1 (en) 2011-08-19 2015-07-03 Musclepharm Corporation Compositions and methods for use in promoting lean body mass
EP2574333B1 (en) 2011-09-27 2017-01-11 Friulchem SpA N-acetylcysteine effervescent tablet and its therapeutical applications
EP2580967A1 (en) 2011-10-11 2013-04-17 Nestec S.A. Accelerating muscle recovery after immobilization-induced muscle atrophy
EP2583563A1 (en) 2011-10-21 2013-04-24 Nestec S.A. Whey protein micelles against muscle atrophy and sarcopenia
EP2583565A1 (en) 2011-10-21 2013-04-24 Nestec S.A. Use of whey protein micelles for enhancing energy expenditure and satiety
US9364463B2 (en) 2011-11-18 2016-06-14 Board Of Trustees Of The University Of Arkansas Use of amino acid supplementation for improved muscle recovery
CN108478551A (zh) 2011-11-21 2018-09-04 埃默斯医疗股份有限公司 用于治疗糖尿病和相关病症的方法和组合物
WO2013081154A1 (ja) 2011-12-02 2013-06-06 味の素株式会社 キナーゼ阻害剤の副作用低減剤
AU2013210373A1 (en) 2012-01-19 2014-09-04 Shoichi Shirotake Antibacterial agent against plant disease-causing bacteria
US9198454B2 (en) 2012-03-08 2015-12-01 Nusirt Sciences, Inc. Compositions, methods, and kits for regulating energy metabolism
WO2013188258A1 (en) 2012-06-11 2013-12-19 Abbott Laboratories Use of hmb to improve health outcomes for hospitalized patients
JP6368306B2 (ja) 2012-07-31 2018-08-01 ネステク ソシエテ アノニム 炎症性腸疾患（ｉｂｄ）患者の筋骨格の健康を促進させるための栄養組成物
CA2884717A1 (en) 2012-09-14 2014-03-20 Nestec S.A. Novel flavour compositions with improved flavour and/or flavour shelf-life
US8747921B2 (en) 2012-09-19 2014-06-10 Quality Ip Holdings, Inc. Methods for improving health in humans
US9198889B2 (en) 2012-09-19 2015-12-01 Quality IP Holdings, LLC Methods for treating post-traumatic stress disorder
US9066953B2 (en) 2012-09-20 2015-06-30 Quality IP Holdings, LLC Methods for increasing endurance and fat metabolism in humans
CN102961377A (zh) 2012-11-08 2013-03-13 湖北一半天制药有限公司 复方氨基酸注射液（20aa）的制备方法
ES2633769T3 (es) 2012-12-04 2017-09-25 Nestec S.A. Hexanoilglicina como biomarcador para la predisposición al aumento de peso y a la obesidad
CA2899925A1 (en) 2013-02-04 2014-08-07 Seres Therapeutics, Inc. Compositions and methods for inhibition of pathogenic bacterial growth
KR101969199B1 (ko) 2013-03-11 2019-04-15 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 폐 기능의 개선 및 방사선 유발된 폐 합병증의 예방 및/또는 치료를 위한 물질 및 방법
CN105228627B (zh) 2013-03-15 2018-07-13 纽斯尔特科学公司 亮氨酸和烟酸降低脂质水平
CN105246357A (zh) 2013-03-26 2016-01-13 普瑞米尔营养公司 提高组合训练后肌肉蛋白质合成的方法
ES2617714T5 (es) 2013-04-15 2021-02-11 Nestle Sa Empleo de la proteína de suero en combinación con la estimulación eléctrica muscular
ES2844199T3 (es) 2013-04-16 2021-07-21 Childrens Hospital Philadelphia Composiciones y métodos para el tratamiento de lesiones cerebrales
WO2014191856A1 (en) 2013-05-31 2014-12-04 Nestec S.A. Methods for enhancement of muscle protein synthesis
EP3019024B1 (en) 2013-06-28 2017-02-01 Nestec S.A. Compositions and methods for enhancing exercise performance
WO2015015149A1 (en) 2013-07-31 2015-02-05 Leeds Metropolitan University Dietary supplement
US20180125926A1 (en) 2013-09-25 2018-05-10 Axcella Health Inc. Compositions and Formulations and Methods of Production and Use Thereof
EP3048904A2 (en) 2013-09-25 2016-08-03 Pronutria Biosciences, Inc. Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof
EP3054938A1 (en) 2013-10-09 2016-08-17 Nestec S.A. Compositions comprising citrulline and leucine and their use in the treatment of diabetes and metabolic syndrome
WO2015061607A1 (en) 2013-10-23 2015-04-30 Whitehead Institute For Biomedical Research Mtorc1 modulation by amino acids and uses thereof
EP3110507B1 (en) 2014-02-27 2020-11-18 NuSirt Sciences, Inc. Compositions and methods for the reduction or prevention of hepatic steatosis
GB2523578A (en) 2014-02-28 2015-09-02 Daniel Nelson A nutritional supplement
WO2015161448A1 (en) 2014-04-22 2015-10-29 Wuhan Ll Science And Technology Development Co., Ltd. Ornithine-containing or aspartate-containing compositions and the uses thereof
CN105092753B (zh) 2014-05-20 2016-09-07 中国科学院大连化学物理研究所 组合型胺类代谢标志物的应用及试剂盒
WO2016003263A1 (en) 2014-07-01 2016-01-07 N.V. Nutricia Amino acid based diet with improved taste
US10217645B2 (en) 2014-07-25 2019-02-26 Versum Materials Us, Llc Chemical mechanical polishing (CMP) of cobalt-containing substrate
US20160158305A1 (en) 2014-09-19 2016-06-09 Chip E. Thomson Additives and supplements
WO2016058919A1 (en) 2014-10-14 2016-04-21 Nestec S.A. Improvement in muscle functionality of elderly males
US10039735B2 (en) 2014-11-24 2018-08-07 Ucl Business Plc Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
UA120627C2 (uk) 2014-12-04 2020-01-10 Профешенал Дайатетікс С.П.А. Композиція на основі амінокислоти для відновлення фіброеластину в дермальній сполучній тканині
US10894024B2 (en) 2014-12-08 2021-01-19 Synaptamine, Inc. Anti-RDS compounds and method of manufacture and administration thereof to induce dopamine homeostatis
EP3034074A1 (en) 2014-12-18 2016-06-22 Universitat De València, Estudi General Compound for treatment of myotonic dystrophy type 1
JP6959136B2 (ja) 2015-01-23 2021-11-02 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 患者の示差的な栄養所要量の決定方法
US20180021278A1 (en) 2015-01-23 2018-01-25 Nestec S.A. Treatment or prevention of inflammation using serine
AU2016208455A1 (en) 2015-01-23 2017-06-15 Société des Produits Nestlé S.A. Nutritional composition useful in the treatment of IBD patients
US20170368026A1 (en) 2015-01-23 2017-12-28 Nestec S.A. Promotion of healing of intestinal mucosa using proline, serine and threonine
JP6847668B2 (ja) 2015-01-27 2021-03-24 昇一 城武 ナノ粒子を有効成分とする皮膚炎の治療又は予防剤
BR112017014924A2 (pt) 2015-02-13 2018-03-20 Nestec Sa Tratamento ou prevenção de caquexia induzida por cirurgia e/ou expressão de células supressoras de origem mieloide e citoquinas pró- inflamatórias
US20180036270A1 (en) 2015-02-13 2018-02-08 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College A method of protecting against carbonyl stress induced ischemia-reperfusion injury in the diabetic brain via administration of n-acetylcysteine
FR3032883B1 (fr) * 2015-02-24 2017-03-17 International Nutrition Res Company Composition pour la prevention et le traitement de la steatose et de la steatohepatite metaboliques
US20160302451A1 (en) 2015-04-16 2016-10-20 Michael Hudnall Medical Food for Patients with Chronic Liver Disease
RU2755904C2 (ru) 2015-04-20 2021-09-22 Осера Терапьютикс, Инк. Составы l-орнитин фенилацетата
US10123985B2 (en) 2015-06-08 2018-11-13 Whitehead Institute For Biomedical Research Therapeutic strategies for treating mitochondrial disorders
ES2860427T3 (es) 2015-06-22 2021-10-05 Nestle Sa Composiciones y métodos para mejorar la neurogénesis en animales
MX380541B (es) 2015-06-30 2025-03-12 Soc Des Produits Nestle S A Star Composición adecuada para proteger microorganismos.
RU2755478C2 (ru) 2015-07-15 2021-09-16 Юниджен, Инк. Композиции, способы и медицинские композиции для лечения и поддержания здоровья печени
ES2875601T3 (es) 2015-08-14 2021-11-10 Nestle Sa Composiciones alimentarias semihúmedas que mantienen una textura blanda
EP3337473A4 (en) 2015-08-18 2019-04-17 Ocera Therapeutics, Inc. TREATMENT AND PREVENTION OF MUSCLE WOUND BY L-ORNITHIN IN COMBINATION WITH AT LEAST ONE PHENYL ACETATE AND PHENYL BUTYRATE
US11019817B2 (en) 2015-08-25 2021-06-01 Shoichi Shirotake Antimicrobial agent against germs which has excellent plant disease control effect
US20170079897A1 (en) 2015-09-20 2017-03-23 Matthew Brissette MINUS Composition for hair application and methods of hair care
AU2016325556B2 (en) 2015-09-25 2023-02-16 Ocera Therapeutics, Inc. Treatment and prevention of neuronal cell loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate
US20170196944A1 (en) 2015-09-28 2017-07-13 Robert Portman Method to reduce muscle atrophy following orthopedic surgery
AU2016353350B2 (en) 2015-11-13 2021-09-23 Ocera Therapeutics, Inc. Formulation of L-ornithine phenylacetate
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
CA3001091A1 (en) 2015-11-20 2017-05-26 Nestec S.A. Methods using whey protein to improve or maintain muscle quality
GB2561747B (en) 2015-12-21 2021-05-12 Nanjing Jianrong Bio Tech Co Ltd Composition for treating motor neuron diseases and use thereof
EA201891592A1 (ru) 2016-01-08 2019-02-28 КОЛОНАРИКОНСЕПТС ЭлЭлСи Основанная на пищевых продуктах доставка терапевтического агента для лечения печеночной энцефалопатии
GB201600990D0 (en) 2016-01-19 2016-03-02 Abbott Lab Pharmaceutical or nutritional combination
US20190133147A1 (en) 2016-05-11 2019-05-09 Tsubo Solutions Pty Ltd Confectionery product
JP2019518744A (ja) 2016-05-27 2019-07-04 ネステク ソシエテ アノニム 運動障害を治療又は予防するための栄養組成物
PL238958B1 (pl) 2016-06-29 2021-10-25 Olimp Laboratories Spolka Z Ograniczona Odpowiedzialnoscia Kompozycja aminokwasowa do stosowania przed wysiłkiem fizycznym
US20180015122A1 (en) 2016-07-14 2018-01-18 Companion Supplements, LLC Pharmaceutical composition effective in preventing adverse effects associated with the use of glucocorticoids
US11033522B2 (en) 2016-08-09 2021-06-15 David C Scott Free amino acid preparation and uses thereof
JOP20190146A1 (ar) * 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
JOP20190147A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض واضطرابات العضلات
CN106632605B (zh) 2016-12-22 2020-06-16 浙江海洋大学 利用金枪鱼下脚料制备的具有肝损伤修复作用的活性肽
SE540582C2 (en) 2016-12-22 2018-10-02 Scandibio Therapeutics Ab Substances for treatment of fatty liver-related conditions
KR20190119046A (ko) 2017-01-19 2019-10-21 오톨로직 파마슈틱스, 인크. N-아세틸시스테인의 제제 및 이의 용도
US11617731B2 (en) 2017-04-28 2023-04-04 Axcella Health, Inc. Amino acid compositions and their use for the treatment of traumatic brain injury
CN107242552A (zh) 2017-07-07 2017-10-13 上海东锦食品集团有限公司 具有缓解体力疲劳及增强免疫力功能的保健食品组合物
IL296055A (en) 2017-08-14 2022-10-01 Axcella Health Inc Amino acid compositions for the treatment of liver disease
WO2019036442A1 (en) 2017-08-14 2019-02-21 Axcella Health Inc. AMINO ACIDS BRANCHED FOR THE TREATMENT OF NEURONAL INJURY
CN108041501A (zh) 2017-12-22 2018-05-18 北京康比特体育科技股份有限公司 一种促进疲劳恢复的蛋白组合物及其制备方法
WO2019246221A1 (en) 2018-06-20 2019-12-26 Axcella Health Inc. Compositions and methods for the treatment of liver diseases and disorders
CU20200106A7 (es) 2018-06-20 2021-08-06 Axcella Health Inc Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias
WO2019246310A1 (en) 2018-06-20 2019-12-26 Axcella Health Inc. Compositions and methods for the reduction or treatment of inflammation
CN112689508A (zh) 2018-06-20 2021-04-20 胺细拉健康公司 减少或治疗胰岛素抗性和代谢病状的组合物和方法
JOP20200324A1 (ar) 2018-06-20 2020-12-14 Axcella Health Inc تركيبات للعلاج والصحة تحتوي على أحماض أمينية ذات طعم مُر
CN112823018A (zh) 2018-06-20 2021-05-18 胺细拉健康公司 制备氨基酸组合物的方法
WO2019246298A1 (en) 2018-06-20 2019-12-26 Axcella Health Inc. Compositions and methods for the reduction or treatment of fibrosis
MA52971A (fr) 2018-06-20 2021-04-28 Axcella Health Inc Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle
CN108524453A (zh) 2018-07-05 2018-09-14 扬子江药业集团广州海瑞药业有限公司 一种门冬氨酸鸟氨酸的药物组合物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001056402A2 (en) * 2000-02-01 2001-08-09 Muscletech Research And Development Inc. Alpha lipoic acid based food supplement to increase lean muscle mass and strength
EP1541141A1 (en) * 2002-08-30 2005-06-15 Ajinomoto Co., Inc. Therapeutic agent for hepatic disease
WO2005084323A2 (en) * 2004-03-02 2005-09-15 Technical Sourcing International, Inc. Compositions of bio-active compounds from fenugreek seed and methods for producing same
WO2011097273A1 (en) * 2010-02-02 2011-08-11 Martek Biosciences Corporation Methods and compositions for treating non-alcoholic fatty liver disease with docosahexaenoic acid and n-acetyl lcystenine
EP2792354A2 (en) * 2011-03-16 2014-10-22 Obshchestvo S Ogranichennoj Otvetstvennostju «Biotekhnologii Pyshchino» Composition of protectors of acute and chronic hepatic encephalopathy and method for treating acute and chronic hepatic encephalopathy

Non-Patent Citations (18)

* Cited by examiner, † Cited by third party
Title
COOL B ET AL., CELL METAB, 2006
FOLCH J. ET AL., J. BIOL. CHEM., vol. 226, 1957, pages 497
GIDEON SMITH: "Animal Models of Cutaneous and Hepatic Fibrosis", PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE, vol. 105, pages 371 - 408
KAWANO Y; COHEN DE, J GASTROENTEROL, 2013
KLEINER D.E. ET AL., HEPATOLOGY, vol. 41, 2005, pages 1313
KLEINER ET AL., HEPATOLOGY, vol. 41, no. 6, 2005, pages 1313 - 21
LEFEBVRE E ET AL., PLOS ONE, 2016
NAGANUMA A ET AL: "SUN-P050: Effect of the Medical Walking and Leucine Enriched Amino Acid Containing Food for Female Non-Alcoholic Fatty Liver Disease : Randomized Controlled Trial", CLINICAL NUTRITION, vol. 35, September 2016 (2016-09-01), XP029729663, ISSN: 0261-5614, DOI: 10.1016/S0261-5614(16)30393-4 *
PETERSON RG ET AL., PLOS ONE, 2017
SAITO K. ET AL., SCI REP, vol. 5, 2015, pages 12466
SELLMANN CATHRIN ET AL: "Oral arginine supplementation protects female mice from the onset of non-alcoholic steatohepatitis", AMINO ACIDS, SPRINGER VERLAG, AU, vol. 49, no. 7, 5 August 2016 (2016-08-05), pages 1215 - 1225, XP036258517, ISSN: 0939-4451, [retrieved on 20170422], DOI: 10.1007/S00726-017-2423-4 *
SETSHEDI M ET AL: "S1846 N-Acetylcysteine Improves Hepatic Insulin Resistance Associated With High-Fat Diet and Alcohol-Induced Steatohepatitis", GASTROENTEROLOGY, W.B. SAUNDERS CO, US, vol. 138, no. 5, 1 May 2010 (2010-05-01), pages S - 801, XP027026219, ISSN: 0016-5085, [retrieved on 20100427] *
SHRESTHA NIRAJAN ET AL: "Glutamine inhibits CCl4induced liver fibrosis in mice and TGF-[beta]1 mediated epithelial-mesenchymal transition in mouse hepatocytes", FOOD AND CHEMICAL TOXICOLOGY, PERGAMON, GB, vol. 93, 29 April 2016 (2016-04-29), pages 129 - 137, XP029563064, ISSN: 0278-6915, DOI: 10.1016/J.FCT.2016.04.024 *
SITCHERAN R; COMB WC; COGSWELL PC; BALDWIN AS: "Essential role for epidermal growth factor receptor in glutamate receptor signaling to NF-kappaB", MOL CELL BIOL, vol. 28, no. 16, 9 June 2008 (2008-06-09), pages 5061 - 70
TEUFEL A ET AL., GASTROENTEROLOGY, 2016
WISHART DS; TZUR D; KNOX C ET AL.: "HMDB: the Human Metabolome Database", NUCLEIC ACIDS RES, vol. 35, January 2007 (2007-01-01), pages D521 - 6
WISHART DS; TZUR D; KNOX C ET AL.: "HMDB: the Human Metabolome Database", NUCLEIC ACIDS RES., vol. 35, January 2007 (2007-01-01), pages D521 - 6
WOBSER H ET AL., CELL RES, 2009

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US11617731B2 (en) 2017-04-28 2023-04-04 Axcella Health, Inc. Amino acid compositions and their use for the treatment of traumatic brain injury
WO2019036442A1 (en) * 2017-08-14 2019-02-21 Axcella Health Inc. AMINO ACIDS BRANCHED FOR THE TREATMENT OF NEURONAL INJURY
US10660870B2 (en) 2017-08-14 2020-05-26 Axcella Health Inc. Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting
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US10596136B2 (en) 2018-06-20 2020-03-24 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle
US11833127B2 (en) 2018-06-20 2023-12-05 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle
US10973793B2 (en) 2018-06-20 2021-04-13 Axcella Health Inc. Compositions and methods for the treatment of fat infiltration in muscle
KR102395036B1 (ko) 2019-07-30 2022-05-09 주식회사 고바이오랩 비알코올성 지방간 질환의 예측 또는 진단용 키트, 및 진단방법
KR102401535B1 (ko) * 2019-07-30 2022-05-24 주식회사 고바이오랩 간 손상 예방, 개선, 또는 치료용 조성물
KR20210014605A (ko) * 2019-07-30 2021-02-09 주식회사 고바이오랩 간 손상 예방, 개선, 또는 치료용 조성물
KR20210014609A (ko) * 2019-07-30 2021-02-09 주식회사 고바이오랩 비알코올성 지방간 질환의 예측 또는 진단용 키트, 및 진단방법
WO2021020923A1 (ko) * 2019-07-30 2021-02-04 주식회사 고바이오랩 간 손상 예방, 개선, 또는 치료용 조성물 및 간 손상 예방, 개선, 또는 치료방법
RU2810601C2 (ru) * 2019-07-30 2023-12-27 Кобиолабс, Инк. Композиция и способ для предотвращения, снятия симптомов или терапевтического воздействия на поражение печени
US12274718B2 (en) 2019-07-30 2025-04-15 Kobiolabs, Inc. Composition and method for preventing, alleviating, or treating liver injury
US20230203079A1 (en) * 2020-05-15 2023-06-29 Beijing Guanghe Original Technology Co., Ltd. Amino Acid Composition and Method for Catalytic Synthesis of Amino Acid by Means of Energy Radiation
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WO2024030909A1 (en) 2022-08-01 2024-02-08 Axcella Health Inc. Biomarkers of amino acid composition treatment response in long covid

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