Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/86—Polyethers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/347—Phenols
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/42—Amides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/67—Vitamins
  • A61K8/678—Tocopherol, i.e. vitamin E
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/85—Polyesters
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
  • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

• the present invention relates to a dentifrice composition contained in a container.
• the dentifrice composition is stored in a tube-shaped container in which a discharge port is formed, and the dentifrice composition of the contents can be taken out from the discharge port by pressing the main body of the container at the time of use.
• the dentifrice composition contains various medicinal ingredients so that a desired effect can be exhibited. In some cases, the concentration of these medicinal components in the composition discharged from the container is discharged, and various studies have been made to prevent this.
• Patent Document 1 discloses a dentifrice composition containing vitamin E or a derivative thereof, an anionic surfactant, and an abrasive, and specific polyoxyethylene alkyl ether and polyoxyethylene hydrogenated castor oil. Is contained in a specific amount ratio, thereby suppressing adsorption of vitamin E or the like into a container.
• Patent Document 2 discloses a dentifrice composition containing triclosan and / or isopropylmethylphenol, which contains a cationic surfactant and a specific polyoxyethylene hydrogenated castor oil in a specific quantity ratio. In this way, adsorption of triclosan or the like to the container is suppressed.
• Patent Document 3 discloses that non-ionic surfactants such as sodium alkyl sulfate, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil and the like are used for promoting absorption of vitamin E nicotinic acid ester in the oral cavity. Techniques for coexisting agents are disclosed.
• the present invention includes the following components (A) to (E): (A) One or more oil-soluble medicinal components selected from tocopherol, triclosan and isopropylmethylphenol (B) Anionic surfactant 0.3% by mass to 2% by mass (C) Polyoxyethylene cured castor Oil 0.15 mass% or more and 5 mass% or less (D) Polyoxyethylene sorbitan fatty acid ester (E) Water 15 mass% or more and 50 mass% or less are contained, and the mass of content of a component (C) and a component (D) The dentifrice composition having a ratio ((C) / (D)) of 0.2 or more and 5 or less relates to a dentifrice composition in a container accommodated in a container having an innermost layer made of polyethylene.
• the present invention relates to a dentifrice composition in a container having effective foaming properties while effectively preventing adsorption of medicinal ingredients to the container.
• the present inventors store the dentifrice composition in a container having an innermost layer made of polyethylene, adsorption of a specific oil-soluble medicinal component occurs, and the content of the component in the composition after storage decreases.
• a specific amount of an anionic surfactant and polyoxyethylene hydrogenated castor oil, and polyoxyethylene sorbitan fatty acid ester having a specific mass ratio with polyoxyethylene hydrogenated castor oil It has been found that a dentifrice composition capable of effectively preventing adsorption to such a container and having good foaming properties can be obtained.
• the oil-soluble medicinal component is effectively prevented from adsorbing to a container having an innermost layer made of polyethylene, and the content of the oil-soluble medicinal component in the composition after storage Can be prevented, and excellent foaming properties can be exhibited.
• the dentifrice composition in a container of the present invention is contained in a container having an innermost layer made of polyethylene, and contains one or more oil-soluble medicinal components (A) selected from tocopherol, triclosan, and isopropylmethylphenol. contains.
• A oil-soluble medicinal components
• the dentifrice composition containing the oil-soluble medicinal component of the component (A) is stored in a container whose innermost layer is made of polyethylene, the content of the component (A) after storage may be reduced. This is because the component (A) has an affinity for polyethylene because there is a tendency for the content of the component (A) to decrease when the thickness of the composition existing near the innermost layer or the polyethylene layer is thick.
• the dentifrice composition in a container of the present invention can effectively prevent a decrease in the concentration of the component (A).
• tocopherol of component (A) examples include dl- ⁇ -tocopherol acetate and tocopherol nicotinate.
• Component (A), triclosan, is a halogenated diphenyl ether type bactericide having a broad antibacterial spectrum, and its chemical name is 2 ′, 4,4′-trichloro-2-hydroxydiphenyl ether, for example, Ciba Specialty ⁇ Chemicals Co., Ltd. is sold under the trade name of Iruga Care MP.
• the component (A) isopropylmethylphenol is 1-hydroxy-4-isopropyl-3-methylphenol, and is sold, for example, by Osaka Kasei Co., Ltd. under the trade name Biosome. Isopropylmethylphenol is also referred to as 3-methyl-4-isopropylphenol and cymene-5-ol.
• the content of the component (A) is preferably 0.01% by mass or more, more preferably 0.02% by mass in the dentifrice composition of the present invention from the viewpoint of sufficiently obtaining the medicinal effect by such components. % Or more.
• the content of the component (A) is preferably 2 in the dentifrice composition of the present invention from the viewpoint of ensuring good stability of the composition and from the viewpoint of use feeling such as taste and irritation of the composition. It is not more than mass%, more preferably not more than 1.5 mass%, and still more preferably not more than 1 mass%.
• the content of the component (A) is preferably 0.01 to 2% by mass, more preferably 0.02 to 1.5% by mass, in the dentifrice composition of the present invention.
• the content is preferably 0.02 to 1% by mass.
• the dentifrice composition in a container of the present invention contains 0.3% by mass or more and 2% by mass or less of an anionic surfactant (B). By containing such a component (B), it is possible to ensure good foamability and foam quality and excellent detergency.
• anionic surface activity of component (B) examples include acyl amino acid salts such as sodium acyl glutamate and sodium acyl sarcosine, alkyl phosphates such as sodium alkyl phosphate, alkyl sulfate salts, higher fatty acid sulfonated monoglyceride salts, Examples thereof include fatty acid ester salts of isethionic acid, N-methyl long-chain acyl taurine sodium salt, polyoxyethylene monoalkyl phosphate, and the like.
• the hydrophobic alkyl group and acyl group of these anionic surfactants preferably have 6 to 18 carbon atoms, and more preferably 10 to 14 carbon atoms. Moreover, it is preferable that it is a sodium salt.
• acylamino acid salts N-methyl long-chain acyltaurine sodium salts and alkyl sulfate ester salts are more preferable, and availability, etc.
• alkyl sulfate salts are more preferable.
• the content of component (B) is 0.3% by mass or more, preferably 0.5% by mass or more, in the dentifrice composition of the present invention, from the viewpoint of ensuring good foaming properties. is there.
• Content of a component (B) is 2 mass% or less in the dentifrice composition in a container of this invention from a viewpoint of the defoaming property at the time of manufacture, and a moderate foaming property, Preferably it is 1 0.8 mass% or less, more preferably 1.5 mass% or less.
• the content of the component (B) is 0.3 to 2% by mass, preferably 0.5 to 1.8% by mass, more preferably in the dentifrice composition of the present invention. 0.5 to 1.5% by mass.
• the dentifrice composition in a container of the present invention contains 0.15% by mass or more and 5% by mass or less of polyoxyethylene hydrogenated castor oil (C).
• C polyoxyethylene hydrogenated castor oil
• the average number of added moles of ethylene oxide (EO) in the component (C) imparts viscosity stability at a low temperature from the viewpoint of ensuring good foaming properties while preventing the component (A) from adsorbing to the container. From the viewpoint, it is preferably 15 to 80, more preferably 20 to 60, and further preferably 25 to 50.
• the content of the component (C) is 0.15% by mass or more, preferably 0 in the dentifrice composition of the present invention, from the viewpoint of effectively preventing the component (A) from being adsorbed to the container. .2% by mass or more, and more preferably 0.3% by mass or more.
• the content of the component (C) is 5% in the dentifrice composition of the present invention from the viewpoint of maintaining good foaming properties by combined use with the component (D) and suppressing an increase in viscosity at low temperatures. % Or less, preferably 3% by mass or less.
• the content of the component (C) is 0.15 to 5% by mass, preferably 0.2 to 3% by mass, more preferably 0.8% in the dentifrice composition in a container of the present invention. 3 to 3% by mass.
• the dentifrice composition in a container of the present invention contains polyoxyethylene sorbitan fatty acid ester (D).
• polyoxyethylene sorbitan fatty acid ester (D) By containing this component (D) in combination with the component (C), the adsorption of the component (A) to the container is effectively prevented, and the content of the component (A) in the dentifrice composition is reduced. While preventing, excellent foamability can be brought about, and the viscosity stability under low temperature can be improved.
• Component (D) is preferably an ester of a fatty acid having 8 to 22 carbon atoms, more preferably an ester of a fatty acid having 12 to 20 carbon atoms, and an ester of a fatty acid having 16 to 20 carbon atoms. Further preferred.
• the average added mole number of ethylene oxide in the component (D) is preferably 2 to 40, more preferably 5 to 30, and further preferably 15 to 25.
• the HLB of the component (D) is preferably 8 to 20, and more preferably 10 to 18.
• HLB Hydrophilic-Lypophilic Balance
• component (D) for example, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monomyristic acid, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoleic monooleate
• component (D) for example, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monomyristic acid, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoleic monooleate
• oxyethylene sorbitan examples include oxyethylene sorbitan. These may be used alone or in combination of two or more. Among them, from the viewpoint of improving low-temperature stability while exhibiting excellent foamability, one or two selected from polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate and polyoxyethylene sorbitan monooleate More than seeds are preferred, and polyoxyethylene sorbitan monostearate is more preferred.
• the mass ratio ((C) / (D)) of the content of component (C) and component (D) effectively prevents adsorption of component (A) to the container, and the component ( From the viewpoint of combining excellent foaming properties and good low-temperature stability while suppressing a decrease in the content of A), it is 0.2 or more, preferably 0.5 or more, more preferably 0.7. That's it.
• the mass ratio ((C) / (D)) of the content of the component (C) and the component (D) is low in foaming properties while suppressing a decrease in the content of the component (A) in the composition after storage.
• the mass ratio ((C) / (D)) of the content of component (C) to component (D) is 0.2 to 5, preferably 0.5 to 4, more preferably It is 0.5 to 2, more preferably 0.5 to 1.7, and still more preferably 0.7 to 1.5.
• the content of the component (D) is preferably 0.1% by mass or more in the dentifrice composition of the present invention from the viewpoint of suppressing an increase in viscosity at a low temperature while exhibiting excellent foamability. More preferably, it is 0.15 mass% or more, More preferably, it is 0.3 mass% or more.
• the content of component (C) is preferably 5% by mass or less in the dentifrice composition of the present invention from the viewpoint of suppressing sufficient foaming and viscosity increase at low temperatures even when used in combination with component (D). More preferably, it is 3 mass% or less.
• the content of the component (D) is preferably 0.1 to 5% by mass, more preferably 0.15 to 3% by mass, and further preferably 0.3 to 3% by mass.
• the dentifrice composition in a container of the present invention contains 15% by mass or more and 50% by mass or less of water (E).
• the water of the component (E) in the present invention includes not only purified water blended in the toothpaste composition but also water contained in each blended component, for example, 70% sorbitol liquid used for formulation. , Means the total moisture contained in the toothpaste composition.
• the content of the component (E) is 15% by mass in the dentifrice composition of the present invention from the viewpoint of dispersing or dissolving each component satisfactorily and from the viewpoint of improving dischargeability from the container.
• the content is preferably 18% by mass or more, and even with such a water content, the storage stability of the component (A) can be ensured.
• the content of the component (E) is 50% by mass or less in the dentifrice composition of the present invention from the viewpoint of maintaining good dispersibility in the oral cavity and good shape retention, and preferably It is 40 mass% or less.
• the content of the component (E) is 15 to 50% by mass, preferably 18 to 40% by mass, in the dentifrice composition of the present invention.
• the water content in the dentifrice composition with a container of this invention can also be computed by calculation from the water content mix
• a Karl Fischer moisture meter for example, a trace moisture measuring device (Hiranuma Sangyo) can be used. In this apparatus, 5 g of the dentifrice composition can be taken and suspended in 25 g of anhydrous methanol, and 0.02 g of this suspension can be collected to measure the amount of water.
• the dentifrice composition in a container of the present invention further contains a binder (F).
• a binder F
• the composition is imparted with an appropriate viscosity to have good shape retention, and even in a container that discharges by pressing, such as a tube container or a squeeze container, the discharge property is ensured. can do.
• component (F) examples include sodium alginate, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum , Psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate and methoxyethylene maleic anhydride copolymer. These may be used alone or in combination of two or more. Especially, 1 type (s) or 2 or more types chosen from sodium carboxymethylcellulose, a carrageenan, and a xanthan gum are preferable, and it is more preferable to contain combining 2 or more types.
• the content of the component (F) is preferably 0.3% by mass or more, and more preferably in the dentifrice composition of the present invention, from the viewpoint of ensuring storage stability, shape retention and dischargeability. It is 0.5 mass% or more.
• the content of component (F) is preferably 2% by mass or less, more preferably 1.5% by mass or less, in the dentifrice composition of the present invention, from the viewpoint of dispersing or dissolving each component satisfactorily. More preferably, it is 1.2 mass% or less.
• the content of the component (F) is preferably 0.3 to 2% by mass, more preferably 0.5 to 1.5% by mass, in the dentifrice composition of the present invention. Preferably, the content is 0.5 to 1.2% by mass.
• the container-containing dentifrice composition of the present invention preferably further contains one or more polyhydric alcohols selected from propylene glycol, polyethylene glycol, and 1,3-butylene glycol.
• polyhydric alcohols selected from propylene glycol, polyethylene glycol, and 1,3-butylene glycol.
• propylene glycol is preferable from the viewpoint of more effectively suppressing increase in viscosity.
• the content of the polyhydric alcohol is preferably 1% by mass or more, more preferably 2% by mass or more in the dentifrice composition of the present invention from the viewpoint of imparting good viscosity stability at low temperatures. is there.
• the content of the polyhydric alcohol is preferably 10% by mass or less and more preferably 8% by mass or less in the dentifrice composition of the present invention from the viewpoint of taste and feeling of use.
• the content of the polyhydric alcohol is preferably 1 to 10% by mass, more preferably 2 to 8% by mass in the dentifrice composition of the present invention.
• the dentifrice composition in a container of the present invention further contains a sugar alcohol.
• a sugar alcohol By containing such a sugar alcohol, the stability of the component (A) can be enhanced, and a good feeling of use, a refreshing feeling, a taste, and the like can be imparted.
• sugar alcohols include erythritol, sorbitol, xylitol, lactitol, reduced palatinose, maltitol, mannitol and the like. These may be used alone or in combination of two or more. Of these, one or more selected from erythritol, xylitol, and sorbitol are preferable.
• the content of the sugar alcohol is preferably 30% by mass or more, more preferably 40% by mass in the dentifrice composition of the present invention from the viewpoint of further improving the stability of the component (A) and from the viewpoint of taste. % Or more, and more preferably 50% by mass or more.
• the content of the sugar alcohol is preferably 75% by mass or less, and more preferably in the dentifrice composition of the present invention, from the viewpoint of the balance between solubility and viscosity or shape retention and dispersibility in the oral cavity. 70% by mass or less.
• the mass ratio of the content of sugar alcohol with low solubility selected from erythritol, reduced palatinose and mannitol in sugar alcohol is preferably 0.3 to 1, more preferably 0.5 to 0.8.
• the total content of sugar alcohol and polyhydric alcohol is preferably 40 in the dentifrice composition of the present invention. % By mass or more, more preferably 50% by mass or more, further preferably 60% by mass or more, 80% by mass or less, more preferably 75% by mass or less, and further preferably 70% by mass or less. It is.
• the total content of sugar alcohol and polyhydric alcohol is preferably 40 to 80% by mass, more preferably 50 to 75% by mass, and still more preferably in the dentifrice composition of the present invention. 60 to 70% by mass.
• the dentifrice composition of the present invention in addition to the above components, other components that can be used in the oral composition, such as abrasives, foaming aids, fluoride ion supply compounds, fragrances, pH adjusters, preservatives, etc. Can be appropriately contained in such a range that the effects of the present invention are not inhibited.
• the toothpaste composition in a container of the present invention can be made into a toothpaste composition or a gel-like toothpaste composition depending on the intended use.
• the dentifrice composition in a container of the present invention can be produced according to a conventional method, and can be obtained by appropriately mixing the above components. Also, for example, oil-soluble components such as component (A), component (C), component (D) and perfume are mixed in advance, and water-soluble components such as component (B) and water and the remaining components are mixed appropriately. Then, they can be obtained by mixing them.
• oil-soluble components such as component (A), component (C), component (D) and perfume are mixed in advance
• water-soluble components such as component (B) and water and the remaining components are mixed appropriately. Then, they can be obtained by mixing them.
• the container used in the dentifrice composition of the present invention has an innermost layer made of polyethylene.
• a container is preferably a tube container in which a discharge port is formed through a shoulder from the viewpoint of dischargeability of the stored dentifrice composition.
• a container includes a container body and a cap, and the container body has a discharge port and a body part.
• the body portion is formed by fusing one end of a cylindrical shape, and the other end of the body portion is continuous with an outer edge end portion of the shoulder portion, and the shoulder portion includes a discharge port protruding from the center.
• drum of a container main body has a multilayer structure, and the edge part is melt
• the container has an innermost layer made of polyethylene, preferably an innermost layer made of low-density polyethylene, more preferably made of linear low-density polyethylene. It has an innermost layer.
• the other layers include a metal layer such as aluminum, a synthetic resin layer such as polypropylene and polyethylene terephthalate, and a paper layer.
• the thickness of the innermost polyethylene layer of the container of the present invention is preferably 50 ⁇ m or more and 200 ⁇ m or less, and more preferably 70 ⁇ m or more and 180 ⁇ m or less.
• the discharge port protrudes in a cylindrical shape, and an engaging portion or a screw groove for mounting a cap is formed on the cylindrical outer peripheral surface.
• the cap is provided with a cylindrical portion formed with a protrusion for engaging with the engagement portion of the discharge port or a screw groove for screwing with the screw groove of the discharge port.
• the discharge port is engaged with the cap.
• the opening at the tip of the discharge port can be sealed by joining or screwing.
• the shoulder continuous to the other end of the body is 3 times the thickness of the body from the viewpoint of engaging or screwing with the cap through the discharge port and securing the three-dimensionality of the body.
• the thickness is preferably the above, more preferably 4 times or more, and from the viewpoint of the moldability of the shoulder, it is preferably 0.8 mm or more, preferably 1 mm or more. More preferably, it is 2 mm or more, and from the viewpoint of usability and cost, it is preferably 2.5 mm or less, and preferably 2 mm or less.
• the dentifrice composition of the present invention is made of polyethylene having a thick shoulder or made of low-density polyethylene, and the component (A) after storage even in a container in which the component (A) is easily adsorbed in the vicinity of the shoulder. The decrease in the content of can be suppressed.
• the oil-soluble medicinal component of component (A) is adsorbed and the content of component (A) in the composition tends to decrease.
• the container dentifrice composition of the invention has excellent foaming properties while effectively preventing this, and can maintain the viscosity of the composition stably even in a low temperature environment.
• the present invention further discloses the following preferred compositions.
• the content of component (A) is preferably 0.01% by mass or more, more preferably 0.02% by mass or more, preferably 2% by mass or less, more preferably 1.5% by mass.
• Component (B) is preferably an acyl amino acid salt such as sodium acylglutamate or sodium acylsarcosine, an alkyl phosphate such as sodium alkyl phosphate, an alkyl sulfate ester salt, a higher fatty acid sulfonated monoglyceride salt, or isethionic acid.
• an acyl amino acid salt such as sodium acylglutamate or sodium acylsarcosine
• an alkyl phosphate such as sodium alkyl phosphate
• an alkyl sulfate ester salt such as sodium alkyl phosphate
• a higher fatty acid sulfonated monoglyceride salt or isethionic acid.
• the dentifrice composition in any one container is preferably 0.5% by mass or more, preferably 1.8% by mass or less, more preferably 1.5% by mass or less.
• the average added mole number of ethyleneoxy groups in component (C) is preferably 15 to 80, more preferably 20 to 60, and further preferably 25 to 50.
• the content of the component (C) is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, and preferably 3% by mass or less.
• Component (D) is preferably an ester of a fatty acid having 8 to 22 carbon atoms, more preferably an ester of a fatty acid having 12 to 20 carbon atoms, and still more preferably an ester of a fatty acid having 16 to 20 carbon atoms.
• the average added mole number of the ethyleneoxy group in the component (D) is preferably 2 to 40, more preferably 5 to 30, and further preferably 15 to 25.
• Component (D) is preferably composed of polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monomyristic acid, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate One or more selected, more preferably one or more selected from polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate and polyoxyethylene sorbitan monooleate, and more The dentifrice composition in a container according to any one of the above [1] to [9], which is preferably polyoxyethylene sorbitan monostearate.
• the mass ratio ((C) / (D)) of the content of component (C) and component (D) is preferably 0.5 or more, more preferably 0.7 or more, preferably 4 or less, more preferably 2 or less, still more preferably 1.7 or less, and still more preferably 1.5 or less, in any one of the above [1] to [10] .
• the content of the component (D) is preferably 0.1% by mass or more, more preferably 0.15% by mass or more, further preferably 0.3% by mass or more, preferably 5
• the dentifrice composition in any one of the above [1] to [12], wherein the content of the component (E) is preferably 18% by mass or more, and preferably 40% by mass or less.
• the dentifrice composition contains (F) a binder, and preferably component (F) is sodium alginate, sodium carboxymethylcellulose, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethylcellulose, hydroxypropylcellulose.
• the content of component (F) is preferably 0.3% by mass or more, more preferably 0.5% by mass or more, preferably 2% by mass or less, more preferably 1.5% by mass.
• the dentifrice composition further contains one or more polyhydric alcohols selected from propylene glycol, polyethylene glycol and 1,3-butylene glycol, and preferably contains propylene glycol.
• the content of the polyhydric alcohol is preferably 1% by mass or more, more preferably 2% by mass or more, preferably 10% by mass or less, more preferably 8% by mass or less.
• the dentifrice composition contains a sugar alcohol, preferably the sugar alcohol is one or more selected from erythritol, sorbitol, xylitol, lactitol, reduced palatinose, maltitol, mannitol, more preferably Is a dentifrice composition in a container according to any one of [1] to [17] above, which is one or more selected from erythritol, xylitol, and sorbitol.
• the content of the sugar alcohol is preferably 30% by mass or more, more preferably 40% by mass or more, further preferably 50% by mass or more, preferably 75% by mass or less, and more preferably.
• the mass ratio of sugar alcohol content selected from erythritol, reduced palatinose, and mannitol in the sugar alcohol is preferably 0.3 to 0.9, more preferably [18] or [19]
• the container includes an innermost layer made of polyethylene, preferably an innermost layer made of low-density polyethylene, and more preferably an innermost layer made of linear low-density polyethylene. Or a dentifrice composition in a container.
• the container is a tube container in which a discharge port is formed through a shoulder, preferably the shoulder and the discharge port are made of polyethylene, more preferably low density polyethylene, and the thickness of the shoulder. Is preferably 0.8 mm or more, more preferably 1 mm or more, further preferably 1.2 mm or more, preferably 2.5 mm or less, more preferably 2 mm or less.
• the dentifrice composition in any one container.
• Examples 1 to 12, Comparative Examples 1 to 4 According to the formulations shown in Tables 1 to 3, dissolve at 60 ° C. so that component (C) and component (D) dissolve, and add and mix component (A) and perfume to obtain an oil-soluble mixture. On the other hand, components other than component (A), component (C), component (D), and fragrance
• a tube container was used as the container. The body of the container body of the tube container has an innermost layer of linear low density polyethylene, and an outermost layer is provided with a printing layer (including varnish).
• Printing layer / low density polyethylene 50 ⁇ m / adhesive / high density polyethylene It consisted of a multilayer resin layer comprising an aluminum layer in the intermediate layer, which was composed of 80 ⁇ m / adhesive / aluminum 12 ⁇ m / adhesive / polyethylene terephthalate 12 ⁇ m / adhesive / linear low density polyethylene 100 ⁇ m.
• the tube container was provided with a shoulder portion integrally provided with a discharge port, the shoulder portion and the discharge port were made of low-density polyethylene, and the thickness of the shoulder portion was 1.3 mm on average.
• the discharge port is provided with a screw groove
• the obtained dentifrice composition is filled in such a container
• the cap is screwed and sealed and stored
• the dentifrice composition discharged from the discharge port after storage According to the method shown below, content of each component and evaluation of the viscosity were performed. Foaming was evaluated on the dentifrice composition before storage. The results are shown in Tables 1 to 3.
• the amounts of dl- ⁇ -tocopherol acetate, triclosan, and isopropylmethylphenol were measured by HPLC, measured for the above three compositions, and averaged in terms of content per gram. The value was calculated and set as “amount after storage at 50 ° C.”.
• ⁇ Viscosity at low temperature and room temperature> The viscosity of the dentifrice composition was measured under the following conditions, and the value measured at 5 ° C. was the viscosity at low temperature and the value measured at 25 ° C. was the viscosity at room temperature. The viscosity at each temperature was measured after storage at 5 ° C for 1 week at 5 ° C, and the viscosity at 25 ° C was measured after storage at 25 ° C for 24 hours.
• Measuring instrument Helipath viscometer DVR-B2 (manufactured by Toki Sangyo Co., Ltd.) Measuring rotor: 25 ° C Rotor TC, 5 ° C Rotor TE Rotation speed: 2.5rpm Measurement time: 60 seconds
• Comparative Example 1 which does not contain component (C) and component (D) has very good foaming, whereas the residual ratio after storage of component (A) is high.
• the comparative example 2 which is low and does not contain the component (D) has a high residual ratio after storage of the component (A), it lacks foaming performance in the oral cavity during tooth brushing, and the viscosity increases at low temperatures.
• compositions of Examples 1 to 12 have a higher residual ratio after storage of the oil-soluble medicinal component of component (A) than the compositions of Comparative Examples 1 to 4, and ensure foaming. did it.
• dentifrice compositions of Examples 1 to 5, 7 to 8, and 10 to 12 further suppress an increase in viscosity at low temperatures
• dentifrice compositions of Examples 1 to 4, 7, and 11 It can be seen that the effect of good foaming and suppression of increase in viscosity at low temperatures is high while maintaining the residual ratio after storage of A) high.

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