JP2005247786A - 歯磨剤組成物及び歯磨剤製品 - Google Patents
歯磨剤組成物及び歯磨剤製品 Download PDFInfo
- Publication number
- JP2005247786A JP2005247786A JP2004062835A JP2004062835A JP2005247786A JP 2005247786 A JP2005247786 A JP 2005247786A JP 2004062835 A JP2004062835 A JP 2004062835A JP 2004062835 A JP2004062835 A JP 2004062835A JP 2005247786 A JP2005247786 A JP 2005247786A
- Authority
- JP
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- Prior art keywords
- vitamin
- derivative
- polyoxyethylene
- sodium
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 72
- 229940034610 toothpaste Drugs 0.000 title abstract description 11
- 239000000606 toothpaste Substances 0.000 title abstract description 11
- 229940095688 toothpaste product Drugs 0.000 title abstract 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 136
- -1 polyoxyethylene Polymers 0.000 claims abstract description 112
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 66
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 65
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 64
- 229940046009 vitamin E Drugs 0.000 claims abstract description 64
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 64
- 239000011709 vitamin E Substances 0.000 claims abstract description 64
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000004359 castor oil Substances 0.000 claims abstract description 30
- 235000019438 castor oil Nutrition 0.000 claims abstract description 30
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 30
- 238000002156 mixing Methods 0.000 claims abstract description 25
- 239000003945 anionic surfactant Substances 0.000 claims abstract description 21
- 239000004094 surface-active agent Substances 0.000 claims abstract description 14
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 12
- 239000000551 dentifrice Substances 0.000 claims description 48
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 claims description 25
- 229920000092 linear low density polyethylene Polymers 0.000 claims description 14
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 229920001281 polyalkylene Polymers 0.000 claims 1
- 235000019640 taste Nutrition 0.000 abstract description 31
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- 238000005187 foaming Methods 0.000 abstract description 23
- 230000000694 effects Effects 0.000 abstract description 9
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- 230000007774 longterm Effects 0.000 abstract description 4
- 238000003860 storage Methods 0.000 abstract description 4
- 230000001747 exhibiting effect Effects 0.000 abstract 1
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- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 19
- 229940042585 tocopherol acetate Drugs 0.000 description 19
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 16
- 238000004519 manufacturing process Methods 0.000 description 16
- 238000000034 method Methods 0.000 description 15
- 239000000796 flavoring agent Substances 0.000 description 14
- 235000019634 flavors Nutrition 0.000 description 14
- 229920001684 low density polyethylene Polymers 0.000 description 12
- 239000004702 low-density polyethylene Substances 0.000 description 12
- 235000002639 sodium chloride Nutrition 0.000 description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 10
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
- 238000011156 evaluation Methods 0.000 description 10
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- 238000002360 preparation method Methods 0.000 description 10
- 239000011734 sodium Substances 0.000 description 10
- 229910052708 sodium Inorganic materials 0.000 description 10
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 9
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- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 7
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 7
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 7
- 239000000377 silicon dioxide Substances 0.000 description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 7
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 6
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 6
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
- 239000005020 polyethylene terephthalate Substances 0.000 description 6
- 229920000139 polyethylene terephthalate Polymers 0.000 description 6
- 239000008213 purified water Substances 0.000 description 6
- 229940085605 saccharin sodium Drugs 0.000 description 6
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 6
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 5
- 230000001680 brushing effect Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 238000013329 compounding Methods 0.000 description 5
- 239000000975 dye Substances 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000008719 thickening Effects 0.000 description 5
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 235000019658 bitter taste Nutrition 0.000 description 4
- 235000010418 carrageenan Nutrition 0.000 description 4
- 239000000679 carrageenan Substances 0.000 description 4
- 229920001525 carrageenan Polymers 0.000 description 4
- 229940113118 carrageenan Drugs 0.000 description 4
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 4
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 4
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 239000005977 Ethylene Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 3
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- 230000008859 change Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
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- 239000002304 perfume Substances 0.000 description 3
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 3
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 3
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Landscapes
- Cosmetics (AREA)
Abstract
【効果】 本発明の歯磨剤組成物は、長期保管後においてもビタミンE又はその誘導体の容器等への吸着が少なく、ビタミンE又はその誘導体の薬効が持続的に発揮されて、外観安定性に優れ、製造が容易で、かつ良好な起泡性及び味を有する。
【選択図】 なし
Description
R−O−(EO)nH (1)
(但し、Rは炭素数14〜18のアルキル基を示し、nはエチレンオキサイド(EO)の平均付加モル数を表し、nは3〜8の範囲である。)
で示されるものが使用される。上記ポリオキシエチレンアルキルエーテルは、炭素数14〜18、好ましくは炭素数16〜18のアルキル基を有するもので、アルキル基の炭素数が14未満では十分な起泡性が得られず、またアルキル基の炭素数が18を超える場合には歯磨使用中に独特の異味・油っぽさが生じる問題がある。このようなポリオキシエチレンアルキルエーテルとして具体的には、ポリオキシエチレンセチルエーテル、ポリオキシエチレンミリスチルエーテル、ポリオキシエチレンステアリルエーテル等が挙げられ、特にポリオキシエチレンステアリルエーテルが好適である。また、上記ポリオキシエチレンアルキルエーテルのエチレンオキサイドの平均付加モル数は3〜8モル、好ましくは3〜5モルの範囲である。平均付加モル数が3モルより低い場合には、歯磨製剤中に液体成分の遊離が生じ、8モルを超えると独特の油っぽさ・香味発現の劣化が起こり、使用感に劣るものとなってしまう。上記ポリオキシエチレンアルキルエーテルの配合量は、起泡性や味の点で組成物全体の0.4〜5.0質量%、特に0.6〜2.5質量%が好適であり、配合量が0.4質量%未満であると使用直後の起泡性が抑制される傾向にあり、また配合量が5.0質量%を超えると苦味や独特のベタツキが発生し、使用感に問題が生じる場合がある。このようなポリオキシエチレンアルキルエーテルとしては、日本エマルジョン(株)のEMALEX105、107、603、605、608、日光ケミカルズ(株)のNIKKOL BS−4、花王(株)のEMALGEN1108、青木油脂工業(株)のBLAUNON CH−305、CH−308、SR−705、SR−707等の市販品を使用することができる。
下記表1〜3に示す組成の歯磨剤組成物をニーダーを用いて脱気混合し、調製した。歯磨剤組成物の仕込み量は5kgとした。なお、下記例においては、ポリオキシエチレンアルキルエーテルとポリオキシエチレン硬化ヒマシ油を予め200mLのガラス製ビーカーに所定量秤量し、水浴を用いて80℃に加温して混合分散させ、得られた界面活性剤混合物と、他成分とを用いて常法により調製した。但し、比較例13においてはポリオキシエチレンアルキルエーテルとポリオキシエチレン硬化ヒマシ油を所定量秤量し、水浴を用いて80℃に加温して融解したものを個別に配合した。この得られた歯磨剤組成物を、後述するチューブAもしくはBに充填し、ビタミンE又はその誘導体の残存率、外観安定性、起泡性、味、製造適性を下記方法で評価した。結果を表1〜3に示す。
最外層よりLDPE55/PET12/LDPE20/白LDPE60/EMAA20/AL10/EMAA30/LDPE20/LLDPE30、厚さ257μm、直径26mm、充填量50g
チューブB(大日本印刷(株)製):
最外層よりLDPE80/LDPE25/PET12/LDPE25/白LDPE100/SiOx−PET12/EMAA25/LLDPE80、厚さ359μm、直径37mm、充填量100g
数値は厚さ(μm)を示す。
略号の示すところは以下の通りである。
LDPE:低密度ポリエチレン
白LDPE:白色低密度ポリエチレン
LLDPE:直鎖状低密度ポリエチレン
AL:アルミニウム
PET:ポリエチレンテレフタレート
EMAA:エチレン・メタクリル酸の共重合体樹脂
SiOx−PET:ガラス蒸着ポリエチレンテレフタレート
調製直後における組成物中のビタミンE又はその誘導体を定量(質量%)した値を初期値とし、50℃の恒温槽にて1ヶ月加速劣化させた後の組成物中に含まれるビタミンE又はその誘導体の濃度を評価サンプル値(質量%)とし、下記式にてビタミンE又はその誘導体の残存率を計算した。なお、ビタミンE又はその誘導体の定量は、歯磨剤を2g分取し(チューブから押し出した最初の2gを使用)、メタノールでビタミンE又はその誘導体を抽出した後、第14改正日本薬局方第一部医薬品各条の「トコフェロール」、「酢酸トコフェロール」もしくは「ニコチン酸トコフェロール」の項に定める方法で行った。
ビタミンE又はその誘導体の残存率(%)
=[評価サンプル値(質量%)/初期値(質量%)]×100
ビタミンE又はその誘導体の評価基準は以下の通りである。
◎:ビタミンE又はその誘導体の残存率95%以上
○:ビタミンE又はその誘導体の残存率90%以上95%未満
△:ビタミンE又はその誘導体の残存率80%以上90%未満
×:ビタミンE又はその誘導体の残存率80%未満
チューブに充填した歯磨剤組成物を50℃の恒温槽にて1ヶ月加速劣化させた後、紙の上に押し出し、液体成分の遊離の有無、肌荒れの有無、変色の有無を観察し、5℃の恒温槽にて保管したサンプルを標準品として総合的に評価した。
外観安定性の評価基準は以下の通りである。
◎:標準品とほとんど変化がなく良好であった
○:標準品とあまり変化がなく良好であった
△:標準品とやや異なり、あまり良好ではなかった
×:標準品と著しく異なり、劣悪であった
専門家パネラー(10名)を用い、歯磨剤組成物1gを市販の歯ブラシ(デンターシステマライオン、レギュラー、毛の硬さ=ふつう、ライオン(株)製)に取り、1分間ブラッシングし、歯磨剤組成物の起泡性及び味を下記の基準に従って評価し、その平均値をそれぞれ起泡性、味の評価結果とした。
起泡性 5:ブラッシング開始後、直ちに十分起泡した
4:ブラッシング開始後、10秒程度で十分起泡した
3:ブラッシング開始後、20秒程度で起泡した
2:ブラッシング開始後、30秒程度で起泡した
1:ブラッシング終了時においても十分な起泡が得られなかった
味:比較例1の組成に、2−アルキル−N−カルボキシメチル−N−ヒドロキシエチ
ルイミダゾリニウムベタイン40%水溶液(NIKKOL AM−101、日光
ケミカルズ(株)製)5.0%を加え、精製水の配合量でバランスした歯磨剤を
調製し、これを標準品として評価を行った。
5:標準品と比較して油っぽさが全くなく、きわめて良好な味だった
4:標準品と比較して油っぽさがほとんどなく、良好な味だった
3:標準品と比較して油っぽさがあまりなく、やや良好な味だった
2:標準品よりは油っぽさがやや少ないが、あまり良好でない味だった
1:標準品と同等レベルで、油っぽく、使用に耐えない味だった
歯磨剤組成物の製造にあたり、ポリオキシエチレンアルキルエーテルとポリオキシエチレン硬化ヒマシ油を200mLのガラス製ビーカーに所定量秤量し、水浴を用いて80℃に加温して混合分散させたものを水浴から取り出した後、25℃に放置し、凝固するまでの時間を測定し、下記の基準に従って評価した。
◎:水浴から取り出した後、2分以上5分まで経過しても凝固しなかった
○:水浴から取り出した後、1分以上2分未満で凝固した
△:水浴から取り出した後、20秒以上1分未満で凝固した
×:水浴から取り出した後、ただちに凝固した
プロピレングリコール 5.0質量%
70%ソルビット液 40.0
キサンタンガム 0.5
カラギーナン 0.5
サッカリンナトリウム 0.2
ラウリル硫酸ナトリウム 1.2
(NIKKOL SLS、日光ケミカルズ製)
ポリオキシエチレンステアリルエーテル(EO平均付加モル数5) 1.4
(BLAUNON SR−705、青木油脂工業製)
ポリオキシエチレン硬化ヒマシ油(EO平均付加モル数40) 1.4
(HC−40、日本エマルジョン製)
アスコルビン酸−2−リン酸マグネシウム 0.2
ニコチン酸トコフェロール 0.1
(ビタミンEニコチネート、BASF武田ビタミン製)
水酸化ナトリウム 0.1
無水ケイ酸 25.0
酸化チタン 1.0
塩化セチルピリジニウム 0.05
香料A 0.9
精製水 残
合計 100.0質量%
チューブAに収容した。
ニコチン酸トコフェロールの安定性 ◎
外観安定性 ◎
起泡性 5
味 5
製造適性 ◎
なお、香料Aの代りに香料B、C、D、E、F、G、H、Iを用いても同様の結果が得られた。また、チューブAの代りにチューブBを用いても同様の結果が得られた。
プロピレングリコール 3.0質量%
70%ソルビット液 20.0
第2リン酸水素カルシウム2水和物 40.0
増粘性シリカ 3.0
カルボキシメチルセルロースナトリウム 1.2
カラギーナン 0.4
ミリスチル硫酸ナトリウム 1.5
(NIKKOL SMS、日光ケミカルズ製)
ポリオキシエチレンステアリルエーテル(EO平均付加モル数3) 1.2
(EMALEX603、日本エマルジョン製)
ポリオキシエチレン硬化ヒマシ油(EO平均付加モル数20) 1.2
(HC−20、日本エマルジョン製)
サッカリンナトリウム 0.2
酸化チタン 0.3
香料B 1.0
酢酸dl−α−トコフェロール 0.1
(酢酸トコフェロール、DSMニュートリション・ジャパン製)
トリクロサン 0.1
ε−アミノカプロン酸 0.03
モノフルオロリン酸ナトリウム 0.7
イソプロピルメチルフェノール 0.1
パラオキシ安息香酸メチル 0.1
精製水 残
合計 100.0質量%
チューブAに収容した。
酢酸トコフェロールの安定性 ○
外観安定性 ○
起泡性 5
味 5
製造適性 ◎
なお、香料Bの代りに香料A、C、D、E、F、G、H、Iを用いても同様の結果が得られた。また、チューブAの代りにチューブBを用いても同様の結果が得られた。
炭酸カルシウム 45.0質量%
増粘性シリカ 3.0
ポリアクリル酸ナトリウム 0.3
キサンタンガム 0.45
カラギーナン 0.5
70%ソルビット液 20.0
ラウロイルサルコシン酸ナトリウム 1.5
(ソイポンSLP、川研ファインケミカル製)
ポリオキシエチレンセチルエーテル(EO平均付加モル数7) 1.2
(EMALEX107、日本エマルジョン製)
ポリオキシエチレン硬化ヒマシ油(EO平均付加モル数80) 1.0
(BLAUNON RCW−80、青木油脂工業製)
サッカリンナトリウム 0.2
プロピレングリコール 4.0
酸化チタン 0.3
香料C 1.0
dl−α−トコフェロール 0.1
(dl−α−トコフェロール、BASF武田ビタミン製)
モノフルオロリン酸ナトリウム 0.7
トリクロサン 0.3
トラネキサム酸 0.05
グリチルリチン酸ジカリウム 0.1
トウキ水抽出エキス 0.01
精製水 残
合計 100.0質量%
チューブAに収容した。
dl−α−トコフェロールの安定性 ○
外観安定性 ○
起泡性 5
味 4
製造適性 ◎
なお、香料Cの代りに香料A、B、D、E、F、G、H、Iを用いても同様の結果が得られた。また、チューブAの代りにチューブBを用いても同様の結果が得られた。
非晶質無水ケイ酸 18.0質量%
70%ソルビット液 40.0
ラウリル硫酸ナトリウム 1.5
アルギン酸ナトリウム 0.3
キサンタンガム 0.4
ポリアクリル酸ナトリウム 0.3
サッカリンナトリウム 0.1
キシリトール 5.0
プロピレングリコール 3.0
香料D 1.1
酢酸dl−α−トコフェロール 0.1
(酢酸トコフェロール、DSMニュートリション・ジャパン製)
アラニン 0.3
ポリオキシエチレンミリスチルエーテル(EO平均付加モル数8) 1.4
(EMALGEN1108、花王製)
ポリオキシエチレン硬化ヒマシ油(EO平均付加モル数20) 1.4
(NIKKOL HCO−20、日光ケミカルズ製)
増粘性シリカ 3.0
酸化チタン 0.3
デキストラナーゼ(13000単位/g) 0.1
ムタナーゼ(10000単位/g) 0.05
安息香酸ナトリウム 0.5
精製水 残
合計 100.0質量%
チューブAに収容した。
酢酸トコフェロールの安定性 ○
外観安定性 ◎
起泡性 4
味 4
製造適性 ◎
なお、香料Dの代りに香料A、B、C、E、F、G、H、Iを用いても同様の結果が得られた。また、チューブAの代りにチューブBを用いても同様の結果が得られた。
酢酸dl−α−トコフェロール 0.1質量%
(酢酸トコフェロール、DSMニュートリション・ジャパン製)
ラウリル硫酸ナトリウム 1.0
(NIKKOL SLS、日光ケミカルズ製)
非晶質無水ケイ酸 15.0
ポリオキシエチレンステアリルエーテル(EO平均付加モル数5) 1.2
ポリオキシエチレン硬化ヒマシ油(EO平均付加モル数20) 1.2
オウバクエキス 0.03
トラネキサム酸 0.05
塩化セチルピリジニウム 0.03
トリポリリン酸ナトリウム 1.0
フッ化ナトリウム 0.21
プロピレングリコール 5.0
ポリエチレングリコール#4000 0.5
70%ソルビット液 50.0
カルボキシメチルセルロースナトリウム 1.5
増粘性シリカ 5.0
酸化チタン 0.5
サッカリンナトリウム 0.1
香料E 1.2
精製水 残
合計 100.0質量%
チューブAに収容した。
酢酸トコフェロールの安定性 ◎
外観安定性 ◎
起泡性 5
味 5
製造適性 ◎
なお、香料Eの代りに香料A、B、C、D、F、G、H、Iを用いても同様の結果が得られた。また、チューブAの代りにチューブBを用いても同様の結果が得られた。
Claims (2)
- ビタミンE又はその誘導体、アニオン性界面活性剤、及び研磨剤を含有する歯磨剤組成物に、炭素数14〜18のアルキル基を有し、エチレンオキサイドの平均付加モル数が3〜8であるポリオキシエチレンアルキルエーテルと、エチレンオキサイドの平均付加モル数が10〜80であるポリオキシエチレン硬化ヒマシ油とを1:9〜9:1の質量比率で混合分散させてなる界面活性剤を配合したことを特徴とする歯磨剤組成物。
- 請求項1記載の歯磨剤組成物を容器最内層が直鎖状低密度ポリエチレンからなる容器に充填したことを特徴とする歯磨剤製品。
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