WO2007120702A2 - Use of gpr119 receptor agonists for increasing bone mass and for treating osteoporosis, and combination therapy relating thereto - Google Patents
Use of gpr119 receptor agonists for increasing bone mass and for treating osteoporosis, and combination therapy relating thereto Download PDFInfo
- Publication number
- WO2007120702A2 WO2007120702A2 PCT/US2007/008926 US2007008926W WO2007120702A2 WO 2007120702 A2 WO2007120702 A2 WO 2007120702A2 US 2007008926 W US2007008926 W US 2007008926W WO 2007120702 A2 WO2007120702 A2 WO 2007120702A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bone
- pyrimidin
- yloxy
- gprl
- agonist
- Prior art date
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- 0 CN=C(CN(CC1)C(C[C@@](Cc(cc2)cc(F)c2F)N)=O)N1*=C Chemical compound CN=C(CN(CC1)C(C[C@@](Cc(cc2)cc(F)c2F)N)=O)N1*=C 0.000 description 4
- NLZVDCPYMGFJGT-UHFFFAOYSA-N CC(C)c1cc(NCCC#N)nc(-c(cc2)ccc2Br)n1 Chemical compound CC(C)c1cc(NCCC#N)nc(-c(cc2)ccc2Br)n1 NLZVDCPYMGFJGT-UHFFFAOYSA-N 0.000 description 1
- VMFDDLZZCBFONT-SSDOTTSWSA-N N[C@@H](CC(I)=O)Cc(cc1)cc(F)c1F Chemical compound N[C@@H](CC(I)=O)Cc(cc1)cc(F)c1F VMFDDLZZCBFONT-SSDOTTSWSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07755258A EP2004157B1 (en) | 2006-04-11 | 2007-04-10 | Use of gpr119 receptor agonists for increasing bone mass and for treating osteoporosis, as well as combination therapy relating thereto |
MX2008013135A MX2008013135A (es) | 2006-04-11 | 2007-04-10 | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras condiciones caracterizadas por la masa osea baja, y combinacion de terapia que se relaciona con los mismos. |
MEP-274/08A MEP27408A (en) | 2006-04-11 | 2007-04-10 | Use of gpr119 receptor agonists for increasing bone mass and for treating osteoporosis, and combination therapy relating thereto |
AT07755258T ATE494888T1 (de) | 2006-04-11 | 2007-04-10 | Verwendung von gpr119-rezeptoragonisten zur vermehrung der knochenmasse und zur behandlung von osteoporose sowie kombinationstherapie dafür |
AU2007238728A AU2007238728A1 (en) | 2006-04-11 | 2007-04-10 | Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis, and combination therapy relating thereto |
DE602007011908T DE602007011908D1 (de) | 2006-04-11 | 2007-04-10 | Verwendung von gpr119-rezeptoragonisten zur vermehrung der knochenmasse und zur behandlung von osteoporose sowie kombinationstherapie dafür |
JP2009505453A JP2009533447A (ja) | 2006-04-11 | 2007-04-10 | 骨質量を増加させるため、および骨粗しょう症を処置するためのgpr119レセプターアゴニストの使用、ならびに、これらに関する併用療法 |
US11/989,038 US7816364B2 (en) | 2006-04-11 | 2007-04-10 | GRP119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto |
EA200870425A EA200870425A1 (ru) | 2006-04-11 | 2007-04-10 | Применение агонистов рецептора grp119 для повышения костной массы и для лечения остеопороза и связанной с ними комбинированной терапии |
CA2650399A CA2650399C (en) | 2006-04-11 | 2007-04-10 | Gpr119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto |
IL194214A IL194214A0 (en) | 2006-04-11 | 2008-09-18 | Gpr119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto |
NO20084748A NO20084748L (no) | 2006-04-11 | 2008-11-10 | GPR119 reseptor agonister i fremgangsmåter for å øke benmasse og å behandle osteoporose og andre tilstander kjennetegnet ved lav benmasse, samt kombinasjonsterapi relatert dertil |
US12/752,671 US8101626B2 (en) | 2006-04-11 | 2010-04-01 | GPR119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79161306P | 2006-04-11 | 2006-04-11 | |
US60/791,613 | 2006-04-11 | ||
US83473706P | 2006-07-31 | 2006-07-31 | |
US60/834,737 | 2006-07-31 | ||
US85124406P | 2006-10-12 | 2006-10-12 | |
US60/851,244 | 2006-10-12 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/989,038 A-371-Of-International US7816364B2 (en) | 2006-04-11 | 2007-04-10 | GRP119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto |
US12/752,671 Continuation US8101626B2 (en) | 2006-04-11 | 2010-04-01 | GPR119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007120702A2 true WO2007120702A2 (en) | 2007-10-25 |
WO2007120702A3 WO2007120702A3 (en) | 2008-05-22 |
Family
ID=38521309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/008926 WO2007120702A2 (en) | 2006-04-11 | 2007-04-10 | Use of gpr119 receptor agonists for increasing bone mass and for treating osteoporosis, and combination therapy relating thereto |
Country Status (20)
Cited By (68)
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EP2108960A1 (en) * | 2008-04-07 | 2009-10-14 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY |
US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
WO2010029089A2 (en) * | 2008-09-10 | 2010-03-18 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
WO2010088518A2 (en) * | 2009-01-31 | 2010-08-05 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
WO2010116760A1 (ja) * | 2009-04-10 | 2010-10-14 | 花王株式会社 | Gip上昇抑制剤 |
US7820815B2 (en) | 2004-11-05 | 2010-10-26 | Boehringer Ingelheim International Gmbh | Process for the preparation of chiral 8-(-3-aminopiperidin-1-yl) xanthines |
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WO2011113947A1 (en) | 2010-03-18 | 2011-09-22 | Boehringer Ingelheim International Gmbh | Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions |
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US8106060B2 (en) | 2005-07-30 | 2012-01-31 | Boehringer Ingelheim International Gmbh | 8-(3-amino-piperidin-1-yl)-xanthines, their preparation, and their use as pharmaceuticals |
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US8153635B2 (en) | 2007-09-20 | 2012-04-10 | Irm Llc | Compounds and compositions as modulators of GPR119 activity |
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NO20084748L (no) | 2009-01-08 |
MEP27408A (en) | 2010-10-10 |
US7816364B2 (en) | 2010-10-19 |
JP2009533447A (ja) | 2009-09-17 |
US8101626B2 (en) | 2012-01-24 |
US20100190750A1 (en) | 2010-07-29 |
KR20080108610A (ko) | 2008-12-15 |
MX2008013135A (es) | 2008-10-27 |
DE602007011908D1 (de) | 2011-02-24 |
UY30277A1 (es) | 2008-01-31 |
DOP2007000069A (es) | 2007-10-31 |
EP2253311A3 (en) | 2011-06-22 |
EP2004157B1 (en) | 2011-01-12 |
EA200870425A1 (ru) | 2009-04-28 |
ATE494888T1 (de) | 2011-01-15 |
US20090270422A1 (en) | 2009-10-29 |
IL194214A0 (en) | 2009-08-03 |
AR060409A1 (es) | 2008-06-18 |
EP2004157A2 (en) | 2008-12-24 |
EP2253311A2 (en) | 2010-11-24 |
PA8722801A1 (es) | 2008-11-19 |
CA2650399C (en) | 2012-02-21 |
TW200811178A (en) | 2008-03-01 |
WO2007120702A3 (en) | 2008-05-22 |
PE20071221A1 (es) | 2007-12-14 |
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