WO2005037824A2 - Verfahren zur herstellung von aminocrotonylverbindungen - Google Patents
Verfahren zur herstellung von aminocrotonylverbindungen Download PDFInfo
- Publication number
- WO2005037824A2 WO2005037824A2 PCT/EP2004/011378 EP2004011378W WO2005037824A2 WO 2005037824 A2 WO2005037824 A2 WO 2005037824A2 EP 2004011378 W EP2004011378 W EP 2004011378W WO 2005037824 A2 WO2005037824 A2 WO 2005037824A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- amino
- chloro
- tetrahydrofuran
- fluorophenyl
- yloxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2011004537A MX338920B (es) | 2003-10-17 | 2004-10-12 | Proceso para la preparacion de compuestos de aminocrotonilo. |
EP12155662.5A EP2508521B2 (de) | 2003-10-17 | 2004-10-12 | Dimaleat einer Aminocrotonylverbindung und Verfahren zu ihrer Herstellung |
RS20060260A RS53398B (en) | 2003-10-17 | 2004-10-12 | PROCEDURE FOR OBTAINING AMINO CROTONYL UNITS |
EP04765927.1A EP1678165B1 (de) | 2003-10-17 | 2004-10-12 | Verfahren zur herstellung von aminocrotonylverbindungen |
CN2004800305555A CN1867564B (zh) | 2003-10-17 | 2004-10-12 | 氨基巴豆基化合物的制备方法 |
EA200600604A EA016624B1 (ru) | 2003-10-17 | 2004-10-12 | Способ получения аминокротонильных соединений и лекарственное средство |
BR122013033343A BR122013033343B8 (pt) | 2003-10-17 | 2004-10-12 | dimaleato de 4-[(3-cloro-4-fluorfenil)amino]-6-{[4-(n,n-dimetilamino)-1-oxo-2-buten-1-il]amino}-7-((s)-tetraidrofuran-3-ilóxi)-quinazolina, seu uso e seu processo de preparação, e composições farmacêuticas |
MEP-2008-508A ME00341B (de) | 2003-10-17 | 2004-10-12 | Verfahren zur herstellung von aminocrotonylverbindungen |
NZ547154A NZ547154A (en) | 2003-10-17 | 2004-10-12 | Method for the production of amino crotonyl compounds |
PL04765927T PL1678165T3 (pl) | 2003-10-17 | 2004-10-12 | Sposób wytwarzania związków aminokrotonylowych |
YUP-2006/0260A RS20060260A (en) | 2003-10-17 | 2004-10-12 | Method for the production of amino crotonyl compounds |
ES04765927.1T ES2440466T3 (es) | 2003-10-17 | 2004-10-12 | Procedimiento para la preparación de compuestos de aminocrotonilo |
SI200432099T SI1678165T1 (sl) | 2003-10-17 | 2004-10-12 | Postopek za pripravo aminokrotonilnih spojin |
KR1020067009605A KR101180752B1 (ko) | 2003-10-17 | 2004-10-12 | 아미노 크로토닐 화합물의 제조방법 |
MXPA06004076A MXPA06004076A (es) | 2003-10-17 | 2004-10-12 | Proceso para la preparacion de compuestos de aminocrotonilo. |
DK04765927.1T DK1678165T3 (da) | 2003-10-17 | 2004-10-12 | Fremgangsmåde til fremstilling af aminocrotonylforbindelser |
JP2006534662A JP4594317B2 (ja) | 2003-10-17 | 2004-10-12 | アミノクロトニル化合物の調製方法 |
AU2004281938A AU2004281938B2 (en) | 2003-10-17 | 2004-10-12 | Method for the production of amino crotonyl compounds |
KR1020127003787A KR101282812B1 (ko) | 2003-10-17 | 2004-10-12 | 아미노 크로토닐 화합물의 제조방법 |
CA2541928A CA2541928C (en) | 2003-10-17 | 2004-10-12 | Method for the production of amino crotonyl compounds |
BRPI0415424A BRPI0415424B8 (pt) | 2003-10-17 | 2004-10-12 | processo para preparação de compostos de aminocrotonila |
IL174951A IL174951A (en) | 2003-10-17 | 2006-04-11 | METHOD FOR MAKING AMINO CROTONIL COMPOUNDS |
NO20062181A NO333971B1 (no) | 2003-10-17 | 2006-05-15 | Fremgangsmåte for fremstilling av 4-[(3-klor-4-fluorfenyl)amino]-6-{[4-(N,N-dimetylamino)-1- okso-2-buten-1-yl]amino}-7-((S)-tetrahydrofuran-3-yloksy)kinazolin |
HK07102938.4A HK1095817A1 (en) | 2003-10-17 | 2007-03-19 | Method for the production of amino crotonyl compounds |
AU2011201171A AU2011201171B2 (en) | 2003-10-17 | 2011-03-16 | Method for the production of amino crotonyl compounds |
IL216249A IL216249A (en) | 2003-10-17 | 2011-11-10 | Di-malate salt of a crotonylated amino compound, a process for its preparation and use |
NO20130663A NO335103B1 (no) | 2003-10-17 | 2013-05-10 | Forbindelse, farmasøytisk preparat inneholdende forbindelsen, anvendelse av forbindelsen samt fremgangsmåte for fremstilling derav |
HRP20131214TT HRP20131214T1 (hr) | 2003-10-17 | 2013-12-20 | Postupak za proizvodnju aminokrotonilskih spojeva |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10349113.9 | 2003-10-17 | ||
DE10349113A DE10349113A1 (de) | 2003-10-17 | 2003-10-17 | Verfahren zur Herstellung von Aminocrotonylverbindungen |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005037824A2 true WO2005037824A2 (de) | 2005-04-28 |
WO2005037824A3 WO2005037824A3 (de) | 2005-07-21 |
Family
ID=34428508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/011378 WO2005037824A2 (de) | 2003-10-17 | 2004-10-12 | Verfahren zur herstellung von aminocrotonylverbindungen |
Country Status (35)
Country | Link |
---|---|
US (2) | US20050085495A1 (de) |
EP (2) | EP2508521B2 (de) |
JP (2) | JP4594317B2 (de) |
KR (2) | KR101282812B1 (de) |
CN (2) | CN1867564B (de) |
AR (1) | AR046118A1 (de) |
AU (2) | AU2004281938B2 (de) |
BR (2) | BR122013033343B8 (de) |
CA (2) | CA2759063C (de) |
CY (2) | CY1114866T1 (de) |
DE (1) | DE10349113A1 (de) |
DK (2) | DK1678165T3 (de) |
EA (1) | EA016624B1 (de) |
EC (1) | ECSP066509A (de) |
ES (2) | ES2440466T3 (de) |
HK (1) | HK1095817A1 (de) |
HR (2) | HRP20160246T4 (de) |
HU (1) | HUE028254T2 (de) |
IL (2) | IL174951A (de) |
ME (1) | ME00341B (de) |
MX (2) | MX338920B (de) |
MY (2) | MY155425A (de) |
NO (2) | NO333971B1 (de) |
NZ (2) | NZ547154A (de) |
PE (2) | PE20050965A1 (de) |
PL (2) | PL1678165T3 (de) |
PT (2) | PT1678165E (de) |
RS (3) | RS53398B (de) |
SG (1) | SG139743A1 (de) |
SI (2) | SI1678165T1 (de) |
TW (2) | TWI348468B (de) |
UA (2) | UA91006C2 (de) |
UY (2) | UY28559A1 (de) |
WO (1) | WO2005037824A2 (de) |
ZA (1) | ZA200602234B (de) |
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WO2007054551A1 (en) | 2005-11-11 | 2007-05-18 | Boehringer Ingelheim International Gmbh | Combination treatment of cancer comprising egfr/her2 inhibitors |
WO2007054550A1 (en) * | 2005-11-11 | 2007-05-18 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
WO2008034776A1 (en) | 2006-09-18 | 2008-03-27 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring egfr mutations |
JP2009528981A (ja) * | 2006-01-26 | 2009-08-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アミノクロトニルアミノ置換キナゾリン誘導体の合成方法 |
WO2010081817A1 (en) | 2009-01-14 | 2010-07-22 | Boehringer Ingelheim International Gmbh | Method for treating colorectal cancer |
US7846936B2 (en) | 2003-04-29 | 2010-12-07 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
WO2011003853A2 (en) | 2009-07-06 | 2011-01-13 | Boehringer Ingelheim International Gmbh | Process for drying of bibw2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient |
WO2011069962A1 (en) | 2009-12-07 | 2011-06-16 | Boehringer Ingelheim International Gmbh | Bibw 2992 for use in the treatment of triple negative breast cancer |
WO2011134898A1 (en) | 2010-04-27 | 2011-11-03 | Boehringer Ingelheim International Gmbh | New combination therapy in treatment of oncological and fibrotic diseases |
WO2012027445A1 (en) | 2010-08-26 | 2012-03-01 | Boehringer Ingelheim International Gmbh | Methods of administering an egfr inhibitor |
EP2448409A1 (de) * | 2009-07-02 | 2012-05-09 | Newgen Therapeutics, Inc. | Phosphorhaltige chinazolinverbindungen und anwendungsverfahren dafür |
USRE43431E1 (en) | 2000-12-20 | 2012-05-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
WO2012121764A1 (en) | 2010-11-25 | 2012-09-13 | Ratiopharm Gmbh | Novel salts and polymorphic forms of afatinib |
WO2012156437A1 (en) | 2011-05-17 | 2012-11-22 | Boehringer Ingelheim International Gmbh | Method for egfr directed combination treatment of cancer |
CN101304978B (zh) * | 2005-11-08 | 2012-12-26 | 韩美药品株式会社 | 作为多元抑制剂的喹唑啉衍生物、药物组合物及用途 |
WO2013052157A1 (en) | 2011-10-06 | 2013-04-11 | Ratiopharm Gmbh | Crystalline forms of afatinib di-maleate |
US8426586B2 (en) | 2003-10-17 | 2013-04-23 | Boehringer Ingelheim International Gmbh | Process for preparing amino crotonyl compounds |
US8431585B2 (en) | 2002-05-11 | 2013-04-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of inhibitors of the EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH)/prostatic hypertrophy |
US8545884B2 (en) | 2008-06-06 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Solid pharmaceutical formulations comprising BIBW 2992 |
EP2647375A1 (de) | 2009-05-14 | 2013-10-09 | Boehringer Ingelheim International Gmbh | Kombination von Vargatef und Dabigatrans zur Behandlung von onkologischen und fibrotischen Erkrankungen |
US8722694B2 (en) | 1999-06-21 | 2014-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
WO2014118197A1 (en) | 2013-02-01 | 2014-08-07 | Boehringer Ingelheim International Gmbh | Radiolabeled quinazoline derivatives |
WO2015103456A1 (en) * | 2014-01-02 | 2015-07-09 | Teva Pharmaceuticals International Gmbh | Crystalline forms of afatinib di-maleate |
US9187459B2 (en) | 2011-05-17 | 2015-11-17 | Newgen Therapeutics, Inc. | Quinazoline-7-ether compounds and methods of use |
US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
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WO2018140554A1 (en) | 2017-01-25 | 2018-08-02 | Tp Therapeutics, Inc. | Combination therapy involving diaryl macrocyclic compounds |
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CN108430990B (zh) | 2015-12-25 | 2020-08-25 | 山东轩竹医药科技有限公司 | 喹唑啉衍生物的晶体及其制备方法 |
CN106916147A (zh) * | 2015-12-25 | 2017-07-04 | 中美华世通生物医药科技(武汉)有限公司 | 化合物及其制备方法和用途 |
CN107488171B (zh) * | 2016-06-10 | 2020-08-28 | 山东新时代药业有限公司 | 一种阿法替尼制备方法 |
CN107488153B (zh) * | 2016-06-10 | 2020-06-23 | 山东新时代药业有限公司 | 一种阿法替尼中间体化合物 |
CN107488172B (zh) * | 2016-06-10 | 2020-06-12 | 山东新时代药业有限公司 | 一种阿法替尼的制备方法 |
CN107488194B (zh) * | 2016-06-10 | 2021-07-30 | 山东新时代药业有限公司 | 一种阿法替尼中间体及其制备方法 |
CN106243092B (zh) * | 2016-07-28 | 2019-02-15 | 南京臣功制药股份有限公司 | 一种高选择性制备马来酸阿法替尼的方法 |
MA46852A (fr) | 2016-11-17 | 2019-09-25 | Univ Texas | Composés à activité antitumorale contre des cellules cancéreuses porteuses de mutations egfr ou her2 exon 20 |
CN108358900A (zh) * | 2018-03-30 | 2018-08-03 | 东北制药集团股份有限公司 | 一种阿法替尼及其马来酸盐的制备方法 |
CN109824657A (zh) * | 2019-03-26 | 2019-05-31 | 石药集团中奇制药技术(石家庄)有限公司 | 一种二马来酸阿法替尼新晶型及其制备方法和应用 |
CN110563710B (zh) * | 2019-09-21 | 2020-05-19 | 广东安诺药业股份有限公司 | 一种马来酸阿法替尼的制备方法 |
CN110590754A (zh) * | 2019-09-21 | 2019-12-20 | 广东安诺药业股份有限公司 | 一种马来酸阿法替尼中间体的制备方法 |
CN113121512B (zh) * | 2019-12-30 | 2022-11-04 | 江苏晶立信医药科技有限公司 | 一种喹唑啉基丁烯酰胺类化合物的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002050043A1 (de) | 2000-12-20 | 2002-06-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Chinazolinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8618846D0 (en) | 1986-08-01 | 1986-09-10 | Smithkline Beckman Corp | Chemical process |
JPS6442472A (en) | 1987-08-10 | 1989-02-14 | Kanebo Ltd | Quinazoline derivative, production thereof and brain function disorder improving agent containing said derivative as active ingredient |
GB9005014D0 (en) * | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
RU2043352C1 (ru) * | 1991-07-01 | 1995-09-10 | Пермский фармацевтический институт | 2-пропил-3- (5-нитрофурфулиден)амино- 4(3н)-хиназолинон, проявляющий противостафилококковую и анальгетическую активность |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
GB9401182D0 (en) | 1994-01-21 | 1994-03-16 | Inst Of Cancer The Research | Antibodies to EGF receptor and their antitumour effect |
EP2295415A1 (de) | 1995-03-30 | 2011-03-16 | OSI Pharmaceuticals, Inc. | Chinazolinderivate |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
SI9620103A (sl) | 1995-07-06 | 1998-10-31 | Novartis Ag | Pirolopirimidini in postopki za njihovo pripravo |
PL190489B1 (pl) | 1996-04-12 | 2005-12-30 | Warner Lambert Co | Nieodwracalne inhibitory kinaz tyrozyny, kompozycja farmaceutyczna je zawierająca i ich zastosowanie |
UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
ZA986732B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
US6297258B1 (en) * | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
US6262088B1 (en) | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
ID29800A (id) * | 1999-02-27 | 2001-10-11 | Boehringer Ingelheim Pharma | Turunan-turunan 4-amino-kinazolin dan kinolin yang mempunyai efek inhibitor pada transduksi signal yang dimediasi oleh tirosin kinase |
DE19911366A1 (de) | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE19911509A1 (de) | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
YU90901A (sh) | 1999-06-21 | 2004-07-15 | Boehringer Ingelheim Pharma Gmbh. & Co.Kg. | Biciklični heterocikli, lekovi koji sadrže ta jedinjenja, njihova primena i postupci za njihovo pripremanje |
US6627634B2 (en) * | 2000-04-08 | 2003-09-30 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them |
US20030158196A1 (en) * | 2002-02-16 | 2003-08-21 | Boehringer Ingelheim Pharma Gmbh Co. Kg | Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors |
US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
DE10204462A1 (de) * | 2002-02-05 | 2003-08-07 | Boehringer Ingelheim Pharma | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
US20030225079A1 (en) * | 2002-05-11 | 2003-12-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of inhibitors of the EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH)/prostatic hypertrophy |
PE20040945A1 (es) * | 2003-02-05 | 2004-12-14 | Warner Lambert Co | Preparacion de quinazolinas substituidas |
US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
DE10349113A1 (de) | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
SI1948180T1 (sl) | 2005-11-11 | 2013-06-28 | Boehringer Ingelheim International Gmbh | Kombinacijsko zdravljenje raka, ki obsega EGFR/HER2 inhibitorje |
CA2833706C (en) * | 2005-11-11 | 2014-10-21 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
JP5241513B2 (ja) * | 2006-01-26 | 2013-07-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アミノクロトニルアミノ置換キナゾリン誘導体の合成方法 |
MX2009002710A (es) | 2006-09-18 | 2009-03-25 | Boehringer Ingelheim Int | Metodos para tratar canceres que portan mutaciones de egfr. |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
UY31867A (es) * | 2008-06-06 | 2010-01-29 | Boehringer Ingelheim Int | Nuevas formulaciones farmacéuticas sólidas que comprenden bibw 2992 |
EP2387401A1 (de) * | 2009-01-14 | 2011-11-23 | Boehringer Ingelheim International GmbH | Verfahren zur behandlung von kolorektalkarzinom |
SI2451445T1 (sl) * | 2009-07-06 | 2019-07-31 | Boehringer Ingelheim International Gmbh | Postopek za sušenje BIBW2992, njegovih soli in trdnih farmacevtskih formulacij, ki obsegajo to aktivno sestavino |
JP2013512882A (ja) | 2009-12-07 | 2013-04-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | トリプルネガティブ乳癌の治療に使用するbibw2992 |
US9012464B2 (en) | 2010-11-25 | 2015-04-21 | Ratiopharm Gmbh | Salts and polymorphic forms of Afatinib |
WO2013052157A1 (en) | 2011-10-06 | 2013-04-11 | Ratiopharm Gmbh | Crystalline forms of afatinib di-maleate |
CN104540820B (zh) | 2013-07-16 | 2016-12-21 | 杭州普晒医药科技有限公司 | 阿法替尼酸加成盐及其晶型、其制备方法及药物组合物 |
WO2016027243A1 (en) | 2014-08-21 | 2016-02-25 | Dr. Reddy’S Laboratories Limited | Novel solid state forms of afatinib dimaleate |
CN104892584B (zh) | 2015-05-27 | 2018-03-23 | 重庆泰濠制药有限公司 | 一种阿法替尼双马来酸盐无定型态及其制备方法、制剂 |
CN104926800A (zh) | 2015-06-26 | 2015-09-23 | 河北神威药业有限公司 | 一种阿法替尼二马来酸盐的结晶形式及其制备方法 |
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002050043A1 (de) | 2000-12-20 | 2002-06-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Chinazolinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
Cited By (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8722694B2 (en) | 1999-06-21 | 2014-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
USRE43431E1 (en) | 2000-12-20 | 2012-05-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
US8586608B2 (en) | 2000-12-20 | 2013-11-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
US8431585B2 (en) | 2002-05-11 | 2013-04-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of inhibitors of the EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH)/prostatic hypertrophy |
US7846936B2 (en) | 2003-04-29 | 2010-12-07 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
US8426586B2 (en) | 2003-10-17 | 2013-04-23 | Boehringer Ingelheim International Gmbh | Process for preparing amino crotonyl compounds |
CN101304978B (zh) * | 2005-11-08 | 2012-12-26 | 韩美药品株式会社 | 作为多元抑制剂的喹唑啉衍生物、药物组合物及用途 |
EP2340837A1 (de) | 2005-11-11 | 2011-07-06 | Boehringer Ingelheim International GmbH | Kombinationsbehandlung gegen Krebs mit EGFR/HER2-Hemmern |
US8404697B2 (en) | 2005-11-11 | 2013-03-26 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
WO2007054551A1 (en) | 2005-11-11 | 2007-05-18 | Boehringer Ingelheim International Gmbh | Combination treatment of cancer comprising egfr/her2 inhibitors |
US9089571B2 (en) | 2005-11-11 | 2015-07-28 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
US9539258B2 (en) | 2005-11-11 | 2017-01-10 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
EP3173084A1 (de) * | 2005-11-11 | 2017-05-31 | Boehringer Ingelheim International GmbH | Chinazolinderivate zur behandlung von krebserkrankungen |
WO2007054550A1 (en) * | 2005-11-11 | 2007-05-18 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
US8188274B2 (en) | 2006-01-26 | 2012-05-29 | Boehringer Ingelheim International Gmbh | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
US7960546B2 (en) | 2006-01-26 | 2011-06-14 | Boehringer Ingelheim International Gmbh | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
US8067593B2 (en) | 2006-01-26 | 2011-11-29 | Boehringer Ingelheim International Gmbh | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
JP2009528981A (ja) * | 2006-01-26 | 2009-08-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アミノクロトニルアミノ置換キナゾリン誘導体の合成方法 |
US8877764B2 (en) | 2006-09-18 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring EGFR mutations |
WO2008034776A1 (en) | 2006-09-18 | 2008-03-27 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring egfr mutations |
US8545884B2 (en) | 2008-06-06 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Solid pharmaceutical formulations comprising BIBW 2992 |
WO2010081817A1 (en) | 2009-01-14 | 2010-07-22 | Boehringer Ingelheim International Gmbh | Method for treating colorectal cancer |
EP2647375A1 (de) | 2009-05-14 | 2013-10-09 | Boehringer Ingelheim International Gmbh | Kombination von Vargatef und Dabigatrans zur Behandlung von onkologischen und fibrotischen Erkrankungen |
EP2448409A1 (de) * | 2009-07-02 | 2012-05-09 | Newgen Therapeutics, Inc. | Phosphorhaltige chinazolinverbindungen und anwendungsverfahren dafür |
EP2448409A4 (de) * | 2009-07-02 | 2013-04-10 | Newgen Therapeutics Inc | Phosphorhaltige chinazolinverbindungen und anwendungsverfahren dafür |
US8987284B2 (en) | 2009-07-02 | 2015-03-24 | Newgen Therapeutics, Inc. | Phosphorus containing quinazoline compounds and methods of use |
US10004743B2 (en) | 2009-07-06 | 2018-06-26 | Boehringer Ingelheim International Gmbh | Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient |
WO2011003853A2 (en) | 2009-07-06 | 2011-01-13 | Boehringer Ingelheim International Gmbh | Process for drying of bibw2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient |
US20120107399A1 (en) * | 2009-07-06 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Process for drying of bibw2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient |
US9545381B2 (en) * | 2009-07-06 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient |
WO2011069962A1 (en) | 2009-12-07 | 2011-06-16 | Boehringer Ingelheim International Gmbh | Bibw 2992 for use in the treatment of triple negative breast cancer |
WO2011134898A1 (en) | 2010-04-27 | 2011-11-03 | Boehringer Ingelheim International Gmbh | New combination therapy in treatment of oncological and fibrotic diseases |
WO2012027445A1 (en) | 2010-08-26 | 2012-03-01 | Boehringer Ingelheim International Gmbh | Methods of administering an egfr inhibitor |
WO2012121764A1 (en) | 2010-11-25 | 2012-09-13 | Ratiopharm Gmbh | Novel salts and polymorphic forms of afatinib |
EA024026B1 (ru) * | 2010-11-25 | 2016-08-31 | Рациофарм Гмбх | Новые соли и полиморфные формы афатиниба |
US11524956B2 (en) | 2011-03-04 | 2022-12-13 | Newgen Therapeutics, Inc. | Alkyne substituted quinazoline compound and methods of use |
US9187459B2 (en) | 2011-05-17 | 2015-11-17 | Newgen Therapeutics, Inc. | Quinazoline-7-ether compounds and methods of use |
TWI555745B (zh) * | 2011-05-17 | 2016-11-01 | 江蘇康緣藥業股份有限公司 | 喹唑啉-7-醚化合物及其使用方法 |
WO2012156437A1 (en) | 2011-05-17 | 2012-11-22 | Boehringer Ingelheim International Gmbh | Method for egfr directed combination treatment of cancer |
US8828391B2 (en) | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
WO2013052157A1 (en) | 2011-10-06 | 2013-04-11 | Ratiopharm Gmbh | Crystalline forms of afatinib di-maleate |
WO2014118197A1 (en) | 2013-02-01 | 2014-08-07 | Boehringer Ingelheim International Gmbh | Radiolabeled quinazoline derivatives |
US9725439B2 (en) | 2013-09-28 | 2017-08-08 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Quinazoline derivative and preparation method therefor |
EP3050880A4 (de) * | 2013-09-28 | 2017-04-26 | Chia Tai Tianqing Pharmaceutical Group Co.,Ltd | Chinazolinderivat und herstellungsverfahren dafür |
US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
WO2015103456A1 (en) * | 2014-01-02 | 2015-07-09 | Teva Pharmaceuticals International Gmbh | Crystalline forms of afatinib di-maleate |
US9630952B2 (en) | 2014-01-02 | 2017-04-25 | IVAX International GmbH | Crystalline forms of afatinib di-maleate |
EA031059B1 (ru) * | 2014-01-02 | 2018-11-30 | Тева Фармасьютикалз Интернэшнл Гмбх | Кристаллическая форма альфа дималеата афатиниба |
EP3201190A4 (de) * | 2014-10-01 | 2018-03-14 | Sun Pharmaceutical Industries Ltd | Kristalline form von afatinib-dimaleat |
EP3023421A1 (de) | 2014-11-21 | 2016-05-25 | Sandoz Ag | Kristalline Formen von Afatinib-Dimaleat |
WO2016079313A1 (en) * | 2014-11-21 | 2016-05-26 | Sandoz Ag | Crystalline forms of afatinib dimaleate |
CN105801567A (zh) * | 2014-12-31 | 2016-07-27 | 徐州万邦金桥制药有限公司 | 一种双马来酸阿法替尼的纯化方法 |
US9708301B2 (en) | 2015-01-15 | 2017-07-18 | Hangzhou Pushai Pharmaceutical Technology | Crystalline forms of afatinib monomaleate, preparation methods and pharmaceutical compositions thereof |
US10231973B2 (en) | 2015-03-20 | 2019-03-19 | Chai Tai Tianqing Pharmaceutical Group Co., Ltd. | Salts of quinazoline derivative and method for preparing the same |
EP3567038A1 (de) * | 2015-04-17 | 2019-11-13 | Hetero Labs Ltd. | Verfahren zur herstellung von chinazolinylderivaten |
WO2016166720A3 (en) * | 2015-04-17 | 2017-02-02 | Hetero Research Foundation | Polymorphs of afatinib and its salts and process for the preparation of quinazolinyl derivatives |
US10329281B2 (en) | 2015-04-17 | 2019-06-25 | Hetero Labs Ltd | Polymorphs and process for the preparation of quinazolinyl derivatives |
WO2017093789A1 (en) * | 2015-12-03 | 2017-06-08 | Mylan Laboratories Ltd. | Polymorphic forms of afatinib dimaleate |
CN105669658B (zh) * | 2016-04-05 | 2018-06-29 | 北京民康百草医药科技有限公司 | 一种阿法替尼的精制方法 |
CN105669658A (zh) * | 2016-04-05 | 2016-06-15 | 北京民康百草医药科技有限公司 | 一种阿法替尼的精制方法 |
WO2018140554A1 (en) | 2017-01-25 | 2018-08-02 | Tp Therapeutics, Inc. | Combination therapy involving diaryl macrocyclic compounds |
US11136314B2 (en) | 2017-04-06 | 2021-10-05 | Johnson Matthey Public Limited Company | Forms of afatinib dimaleate |
WO2018187643A1 (en) | 2017-04-06 | 2018-10-11 | Johnson Matthey Public Limited Company | Novel forms of afatinib dimaleate |
WO2019240505A1 (ko) | 2018-06-14 | 2019-12-19 | 주식회사 에이티파머 | 알로페론을 포함하는 췌장암 치료용 조성물 및 치료 보조제 |
KR20190141607A (ko) | 2018-06-14 | 2019-12-24 | 주식회사 에이티파머 | 알로페론을 포함하는 췌장암 치료용 조성물 및 치료 보조제 |
KR20200008950A (ko) | 2018-07-17 | 2020-01-29 | 주식회사 에이티파머 | 알로페론을 포함하는 폐섬유증 치료용 조성물 |
KR20210106158A (ko) | 2020-02-20 | 2021-08-30 | 서울대학교산학협력단 | 알로페론을 포함하는 항암 치료 보조제 |
KR20210106157A (ko) | 2020-02-20 | 2021-08-30 | 서울대학교산학협력단 | 알로페론을 포함하는 난소암 치료용 조성물 및 치료 보조제 |
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