WO2003002536A1 - Compose diamine cyclique asymetrique - Google Patents
Compose diamine cyclique asymetrique Download PDFInfo
- Publication number
- WO2003002536A1 WO2003002536A1 PCT/JP2002/006490 JP0206490W WO03002536A1 WO 2003002536 A1 WO2003002536 A1 WO 2003002536A1 JP 0206490 W JP0206490 W JP 0206490W WO 03002536 A1 WO03002536 A1 WO 03002536A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- trimethoxyphenyl
- pyridine
- yield
- synthesis
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Definitions
- the present invention provides an asymmetric cyclic diamine compound or a diamine compound having an activity of inhibiting cell adhesion and cell invasion, which is useful as an anti-asthmatic agent, an anti-allergy agent, an anti-rheumatic agent, an anti-atherosclerotic agent, an anti-inflammatory agent, etc.
- the present invention relates to a salt and a medicine containing the salt.
- Leukocytes in the activated bloodstream adhere to vascular endothelial cells via an interaction called rolling (ro 11 ing) or tethering (tethering) with similarly activated vascular endothelial cells. adhe si on) Thereafter, it infiltrates the vascular endothelium (tran smigration) and infiltrates the site of inflammation (Springer TA. Et al., Annu. Rev. Phy sio 1.57, 827-872 (1995)).
- the adhesion between leukocytes and vascular endothelial cells depends on the stimulation of cytokines and other factors, including the immunoglobulin superfamily (ICAM-1, VCAM-1, etc.) and the selectin family (E-selectin, etc.)
- ICM-1 immunoglobulin superfamily
- VCAM-1 VCAM-1
- E-selectin selectin family
- Various cell adhesion molecules such as the integrin family (LFA-1, VLA-4, etc.) and CD44 play important roles (Clinical Immunity, 30, Suppi. 18 (1998)). It has been pointed out that there is a relationship with enhanced expression of adhesion molecules.
- drugs that can inhibit adhesion via cell adhesion molecules include allergic diseases such as bronchial asthma, dermatitis, rhinitis and conjunctivitis, rheumatoid arthritis, nephritis, inflammatory bowel disease, diabetes, and atherosclerosis. It is considered to be effective as a prophylactic and therapeutic agent for autoimmune diseases such as those and chronic inflammatory diseases.
- ICAM-1, VCAM-1, P-selectin, and E-selectin on vascular endothelial cells that serve as antibodies or ligands for leukocyte-side cell adhesion molecules such as LFA-1, Mac-1, and VLA-4 It has been reported that antibodies against such factors suppress leukocyte infiltration into inflammatory sites in various animal disease models. For example, neutralizing antibodies to VCAM-1 and its counterreceptor, VLA-4, can delay the onset of diabetes in an N0D mouse model (Michie S A. et al., Curr. r. Top. Micr ob iol. Immu no 1.231, 65-83 (1998)).
- antibodies against VLA-4 or ICAM-1 and its counterpart LFA-1 inhibit eosinophil infiltration in guinea pig or mouse models of allergic conjunctivitis (Ebihara et al., Current Ey e Res. 19, 20-25 (1999), Whitcup SM. et al., C1 inn. Immu no 1.93, 107-113 (1999)), a monoclonal antibody against VCAM-1 Suppresses leukocyte infiltration and delays colitis in an induced colitis model (Soriano A. et al., Lab. Invest. 80, 1541-1551 (2000)).
- anti-VL A-4 antibody and anti-CD44 antibody suppress its onset in a mouse collagen-induced arthritis model (Zeid 1er A. et al., Au to immunity 21, 245-252 (1995)).
- suppression of leukocyte infiltration into inflamed tissues is also observed, as in the inflammation model test (Bend jell ouhl F. et al., Clin. Exp.I mmu no 1.119, 57-63 (2000), Wo 1 yniec WW. Et al., Am. J. Respir. Cell Mo and Biol. 18, 777-785 (1998), Builard DC. J. Immu no 1.157, 3153-3158 (1996)).
- the present invention provides a substance having an inhibitory action on cell adhesion and cell invasion, and further having an excellent anti-asthmatic action, anti-allergic action, anti-rheumatic action, anti-atherosclerotic action, anti-inflammatory action and the like. Aim. Disclosure of the invention
- a compound represented by the following general formula (1) has an excellent cell adhesion inhibitory action. It has a cell invasion inhibitory effect and is useful as an anti-allergic agent, an anti-asthmatic agent, an anti-rheumatic agent, an anti-atherosclerotic agent, an anti-inflammatory agent and the like, and completed the present invention.
- R RK R 4 R 5 and R s are the same or different and represent a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, or a nitro group; R, a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom , A nitro group, a naphthyl group, or an alkyl group, an alkoxy group, a halogen atom, a nitro group and a phenyl group.
- X and Y are the same or different and each represents CH or N); and m represents a number of 1 or 2.
- the present invention also provides a medicine containing the above cyclic diamine compound, an acid addition salt thereof or a hydrate thereof as an active ingredient.
- the present invention provides a pharmaceutical composition comprising the above cyclic diamine compound, an acid addition salt thereof or a hydrate thereof, and a pharmaceutically acceptable carrier.
- the present invention further provides the use of the above-mentioned cyclic diamine compound, an acid addition salt thereof or a hydrate thereof for the production of a medicament.
- the present invention is characterized in that an effective amount of the above-mentioned cyclic diamine compound, its acid addition salt or a hydrate thereof is administered to a patient in need thereof, further comprising cell adhesion and Z or cell infiltration.
- a method for treating a disease is provided.
- the alkyl group represented by 1 to! ⁇ Is preferably a C 6 -alkyl group, specifically, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, and a tert group.
- Examples include a monobutyl group, a pentyl group, and a hexyl group.
- Particularly preferred are a methyl group, an ethyl group, an n-propyl group, an isopropyl group, and a tert-butyl group.
- the alkoxy group represented by R ⁇ R 6 is preferably a C 6 -alkoxy group. Specific examples include a methoxy group, an ethoxy group, an isopropoxy group, an n-butoxy group, and an isobutoxy group. A methoxy group, an ethoxy group and an isopropoxy group are preferred.
- the halogen atom represented by R ′ to R 6 include a chlorine atom, a bromine atom, a fluorine atom, and an iodine atom.
- R 3 is an alkyl group, an alkoxy group, a halogen atom, a nitro group or a phenyl group 13 selected from the above may be a phenyl group which may be substituted, and the substituent on the phenyl group may be the same as the above-mentioned alkyl group, alkoxy group and halogen atom.
- the ring having X and Y in the formula (2) includes a benzene ring, a pyridine ring and a pyrimidine ring.
- the acid addition salt of the compound (1) of the present invention is not particularly limited as long as it is a pharmaceutically acceptable salt.
- examples thereof include hydrochloride, hydrobromide, hydroiodide, sulfate, and phosphate.
- Acid addition salts of mineral acids such as benzoate, methanesulfonate, ethanesulfonate, benzenesulfonate, ⁇ -toluenesulfonate, oxalate, maleate, fumarate, Acid addition salts of organic acids such as tartrate, citrate and acetate can be mentioned.
- the compound (1) of the present invention may exist in the form of a solvate represented by a hydrate, and the solvate is also included in the present invention.
- the compound (1) of the present invention can be produced, for example, according to the following method a, method b or method c.
- R 7 represents a halogen atom, an alkylsulfonyloxy group or an arylsulfonyloxy group
- m and Z represent Same as
- the mono-substituted product (10) is obtained by stirring at room temperature to 10 O in the presence of lithium carbonate, preferably for 1 hour to several days, preferably for 5 hours at room temperature.
- the compound of the present invention (1a) is obtained by condensing 11)
- the condensation reaction is carried out in the presence of potassium carbonate in a solvent such as DMF, DMSO, acetonitrile and the like from room temperature to 100 ° (: preferably 70 °). 1 hour to number at C During, it is preferably carried out by 2 hours ⁇ ⁇ .
- the halogen atom represented by R 7 is preferably a chlorine atom or a bromine atom.
- the alkylsulfonyloxy group is preferably a methylsulfonyloxy group, and the arylsulfonyloxy group is preferably a P-toluenesulfonyloxy group.
- the compound (11) is produced, for example, according to the following reaction formula.
- R 8 represents a hydrogen atom or a lower alkyl group
- Z and R 7 are the same as above
- the carboxylic acid compound or its ester derivative (12) is reduced with a reducing agent such as lithium aluminum hydride to obtain an alcohol compound (13), which is then added to a halogenating agent such as dithithionyl salt or methanesulfonylation. Act on the agent Gives compound (11).
- a halogenating agent such as dithithionyl salt or methanesulfonylation.
- the reduction reaction is performed in the same manner as in the synthesis of the compound (7).
- thionyl chloride and the alcohol form (13) are used in a solvent such as chloroform, dichloromethane, ethyl acetate, ether, THF, and dioxane.
- methanesulfonyl chloride is used.
- alcohol form (13) in the presence of a base such as triethylamine, pyridine or the like in a solvent such as chloroform, dichloromethane, ethyl acetate, ether, THF, dioxane, pyridine, etc.
- a base such as triethylamine, pyridine or the like
- a solvent such as chloroform, dichloromethane, ethyl acetate, ether, THF, dioxane, pyridine, etc.
- the compound (11) and the diamine derivative (9) are condensed to obtain a mono-substituted compound (14), and the compound (8) is reacted with the monosubstituted compound (14) to obtain the compound of the present invention (la) can get.
- the condensation reaction of the compound (11) with the diamine derivative (9) and the condensation reaction of the compound (14) with the compound (8) are carried out, respectively, with the compound (10) and the compound (11) and the compound (8).
- R 9 represents a halogen atom or a hydroxy group
- Z and m are the same as described above.
- the compound (15), which is an acid chloride compound or a carboxylic acid compound, is condensed with the compound (10) to obtain the compound (lb) of the present invention.
- the reaction between the acid chloride derivative (15) and the compound (10) is carried out in a solvent such as chloroform and dichloromethane at 0 ° C. to a reflux temperature, preferably at room temperature for 1 hour to several days, preferably 5 hours. It is performed by stirring.
- the reaction between the carboxylic acid compound (15) and the compound (10) can be carried out, for example, in a solvent such as chloroform and dichloromethane, in a solvent such as dicyclohexylcarpo- imide, 1-ethyl-3- (3-dimethylaminopropyl) lipoimide.
- a solvent such as chloroform and dichloromethane
- a solvent such as dicyclohexylcarpo- imide, 1-ethyl-3- (3-dimethylaminopropyl) lipoimide.
- ⁇ Hydrochloride water-soluble carbodiimide ⁇ hydrochloride
- reflux temperature from 0 ° C in the presence of dehydrating condensing agent such as diisopropyl carbodiimide, preferably at room temperature for 10 minutes
- the reaction is carried out for several days, preferably for 6 hours.
- the compound (1) of the present invention can be obtained by the above-mentioned method, and if necessary, can be purified by a conventional purification means such as a recrystallization method or column chromatography. If necessary, the desired salt or solvate can be prepared by a conventional method.
- the thus-obtained compound (1) of the present invention exhibits an excellent cell adhesion inhibitory action as shown in Examples described later, and exhibits asthma, arregii, rheumatism in animals including humans. It is useful as a medicament for treating or preventing arteriosclerosis, inflammation and the like.
- the medicament of the present invention comprises the compound (1), a salt thereof, or a solvate thereof as an active ingredient.
- the administration form is not particularly limited and can be appropriately selected depending on the purpose of treatment. Preparations, injections, suppositories, ointments, inhalants, eye drops, nasal drops, and patches.These dosage forms are formulated with a pharmaceutically acceptable carrier. It can be produced by a known and commonly used formulation method.
- an excipient and, if necessary, a binder, a disintegrant, a lubricant, a coloring agent, a flavoring agent, a flavoring agent, etc. are added to the compound of the present invention (1).
- Tablets, coated tablets, granules, powders, capsules and the like can be manufactured by a conventional method.
- Such additives may be those commonly used in the art, such as lactose, sucrose, sodium chloride, dextrose, starch, calcium carbonate, kaolin, microcrystalline cellulose.
- Is refined talc, stearate, borax, polyethylene glycol, etc., and flavoring agents are sucrose, orange peel, Examples thereof include citric acid and tartaric acid.
- a flavoring agent, a buffer, a stabilizing agent, a flavoring agent, etc. are added to the compound (1) of the present invention to produce an oral solution, a syrup, an elixir, etc. in a conventional manner.
- vanillin or the like can be used as a flavoring agent
- sodium citrate or the like can be used as a buffer
- tragacanth, gum arabic, or gelatin can be used as a stabilizer.
- a pH adjuster, a buffer, a stabilizing agent, an isotonic agent, a local anesthetic, etc. are added to the compound (1) of the present invention, and subcutaneous, intramuscular and intravenous injections are performed by a conventional method.
- Agent can be manufactured.
- the pH regulator and the buffer include sodium citrate, sodium acetate, sodium phosphate and the like.
- the stabilizer include sodium pyrosulfite, EDTA, thioglycolic acid, thiolactic acid and the like.
- Local anesthetics include proforce hydrochloride, lidocaine hydrochloride and the like.
- the isotonic agent include sodium chloride, glucose and the like.
- the compound (1) of the present invention may be formulated with a pharmaceutical carrier known in the art, for example, polyethylene glycol, lanolin, cocoa butter, fatty acid triglyceride, and, if necessary, Tween (registered trademark). After adding a surfactant such as described above, it can be produced by a conventional method.
- a pharmaceutical carrier known in the art, for example, polyethylene glycol, lanolin, cocoa butter, fatty acid triglyceride, and, if necessary, Tween (registered trademark).
- a base, a stabilizer, a wetting agent, a preservative and the like usually used for the compound (1) of the present invention are blended as required, and mixed and formulated by a conventional method.
- Bases include liquid paraffin, white petrolatum, beeswax, octyldodecyl alcohol, paraffin and the like.
- the preservative include methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate and the like.
- inhalants In addition to the above, inhalants, eye drops, and nasal drops can be prepared by conventional methods.
- the dosage of the medicament of the present invention varies depending on the age, body weight, symptoms, administration form, number of administrations and the like, but it is usually 1 to 100 m / day as the compound of the present invention (1) for adults. It is preferable to administer g orally or parenterally in one or several divided doses.
- Ethyl 3- (2,3,4-trimethoxyphenyl) propenoate (1.15 g) is dissolved in ethanol (20 mL), and 10% potassium hydroxide (1.21 g) is added to the solution. After stirring at room temperature for 5 hours, the reaction solution was concentrated under reduced pressure. Water was added to the residue, the pH was adjusted to 2 with 2M hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the title compound.
- Example 1 1-[[2- (3,4,5-trimethoxyphenyl) pyridine-14-yl] methyl] piperazine (172 mg) and 4-methylbenzyl chloride (97 mg) were treated as in Example 1. The title compound was obtained by reacting in the same manner to give a maleate. Yield: 63mg (19%)
- Example 1 1-[[2- (3,4,5-trimethoxyphenyl) pyridine-4-yl] methyl] piperazine (172 mg) and 2-bromomethylnaphthylene (132 mg) The title compound was obtained by reacting in the same manner as described above to obtain a maleate salt.
- Phenylporonic acid (147 mg) and ethyl 2-nicotinate ethyl ester (200 mg) were treated in the same manner as in Production Example 1 to obtain the title compound.
- 5,6,7-trimethoxynaphthylene_2-capillonitril (5.8 g ) was dissolved in ethanol (40 mL), an aqueous solution (1 OmL) of potassium hydroxide (11.2 g) was added, and the mixture was stirred under reflux for 1 hour. After allowing to cool, the solvent is distilled off, the residue is dissolved in water, washed with ether, the aqueous layer is neutralized with dilute hydrochloric acid, extracted with ethyl acetate, and the organic layer is washed with water and saturated saline, and then sulfuric anhydride is added. After drying over magnesium, concentration under reduced pressure gave the title compound.
- methyltriphenylphosphonium bromide (2.8 g) was suspended in anhydrous THF (10 mL), and the suspension was diluted with 1.7 to 1.7 M M-tert-butyllithium hexane solution (3.3 mL). Was added dropwise.
- the reaction solution was returned to room temperature, stirred for 1 hour, then cooled again to ⁇ 20, and a solution of 5,6,7-trimethoxynaphthylene-2-carbaldehyde (1.26 g) in anhydrous THF ( (30 mL) dropwise at room temperature. Stirred at night.
- the solvent was distilled off, water was added to the residue, and the mixture was extracted with ethyl acetate.
- Example 46 1-[[2- (3,4,5-trimethoxyphenyl) pyridine_4-1yl] methyl] piperazine (103 mg) and 4-chlorobenzoyl (66 mg) were used. The same reaction was performed to obtain the title compound as a free base.
- Example 56 [[2- (3,4,5-trimethoxyphenyl) pyridine-4-yl] methyl] pidazine (103 mg) and 3,4,5-trimethoxycinnamic acid (65 m g) was reacted as in Example 56 to give the title compound as the free base.
- U937 which is a cell derived from human monocyte Z histiocyte fluorescently labeled with PKH2 (Dainippon Pharmaceutical Co., Ltd.), were added to each well. After standing at room temperature for 1 hour, unadhered U937 was washed out, the cells were lysed with l% Triton X-100, and the remaining fluorescence intensity was measured (excitation wavelength 485 nm, measurement Wavelength 530 nm).
- HUVEC is EGM—
- U937 was cultured in RPM 11640 containing 10% FCS.
- the drug was added to HUVEC at the time of addition of IL-li3 or TNFQ !, and to U937 at 24 hours before the cell adhesion test.
- Table 1 shows the results.
- test compound 1 of JP-A-9-143075 and dilazep of JP-A-11-92382 were simultaneously evaluated.
- Dilazep 120 Specific formulation examples are shown below.
- the compound (1) of the present invention has excellent cell adhesion and cell infiltration inhibitory effects, and is useful for the prevention and treatment of allergy, asthma, rheumatism, arteriosclerosis, inflammation and the like.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Ceramic Products (AREA)
- Carbon And Carbon Compounds (AREA)
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02736189A EP1400513B1 (en) | 2001-06-29 | 2002-06-27 | Unsymmetrical cyclic diamine compound |
JP2003508917A JP4235104B2 (ja) | 2001-06-29 | 2002-06-27 | 非対称環状ジアミン化合物 |
DE60224535T DE60224535T2 (de) | 2001-06-29 | 2002-06-27 | Unsymmetrische zyklische diaminverbindung |
CA2451241A CA2451241C (en) | 2001-06-29 | 2002-06-27 | Unsymmetrical cyclic diamine compound |
KR1020037016483A KR100873692B1 (ko) | 2001-06-29 | 2002-06-27 | 비대칭 환상 디아민 화합물 |
HK04106465A HK1065030A1 (en) | 2001-06-29 | 2004-08-27 | Unsymetrical cyclic diamine compound |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/893,699 | 2001-06-29 | ||
US09/893,699 US6552188B2 (en) | 2001-06-29 | 2001-06-29 | Unsymmetrical cyclic diamine compound |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003002536A1 true WO2003002536A1 (fr) | 2003-01-09 |
Family
ID=25401927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/006490 WO2003002536A1 (fr) | 2001-06-29 | 2002-06-27 | Compose diamine cyclique asymetrique |
Country Status (12)
Country | Link |
---|---|
US (1) | US6552188B2 (ja) |
EP (1) | EP1400513B1 (ja) |
JP (1) | JP4235104B2 (ja) |
KR (1) | KR100873692B1 (ja) |
CN (1) | CN100491352C (ja) |
AT (1) | ATE383340T1 (ja) |
CA (1) | CA2451241C (ja) |
DE (1) | DE60224535T2 (ja) |
ES (1) | ES2299578T3 (ja) |
HK (1) | HK1065030A1 (ja) |
TW (1) | TWI248434B (ja) |
WO (1) | WO2003002536A1 (ja) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2003002535A1 (ja) * | 2001-06-29 | 2004-10-14 | 興和株式会社 | 六員環式基を有する環状ジアミン化合物 |
JPWO2003020703A1 (ja) * | 2001-08-30 | 2004-12-16 | 興和株式会社 | 環状アミン化合物 |
JP2006510737A (ja) * | 2002-12-13 | 2006-03-30 | サイトピア・リサーチ・ピーティーワイ・リミテッド | ニコチンアミド系キナーゼ阻害薬 |
WO2006082834A1 (ja) * | 2005-02-02 | 2006-08-10 | Kowa Co., Ltd. | ケラチノサイト増殖に起因する疾患の予防・治療剤 |
US8536186B2 (en) | 2008-08-04 | 2013-09-17 | Chdi Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
US8883785B2 (en) | 2010-01-25 | 2014-11-11 | Chdi Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
US9428464B2 (en) | 2011-08-30 | 2016-08-30 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
US9981918B2 (en) | 2011-08-30 | 2018-05-29 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
US10258621B2 (en) | 2014-07-17 | 2019-04-16 | Chdi Foundation, Inc. | Methods and compositions for treating HIV-related disorders |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6632810B2 (en) | 2001-06-29 | 2003-10-14 | Kowa Co., Ltd. | Cyclic diamine compound with condensed-ring groups |
AR037233A1 (es) * | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
WO2004032931A1 (ja) * | 2002-10-11 | 2004-04-22 | Kowa Co., Ltd. | 癌の処置方法 |
WO2004032933A1 (ja) * | 2002-10-11 | 2004-04-22 | Kowa Co., Ltd. | 癌の処置方法 |
MXPA06001638A (es) * | 2003-08-13 | 2006-04-28 | Amgen Inc | Antagonistas del receptor de la hormona concentradora de melanina. |
AU2004266233A1 (en) * | 2003-08-13 | 2005-03-03 | Amgen, Inc. | Melanin concentrating hormone receptor antagonist |
KR100745110B1 (ko) * | 2006-01-31 | 2007-08-01 | 김광훈 | 계속적 현미경 관찰이 가능한 세포 배양장치 |
DK1984338T3 (da) * | 2006-01-31 | 2013-04-22 | Synta Pharmaceuticals Corp | Pyridylphenylforbindelser til inflammations- og immunrelaterede anvendelser |
CN101288403B (zh) * | 2008-06-16 | 2012-04-25 | 陕西上格之路生物科学有限公司 | 一种含吡螨胺的杀虫组合物及其应用 |
CN101647444B (zh) * | 2009-09-17 | 2012-08-22 | 深圳诺普信农化股份有限公司 | 一种含有吡螨胺的农药组合物 |
WO2014179144A1 (en) * | 2013-04-29 | 2014-11-06 | E. I. Du Pont De Nemours And Company | Fungicidal heterocyclic compounds |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0774257A2 (en) * | 1995-11-20 | 1997-05-21 | Kowa Co. Ltd. | Use of piperazine and homopiperazine compounds for the inhibition of cellular adhesion and infiltration |
WO1997022604A1 (en) * | 1995-12-20 | 1997-06-26 | Hoechst Marion Roussel, Inc. | Novel substituted 4-(1h-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
WO1998018782A1 (en) * | 1996-10-28 | 1998-05-07 | Celltech Therapeutics Limited | 2-pyrimidineamine derivatives and processes for their preparation |
JPH1192382A (ja) * | 1997-09-24 | 1999-04-06 | Kowa Co | 細胞接着阻害剤 |
EP0926138A1 (en) * | 1996-08-23 | 1999-06-30 | Kowa Co. Ltd. | Diamide compounds and drugs containing the same |
US6432957B1 (en) * | 2001-06-29 | 2002-08-13 | Kowa Co., Ltd. | Piperazine derivative |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000509070A (ja) | 1996-04-30 | 2000-07-18 | ヘキスト・マリオン・ルセル・インコーポレイテツド | 2,6―ジアルキル―4―シリル―フェノールを使用して血管細胞接着分子―1を阻害する方法および慢性炎症性疾患を治療する方法 |
JPH09309877A (ja) * | 1996-05-20 | 1997-12-02 | Teijin Ltd | 環状ジアミン誘導体並びにその製造及び使用 |
JP3577183B2 (ja) | 1996-06-17 | 2004-10-13 | 花王株式会社 | 動脈硬化症予防・治療剤 |
DE19637237A1 (de) * | 1996-09-13 | 1998-03-19 | Merck Patent Gmbh | Piperazin-Derivate |
JPH10147568A (ja) | 1996-11-19 | 1998-06-02 | Mitsui Chem Inc | ナフタレン誘導体およびそれを有効成分として含有する医薬品 |
JPH10182550A (ja) | 1996-12-25 | 1998-07-07 | Mitsui Chem Inc | ヒドロキシ安息香酸誘導体およびそれを有効成分として含有する医薬品 |
JP2000319277A (ja) | 1999-05-11 | 2000-11-21 | Ono Pharmaceut Co Ltd | 縮合ピラジン化合物およびその化合物を有効成分とする薬剤 |
JP4186518B2 (ja) * | 2001-06-15 | 2008-11-26 | アステラス製薬株式会社 | フェニルピリジン誘導体 |
US6509329B1 (en) * | 2001-06-29 | 2003-01-21 | Kowa Co., Ltd. | Cyclic diamine compound with 6-membered ring groups |
-
2001
- 2001-06-29 US US09/893,699 patent/US6552188B2/en not_active Expired - Fee Related
-
2002
- 2002-06-27 CN CNB028128184A patent/CN100491352C/zh not_active Expired - Fee Related
- 2002-06-27 CA CA2451241A patent/CA2451241C/en not_active Expired - Fee Related
- 2002-06-27 KR KR1020037016483A patent/KR100873692B1/ko not_active IP Right Cessation
- 2002-06-27 JP JP2003508917A patent/JP4235104B2/ja not_active Expired - Fee Related
- 2002-06-27 DE DE60224535T patent/DE60224535T2/de not_active Expired - Lifetime
- 2002-06-27 ES ES02736189T patent/ES2299578T3/es not_active Expired - Lifetime
- 2002-06-27 WO PCT/JP2002/006490 patent/WO2003002536A1/ja active IP Right Grant
- 2002-06-27 EP EP02736189A patent/EP1400513B1/en not_active Expired - Lifetime
- 2002-06-27 AT AT02736189T patent/ATE383340T1/de not_active IP Right Cessation
- 2002-06-28 TW TW091114322A patent/TWI248434B/zh not_active IP Right Cessation
-
2004
- 2004-08-27 HK HK04106465A patent/HK1065030A1/xx not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0774257A2 (en) * | 1995-11-20 | 1997-05-21 | Kowa Co. Ltd. | Use of piperazine and homopiperazine compounds for the inhibition of cellular adhesion and infiltration |
WO1997022604A1 (en) * | 1995-12-20 | 1997-06-26 | Hoechst Marion Roussel, Inc. | Novel substituted 4-(1h-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
EP0926138A1 (en) * | 1996-08-23 | 1999-06-30 | Kowa Co. Ltd. | Diamide compounds and drugs containing the same |
WO1998018782A1 (en) * | 1996-10-28 | 1998-05-07 | Celltech Therapeutics Limited | 2-pyrimidineamine derivatives and processes for their preparation |
JPH1192382A (ja) * | 1997-09-24 | 1999-04-06 | Kowa Co | 細胞接着阻害剤 |
US6432957B1 (en) * | 2001-06-29 | 2002-08-13 | Kowa Co., Ltd. | Piperazine derivative |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2003002535A1 (ja) * | 2001-06-29 | 2004-10-14 | 興和株式会社 | 六員環式基を有する環状ジアミン化合物 |
JPWO2003020703A1 (ja) * | 2001-08-30 | 2004-12-16 | 興和株式会社 | 環状アミン化合物 |
JP2006510737A (ja) * | 2002-12-13 | 2006-03-30 | サイトピア・リサーチ・ピーティーワイ・リミテッド | ニコチンアミド系キナーゼ阻害薬 |
JP4896518B2 (ja) * | 2002-12-13 | 2012-03-14 | ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド | ニコチンアミド系キナーゼ阻害薬 |
WO2006082834A1 (ja) * | 2005-02-02 | 2006-08-10 | Kowa Co., Ltd. | ケラチノサイト増殖に起因する疾患の予防・治療剤 |
JPWO2006082834A1 (ja) * | 2005-02-02 | 2008-06-26 | 興和株式会社 | ケラチノサイト増殖に起因する疾患の予防・治療剤 |
US8536186B2 (en) | 2008-08-04 | 2013-09-17 | Chdi Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
US9145373B2 (en) | 2008-08-04 | 2015-09-29 | Chdi Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
US8883785B2 (en) | 2010-01-25 | 2014-11-11 | Chdi Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
US9428464B2 (en) | 2011-08-30 | 2016-08-30 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
US9981918B2 (en) | 2011-08-30 | 2018-05-29 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
US10258621B2 (en) | 2014-07-17 | 2019-04-16 | Chdi Foundation, Inc. | Methods and compositions for treating HIV-related disorders |
Also Published As
Publication number | Publication date |
---|---|
US6552188B2 (en) | 2003-04-22 |
CA2451241C (en) | 2011-01-04 |
EP1400513A4 (en) | 2005-04-13 |
JP4235104B2 (ja) | 2009-03-11 |
US20030022887A1 (en) | 2003-01-30 |
EP1400513B1 (en) | 2008-01-09 |
ATE383340T1 (de) | 2008-01-15 |
HK1065030A1 (en) | 2005-02-08 |
CA2451241A1 (en) | 2003-06-09 |
EP1400513A1 (en) | 2004-03-24 |
DE60224535T2 (de) | 2009-01-08 |
KR100873692B1 (ko) | 2008-12-15 |
DE60224535D1 (de) | 2008-02-21 |
CN100491352C (zh) | 2009-05-27 |
JPWO2003002536A1 (ja) | 2004-10-14 |
KR20040015271A (ko) | 2004-02-18 |
ES2299578T3 (es) | 2008-06-01 |
TWI248434B (en) | 2006-02-01 |
CN1520402A (zh) | 2004-08-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003002536A1 (fr) | Compose diamine cyclique asymetrique | |
US10988456B2 (en) | O-aminoheteroaryl alkynyl-containing compound, preparation method therefor, and use thereof | |
US6342512B1 (en) | Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals | |
US20050014942A1 (en) | Amide derivatives and drugs | |
KR100878416B1 (ko) | 피페라진 화합물 | |
CN104940200A (zh) | 多取代芳族化合物作为凝血酶的抑制剂 | |
WO2022159986A1 (en) | Combination of a 3-(imidazol-4-yl)-4-(amino)-benzenesulfonamide tead inhibitor with an egfr inhibitor and/or mek inhibitor for use in the treatment of lung cancer | |
CN101537001A (zh) | 作为jak-stat3信号通路抑制剂的化合物的应用 | |
US9096531B2 (en) | Fused imidazole derivative | |
JP2002540198A (ja) | 喘息、アレルギー、および炎症性疾患の治療のための化合物および方法 | |
JP2014518281A (ja) | 電位依存性ナトリウムチャネル遮断薬 | |
TWI236469B (en) | Diamine compound with condensed-ring groups | |
KR20100042671A (ko) | 신규 페닐아세테이트 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 t-형 칼슘 이온 채널의 활성에 의해 유발되는 질환의 예방 또는 치료용 조성물 | |
WO2003002540A1 (en) | Cyclic diamine compound having five-membered cyclic group | |
WO2004032933A1 (ja) | 癌の処置方法 | |
KR100842708B1 (ko) | 6원 환식기를 가지는 환상 디아민 화합물 | |
JPH04134070A (ja) | 新規ピリジン誘導体及びそれを有効成分として含有する制癌剤効果増強剤 | |
JPH03173885A (ja) | ピリミジンジオン誘導体化合物、該化合物の製造法および該化合物を含む抗不整脈剤 | |
KR20170088880A (ko) | 이환식 함질소 방향족 헤테로환 아미드 화합물을 유효 성분으로 하는 의약 조성물 | |
JPH04295471A (ja) | トロポロン誘導体およびこれを有効成分とする虚血性疾患の予防・治療剤 | |
NZ196889A (en) | 6-pyrid-(3 or 4)-yl-4,5-dihydropyridazin-3(2h)-ones |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003508917 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020037016483 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2451241 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002736189 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 028128184 Country of ref document: CN |
|
WWP | Wipo information: published in national office |
Ref document number: 2002736189 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2004111293 Country of ref document: RU Kind code of ref document: A |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWG | Wipo information: grant in national office |
Ref document number: 2002736189 Country of ref document: EP |