Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring

Definitions

• the present invention relates to formulations for dermal control of parasitic insects and mites in humans by means of agonists or
• Antagonists of insect nicotinergic acetyicholine receptors Antagonists of insect nicotinergic acetyicholine receptors.
• Agonists or antagonists of the nicotinergic acetyicholine receptors of insects are known. They include the nicotinyl insecticides and especially the chloronicotinyl insecticides.
• compositions according to the invention have the following composition:
• auxiliaries from the group of thickeners, spreading agents, dyes, antioxidants, propellants, preservatives, Adhesives, emulsifiers, in a concentration of 0 to 30 wt .-% based on the total weight of the formulation.
• Agonists or antanogists of the nicotinergic acetyicholine receptors of insects are known e.g. from European Offenlegungsschriften No. 580 553, 464 830, 428 941, 425 978, 386 565, 383 091, 375 907, 364 844, 315 826, 259 738,
• R represents hydrogen, optionally substituted radicals from the group acyl, alkyl, aryl, aralkyl, heteroaryl or heteroarylalkyl;
• A represents a monofunctional group from the series hydrogen, acyl, alkyl, aryl or represents a bifunctional group which is linked to the radical Z;
• E represents an electron withdrawing group
• R or stands for a bifunctional group which with the radical A or the
• R represents hydrogen and also optionally substituted radicals from the series acyl, alkyl, aryl, aralkyl, heteroarvl, heteroarylalkyl.
• Formyl, alkylcarbonyl, arylcarbonyl, alkylsulfonyl, arylsulfonyl, (alkyl-) - (aryl-) - phosphoryl, which in turn can be substituted, may be mentioned as acyl radicals.
• alkyl C in particular C 1-4 alkyl, in particular methyl, ethyl, i-propyl, see- or t-butyl, which in turn can be substituted.
• Phenyl, naphthyl, especially phenyl, may be mentioned as aryl.
• Phenylmethyl and phenethyl may be mentioned as aralkyl.
• heteroaryl with up to 10 ring atoms and N, O, S, in particular N, as heteroatoms may be mentioned as heteroaryl. Let me mention in detail
• Heteroarylalkyl which may be mentioned are heteroarylmethyl, heteroarylethyl having up to 6 ring atoms and N, O, S, in particular N, as heteroatoms.
• 1 to 4 carbon atoms such as methyl sulfonyl and ethylsulfonyl
• A also represents a bifunctional group.
• Substituted alkylene with 1-4, in particular 1-2 C atoms, may be mentioned, where the substituents listed above are mentioned as substituents and the alkylene groups are represented by
• Heteroatoms from the series N, O, S can be interrupted.
• a and Z together with the atoms to which they are attached, can form a saturated or unsaturated heterocyclic ring.
• the heterocyclic ring can contain a further 1 or 2 identical or different hetero atoms and / or hetero groups.
• the heteroatoms are preferably oxygen, sulfur or nitrogen and the hetero groups are N-alkyl, alkyl of the N-alkyl group preferably containing 1 to 4, in particular 1 or 2, carbon atoms.
• alkyl methyl, ethyl, n- and i-propyl and n-, i- and t-butyl may be mentioned.
• the heterocyclic ring contains 5 to 7, preferably 5 or 6 ring members.
• heterocyclic ring examples include imidazolidine, pyrrolidine, piperidine, piperazine, hexamethyleneimine, hexahydro-l, 3,5-triazine, hexahydrooxodiazine, morpholine, which may optionally be substituted by methyl.
• E stands for an electron-withdrawing radical, in particular NO 2 , CN,
• Haloalkylcarbonyl such as 1,5-halo-C, ⁇ -carbonyl, in particular COCF 3 may be mentioned.
• Z stands for optionally substituted radicals alkyl, -OR, -SR, -NRR, where R and the substituents preferably have the meaning given above.
• Z can form a saturated or unsaturated heterocyclic ring together with the atom to which it is attached and the rest c - at the position of X.
• the heterocyclic ring can contain a further 1 or 2 identical or different heteroatoms and / or hetero groups.
• the hetero atoms are preferably oxygen, sulfur or nitrogen and the hetero groups are N-alkyl, the alkyl or N-alkyl group preferably containing 1 to 4, in particular 1 or 2, carbon atoms.
• the alkyls are methyl, ethyl, n- and called i-propyl and n-, i- and t-butyl.
• the heterocyclic ring contains 5 to 7, preferably 5 or 6 ring members.
• heterocyclic ring examples include pyrrolidine, piperidine, piperazine, hexamethyleneimine, morpholine and N-methylpiperazine.
• Subst represents one of the substituents listed above, in particular halogen, very particularly chlorine,
• the formulations according to the invention contain the active ingredient in concentrations of 0.0001 to 20% by weight, preferably 0.1 to 12.5% by weight, particularly preferably 1 to 10%.
• Preparations which are diluted before use contain the active ingredient in concentrations of 0.5 to 90% by weight, preferably 1 to 50% by weight.
• Possible solvents are: water, cyclic carbonates.
• Preferred cyclic carbonates are ethylene carbonate, propylene carbonate. Propylene carbonate is particularly preferred.
• They are present in a concentration of 2.5 to 99.9999% by weight, preferably 7.5 to 90% by weight, particularly preferably 10 to 90% by weight.
• cyclic and acyclic alcohols such as isopropanol, ethanol, diethylene glycol, 2-octyl-1-dodecanol and tetrahydrofuryl alcohol.
• They are present in a concentration of at least 0 to 95% by weight, preferably 5 to 30% by weight, particularly preferably 5 to 20% by weight.
• auxiliaries are: preservatives such as benzyl alcohol (not required if already present as a solvent), trichlorobutanol, p-hydroxybenzoic acid ester, n-butanol and water as solubility improvers.
• Thickeners are e.g. inorganic thickeners such as bentonites, colloidal silica, aluminum monostearate, organic thickeners such as cellulose derivatives, polyvinyl alcohols, polyvinylpyrrolidones and their copolymers,
• Spreading oils such as adapic acid di-2-ethylhexyl ester, isopropyl mypstat, dipropylene glycol pelargonate, cyclic and acyclic silicone oils such as dimetikones and also their copolymers and terpolymers with ethylene oxide, propylene oxide and formalin, fatty acid esters, triglycerides, fatty alcohols may be mentioned as auxiliaries
• Antioxidants are, for example, sulfites or Metabisulfite as potassium metabisulfite, ascorbic acid, butylhydroxytoluene, "butylhydroxyanisole, tocopherol
• Light stabilizers are e.g. substances from the class of benzophenones or
• Adhesives are, for example, polymeric thickeners, for example cellulose derivatives, starch derivatives, polyacrylates, natural polymers such as alginates, gelatin
• emulsifiers such as nonionic surfactants, for example polyoxyethylated castor oil, polyoxyethylated sorbitan monooleate, sorbitan monostearate,
• ampholytic surfactants such as di-Na-N-lauryl- ⁇ -iminodipropionate or lecithin,
• anionic surfactants such as Na lauryl sulfate, fatty alcohol ether sulfates, mono / dialkyl polyglycol ether orthophosphoric acid ester monoethanolamine salt, cationic surfactants such as cetyltrimethylammonium chloride
• auxiliaries are agents with which the formulations according to the invention can be sprayed or sprayed or rubbed onto the skin. Acting it is the usual propellant gases required for spray cans, such as propane, butane, dimethyl ether, CO 2 or halogenated lower alkanes, or their mixtures with one another.
• propellant gases such as propane, butane, dimethyl ether, CO 2 or halogenated lower alkanes, or their mixtures with one another.
• the formulations according to the invention are suitable for combating parasitic insects, which occur in humans, with favorable warm-blooded animal toxicity. They are effective against all or individual stages of development of the pests and against resistant and normally sensitive types of pests.
• the pests include:
• the formulations according to the invention can additionally contain juvenile hormones or juvenile hormone-like substances such as e.g. Contain diaryl ethers, benzoyl ureas or triazines.
• juvenile hormones or juvenile hormone-like substances such as e.g. Contain diaryl ethers, benzoyl ureas or triazines. This includes in particular compounds of the following formulas:
• the substituted diaryl ethers include in particular
• Benzoyl ureas include compounds of the formula
• the triazines include compounds of the formula
• the amount of the additional active ingredients can be 0 to 10% by weight, based on the total formulation mass, preferably up to 7.5%, particularly preferably up to 5.0%.
• AKD 1022 is a chloromotinyl derivative with the formula
• Ti 435 is a chloromotinyl derivative with the formula
• a spray formulation consisting of
• a spray formulation consisting of
• a spray formulation consisting of
• the weight of these animals is comparable to the weight of 6 to 8 year old children.
• the LD 50 values of the formulations are> 1,800 mg / kg. They show an excellent spreading behavior on the animal fur. The formulas allow excellent results to be expected in humans.

Landscapes

• Life Sciences & Earth Sciences (AREA)
• Dentistry (AREA)
• Pest Control & Pesticides (AREA)
• Plant Pathology (AREA)
• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Agronomy & Crop Science (AREA)
• General Health & Medical Sciences (AREA)
• Wood Science & Technology (AREA)
• Zoology (AREA)
• Environmental Sciences (AREA)
• Agricultural Chemicals And Associated Chemicals (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

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• 1996
  • 1996-04-03 DE DE19613334A patent/DE19613334A1/de not_active Withdrawn
• 1997
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