WO1997009958A1 - Produit cosmetique - Google Patents

Produit cosmetique Download PDF

Info

Publication number
WO1997009958A1
WO1997009958A1 PCT/JP1996/002645 JP9602645W WO9709958A1 WO 1997009958 A1 WO1997009958 A1 WO 1997009958A1 JP 9602645 W JP9602645 W JP 9602645W WO 9709958 A1 WO9709958 A1 WO 9709958A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
acid
bacteria
cosmetic composition
growth
Prior art date
Application number
PCT/JP1996/002645
Other languages
English (en)
Japanese (ja)
Inventor
Nobuchika Urakabe
Keiichiro Okabe
Original Assignee
Kabushiki Kaisya Advance
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabushiki Kaisya Advance filed Critical Kabushiki Kaisya Advance
Priority to AU69455/96A priority Critical patent/AU6945596A/en
Publication of WO1997009958A1 publication Critical patent/WO1997009958A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Definitions

  • the present invention relates to a cosmetic composition, and more particularly to a normal human skin comprising one or more of a growth factor of a resident bacteria, a growth inhibitor of a skin harmful bacterium, and a nutrient of the resident bacteria.
  • the present invention relates to a cosmetic composition which is effective for protecting the skin from damage caused by active oxygen and ultraviolet rays. Background art
  • cosmetics aimed at preventing or improving the dryness and roughness of the skin and protecting against damage by active oxygen and ultraviolet rays have the skin protective and self-cleansing effects of human sebum film such as cream.
  • Simulated materials those with skin activating effects containing raw materials extracted from natural sources, and those that protect skin from damage caused by ultraviolet rays containing materials that reflect or absorb ultraviolet rays have been actively used. I have.
  • an object of the present invention is to solve the above-mentioned problems of the conventional cosmetics and to provide a cosmetic composition effective for normalizing the skin J and protecting against damage by active oxygen and ultraviolet rays.
  • the present invention comprises one or more factors or components selected from among growth factors of skin-resident bacteria, growth-inhibiting factors of skin-harmful bacteria and nutrients of skin-resident bacteria, and a base.
  • a cosmetic composition provided is a cosmetic composition.
  • FIGS. 1 (a), (b) and (c) are graphs showing the effect of keratin or olive oil-containing medium on the growth of skin-resident bacteria.
  • FIG. 2 is a graph showing the effect of stearic acid and oleic acid on the growth of bacteria indigenous to skin.
  • FIGS. 3 (a) and 3 (b) are graphs showing the ultraviolet absorption spectrum of the cell component liquid and the sunscreen cream. BEST MODE FOR CARRYING OUT THE INVENTION
  • the present invention has a remarkable effect on preventing damage caused by oxygen and ultraviolet rays, and have completed the present invention.
  • the present invention is based on the finding that the present case of natural sebum membrane is nothing but skin resident bacteria and its metabolites, and skin resident bacteria are damaged by active oxygen and ultraviolet rays generated on the surface of skin I. This was done by paying attention to the defense.
  • the cosmetic composition of the present invention comprises Propionibacterium acnes or Prophylactic bacterium acnes or Staphylococcus epidermidis.
  • Propionibacterium acnes or Prophylactic bacterium acnes or Staphylococcus epidermidis Such as arginine, isoleucine, leucine, methionine, phenylalanine, proline, and tripfa, which are essential amino acids as growth factors for skin-resident bacteria such as , Tyrosine, parin, and one or more of stearic acid and oleic acid, which are higher fatty acids.
  • the cosmetic composition of the present invention is characterized by containing a high fatty acid as a higher fatty acid as a growth inhibitory factor of skin harmful bacteria such as Staphylococcus aureus X (Staphylococcus aureus). It contains one or more acids, myristic acid, palmitoleic acid, linoleic acid, linolenic acid, arachidic acid, and arachidonic acid.
  • a high fatty acid as a higher fatty acid as a growth inhibitory factor of skin harmful bacteria such as Staphylococcus aureus X (Staphylococcus aureus). It contains one or more acids, myristic acid, palmitoleic acid, linoleic acid, linolenic acid, arachidic acid, and arachidonic acid.
  • the cosmetic composition of the present invention contains one or more components contained in sebum and perspiration as a nutrient source of skin and resident bacteria.
  • the present inventors have conducted intensive studies on the number and type of bacteria resident on the skin, the components of the skin surface, the physiological and biochemical conditions of the skin, and the like for each age group of men and women. And elucidated.
  • Propionibacterium 'Aknes and Sphycococcus epidermidis are resident on the surface of human skin as typical bacteria. It was found that the average number of propionibacterial bacterium ranges from tens of thousands to hundreds of thousands and the number of Staphylococcus epidermidis ranges from hundreds to thousands per cm 2 of skin.
  • bacteria indigenous skin karada bacteria grow and repeat the growth using substances such as sebum and sweat, fats, proteins, and carbohydrates secreted or present in the skin surface layer as nutrient sources.
  • bacteria indigenous to the skin produce a wide variety of metabolites, which emulsify sebum secreted from sebaceous glands and sweat secreted from sweat glands, and prevent drying and inflammation of the skin. It has been found that it protects against damage caused by ultraviolet rays and forms a layer that inhibits the growth of skin harmful bacteria (hereinafter referred to as the “sebum layer”).
  • the main functions that have been elucidated are as follows, for example.
  • Emulsions of sebum and sweat and metabolites of skin frost-resident bacteria protect the skin from drying by suppressing the evaporation of water from the skin.
  • Skin I Enzymes such as superoxide dismutase (SOD) and ribonuclease produced by indigenous bacteria protect skin from damage by eliminating the oxidizing power of active oxygen.
  • SOD superoxide dismutase
  • ribonuclease produced by indigenous bacteria protect skin from damage by eliminating the oxidizing power of active oxygen.
  • V Free fatty acids, which are produced by the metabolism of lipids by indigenous skin bacteria, mainly maintain the surface pH of the skin at a weak acidity (around pH 6) and inhibit the growth of skin harmful bacteria. Is involved in cleansing the skin by However, as a result of comparing and examining the data for men and women of each age group, the number of bacteria indigenous to the skin and the amount of sebum and sweat secreted in the surface layer of skin I with age increase as a result of the fact that the skin that maintains the healthy skin is healthy. It was found that the number of skin oils decreased and the “sebum layer” deteriorated, and that harmful bacteria in sebum multiplied and the healthy balance of skin flora was destroyed.
  • the mixing ratio (% by weight) of the growth factor of the resident bacteria to the cosmetic composition is in accordance with the natural composition of amino acids and higher fatty acids present in the surface layer of healthy skin. It is as follows.
  • Essential amino acids that are growth factors of skin-resident bacteria arginine, isoleucine, leucine, methionine, phenylalanine, proline, tributphan, tyrosine, bali ), 0.01 to 10% by weight, more preferably 0.05 to 1% by weight, respectively, especially essential amino acid which is a growth factor of bacteria indigenous to the skin.
  • keratin or the like containing all essential amino acids in a balanced manner except for tributphan can be used. If keratin is used, it is 0.01 to 50% by weight (more preferably 0.5 to 10% by weight).
  • the amount is preferably 0.01 to 50% by weight, and more preferably 0.5 to 10%. % By weight.
  • the compounding ratio (% by weight) of the growth inhibitory factor of skin harmful bacteria to the cosmetic composition conforms to the natural composition of higher fatty acids present in the surface layer of healthy skin, and is usually as follows.
  • Higher fatty acids LA ⁇ Phosphoric acid, myristic acid,.
  • Luminoleic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid are each 0.05% by weight, more preferably 0.510% by weight. It is.
  • the proportion (% by weight) of the sebum and sweat components as a nutrient source of the resident bacteria in the cosmetics is based on the natural composition of the sebum and sweat components present in the surface layer of healthy skin I. But usually as follows
  • the components of sebum are each 0.050% by weight, more preferably 0.510% by weight. % By weight.
  • the components of sweat are each 0.0001 to 15% by weight, more preferably Is 0.052% by weight.
  • the cosmetic composition of the present invention can contain, as a base and an additive, any components other than the above-described factors or components as long as the effects of the present invention are not impaired.
  • Ingredients normally included in cosmetic compositions such as ethanol, oily ingredients, humectants, thickeners, preservatives, emulsifiers, medicinal ingredients, powders, fragrances, emulsion stabilizers, pH adjusters, etc. can do.
  • the oily components include liquid paraffin, petrolatum, raffin wax, skullane, mitsurou, carnauba baro, olive oil, and lano
  • examples include phosphorus, higher alcohols, fatty acids, synthetic ester oils of higher alcohols and fatty acids, and silicone oils, and humectants such as sorbitol, xylitol, and grease.
  • the thickening agent include alcohol, sodium lipidone carboxylate, lactic acid, sodium lactate, polyoxypropylene fatty acid ester, and polyethylene glycol.
  • Examples include water-soluble polymers such as ruboxyvinyl polymer, ruboxymethylcellulose, polyvinyl alcohol, carrageenan, and gelatin, and electrolytes such as sodium chloride and potassium chloride.
  • emulsifying agents include urea, methyl paraben, ethyl paraben, propyl paraben, butyl paraben, sodium benzoate, and the like.
  • emulsifying agents include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, and polyoxyethylene.
  • Sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester And non-ionic surfactants such as polyoxyethylene glycol glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, and polyoxyethylene sorbitol fatty acid ethylene, and the like. Recital, My power, kaolin, silica, penite, vermiculite, zinc white, mica, mica titan, titanium chloride, magnesium oxide, zirconium oxide, barium sulfide, bengala
  • Iron oxide, ultramarine and the like, and examples of the pH adjusting agent include buffering agents such as sodium lactic acid-lactate and sodium monocitrate.
  • various active ingredients include alantoin, vitamin E derivative, glycyrrhizin, ascorbic acid derivative, kojic acid, arbutin, and the like. Addition of an acetic acid derivative, a brassentia extract, an anti-inflammatory agent, quinine, various plant extracts, and the like can improve the melanin-suppressing effect.
  • various ultraviolet absorbing or reflecting substances it is possible to obtain a cosmetic that enhances the preventive and therapeutic effects of sunburn.
  • the compounding amount is, for example, 1 to 20 mg per 1 cm2 of the skin surface in the case of a cream or ointment, and the same in the case of a liquid preparation.
  • the amount is up to 10 mg, but it is not limited to this.
  • the cosmetic of the present invention can be used for makeup cosmetics such as cosmetics such as lotions, creams, emulsions, and packs, and foundations, lipsticks, and almost reds. It can be widely applied to cosmetics for hair, such as cosmetics, shampoos, rinses, and hair tonics, and other cosmetics.
  • the growth factor of the indigenous skin bacteria and the growth inhibitory factor of the skin-harmful bacteria according to the present invention can be applied not only to cosmetics but also to products in related fields such as various chemicals and drugs.
  • the cosmetics of the present invention by virtue of the skin if bacterial flora that differs from one human to another, proliferate and activate skin Iff resident bacteria and inhibit the growth of skin harmful bacteria, and therefore, have a healthy skin flora. It can provide a "sebum layer" that is closer to nature than it is composed. In addition, it proliferates the skin flora specific to each human. ⁇ It is much safer than adding skin bacteria from the outside because it activates.
  • This “sebum layer” protects the skin from dryness, acts as a barrier layer against externally applied chemical and physical damage, protects against damage caused by active oxygen and ultraviolet rays, and further protects the skin. Good skin protection, such as inhibiting the growth of harmful bacteria. ⁇ Achieves self-cleansing, making skin beautiful and healthy.
  • Propionibacterium akunes isolated from healthy adults (Hereinafter referred to as “Pa”).
  • Table 1 shows the results of examining the amino acid requirement of Kocani Papasginichitopu in the evening.
  • Propionibacterium acnes Pg: Propionibacterium granulosum, Se; Sufi Filococcus epidermidice, KS81, NN48, Y067 ; "Pa” in media containing strain code total a Mi Amino acids, Rpgj, and Te 37 "Se", was the growth rate at 72 hours 48 hours (0 D 6 .. value) 100% In contrast, the growth rate when each amino acid was depleted was 25 %, The amino acid was defined as an essential amino acid.
  • essential amino acids as growth factors for skin-resident bacteria include arginine, isoleucine, leucine, methionine, phenylalanine, proline, and triline. Butphan, tyrosin, and balin were found. Methionine, phenylalanine, and tyrosin were essential for the genus Propionibacterium, and proline was essential for the genus Sukkoficus.
  • the other amino acids were essential for the genus Propionibatatum and Staphylococcus coccus II.
  • Keratin derived from human keratin is used as a growth factor source containing an essential amino acid as a growth factor of skin-resident bacteria in a well-balanced manner, and skin-resident bacteria ⁇ Pa '', rpgj, And the proliferation effect of “Se” was confirmed.
  • the amino acid composition of keratin derived from human keratin is shown in Table 2, which contains a balanced balance of essential amino acids of all skin-resident bacteria except for tributphan. o
  • the PYG broth medium (medium composition: g Z 1>; triptycase 1, yeast extract 0.2, glucose 2, NaCl 2.5, NaH 2 P043, K2HPO47. Since cystine hydrochloride 0.2, pH 6.8) is used, the insufficient tributane is added to the medium with triptycase (containing 0.9% tributane) and yeast extract. (Containing 1.0% tributane).
  • Fig. 1 shows the growth of each skin-resident bacterium when keratin was added to the medium and when keratin was not added (control).
  • Fig. 1 (a) is a propionate battery, ATCC 11827 standard strain), and Fig.
  • FIG. 1 (b) is a propionium powder, granulosum (collected from healthy individuals) NN48, Fig. 1 ( c) shows the case of Staphylococcus epidermidis Y067 (collected from healthy people).
  • keratin was added, “Pa”, rpgj, and “Se” showed a clear proliferation effect as compared with the case where keratin was not added.
  • skin resident thin Compared to the case of adding the same amount of olive oil, which is a nutrient source of bacteria,
  • Keratin exhibited an excellent growth-promoting effect on all the growths of “Pa”, “Pg”, and “Se”.
  • Example 3 [Effects of stearic acid and oleic acid on the growth of bacteria resident on skin]
  • a typical skin-resident bacterium “Paj standard bacterial propioni bacterium”, was obtained by adding gZml of various higher fatty acids to a PYG pros medium (the medium composition was the same as in Example 2) and culturing at 37 ° C for 48 hours.
  • the growth results of ATCC 11827 are shown in Fig. 2.
  • stearic acid and oleic acid showed a clear “Pa” growth effect.
  • GA agar plate to which various higher fatty acids are added stepwise from 5 mgZml to 0.010 mg / ml (in 74.0 g / 1; peptone 10.0, soybean peptone 3.0, proteose peptone 10.0, digested serum powder 13.5, yeast extract) 5.0, Meat Extract 2.2, Liver Extract Powder 1.2, Bactose Sugar 3.0, Cadmium Dihydrogen Phosphate 3.0, Sodium Chloride 3.0, Soluble Starch 5.0, L-cistine Hydrochloride 0.3, Nattothioglycolic Acid Li Umm 0.3, agar 15.0, to pH7.1), skin harmful, which is a typical bacterium bacteria scan evening _ I - Lock dregs * ⁇ window Reus (hereinafter referred to as "Sa" of) the field of 10 8 Zml bacterial solution
  • Table 3 shows the results of confirming the growth-inhibiting effect of the cells coated with a wire and cultured aerobically at
  • arachidic acid 20: 4 arachidonic acid Among various higher fatty acids, lauric acid, myristic acid, palmitoleic acid, linoleic acid, linolenic acid, arachidic acid, When arachidonic acid was 2.5 mg / ml or less, it exhibited the growth inhibitory effect of “Sa”. In particular, it inhibited growth at low concentrations against two strains, namely, rauric acid, palmitoleic acid and linolenic acid “Sa”. Furthermore, the sebum component as a nutrient source of the skin It resident bacteria according to the present invention
  • the sebum component and sweat component were added to the PYG broth medium (the medium composition was the same as in Example 2) at the ratios shown in Table 4, and the results were compared with the case where no sebum component and sweat component were added.
  • the growth promotion rate of "Pa” (determined by the size of the colony) increased by about 20%
  • the growth promotion rate of "Se” increased by about 30%
  • the growth of sebum and sweat components indigenous bacteria on skin The effect was shown.
  • the growth effects and associated activation of the skin-resident bacteria described above provide a more natural ⁇ sebum layer '' composed of healthy skin flora, protects the skin from drying, and adds external chemistry.
  • ⁇ Working as barrier layer against physical obstacles, preventing damage due to active oxygen and ultraviolet rays, and also good skin protection such as inhibiting the growth of skin harmful bacteria Achieves action and makes skin beautiful and healthy.
  • Reactive oxygen ( ⁇ 2 ⁇ ) etc. are used for peroxidation of lipids, gene cleavage, protein It is considered to be a cause of degeneration, etc., and is one of the factors that promote tissue damage and aging.
  • the surface of the skin It is constantly exposed to the outside air, so it is in an environment where active oxygen is likely to be generated. It was shown that the indigenous skin bacteria, which normally inhabit and grow on the surface of the skin, scavenge active oxygen by enzymes such as superoxide dismutase (hereinafter referred to as SOD) and power tarase.
  • SOD superoxide dismutase
  • NBT Nonroble-tetrazolium
  • the NBT is reduced by ⁇ 2- and color is developed. Is measured by the absorbance at a wavelength of 560 nm, the concentration of O 2- can be measured.
  • the SOD activity can be measured with a degree of decrease in the absorbance, as compared with the control containing no indigenous skin bacteria.
  • Tables 5 and 6 show the extracellular SOD activity and the intracellular SOD activity actually measured with a standard strain of skin-resident bacteria.
  • Table 7 shows the results of measuring the SOD activity of 10 “Pa” strains and 9 “Se” strains isolated from healthy individuals.
  • UVA long wavelength ultraviolet
  • UVB medium wavelength ultraviolet
  • UVC short wavelength ultraviolet
  • UVA one of the ultraviolet rays that reach the surface of the earth
  • UVB causes inflammation on the skin surface and causes pigmentation that causes stains and freckles. It has been clarified that the skin / resident bacteria protect against the damage caused by ultraviolet rays by absorbing ultraviolet rays, which can damage the skin and promote aging.
  • Fig. 3 (a) shows the case of the cell component
  • Fig. 3 (b) shows the case of the sunscreen clean
  • the cell component solution was mixed with the UVA and UVB. It showed an absorption rate of about 90% of the solution.
  • Table 8 Ultraviolet absorption rate (%) of cell component liquid and sans clean
  • Sunscreen cream 100 100 In the case of the sunscreen cream, the absorption efficiency decreases over time.However, in the case of indigenous skin-captive bacteria that grow on the skin layer, It constantly grows and protects you from UV damage. It can be said that the growth and activation of skin-resident bacteria according to the present invention have an effect of increasing the ability to protect the skin from ultraviolet damage.
  • squalene is an unsaturated hydrocarbon and is unstable and difficult to use as a raw material for cosmetics.
  • Example 1 in which squalane with similar biological effects was prescribed
  • 0.2 ml of the base agar medium (03.5 cm dish; yeast extract, cystine hydrochloride, It is excluding Ranio Tray Nsan'na Application Benefits ⁇ beam, Application Benefits Puchikaze (BBC) 1.5% hard Toekisu (Nissui) 0.5% glyceryl Li down 1%, 0.2% saline, K 2 HP0 4 0.2%, promok Resin purple 0.002%, agar 1.5%, pH 6.8, 3ml), apply and absorb, and apply a suspension of normal bacteria suspended from ⁇ ⁇ ⁇ ⁇ ⁇ Cultures were performed, and the growth of colonies of bacteria with normal skin frost was compared and examined by number and size.
  • BBC Application Benefits Puchikaze
  • Table 10 shows changes in the composition of free fatty acids by using lotion and cream.
  • Palmitic acid (C I6: 0) 40 35 26 palmitic Train acid (ClB: 1) 9 16 18 Stearic acid (C, 8: 0) 20 20 22 Orein acid (C 18: 1) 11 12 14 linoleic ⁇ (C I8 : 2) 1 1
  • Linolenic acid ( C18 : 3)
  • Parumichi phosphate (C 16: 0) indicates a decreasing tendency
  • Pulse Mi Tray phosphate (C 1 6: 1)
  • the O ray emission Acid ( C18 : 1) showed an increasing trend.
  • these changes are indicators of the lybase activity of the proliferating skin-resident bacteria
  • palmitoleic acid inhibits the growth of the skin harmful bacterium “Sa” at low concentrations (Table 3).
  • oleic acid promotes the growth of “Paj and“ Se ”, bacteria indigenous to the skin exist between the bacteria indigenous to the captive skin and the skin in the formation of the“ sebum layer ”. It can be evaluated as a result of being actively involved in maintaining the homeostasis of the ecosystem.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

Composition cosmétique qui est efficace pour normaliser la peau et la protéger contre les dommages dus à l'oxygène actif et aux rayons ultraviolets, résolvant ainsi les problèmes rencontrés pour les cosmétiques traditionnels. Ladite composition contient des acides aminés ou des acides gras supérieurs requis essentiellement par des bactéries dermiques indigènes en tant que facteur de prolifération desdites bactéries, des acides gras supérieurs en tant que facteur inhibiteur de croissance des bactéries dermiques nuisibles, des constituants de sébum ou de transpiration en tant qu'agents nutritifs pour des bactéries dermiques indigènes, et une base. Ledit produit cosmétique peut fournir une 'couche sébacée' similaire à la couche naturelle, composée de diverses bactéries dermiques normales, ce qui permet donc de rendre la peau belle et saine.
PCT/JP1996/002645 1995-09-14 1996-09-13 Produit cosmetique WO1997009958A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU69455/96A AU6945596A (en) 1995-09-14 1996-09-13 Cosmetic

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7/260982 1995-09-14
JP7260982A JPH0977653A (ja) 1995-09-14 1995-09-14 化粧料

Publications (1)

Publication Number Publication Date
WO1997009958A1 true WO1997009958A1 (fr) 1997-03-20

Family

ID=17355442

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1996/002645 WO1997009958A1 (fr) 1995-09-14 1996-09-13 Produit cosmetique

Country Status (3)

Country Link
JP (1) JPH0977653A (fr)
AU (1) AU6945596A (fr)
WO (1) WO1997009958A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001357A1 (fr) * 1998-07-07 2000-01-13 Quest International B.V. Procede permettant de reduire ou de prevenir les mauvaises odeurs

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4641150B2 (ja) * 2004-04-20 2011-03-02 伯東株式会社 抗酸化物質分泌促進剤及び抗酸化物質の製造方法
JP2006282650A (ja) * 2005-03-31 2006-10-19 Sunstar Inc 皮膚化粧料
JP2007008909A (ja) * 2005-07-04 2007-01-18 Advance Co Ltd 抗菌選択性をもつ化粧料
KR101406808B1 (ko) * 2011-11-18 2014-06-12 가부시키가이샤 바이오제노믹스 미용 방법, 스킨케어용 조성물 및 건조 균체

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04288008A (ja) * 1991-03-14 1992-10-13 Taiyo Kagaku Co Ltd エリスリトールエステルを含有する化粧料
JPH05339140A (ja) * 1992-03-25 1993-12-21 Pola Chem Ind Inc 皮膚化粧料
JPH06271420A (ja) * 1993-03-16 1994-09-27 Mitsubishi Kasei Corp 化粧料または皮膚外用剤の吸水性改善剤
JPH06287128A (ja) * 1993-03-31 1994-10-11 Sunstar Inc 保湿用乳化化粧料
JPH06293641A (ja) * 1993-04-05 1994-10-21 Pola Chem Ind Inc 皮膚外用剤
JPH07196436A (ja) * 1993-12-28 1995-08-01 Pola Chem Ind Inc 皮膚化粧料

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139920A (ja) * 1983-01-28 1984-08-11 Shiseido Co Ltd 乳化組成物
MY101125A (en) * 1985-12-23 1991-07-31 Kao Corp Gel-like emulsion and o/w emulsions obtained from gel-like emulsion
JPH082801B2 (ja) * 1989-11-09 1996-01-17 株式会社資生堂 経皮吸収促進剤及び皮膚外用剤
JP3251718B2 (ja) * 1992-06-29 2002-01-28 花王株式会社 化粧料
JP3251719B2 (ja) * 1992-06-29 2002-01-28 花王株式会社 皮膚化粧料
JP3220294B2 (ja) * 1992-07-02 2001-10-22 花王株式会社 皮膚保護剤組成物
JPH07238009A (ja) * 1994-02-24 1995-09-12 Kao Corp 皮膚保護化粧料
JPH0920630A (ja) * 1995-07-06 1997-01-21 Nippon Zetotsuku Kk 化粧料

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04288008A (ja) * 1991-03-14 1992-10-13 Taiyo Kagaku Co Ltd エリスリトールエステルを含有する化粧料
JPH05339140A (ja) * 1992-03-25 1993-12-21 Pola Chem Ind Inc 皮膚化粧料
JPH06271420A (ja) * 1993-03-16 1994-09-27 Mitsubishi Kasei Corp 化粧料または皮膚外用剤の吸水性改善剤
JPH06287128A (ja) * 1993-03-31 1994-10-11 Sunstar Inc 保湿用乳化化粧料
JPH06293641A (ja) * 1993-04-05 1994-10-21 Pola Chem Ind Inc 皮膚外用剤
JPH07196436A (ja) * 1993-12-28 1995-08-01 Pola Chem Ind Inc 皮膚化粧料

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000001357A1 (fr) * 1998-07-07 2000-01-13 Quest International B.V. Procede permettant de reduire ou de prevenir les mauvaises odeurs
US6503489B1 (en) 1998-07-07 2003-01-07 Quest International B.V. Method of reducing or preventing malodour

Also Published As

Publication number Publication date
JPH0977653A (ja) 1997-03-25
AU6945596A (en) 1997-04-01

Similar Documents

Publication Publication Date Title
KR101972071B1 (ko) 피부톤 개선 또는 피부 탄력 증진용 화장료 조성물
EP0673643B1 (fr) Composition cosmétique contenant en association une superoxyde dismutase et une porphyrine
KR102194315B1 (ko) 락토바실러스 람노서스 균주를 접종하여 발효시킨 병풀 발효 추출물을 포함하는 항산화용 또는 피부 마이크로바이옴 균형 유지용 화장료 조성물
KR20180138399A (ko) No 활성 억제제, 이를 포함하는 항염증 제제, 이를 포함하는 화장품 및 이의 제조방법
JP5758174B2 (ja) 抗酸化剤、及び抗酸化化粧料
JP4783436B2 (ja) 皮膚の美白のための黒色酵母からの抽出物
KR20210094867A (ko) 해조류 추출물을 포함하는 화장료 조성물
KR101917774B1 (ko) 블랙커민씨드 추출물을 유효성분으로 포함하는 화장품 보존용 조성물
ES2387059T3 (es) Composiciones blanqueadoras que contienen una enzima derivada del ASCOMYCETE
KR20130061229A (ko) 옥타노하이드록사믹 산을 함유하는 화장료 조성물
EP1129694B1 (fr) Utilisation de composés permettant de modifier les propriétés physico-chimiques de la peau et/ou des muqueuses en tant qu'agents empêchant ou diminuant l'adhésion des micro-organismes sur ces dernières
JP6971518B2 (ja) チモール、テルピネオール、及びカチオン性リン脂質を含む抗菌組成物
KR20170001067A (ko) 피부 외용제용 보존제, 이를 포함하는 화장료 조성물 및 약제학적 조성물
JP5758175B2 (ja) 抗酸化剤、及び抗酸化化粧料
WO1997009958A1 (fr) Produit cosmetique
JPH09291023A (ja) 皮膚外用剤
JP4294640B2 (ja) 防腐殺菌剤、該防腐殺菌剤を配合した化粧品又は医薬品、及び防腐殺菌方法
CN111265434A (zh) 一种植物来源乳化剂油包水膏霜及其制备方法
JP3606580B2 (ja) 化粧料
JP6157659B1 (ja) 紫外線誘発性脂質過酸化を低減する相乗的組成物、配合物及び関連の方法
JP2009191019A (ja) 皮膚若しくは毛髪用化粧料
KR20190075974A (ko) 신규 방법
KR20190021114A (ko) 식물 추출물을 포함하는 피부 항염, 피지 분비 억제용, 또는 여드름 개선용 조성물
KR101805395B1 (ko) 피부 보습용 화장료 조성물
JP2007137768A (ja) 皮膚若しくは毛髪用化粧料

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA CN KR US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

ENP Entry into the national phase

Ref country code: US

Ref document number: 1997 836716

Date of ref document: 19970513

Kind code of ref document: A

Format of ref document f/p: F

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase