WO1980000916A1 - Preparation a liberation prolongee utilisee en contact adhesif avec une surface humide - Google Patents

Preparation a liberation prolongee utilisee en contact adhesif avec une surface humide Download PDF

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Publication number
WO1980000916A1
WO1980000916A1 PCT/JP1979/000284 JP7900284W WO8000916A1 WO 1980000916 A1 WO1980000916 A1 WO 1980000916A1 JP 7900284 W JP7900284 W JP 7900284W WO 8000916 A1 WO8000916 A1 WO 8000916A1
Authority
WO
WIPO (PCT)
Prior art keywords
adhesive layer
sustained
adhesive
wet surface
release preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1979/000284
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
Y Suzuki
H Ikura
G Yamashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to DE7979901518T priority Critical patent/DE2967009D1/de
Publication of WO1980000916A1 publication Critical patent/WO1980000916A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug

Definitions

  • the present invention relates to a sustained-release preparation which is used by being adhered to a human or a moist surface such as mucous membrane or skin of an animal. More specifically, the present invention provides that the drug is present in at least one of at least one of a layer that adheres to the wet surface and a layer that does not adhere to the wet surface.
  • the present invention relates to a sustained-release preparation having improved handling properties and adhesion properties.
  • the present inventors have intensively studied to develop a sustained-release preparation which is used to adhere to a wet surface such as a mucous membrane, which has improved the disadvantages of the prior art and which is used by adhering to a wet surface such as a mucous membrane.
  • the invention has been reached.
  • the sustained-release preparation used for the wet surface contact of the present invention is:
  • OMPI OMPI, VV'IPO ", Such as sodium polyacrylate, sodium polyacrylate, potassium polyacrylate, ammonium polyamine, etc.
  • the other component layer of the sustained-release preparation of the present invention is a non-adhesive layer having no adhesive property to a wet surface (adhesive strength of about 10 ⁇ ⁇ ⁇ Bottom), this layer needs to be water-soluble or water-collapsed.
  • This layer may contain the drug
  • the water-soluble or water-disintegrating component that constitutes the non-adhesive layer is any pharmaceutically acceptable component having such properties. It is often selected according to the administration site.
  • the components forming such a non-adhesive layer include, for example, lactose, glucose, sucrose, starch, crystalline cellulose, dextrin. , Cyclodextrin, calcium anhydride, calcium silicate, talc, calcium stearate, stearate Magnesium, beeswax, polyethylene glycol, and polyphosphate can be removed.
  • the non-adhesive layer when the drug is included in the adhesive layer, for example, when the drug is adhered to the wet surface in the body cavity, the non-adhesive layer is separated into the body cavity. [3] Dissolution or disintegration Thereafter, the adhesive layer is exposed into the body cavity, gradually swells due to the secretion fluid in the body cavity, and releases the drug gradually together with the swelling. If the drug is included in the non-adhesive layer, for example, when it comes into contact with the wet surface in the body cavity, the non-adhesive layer will gradually dissolve or disintegrate with the body fluid. This leads to a gradual release of the drug along with it.
  • the sustained-release preparation of the present invention contains the drug in any layer, regardless of the color, and is readily available.
  • the adhesive layer disappears by dissolution or disintegration, and only the wetted layer remains in a state of being in contact with the wet surface, so that it is sensitive to the user.
  • the feeling of foreign matter differs depending on the part to be bonded and the part to be bonded, but when the thickness of the adhesive layer is about 2.5 or less thighs, the feeling of foreign matter is sufficient.
  • the layer thickness is about 0.1 female or more, sufficient sustained release can be ensured, and the It is preferable that the layer thickness is about 0.1 to about 2.5; especially preferable is a layer thickness of about 0.1 to 1.0 m. I knew what was going on.
  • the thickness of the non-adhesive layer is preferably selected appropriately from about 0.1 mm to about 2.5 thighs.
  • sustained-release preparation of the present invention has two layers as described above, the non-adhesive layer and the two layers
  • the adhesive and adhesive layers reinforce each other and
  • the ability to make the adhesive layer thinner is possible.
  • the thickness of the adhesive layer is 0.1 to: I.0, there is no problem in mechanical strength.
  • the thickness of the non-adhesive layer should be appropriately selected between 2.5 and 0.1, and the mechanical strength of the entire formulation should not be a problem. It can be more than 0 rat.
  • a thin adhesive layer like this has a characteristic that, for example, even if it is adhered to the oral cavity, there is almost no foreign body sensation. Yes o
  • the sustained-release preparation of the present invention can be produced, for example, by the following method.
  • the polymer powder as the adhesive component and the desired drug and other components added as needed are sufficiently mixed to form an intimate powdery mixture. Or slurried this powder and fine-grained it, and then punch, dice and pour the appropriate amount of these powders or fines. Apply pressure using a dresser to form an adhesive layer.
  • the two-layer tablet can be easily produced by placing the component forming the non-adhesive layer thereon and further applying a pressure. According to the method in which the subsequent pressurization is applied more strongly than the previous kneading pressure, the peeling between the adhesive layer and the non-adhesive layer generally occurs.
  • the pressure to be applied which is unlikely to occur and makes good rolling and good resilience, may be selected and determined as appropriate.
  • intimate mixing refers to a state in which the components contained in the drug product are mixed as homogeneously as possible with each other, and some components are partially localized. Means that it is not localized.
  • OMPI Dosage forms such as granules are also advantageously used depending on the disease site to which it is applied.
  • a drug that is used by mixing at least one of at least one of the adhesive layer and the non-adhesive layer of the present invention it is possible to use a drug that has been conventionally released by slow release. It is expected that a further increase in the therapeutic effect will be expected for the treatment of whole or local diseases or for the prevention or prevention of diseases or veterinary drugs. It is.
  • acetaminophene phenacetin, aspirin, aminopyrin, snorepirin, feninolebuta Zone, mefenamic acid, phenolic acid, fenucenic acid, phenphenic acid, phenyphenic acid, indocyanine Analgesic and anti-inflammatory drugs such as Nesid; Inflammatory enzymes such as chymotrypsin; Hydroconoretizone Predodizon, Predodizon, Toto Flame-extinguishing steroids such as riamsinolone acetate, dexamethasone, and betamethasone; diphenhydramine hydrochloride, male Antihistamines such as chloronoferamic acid phosphate; Tetracycline hydrochloride, Loycomicin, and Radio Antibiotics or bactericides such as mycin, penicillin and its derivatives, cephalosporin derivatives and erythromycin; Physiotherapeutic
  • Cardiotonic drugs such as nitroglyserin and papaverine hydrochloride; antitussives such as codein phosphate and isoprotenolol hydrochloride Oral drugs; mouths of chlorhexidine hydrochloride, xinorelesonezolecin, salt, decadium, cetylpyridinium chloride, taclidin, etc.
  • Lubricants used as needed in the present invention include, for example, tanolec, stearic acid and its salts, and plexus.
  • the binder include starch, dextrin, tragacanth, gelatin, bolivininolepidone, boron, and the like.
  • excipients such as methyl phenol, phenol, etc.
  • Example 1 As a base for the adhesive layer, a poly (acrylic acid) copolymer (a copolymer mainly composed of acrylic acid and acrylic resin mouth, BF 50 parts, 50 parts of hydroxypropinole resin, 50 parts of magnesium stearate, Magnesium stearate Take 0.5 part, further take 0.125 parts of the anti-inflammatory drug triamcinolone acetate as a drug, mix the drug with the base, A powder for a dense adhesive layer was obtained. On the other hand, as a base for the non-adhesive layer, 81 parts of lactose,
  • the powder for the adhesive layer is used as the lower raw material and the powder for the non-adhesive layer is used as the upper raw material, and the weight of the lower layer is reduced using a conventional multi-layer tableting machine.
  • 4 0 n a thickness of about 1.1 «, upper weight approximately 2 0 n 9,. to give a thickness of about 0.4 of a diameter of about 7 bilayer tablet.
  • a two-layer tablet having substantially the same weight, thickness and drug content of the composition combination as shown in Table 1 below was obtained.
  • This example demonstrates the gradual release of drug from the formulation of the present invention.
  • the weight of the lower layer, which is an adhesive layer is about 20; the thickness, about 0.5; and the weight of the upper layer, which is a non-adhesive layer, is about
  • a double-layer tablet of the same composition and combination as in Example 1 was obtained with a thickness of 40 and a thickness of about 0.7 inch. ' This two-layer tablet also shows sufficient adhesion to the mucous membrane in the oral cavity, and gradually releases the drug as the non-adhesive layer dissolves in the oral cavity.
  • Example 4
  • a base for the adhesive layer 20 parts of poly (vinyl linoleic acid), 80 parts of hydroxypropylinolenorose, and magnesium stearate.
  • 0.5 parts of dexamethasone as an anti-inflammatory drug as a drug contained in the adhesive layer 0.125 parts or 0.33 parts Then, the drug was mixed intimately with the base to obtain a powder for the adhesive layer.
  • 90 parts of lactose, 10 parts of hydroxypropynolestat and 0.5 part of magnesium stearate were used as non-adhesive layers. Evenly mixed to form powder for non-adhesive layer
  • the powder for the adhesive layer is used as the lower layer raw material, and the powder for the non-adhesive layer is used as the upper layer raw material, and two-layer tablets are formed using a conventional tableting machine for multi-layer tablets.
  • the weight of the adhesive layer per tablet is reduced.
  • a two-layer tablet with a diameter of 7 mm was made with a thickness of 30 m (about 0.5 «thick).
  • Adhesion retention of the two-layer tablet thus obtained on the wet surface (see below OMPI-v.? O ⁇ , - ⁇ ⁇ )
  • the presence of foreign objects on the inside of the lips and on the tip of the tongue) and the area around the adhesive were examined by 30 panelists.
  • the paneler, who had good adhesion retention of the two-layer tablet and had no foreign-body sensation, was rated “excellent” in the case of 30 25 persons, “good” in the case of 2415 persons, and 1 Table 3 shows the results for the case of 45 people as "OK".
  • Adhesive layer Adhesive layer
  • the sustained-release preparation of the present invention reduces foreign body sensation by reducing the thickness of the adhesive layer, and Sufficient adhesiveness can be obtained even for parts that move rapidly, such as the tongue. .
  • the hardness of the tablet was improved by using a two-layer tablet, and it was confirmed that the tablet did not break during production, packaging, and removal. . Since the non-adhesive layer of the double-layer tablet gradually dissolves or breaks down, the foreign-body sensation of the double-layer tablet and the single-layer tablet in Table 5 is the same. It is.
  • Example 7 This example shows the adhesive strength of the adhesive layer constituting the sustained-release preparation of the present invention to a wet surface.
  • the weight is about 90 Tug-
  • the thickness is about 2 m
  • the diameter is about 7 dia.
  • the sock was obtained by pressure molding. Place these discs on a smooth piece of wood slightly moistened with water, apply a load of 100, and fix one side.
  • a rubber plate lined with a hooked steel plate is slightly moistened with water and placed on the above-mentioned fixed disk on one side. Apply a load of 0 for 30 seconds.
  • the sustained-release preparation provided by the present invention relates to a novel dosage form comprising two layers, an adhesive layer and a non-adhesive layer.
  • the adhesive layer can be firmly adhered to, and especially the thickness of the adhesive layer can be reduced, so that the feeling of foreign substances during use can be minimized. For example, they exhibit excellent effects that are completely different from those of conventionally known technologies.
  • the sustained-release preparation of the present invention is used for the treatment of systemic or local diseases in which the therapeutic effect is expected to be further increased due to the sustained release. It is used as a prophylactic agent, but it is especially adhered to the oral cavity, nasal ears, urinary organs, breeding organs, anus and other body cavities, or to wet surfaces from surgery, incisions, injuries, etc. It is used for other purposes.

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
PCT/JP1979/000284 1978-11-06 1979-11-06 Preparation a liberation prolongee utilisee en contact adhesif avec une surface humide Ceased WO1980000916A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE7979901518T DE2967009D1 (en) 1978-11-06 1979-11-06 Sustained-release preparation used in adhesive contact with wet surface

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13588378A JPS5562012A (en) 1978-11-06 1978-11-06 Slow-releasing preparation
JP78/135883 1978-11-06

Publications (1)

Publication Number Publication Date
WO1980000916A1 true WO1980000916A1 (fr) 1980-05-15

Family

ID=15162001

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1979/000284 Ceased WO1980000916A1 (fr) 1978-11-06 1979-11-06 Preparation a liberation prolongee utilisee en contact adhesif avec une surface humide

Country Status (8)

Country Link
US (1) US4292299A (enExample)
EP (1) EP0020777B1 (enExample)
JP (1) JPS5562012A (enExample)
DE (1) DE2967009D1 (enExample)
HK (1) HK80684A (enExample)
MY (1) MY8600470A (enExample)
SG (1) SG52884G (enExample)
WO (1) WO1980000916A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982000005A1 (en) * 1980-06-26 1982-01-07 Key Pharma Polymeric diffusion matrix containing a vasodilator
FR2497098A1 (fr) * 1980-12-29 1982-07-02 Teijin Ltd Composition polymere servant a proteger une partie lesee de la muqueuse orale
US4569837A (en) * 1983-06-01 1986-02-11 Teijin Limited Pharmaceutical preparation for remedy of periodontal disease and process for production thereof

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HK80684A (en) 1984-11-25
SG52884G (en) 1985-03-08
EP0020777A1 (en) 1981-01-07
EP0020777B1 (en) 1984-05-23
US4292299A (en) 1981-09-29
DE2967009D1 (en) 1984-06-28
JPS5562012A (en) 1980-05-10

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