IT1251114B - Forme farmaceutiche antivirali per applicazione vaginale - Google Patents
Forme farmaceutiche antivirali per applicazione vaginaleInfo
- Publication number
- IT1251114B IT1251114B ITMI912071A ITMI912071A IT1251114B IT 1251114 B IT1251114 B IT 1251114B IT MI912071 A ITMI912071 A IT MI912071A IT MI912071 A ITMI912071 A IT MI912071A IT 1251114 B IT1251114 B IT 1251114B
- Authority
- IT
- Italy
- Prior art keywords
- tablets
- effervescent
- vaginal
- pharmaceutical forms
- preparation
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
- 239000010410 layer Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000003826 tablet Substances 0.000 abstract 2
- 239000000003 vaginal tablet Substances 0.000 abstract 2
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 abstract 1
- 229960004150 aciclovir Drugs 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 239000007938 effervescent tablet Substances 0.000 abstract 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 239000002356 single layer Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Abstract
Sono descritti preparati farmaceutici destinati alla somministrazione vaginale di farmaci antivirali, preferibilmente di acyclovir. Forme farmaceutiche adatte sono:a) compresse vaginali erodibili e compresse vaginali effervescenti b) compresse effervescenti destinate alla preparazione di bagni medicati e/o granulare effervescente o solubile o dispersibile in acqua per la preparazione di bagni medicati c) compresse ad un solo strato (in genere destinate ad un rilascio immediato della sostanza attiva o al rilascio prolungato o sostenuto)d) compresse a due o più strati (essendo ciascuno dei differenti strati progettato per determinare differenti velocità di rilascio).
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI912071A IT1251114B (it) | 1991-07-26 | 1991-07-26 | Forme farmaceutiche antivirali per applicazione vaginale |
EP92915980A EP0596935B1 (en) | 1991-07-26 | 1992-07-20 | Antiviral pharmaceutical compositions for vaginal administration |
DE69205579T DE69205579T2 (de) | 1991-07-26 | 1992-07-20 | Virushemmende pharmazeutische zubereitungen zur vaginalen verabreichung. |
PCT/EP1992/001655 WO1993002662A1 (en) | 1991-07-26 | 1992-07-20 | Antiviral pharmaceutical compositions for vaginal administration |
DK92915980.4T DK0596935T3 (da) | 1991-07-26 | 1992-07-20 | Antivirale farmaceutiske midler til vaginal administration |
JP5503217A JPH06509348A (ja) | 1991-07-26 | 1992-07-20 | 経膣投与用の抗ウイルス性薬剤組成物 |
AU23454/92A AU2345492A (en) | 1991-07-26 | 1992-07-20 | Antiviral pharmaceutical compositions for vaginal administration |
AT92915980T ATE129149T1 (de) | 1991-07-26 | 1992-07-20 | Virushemmende pharmazeutische zubereitungen zur vaginalen verabreichung. |
CA002114216A CA2114216A1 (en) | 1991-07-26 | 1992-07-20 | Antiviral pharmaceutical compositions for vaginal administration |
CN92111077A CN1082894A (zh) | 1991-07-26 | 1992-08-24 | 阴道给药的抗病毒药物组合物 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI912071A IT1251114B (it) | 1991-07-26 | 1991-07-26 | Forme farmaceutiche antivirali per applicazione vaginale |
CN92111077A CN1082894A (zh) | 1991-07-26 | 1992-08-24 | 阴道给药的抗病毒药物组合物 |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI912071A0 ITMI912071A0 (it) | 1991-07-26 |
ITMI912071A1 ITMI912071A1 (it) | 1993-01-27 |
IT1251114B true IT1251114B (it) | 1995-05-04 |
Family
ID=36790864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI912071A IT1251114B (it) | 1991-07-26 | 1991-07-26 | Forme farmaceutiche antivirali per applicazione vaginale |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0596935B1 (it) |
JP (1) | JPH06509348A (it) |
CN (1) | CN1082894A (it) |
AT (1) | ATE129149T1 (it) |
AU (1) | AU2345492A (it) |
CA (1) | CA2114216A1 (it) |
DE (1) | DE69205579T2 (it) |
DK (1) | DK0596935T3 (it) |
IT (1) | IT1251114B (it) |
WO (1) | WO1993002662A1 (it) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4139883A1 (de) * | 1991-11-29 | 1993-06-03 | Michael Prof Dr Dittgen | Verfahren zur herstellung bioadhaesiver arzneimittel |
FR2710265B1 (fr) * | 1993-09-22 | 1995-10-20 | Adir | Composition pharmaceutique bioadhésive pour la libération contrôlée de principes actifs. |
DE4404011A1 (de) * | 1994-02-09 | 1995-08-10 | Jenapharm Gmbh | Neue, adhäsiv wirkende Zubereitungen für mit Flüssigkeit benetzte Oberflächen, Verfahren und Vorrichtung zur Erfassung der Adhäsionszeit diesbezüglicher Zubereitungen |
US6818672B1 (en) | 1999-10-05 | 2004-11-16 | Columbia Laboratories, Inc. | Treating endometriosis or infertility, or improving fertility |
UA74168C2 (uk) * | 1999-10-05 | 2005-11-15 | Коламбіа Леборетеріс (Бермуда) Лімітед | Лікування ендометріозу або безпліддя, або покращення плідності та застосування бета-адренергічного агоніста для виробництва лікарського засобу |
BR0007360A (pt) * | 1999-12-23 | 2001-08-14 | Johnson & Johnson | Composição de liberação controlada |
JP2001240558A (ja) * | 2000-02-29 | 2001-09-04 | Nippon Suisan Kaisha Ltd | 多価不飽和脂肪酸を経粘膜吸収促進剤として含有する固形製剤。 |
EP1318790A4 (en) * | 2000-09-19 | 2006-02-01 | Cima Labs Inc | PHARMACEUTICAL COMPOSITIONS FOR RECTAL AND VAGINAL ADMINISTRATION |
MY144021A (en) * | 2003-09-19 | 2011-07-29 | Drugtech Corp | Pharmaceutical delivery system |
CA2548915C (en) | 2003-12-31 | 2012-10-16 | Cima Labs Inc. | Generally linear effervescent oral fentanyl dosage form and methods of administering |
US7862833B2 (en) | 2003-12-31 | 2011-01-04 | Cima Labs, Inc. | Effervescent oral opiate dosage forms and methods of administering opiates |
EP2662086A1 (en) * | 2012-05-08 | 2013-11-13 | Progressare Medinvest B.V. | Composition for the treatment or prevention of urinary tract infections and dosage form |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3388041A (en) * | 1964-01-27 | 1968-06-11 | Richardson Merrell Inc | High dosage sustained release tablet |
JPS52156913A (en) * | 1976-06-21 | 1977-12-27 | Toko Yakuhin Kogyo Kk | Production of injectionable medicine |
JPS5562012A (en) * | 1978-11-06 | 1980-05-10 | Teijin Ltd | Slow-releasing preparation |
JPS58152809A (ja) * | 1982-03-05 | 1983-09-10 | Eisai Co Ltd | 安定な発泡性「膣」坐剤 |
US4389393A (en) * | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
IT1187750B (it) * | 1985-10-15 | 1987-12-23 | Eurand Spa | Procedimento per la preparazione di compresse,anche a rilascio prolungato,di iscsorbide-5-mononitrato stabilizzato e formulazioni cosi' ottenute |
IT1213323B (it) * | 1986-08-07 | 1989-12-20 | Crinos Industria Farmaco | Composizione per uso locale ad atti vita' spermicida virulicida ,disinfettante e/o battericida |
NZ222698A (en) * | 1987-01-08 | 1990-02-26 | Squibb & Sons Inc | Bioadhesive suppository formulations comprising a medicament, water, a hydrocolloid and low melting point base |
US4983393A (en) * | 1987-07-21 | 1991-01-08 | Maximed Corporation | Intra-vaginal device and method for sustained drug release |
-
1991
- 1991-07-26 IT ITMI912071A patent/IT1251114B/it active IP Right Grant
-
1992
- 1992-07-20 WO PCT/EP1992/001655 patent/WO1993002662A1/en active IP Right Grant
- 1992-07-20 JP JP5503217A patent/JPH06509348A/ja active Pending
- 1992-07-20 AT AT92915980T patent/ATE129149T1/de not_active IP Right Cessation
- 1992-07-20 DK DK92915980.4T patent/DK0596935T3/da active
- 1992-07-20 AU AU23454/92A patent/AU2345492A/en not_active Abandoned
- 1992-07-20 EP EP92915980A patent/EP0596935B1/en not_active Expired - Lifetime
- 1992-07-20 CA CA002114216A patent/CA2114216A1/en not_active Abandoned
- 1992-07-20 DE DE69205579T patent/DE69205579T2/de not_active Expired - Fee Related
- 1992-08-24 CN CN92111077A patent/CN1082894A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0596935A1 (en) | 1994-05-18 |
DE69205579D1 (de) | 1995-11-23 |
DE69205579T2 (de) | 1996-04-04 |
DK0596935T3 (da) | 1996-01-22 |
ITMI912071A0 (it) | 1991-07-26 |
EP0596935B1 (en) | 1995-10-18 |
JPH06509348A (ja) | 1994-10-20 |
AU2345492A (en) | 1993-03-02 |
ITMI912071A1 (it) | 1993-01-27 |
CA2114216A1 (en) | 1993-02-18 |
WO1993002662A1 (en) | 1993-02-18 |
CN1082894A (zh) | 1994-03-02 |
ATE129149T1 (de) | 1995-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960725 |