ATE225649T1 - Arzneizubereitung bestehend aus rhein oder diacerhein mit verbesserter bioverfügbarkeit - Google Patents

Arzneizubereitung bestehend aus rhein oder diacerhein mit verbesserter bioverfügbarkeit

Info

Publication number
ATE225649T1
ATE225649T1 AT97952996T AT97952996T ATE225649T1 AT E225649 T1 ATE225649 T1 AT E225649T1 AT 97952996 T AT97952996 T AT 97952996T AT 97952996 T AT97952996 T AT 97952996T AT E225649 T1 ATE225649 T1 AT E225649T1
Authority
AT
Austria
Prior art keywords
diacerhein
rhein
pct
improved bioavailability
medicinal preparation
Prior art date
Application number
AT97952996T
Other languages
English (en)
Inventor
Cyril Estanove
Alain Prudhomme
Original Assignee
Mazal Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mazal Pharma filed Critical Mazal Pharma
Application granted granted Critical
Publication of ATE225649T1 publication Critical patent/ATE225649T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
AT97952996T 1996-12-23 1997-12-23 Arzneizubereitung bestehend aus rhein oder diacerhein mit verbesserter bioverfügbarkeit ATE225649T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9615867A FR2757397B1 (fr) 1996-12-23 1996-12-23 Composition pharmaceutique a base de rheine ou de diacerheine a biodisponibilite amelioree
PCT/FR1997/002403 WO1998027965A1 (fr) 1996-12-23 1997-12-23 Composition pharmaceutique a base de rheine ou de diacerheine a biodisponibilite amelioree

Publications (1)

Publication Number Publication Date
ATE225649T1 true ATE225649T1 (de) 2002-10-15

Family

ID=9499012

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97952996T ATE225649T1 (de) 1996-12-23 1997-12-23 Arzneizubereitung bestehend aus rhein oder diacerhein mit verbesserter bioverfügbarkeit

Country Status (14)

Country Link
US (1) US6124358A (de)
EP (1) EP0904061B1 (de)
JP (1) JP4166834B2 (de)
CN (1) CN1128612C (de)
AT (1) ATE225649T1 (de)
BR (1) BR9707581A (de)
CA (1) CA2247520C (de)
DE (1) DE69716261T2 (de)
DK (1) DK0904061T3 (de)
ES (1) ES2184148T3 (de)
FR (1) FR2757397B1 (de)
IL (1) IL125794A (de)
PT (1) PT904061E (de)
WO (1) WO1998027965A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2270306C (en) * 1999-04-27 2000-09-26 Bernard Charles Sherman Pharmaceutical compositions comprising co-micronized fenofibrate
AR026801A1 (es) * 2000-01-12 2003-02-26 Medidom Lab Sustancias para uso en el tratamiento de la psoriasis
AU2002214306A1 (en) * 2000-11-17 2002-05-27 Takeda Chemical Industries Ltd. Pharmaceutical preparation containing talc/barium sulfate
US20020128317A1 (en) * 2001-01-23 2002-09-12 Laboratories Negma Treatment of pathological conditions characterized by an increased IL-1 level
FR2821555B1 (fr) * 2001-03-01 2003-05-16 Besins Int Lab Progestatif co-micronise avec un tensioactif, composition pharmaceutique le comprenant, leurs procedes de fabrication et leurs utilisations
US6797727B2 (en) * 2001-07-16 2004-09-28 Transition Therapeutics Inc. Use of rhein or diacerhein compounds for the treatment or prevention of vascular diseases
GB0404953D0 (en) * 2004-03-04 2004-04-07 Arakis Ltd Pro-drugs
WO2006119431A2 (en) 2005-04-29 2006-11-09 The Regents Of The University Of Colorado, A Body Corporate Electromagnetic characterization of tissue
FR2920991A1 (fr) * 2007-09-14 2009-03-20 Wockhardt Ltd Composition a base de diacerheine pour le traitement de l'arthrose
US8821924B2 (en) 2007-09-14 2014-09-02 Wockhardt Ltd. Rhein or diacerein compositions
US20100285114A1 (en) * 2007-09-27 2010-11-11 Rahul Dabre Pharmaceutical compositions of rhein or diacerein
CA2709236A1 (en) * 2007-09-27 2009-04-02 Wockhardt Research Centre Pharmaceutical compositions of rhein or diacerein
ATE551990T1 (de) * 2007-09-27 2012-04-15 Wockhardt Ltd Selbstemulgierende pharmazeutische zusammensetzungen von rhein oder diacerein
AU2013200971B2 (en) * 2007-09-27 2014-05-08 Wockhardt Limited Pharmaceutical compositions of rhein or diacerein
WO2009048940A2 (en) * 2007-10-08 2009-04-16 Dr. Reddy's Laboratories Ltd. Diacerein pharmaceutical formulations
EP2060562A1 (de) * 2007-11-16 2009-05-20 Laboratoire Medidom S.A. Dioxoanthracen-Sulfonat-Derivate
WO2009133431A1 (en) * 2008-04-30 2009-11-05 Wockhardt Research Centre Oral liquid compositions of rhein or diacerein
TWI473610B (zh) * 2008-10-28 2015-02-21 Twi Biotechnology Inc 包含雙醋瑞因（ｄｉａｃｅｒｅｉｎ）之醫藥組合物
AR078101A1 (es) * 2009-08-20 2011-10-12 Anchen Lab Inc Metodos para diagnosticar la diabetes y determinar la eficacia de tratamientos
CN101822660B (zh) * 2010-05-13 2013-07-10 中国人民解放军肾脏病研究所 大黄酸类化合物或其盐在制备预防和治疗胰岛β细胞功能衰退药物中的应用
EP2793854B1 (de) 2011-12-23 2015-12-16 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Formulierungen aus flurbiprofen und diacerein
EP2852324A4 (de) 2012-05-21 2016-02-24 Univ Colorado Regents Dreidimensionale abbildung und therapie von prostatakrebs
US9814448B2 (en) 2012-05-21 2017-11-14 Precision Biopsy, Inc. Three-dimensional optical imaging and therapy of prostate cancer
FR2997627B1 (fr) * 2012-11-08 2015-01-16 Hra Pharma Lab Produit de co-micronisation comprenant de l'ulipristal acetate
EP3316879A4 (de) * 2015-07-01 2019-01-23 TWI Biotechnology, Inc. Topische diacerein- oder rheinformulierungen und verwendungen davon

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA761627B (en) * 1976-03-16 1978-01-25 C Friedmann Improvements in or relating to the treatment of arthritis
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
IT1227626B (it) * 1988-11-28 1991-04-23 Vectorpharma Int Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione
IT1241417B (it) * 1990-03-06 1994-01-14 Vectorpharma Int Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
US5393898A (en) * 1991-06-25 1995-02-28 Madaus Ag Method of preparing diacetyl rhein
WO1994014421A2 (en) * 1992-12-23 1994-07-07 Saitec S.R.L. Process for preparing controlled release pharmaceutical forms and the forms thus obtained
US5652265A (en) * 1995-03-29 1997-07-29 Wisconsin Alumni Research Foundation Production of rhein and rhein derivatives
IT1276781B1 (it) * 1995-06-23 1997-11-03 Gentili Ist Spa Derivati antrachinonmono- e disolfon- sostituiti e composizioni farmaceutiche che li contengono per il trattamento delle patologie

Also Published As

Publication number Publication date
JP4166834B2 (ja) 2008-10-15
JP2000505817A (ja) 2000-05-16
BR9707581A (pt) 1999-07-27
CA2247520A1 (fr) 1998-07-02
FR2757397B1 (fr) 1999-03-05
WO1998027965A1 (fr) 1998-07-02
ES2184148T3 (es) 2003-04-01
IL125794A0 (en) 1999-04-11
PT904061E (pt) 2003-02-28
CN1128612C (zh) 2003-11-26
US6124358A (en) 2000-09-26
EP0904061A1 (de) 1999-03-31
DK0904061T3 (da) 2003-01-27
EP0904061B1 (de) 2002-10-09
DE69716261D1 (de) 2002-11-14
IL125794A (en) 2000-12-06
FR2757397A1 (fr) 1998-06-26
CN1211917A (zh) 1999-03-24
DE69716261T2 (de) 2003-09-18
CA2247520C (fr) 2007-03-27

Similar Documents

Publication Publication Date Title
ATE225649T1 (de) Arzneizubereitung bestehend aus rhein oder diacerhein mit verbesserter bioverfügbarkeit
DK383987A (da) Ny galeniske formuleringer med programmeret afgivelse indeholdende antiphlogistika
ES2134340T3 (es) Uso de acido beta-hidroxi-beta-metilbutirico para promover la retencion de nitrogeno en los seres humanos.
ITMI911149A0 (it) Composizioni farmaceutiche in forma di schiuma per somministrazione intravaginale, cutanea e orale
DK1741426T3 (da) Smelteekstruderede oralt administrerbare hydromorphonformuleringer
ES2188782T3 (es) Formulaciones farmaceuticas que contienen darifenacina.
GEP20053501B (en) Core Tablet for Controlled Release of Gliclazide after Oral Administration
DE69730688D1 (de) Oral anzuwendende arzneizubereitung
BR0012901A (pt) Medicamentos de ß - carbolina
ES2053429T3 (es) El uso de buspirona para la preparacion de composiciones farmaceuticas para aliviar la ansiedad fobica.
ES2147788T3 (es) 3,4-diarilcromanos para el tratamiento de la dermatitis.
EA200501901A1 (ru) Таблетка с основой, позволяющая осуществлять пролонгированное высвобождение триметазидина после введения оральным путём
BR9916860A (pt) Método de reduzir colesterol do sangue e/outriglicerìdios do sangue em um indivìduo mamìfero,preparação em forma de unidade de dosagem, e,conjunto para administrar oralmente a mesma
IT1208452B (it) Preparati farmaceutici con efficacia analgesica, nonche' loro produzione ed impiego
ES2026304A6 (es) Procedimiento de fabricacion de una forma de dosificacion de nicardipina.
IT1244636B (it) Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento.
WO1991018606A3 (en) Orally active nonaddicting analgesics
ES2062138T3 (es) Utilizacion de 5'-deoxi-5'-metiltioadenosina, s-adenosilmetionina y sus sales para la preparacion de composiciones farmaceuticas favorecedoras del crecimiento del cabello en sujetos adolecientes de calvicie.
CA1207238A (en) Use of haloprogin in the treatment of herpes labialis
KR910002434A (ko) 레티노이드의 용도
KR910009265A (ko) 마취제의 제조에 있어서의 이미다조피리딘의 사용
ES2103422T3 (es) Uso de bilobalida y sus derivados para tratar una infeccion en un individuo y composiciones farmaceuticas destinadas a dicho uso.
DE60121142D1 (de) Zusammensetzung die paracetamol und niflumic säure enthält
IT1249653B (it) Preparato veterinario antiprotozoario per cani e gatti, e procedimentod'impiego
AR029631A1 (es) USO DE UN DERIVADO BENZO[D](1,3)-OXAZIN-2-ONA PARA PREPARAR UN MEDICAMENTO Y UN KIT FARMACÉUTICAMENTE uTIL ADAPTADO PARA LA ADMINISTRACIoN ORAL DIARIA

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification