GB581334A
(en)
|
1943-09-29 |
1946-10-09 |
Francis Henry Swinden Curd |
New pyrimidine compounds
|
JPS4921149B1
(GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
|
1970-12-28 |
1974-05-30 |
|
|
JPS4921148B1
(GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
|
1970-12-28 |
1974-05-30 |
|
|
AT340933B
(de)
|
1973-08-20 |
1978-01-10 |
Thomae Gmbh Dr K |
Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze
|
DE2341925A1
(de)
|
1973-08-20 |
1975-03-06 |
Thomae Gmbh Dr K |
Neue pyrimidinderivate und verfahren zu ihrer herstellung
|
US4994386A
(en)
|
1987-07-13 |
1991-02-19 |
Pharmacia Diagnostics, Inc. |
Production of HBLV virus in the HSB-2 cell line
|
US4929726A
(en)
|
1988-02-09 |
1990-05-29 |
Georgia State University Foundation, Inc. |
Novel diazines and their method of preparation
|
EP0330263A1
(en)
|
1988-02-25 |
1989-08-30 |
Merck & Co. Inc. |
Piperazinylalkylpyrimidines as hypoglycemic agents
|
GB9012311D0
(en)
|
1990-06-01 |
1990-07-18 |
Wellcome Found |
Pharmacologically active cns compounds
|
US5358945A
(en)
|
1990-07-03 |
1994-10-25 |
Mitsui Petrochemical Industries, Ltd. |
Pyrimidine compound and pharmaceutically acceptable salts thereof
|
HUP9603433A3
(en)
|
1995-04-13 |
1998-04-28 |
Taiho Pharmaceutical Co Ltd |
4-6-diaryl-pyrimidine-derivatives, process for producing them and pharmaceutical compositions containing them
|
JP3734907B2
(ja)
|
1996-12-19 |
2006-01-11 |
富士写真フイルム株式会社 |
現像処理方法
|
AU727013B2
(en)
|
1997-07-24 |
2000-11-30 |
Zenyaku Kogyo Kabushiki Kaisha |
Heterocyclic compound and antitumor agent comprising the same as effective component
|
JPH11158073A
(ja)
|
1997-09-26 |
1999-06-15 |
Takeda Chem Ind Ltd |
アデノシンa3拮抗剤
|
US6440965B1
(en)
|
1997-10-15 |
2002-08-27 |
Krenitsky Pharmaceuticals, Inc. |
Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
|
US6150362A
(en)
|
1997-12-12 |
2000-11-21 |
Henkin; Jack |
Triazine angiogenesis inhibitors
|
EP0930302B1
(en)
|
1998-01-16 |
2003-04-02 |
F.Hoffmann-La Roche Ag |
Benzosulfone derivatives
|
US6489344B1
(en)
|
1998-06-19 |
2002-12-03 |
Chiron Corporation |
Inhibitors of glycogen synthase kinase 3
|
US7045519B2
(en)
|
1998-06-19 |
2006-05-16 |
Chiron Corporation |
Inhibitors of glycogen synthase kinase 3
|
US6495558B1
(en)
|
1999-01-22 |
2002-12-17 |
Amgen Inc. |
Kinase inhibitors
|
CA2359680A1
(en)
|
1999-01-22 |
2000-07-27 |
David M. Armistead |
Kinase inhibitors
|
US6316444B1
(en)
|
1999-06-30 |
2001-11-13 |
Merck & Co., Inc. |
SRC kinase inhibitor compounds
|
JP2003523942A
(ja)
|
1999-06-30 |
2003-08-12 |
メルク エンド カムパニー インコーポレーテッド |
Srcキナーゼ阻害剤化合物
|
AU6605200A
(en)
|
1999-06-30 |
2001-01-31 |
Merck & Co., Inc. |
Src kinase inhibitor compounds
|
EP1196411B1
(en)
|
1999-07-15 |
2003-09-17 |
Pharmacopeia, Inc. |
Bradykinin b1 receptor antagonists
|
JP2001089452A
(ja)
|
1999-09-22 |
2001-04-03 |
Sankyo Co Ltd |
ピリミジン誘導体
|
CA2400447C
(en)
|
2000-02-17 |
2008-04-22 |
Amgen Inc. |
Kinase inhibitors
|
EP1274705A1
(en)
|
2000-03-29 |
2003-01-15 |
Cyclacel Limited |
2-substituted 4-heteroaryl-pyrimidines and their use in the treatment of proliferative disorders
|
CA2407593C
(en)
|
2000-04-27 |
2011-01-11 |
Yamanouchi Pharmaceutical Co. Ltd. |
Fused heteroaryl derivatives
|
CN1657523A
(zh)
|
2000-04-28 |
2005-08-24 |
田边制药株式会社 |
环状化合物
|
AU2001268711A1
(en)
|
2000-06-23 |
2002-01-08 |
Bristol-Myers Squibb Pharma Company |
Heteroaryl-phenyl substituted factor xa inhibitors
|
AU2001295026B2
(en)
|
2000-09-06 |
2008-04-03 |
Novartis Vaccines And Diagnostics, Inc. |
Inhibitors of glycogen synthase kinase 3
|
DE60128709T2
(de)
|
2000-09-15 |
2007-12-27 |
Vertex Pharmaceuticals Inc., Cambridge |
Triazol-verbindungen als protein-kinase-inhibitoren
|
SE0004053D0
(sv)
|
2000-11-06 |
2000-11-06 |
Astrazeneca Ab |
N-type calcium channel antagonists for the treatment of pain
|
BR0116493A
(pt)
|
2000-12-21 |
2003-09-30 |
Vertex Pharma |
Compostos de pirazol úteis como inibidores de proteìna cinase
|
EP1363890A4
(en)
|
2001-02-07 |
2009-06-10 |
Ore Pharmaceuticals Inc |
MELANOCORTIN-4-RECEPTOR BINDING COMPOUNDS AND METHOD FOR THEIR APPLICATION
|
WO2002064096A2
(en)
|
2001-02-16 |
2002-08-22 |
Tularik Inc. |
Methods of using pyrimidine-based antiviral agents
|
MXPA03010724A
(es)
|
2001-05-25 |
2004-03-02 |
Boehringer Ingelheim Pharma |
Compuestos de carbamato y oxamida como inhibidores de la produccion de citocina.
|
US7087614B2
(en)
|
2001-06-19 |
2006-08-08 |
Bristol-Myers Squibb Co. |
Pyrimidine inhibitors of phosphodiesterase (PDE) 7
|
US6603000B2
(en)
|
2001-07-11 |
2003-08-05 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Synthesis for heteroarylamine compounds
|
WO2003030909A1
(en)
|
2001-09-25 |
2003-04-17 |
Bayer Pharmaceuticals Corporation |
2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
|
WO2004078163A2
(en)
|
2003-02-28 |
2004-09-16 |
Transform Pharmaceuticals, Inc. |
Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
|
DE60314603T2
(de)
|
2002-03-15 |
2008-02-28 |
Vertex Pharmaceuticals Inc., Cambridge |
Zusammensetzungen brauchbar als protein-kinase-inhibitoren
|
DE60332604D1
(de)
|
2002-03-15 |
2010-07-01 |
Vertex Pharma |
Azolylaminoazine als proteinkinasehemmer
|
US7091343B2
(en)
|
2002-03-15 |
2006-08-15 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of protein kinases
|
ATE433973T1
(de)
|
2002-03-15 |
2009-07-15 |
Vertex Pharma |
Azolylaminoazine als inhibitoren von proteinkinasen
|
AU2003245669A1
(en)
|
2002-06-21 |
2004-01-06 |
Cellular Genomics, Inc. |
Certain aromatic monocycles as kinase modulators
|
JP2006510597A
(ja)
|
2002-09-27 |
2006-03-30 |
メルク エンド カムパニー インコーポレーテッド |
置換ピリミジン類
|
WO2004032716A2
(en)
|
2002-10-08 |
2004-04-22 |
Massachusetts Institute Of Technology |
Compounds for modulation of cholesterol transport
|
US7223870B2
(en)
|
2002-11-01 |
2007-05-29 |
Pfizer Inc. |
Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
|
ES2375111T3
(es)
|
2002-11-21 |
2012-02-24 |
Novartis Ag |
Pirimidinas 2,4,6-trisustituidas como inhibidores de fosfotidilinositol (pi) 3-quinasa y su uso en el tratamiento de c�?ncer.
|
WO2004084824A2
(en)
|
2003-03-24 |
2004-10-07 |
Merck & Co., Inc. |
Biaryl substituted 6-membered heterocyles as sodium channel blockers
|
US20050014753A1
(en)
|
2003-04-04 |
2005-01-20 |
Irm Llc |
Novel compounds and compositions as protein kinase inhibitors
|
CA2520323C
(en)
|
2003-04-09 |
2013-07-09 |
Exelixis, Inc. |
Tie-2 modulators and methods of use
|
CN1823048A
(zh)
|
2003-07-15 |
2006-08-23 |
神经能质公司 |
作为类香草醇受体配位体的经取代的嘧啶-4-基胺类似物
|
CA2531619A1
(en)
|
2003-07-16 |
2005-01-27 |
Neurogen Corporation |
Biaryl piperazinyl-pyridine analogues
|
PE20050952A1
(es)
|
2003-09-24 |
2005-12-19 |
Novartis Ag |
Derivados de isoquinolina como inhibidores de b-raf
|
DE602005024382D1
(de)
|
2004-04-13 |
2010-12-09 |
Astellas Pharma Inc |
Polycyclische pyrimidine als kaliumionenkanal-modulatoren
|
GB0415365D0
(en)
|
2004-07-09 |
2004-08-11 |
Astrazeneca Ab |
Pyrimidine derivatives
|
GB0415364D0
(en)
|
2004-07-09 |
2004-08-11 |
Astrazeneca Ab |
Pyrimidine derivatives
|
MY145822A
(en)
|
2004-08-13 |
2012-04-30 |
Neurogen Corp |
Substituted biaryl piperazinyl-pyridine analogues
|
US7652009B2
(en)
*
|
2004-11-30 |
2010-01-26 |
Amgem Inc. |
Substituted heterocycles and methods of use
|
AU2005322328A1
(en)
|
2004-12-13 |
2006-07-06 |
Neurogen Corporation |
Substituted biaryl analogues
|
CA2590299A1
(en)
|
2004-12-13 |
2006-06-22 |
Neurogen Corporation |
Piperazinyl-pyridine analogues
|
KR101328273B1
(ko)
|
2004-12-28 |
2013-11-14 |
키넥스 파마슈티컬즈, 엘엘씨 |
세포 증식 질환의 치료를 위한 조성물 및 방법
|
JP2008528506A
(ja)
|
2005-01-19 |
2008-07-31 |
ニューロジェン・コーポレーション |
ヘテロアリール置換ピペラジニル−ピリジン類縁体
|
EP1877388A2
(en)
|
2005-02-25 |
2008-01-16 |
Kudos Pharmaceuticals Ltd |
Hydrazinomethyl, hydrazonomethyl and 5-membered heterocylic compounds which act as mtor inhibitors and their use as anti cancer agents
|
EP1871762A2
(en)
|
2005-04-18 |
2008-01-02 |
Neurogen Corporation |
Subtituted heteroaryl cb1 antagonists
|
GB2431156A
(en)
|
2005-10-11 |
2007-04-18 |
Piramed Ltd |
1-cyclyl-3-substituted- -benzenes and -azines as inhibitors of phosphatidylinositol 3-kinase
|
US20110034454A1
(en)
|
2006-01-11 |
2011-02-10 |
Allan Paul Dishington |
Morpholino pyrimidine derivatives and their use in therapy
|
JO2660B1
(en)
*
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
EP2012794B1
(en)
*
|
2006-04-13 |
2014-09-17 |
The Trustees of Columbia University in the City of New York |
Compositions and intraluminal devices for inhibiting vascular stenosis
|
TW200833342A
(en)
|
2006-12-28 |
2008-08-16 |
Basf Ag |
2-substituted pyrimidines I in therapy
|
US8173647B2
(en)
|
2007-02-06 |
2012-05-08 |
Gordana Atallah |
PI 3-kinase inhibitors and methods of their use
|
US7957951B2
(en)
|
2007-03-16 |
2011-06-07 |
Robert Bosch Gmbh |
Address translation system for use in a simulation environment
|
AR067478A1
(es)
|
2007-07-09 |
2009-10-14 |
Astrazeneca Ab |
Compuestos derivados de morfolina pirimidina
|
WO2009066084A1
(en)
|
2007-11-21 |
2009-05-28 |
F. Hoffmann-La Roche Ag |
2 -morpholinopyrimidines and their use as pi3 kinase inhibitors
|
KR20100131446A
(ko)
|
2008-03-05 |
2010-12-15 |
노파르티스 아게 |
Egfr 의존성 질환 또는 egfr 족 구성원을 표적으로 하는 작용제에 대한 내성을 획득한 질환의 치료를 위한 피리미딘 유도체의 용도
|
CA2925257C
(en)
|
2008-03-26 |
2019-04-30 |
Carlos Garcia-Echeverria |
5imidazoquinolines and pyrimidine derivatives as potent modulators of vegf-driven angiogenic processes
|
EP2276750A2
(en)
|
2008-03-27 |
2011-01-26 |
Auckland Uniservices Limited |
Substituted pyrimidines and triazines and their use in cancer therapy
|
EP2280948A1
(en)
|
2008-04-09 |
2011-02-09 |
Mitsubishi Tanabe Pharma Corporation |
Pyrimidine, pyridine and triazine derivatives as maxi-k channel openers.
|
GB0815369D0
(en)
|
2008-08-22 |
2008-10-01 |
Summit Corp Plc |
Compounds for treatment of duchenne muscular dystrophy
|
JP2012506898A
(ja)
|
2008-10-31 |
2012-03-22 |
ノバルティス アーゲー |
ホスファチジルイノシトール−3−キナーゼ(PI3K)阻害剤とmTOR阻害剤との併用剤
|
GB2465405A
(en)
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
WO2010068863A2
(en)
|
2008-12-12 |
2010-06-17 |
Cystic Fibrosis Foundation Therapeutics, Inc. |
Pyrimidine compounds and methods of making and using same
|
JP5747440B2
(ja)
|
2009-02-06 |
2015-07-15 |
住友化学株式会社 |
ヒドラジド化合物及びその有害生物防除用途
|
EP2394999B1
(en)
|
2009-02-06 |
2014-01-29 |
Nippon Shinyaku Co., Ltd. |
Aminopyrazine derivative and medicine
|
AU2010223919B2
(en)
|
2009-03-13 |
2016-03-31 |
Les Laboratoires Servier |
Methods and compositions for cell-proliferation-related disorders
|
WO2010120994A2
(en)
|
2009-04-17 |
2010-10-21 |
Wyeth Llc |
Ureidoaryl-and carbamoylaryl-morpholino- pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their synthesis
|
CA2760911A1
(en)
|
2009-05-19 |
2010-11-25 |
George E. Davis |
Compounds and methods for controlling fungi
|
EP2451802A1
(en)
|
2009-07-07 |
2012-05-16 |
Pathway Therapeutics, Inc. |
Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
|
AR077695A1
(es)
|
2009-08-04 |
2011-09-14 |
Schering Corp |
Derivados de pirimidina como inhibidores del factor ixa
|
AR077999A1
(es)
|
2009-09-02 |
2011-10-05 |
Vifor Int Ag |
Antagonistas de pirimidin y triazin-hepcidina
|
NZ598808A
(en)
|
2009-09-09 |
2014-07-25 |
Celgene Avilomics Res Inc |
Pi3 kinase inhibitors and uses thereof
|
EP2509600B1
(en)
|
2009-12-09 |
2017-08-02 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds for use in the treatment of cancer characterized as having an idh mutation
|
GB201004200D0
(en)
|
2010-03-15 |
2010-04-28 |
Univ Basel |
Spirocyclic compounds and their use as therapeutic agents and diagnostic probes
|
AR081331A1
(es)
|
2010-04-23 |
2012-08-08 |
Cytokinetics Inc |
Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
|
US9133123B2
(en)
|
2010-04-23 |
2015-09-15 |
Cytokinetics, Inc. |
Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
|
AR081626A1
(es)
|
2010-04-23 |
2012-10-10 |
Cytokinetics Inc |
Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
|
US20130109643A1
(en)
|
2010-05-10 |
2013-05-02 |
The Johns Hopkins University |
Metabolic inhibitor against tumors having an idh mutation
|
JP6081354B2
(ja)
|
2010-07-16 |
2017-02-15 |
アジオス ファーマシューティカルズ, インコーポレイテッド |
治療活性組成物およびそれらの使用方法
|
PL3040333T3
(pl)
|
2010-10-01 |
2019-03-29 |
Novartis Ag |
Krystaliczne postacie 5-(2,6-di-4-morfolinylo-4-pirymidynylo)-4-trifluorometylopirydyno-2-aminy, inhibitora pik3
|
NZ621551A
(en)
|
2010-10-18 |
2015-09-25 |
Cerenis Therapeutics Holding Sa |
Compounds, compositions and methods useful for cholesterol mobilisation
|
GB201106829D0
(en)
|
2011-04-21 |
2011-06-01 |
Proximagen Ltd |
Heterocyclic compounds
|
BR112013020159A2
(pt)
|
2011-02-11 |
2016-11-08 |
Dana Farber Cancer Inst Inc |
método para inibir células tumorais de hamartoma
|
CN102827073A
(zh)
|
2011-06-17 |
2012-12-19 |
安吉奥斯医药品有限公司 |
治疗活性组合物和它们的使用方法
|
MX2014002470A
(es)
|
2011-09-01 |
2014-07-24 |
Novartis Ag |
Inhibidor de pi3k para uso en el tratamiento de cancer de hueso o para prevenir la diseminacion metastasica de celulas de cancer primario en el hueso.
|
ES2645968T3
(es)
|
2011-09-27 |
2017-12-11 |
Novartis Ag |
3-(pirimidin-4-il)-oxazolidin-2-onas como inhibidores de IDH mutante
|
JP2014528446A
(ja)
|
2011-10-06 |
2014-10-27 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
1,3−置換アゼチジンpde10阻害剤
|
UY34632A
(es)
|
2012-02-24 |
2013-05-31 |
Novartis Ag |
Compuestos de oxazolidin- 2- ona y usos de los mismos
|
US10213432B2
(en)
*
|
2012-05-16 |
2019-02-26 |
Novartis Ag |
Dosage regimen for a PI-3 kinase inhibitor
|
KR20150017367A
(ko)
|
2012-06-06 |
2015-02-16 |
노파르티스 아게 |
종양 질환을 치료하기 위한 17-알파-히드록실라제 (c17,20-리아제) 억제제와 특이적 pi-3k 억제제의 조합물
|
WO2014028566A1
(en)
|
2012-08-16 |
2014-02-20 |
Novartis Ag |
Combination of pi3k inhibitor and c-met inhibitor
|
MX360703B
(es)
|
2012-10-23 |
2018-11-14 |
Novartis Ag |
Proceso mejorado para la elaboración de 5-(2, 6-di-4-morfolinil-4-pirimidinil)-4-trifluoro-metil-piridin-2-amin a.
|
US9296733B2
(en)
|
2012-11-12 |
2016-03-29 |
Novartis Ag |
Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
|
CN105263929B
(zh)
|
2013-03-14 |
2018-08-28 |
诺华股份有限公司 |
作为突变idh抑制剂的3-嘧啶-4-基-噁唑烷-2-酮化合物
|
CN105209460A
(zh)
|
2013-03-14 |
2015-12-30 |
诺华股份有限公司 |
作为突变idh抑制剂的3-嘧啶-4-基-噁唑烷-2-酮化合物
|
CN103483345B
(zh)
|
2013-09-25 |
2016-07-06 |
中山大学 |
Pi3k激酶抑制剂、包含其的药物组合物及其应用
|
CN103694218B
(zh)
|
2013-12-05 |
2016-04-27 |
中山大学 |
嘧啶化合物、pi3k抑制剂、包含pi3k抑制剂的药物组合物及应用
|