UY28341A1 - Proceso químico - Google Patents

Proceso químico

Info

Publication number
UY28341A1
UY28341A1 UY28341A UY28341A UY28341A1 UY 28341 A1 UY28341 A1 UY 28341A1 UY 28341 A UY28341 A UY 28341A UY 28341 A UY28341 A UY 28341A UY 28341 A1 UY28341 A1 UY 28341A1
Authority
UY
Uruguay
Prior art keywords
chemical process
useful
dihydroxyhept
hyperlipoproteinemia
enoic
Prior art date
Application number
UY28341A
Other languages
English (en)
Inventor
Crabb Jeffrey Norman
Horbury John
Taylor Nigel Philip
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33512687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY28341(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of UY28341A1 publication Critical patent/UY28341A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

En la presente se describe un proceso mejorado para la fabricación de sal de calcio de ácido (E)-7-(4-(4-fluorofenil)-6--isopropil-2-(metil(metilsulfonil)amino)pirimidin-5-il) (3R,5S) -3,5- dihidroxihept-6-enoico (1), que es útil para la producción de un producto farmacéutico útil en el tratamiento de, entre otros, hipercolesterolemia, hiperlipoproteinemia y aterosclerosis.
UY28341A 2003-06-05 2004-06-02 Proceso químico UY28341A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0312896.4A GB0312896D0 (en) 2003-06-05 2003-06-05 Chemical process
GBGB0324793.9A GB0324793D0 (en) 2003-06-05 2003-10-24 Chemical process

Publications (1)

Publication Number Publication Date
UY28341A1 true UY28341A1 (es) 2005-01-31

Family

ID=33512687

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28341A UY28341A1 (es) 2003-06-05 2004-06-02 Proceso químico

Country Status (26)

Country Link
US (1) US8063213B2 (es)
EP (1) EP1633727B1 (es)
JP (1) JP4651615B2 (es)
KR (1) KR101099934B1 (es)
CN (1) CN100422157C (es)
AR (1) AR044773A1 (es)
AT (1) ATE464297T1 (es)
AU (1) AU2004245291B2 (es)
BR (1) BRPI0410922B8 (es)
CA (1) CA2527314C (es)
CO (1) CO5640116A2 (es)
DE (1) DE602004026576D1 (es)
ES (1) ES2341858T3 (es)
GB (2) GB0312896D0 (es)
HK (1) HK1087405A1 (es)
IL (1) IL172075A (es)
IS (1) IS2751B (es)
MX (1) MXPA05013128A (es)
MY (1) MY140820A (es)
NO (1) NO332971B1 (es)
NZ (1) NZ543962A (es)
RU (1) RU2361864C2 (es)
SA (1) SA04250223B1 (es)
TW (1) TWI341310B (es)
UY (1) UY28341A1 (es)
WO (1) WO2004108691A1 (es)

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GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
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HU230981B1 (hu) * 2007-10-12 2019-08-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Eljárás rosuvastatin só előállítására
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EP2138165A1 (en) 2008-06-27 2009-12-30 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising a statin
ES2657416T3 (es) 2008-06-27 2018-03-05 Krka, Torvarna Zdravil, D.D., Novo Mesto Composición farmacéutica que comprende una estatina
RU2011112541A (ru) * 2008-09-09 2012-10-20 Биокон Лимитед (In) Способ получения кальциевой соли (3r,5s,6e)6-{2-[4-(4фторфенил)-6-изопропил-2-(метансульфонилметиламино)-пиримидин-5-ил]-винил}-2,2-диметил-[1,3]-диоксан-4-ил)-уксусной кислоты(ацетонид розувастатина кальция)
EP2373609B1 (en) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
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CN105753834B (zh) * 2016-03-25 2018-08-21 河南师范大学 一种瑞舒伐他汀钙关键手性中间体的合成方法

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Also Published As

Publication number Publication date
ES2341858T3 (es) 2010-06-29
NO332971B1 (no) 2013-02-11
AU2004245291A1 (en) 2004-12-16
JP2006526602A (ja) 2006-11-24
TW200510337A (en) 2005-03-16
GB0312896D0 (en) 2003-07-09
AR044773A1 (es) 2005-10-05
CN1798741A (zh) 2006-07-05
BRPI0410922B1 (pt) 2016-02-23
JP4651615B2 (ja) 2011-03-16
CN100422157C (zh) 2008-10-01
CA2527314C (en) 2012-02-21
NO20055730D0 (no) 2005-12-05
BRPI0410922B8 (pt) 2021-05-25
AU2004245291B2 (en) 2008-02-14
MXPA05013128A (es) 2006-03-16
DE602004026576D1 (de) 2010-05-27
HK1087405A1 (en) 2006-10-13
US20080221323A1 (en) 2008-09-11
KR20060017848A (ko) 2006-02-27
BRPI0410922A (pt) 2006-06-27
IS2751B (is) 2011-09-15
CO5640116A2 (es) 2006-05-31
KR101099934B1 (ko) 2011-12-28
EP1633727B1 (en) 2010-04-14
MY140820A (en) 2010-01-29
NZ543962A (en) 2008-09-26
SA04250223B1 (ar) 2008-12-23
IL172075A (en) 2011-06-30
EP1633727A1 (en) 2006-03-15
ATE464297T1 (de) 2010-04-15
RU2005138370A (ru) 2006-07-10
GB0324793D0 (en) 2003-11-26
CA2527314A1 (en) 2004-12-16
TWI341310B (en) 2011-05-01
NO20055730L (no) 2005-12-27
US8063213B2 (en) 2011-11-22
WO2004108691A1 (en) 2004-12-16
RU2361864C2 (ru) 2009-07-20
IS8217A (is) 2006-01-02

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