CO5640116A2 - Produccion mejorada de sal de calcio de rosuvastatina - Google Patents

Produccion mejorada de sal de calcio de rosuvastatina

Info

Publication number
CO5640116A2
CO5640116A2 CO05122683A CO05122683A CO5640116A2 CO 5640116 A2 CO5640116 A2 CO 5640116A2 CO 05122683 A CO05122683 A CO 05122683A CO 05122683 A CO05122683 A CO 05122683A CO 5640116 A2 CO5640116 A2 CO 5640116A2
Authority
CO
Colombia
Prior art keywords
calcium salt
acid
pyrimidin
isopropyl
amino
Prior art date
Application number
CO05122683A
Other languages
English (en)
Inventor
Jeffrey Norman Crabb
John Horbury
Nigel Philip Taylor
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33512687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5640116(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of CO5640116A2 publication Critical patent/CO5640116A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1.- Un proceso para la formación de sal de calcio de ácido (E)-7-[4-(4-ftuorofenil)-6-isopropil-2[metil(metilsulfonil)amino]pirimidin-5-il](3R,5S)-3,5-dihidroxihept-6-enoico, que comprende los pasos a) a g):a) reacción de un (1-6C)alquiléster de ácido (E)-(6-{2- [4- (4-fluorofenil)-6-isopropil-2-[metiI (metiIsulfoniI)amino ]pirimidin-5-il] viniI} ( 4R, 6S)- 2,2-dimetil [1-3]dioxan-4-il) acético en un disolvente orgánico miscible en agua con ácido acuoso a una temperatura elevada;b) reacción de la solución resultante con un hidróxido de metal alcalino acuoso y lavar opcionalmente la solución resultante de sal de metal alcalino acuoso con un disolvente orgánico apropiado;c) ajuste del pH de la solución resultante a entre pH 6 y pH 11; d) retiro del disolvente orgánico miscible en agua; e) filtración opcional de la mezcla resultante;f) adición de una sal de calcio soluble en agua al filtrado para formar sal de calcio de ácido (E)-7-[4- (4-ftuorofenil)-6-isopropil-2-[metil (metilsulfonil)amino]pirimidin-5-il] (3R,5S)-3,5-dihidroxihept -6-enoico; y aislamiento del producto del paso f).
CO05122683A 2003-06-05 2005-12-02 Produccion mejorada de sal de calcio de rosuvastatina CO5640116A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0312896.4A GB0312896D0 (en) 2003-06-05 2003-06-05 Chemical process
GBGB0324793.9A GB0324793D0 (en) 2003-06-05 2003-10-24 Chemical process

Publications (1)

Publication Number Publication Date
CO5640116A2 true CO5640116A2 (es) 2006-05-31

Family

ID=33512687

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05122683A CO5640116A2 (es) 2003-06-05 2005-12-02 Produccion mejorada de sal de calcio de rosuvastatina

Country Status (26)

Country Link
US (1) US8063213B2 (es)
EP (1) EP1633727B1 (es)
JP (1) JP4651615B2 (es)
KR (1) KR101099934B1 (es)
CN (1) CN100422157C (es)
AR (1) AR044773A1 (es)
AT (1) ATE464297T1 (es)
AU (1) AU2004245291B2 (es)
BR (1) BRPI0410922B8 (es)
CA (1) CA2527314C (es)
CO (1) CO5640116A2 (es)
DE (1) DE602004026576D1 (es)
ES (1) ES2341858T3 (es)
GB (2) GB0312896D0 (es)
HK (1) HK1087405A1 (es)
IL (1) IL172075A (es)
IS (1) IS2751B (es)
MX (1) MXPA05013128A (es)
MY (1) MY140820A (es)
NO (1) NO332971B1 (es)
NZ (1) NZ543962A (es)
RU (1) RU2361864C2 (es)
SA (1) SA04250223B1 (es)
TW (1) TWI341310B (es)
UY (1) UY28341A1 (es)
WO (1) WO2004108691A1 (es)

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Also Published As

Publication number Publication date
AU2004245291A1 (en) 2004-12-16
IS8217A (is) 2006-01-02
ES2341858T3 (es) 2010-06-29
TW200510337A (en) 2005-03-16
AR044773A1 (es) 2005-10-05
JP4651615B2 (ja) 2011-03-16
IL172075A (en) 2011-06-30
IS2751B (is) 2011-09-15
BRPI0410922A (pt) 2006-06-27
EP1633727B1 (en) 2010-04-14
CA2527314A1 (en) 2004-12-16
SA04250223B1 (ar) 2008-12-23
GB0324793D0 (en) 2003-11-26
MXPA05013128A (es) 2006-03-16
RU2361864C2 (ru) 2009-07-20
MY140820A (en) 2010-01-29
CN100422157C (zh) 2008-10-01
BRPI0410922B1 (pt) 2016-02-23
KR20060017848A (ko) 2006-02-27
JP2006526602A (ja) 2006-11-24
GB0312896D0 (en) 2003-07-09
DE602004026576D1 (de) 2010-05-27
US20080221323A1 (en) 2008-09-11
CA2527314C (en) 2012-02-21
NO20055730L (no) 2005-12-27
EP1633727A1 (en) 2006-03-15
AU2004245291B2 (en) 2008-02-14
NO20055730D0 (no) 2005-12-05
HK1087405A1 (en) 2006-10-13
RU2005138370A (ru) 2006-07-10
ATE464297T1 (de) 2010-04-15
KR101099934B1 (ko) 2011-12-28
TWI341310B (en) 2011-05-01
WO2004108691A1 (en) 2004-12-16
US8063213B2 (en) 2011-11-22
NO332971B1 (no) 2013-02-11
UY28341A1 (es) 2005-01-31
CN1798741A (zh) 2006-07-05
NZ543962A (en) 2008-09-26
BRPI0410922B8 (pt) 2021-05-25

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