CY1109173T1 - Κρυσταλλικη μορφη του δις [(ε)-7-[4-(4-φθοροφαινυλ)-6-ισοπροπυλ-2-[μεθυλ(μεθυλσουλφονυλ)αμινο]πυριμιδιν-5-υλ](3r,5s)-3,5-διϋδροξυεπτ-6-ενοϊκο οξυ] αλατος ασβεστιου - Google Patents

Κρυσταλλικη μορφη του δις [(ε)-7-[4-(4-φθοροφαινυλ)-6-ισοπροπυλ-2-[μεθυλ(μεθυλσουλφονυλ)αμινο]πυριμιδιν-5-υλ](3r,5s)-3,5-διϋδροξυεπτ-6-ενοϊκο οξυ] αλατος ασβεστιου

Info

Publication number
CY1109173T1
CY1109173T1 CY20091100661T CY091100661T CY1109173T1 CY 1109173 T1 CY1109173 T1 CY 1109173T1 CY 20091100661 T CY20091100661 T CY 20091100661T CY 091100661 T CY091100661 T CY 091100661T CY 1109173 T1 CY1109173 T1 CY 1109173T1
Authority
CY
Cyprus
Prior art keywords
methylsulfonyl
pyrimidin
fluorophenyl
isopropyl
bis
Prior art date
Application number
CY20091100661T
Other languages
English (en)
Inventor
Rebecca Jane Booth
Peter Anthony Cittern
Jeffrey Norman Crabb
John Horbury
David Wyn Calvert Jones
Original Assignee
Astrazeneca Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34276833&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109173(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0321127A external-priority patent/GB0321127D0/en
Priority claimed from GB0404859A external-priority patent/GB0404859D0/en
Application filed by Astrazeneca Uk Limited filed Critical Astrazeneca Uk Limited
Publication of CY1109173T1 publication Critical patent/CY1109173T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Περιγράφονται δύο πολυμορφικές μορφές του δις[(Ε)-7-[4-(4-φθοροφαινυλ)6-ισοπροπυλ-2-[μεθυλ(μεθυλσουλφονυλ)αμινο]πυριμιδιν-5-υλ](3R,5S)-3,5-διϋδροξυεπτ-6-ενοϊκο οξυ] άλατος ασβεστίου, διεργασίες για την παρασκευή τους και η χρήση τους ως αναστολείς HMG Co-A ρεδουκτάσης.
CY20091100661T 2003-09-10 2009-06-24 Κρυσταλλικη μορφη του δις [(ε)-7-[4-(4-φθοροφαινυλ)-6-ισοπροπυλ-2-[μεθυλ(μεθυλσουλφονυλ)αμινο]πυριμιδιν-5-υλ](3r,5s)-3,5-διϋδροξυεπτ-6-ενοϊκο οξυ] αλατος ασβεστιου CY1109173T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0321127A GB0321127D0 (en) 2003-09-10 2003-09-10 Chemical compounds
GB0404859A GB0404859D0 (en) 2004-03-04 2004-03-04 Chemical compound
EP04768376A EP1663989B1 (en) 2003-09-10 2004-09-08 CRYSTALLINE FORM OF BIS (E)-7- 4-(4-FLUOROPHENYL)-6-IS OPROPYL-2- METHYL(METHYLSULFONYL)AMINO PYRIMIDIN-5-YL&r sqb;(3R,5S)-3,5-DIHYDROXYHEPT-6 -ENOICACID CALCIUM SALT

Publications (1)

Publication Number Publication Date
CY1109173T1 true CY1109173T1 (el) 2014-07-02

Family

ID=34276833

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100661T CY1109173T1 (el) 2003-09-10 2009-06-24 Κρυσταλλικη μορφη του δις [(ε)-7-[4-(4-φθοροφαινυλ)-6-ισοπροπυλ-2-[μεθυλ(μεθυλσουλφονυλ)αμινο]πυριμιδιν-5-υλ](3r,5s)-3,5-διϋδροξυεπτ-6-ενοϊκο οξυ] αλατος ασβεστιου

Country Status (32)

Country Link
US (4) US20060293355A1 (el)
EP (1) EP1663989B1 (el)
JP (1) JP2007505090A (el)
KR (1) KR20070019943A (el)
CN (1) CN1878760B (el)
AR (1) AR045628A1 (el)
AT (1) ATE428701T1 (el)
AU (1) AU2004270467B8 (el)
BR (1) BRPI0414236A (el)
CA (1) CA2537962C (el)
CO (1) CO5670355A2 (el)
CY (1) CY1109173T1 (el)
DE (1) DE602004020640D1 (el)
DK (1) DK1663989T3 (el)
ES (1) ES2324042T3 (el)
HK (1) HK1090361A1 (el)
HR (1) HRP20090335T1 (el)
IL (1) IL174073A (el)
IS (1) IS2689B (el)
MX (1) MXPA06002761A (el)
MY (1) MY142615A (el)
NO (1) NO336358B1 (el)
NZ (1) NZ545785A (el)
PL (1) PL1663989T3 (el)
PT (1) PT1663989E (el)
RU (1) RU2363697C2 (el)
SA (1) SA04250297B1 (el)
SI (1) SI1663989T1 (el)
TW (1) TWI370817B (el)
UA (1) UA85062C2 (el)
UY (1) UY28501A1 (el)
WO (1) WO2005023779A1 (el)

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Also Published As

Publication number Publication date
US20120059022A1 (en) 2012-03-08
RU2006111354A (ru) 2007-10-27
WO2005023779A1 (en) 2005-03-17
RU2363697C2 (ru) 2009-08-10
NO336358B1 (no) 2015-08-03
CA2537962C (en) 2012-10-23
TWI370817B (en) 2012-08-21
MY142615A (en) 2010-12-15
BRPI0414236A (pt) 2006-10-31
CO5670355A2 (es) 2006-08-31
NO20061181L (no) 2006-03-29
KR20070019943A (ko) 2007-02-16
UY28501A1 (es) 2005-04-29
IS2689B (is) 2010-10-15
PT1663989E (pt) 2009-06-09
AU2004270467B2 (en) 2008-08-21
US8436167B2 (en) 2013-05-07
IS8385A (is) 2006-03-30
ES2324042T3 (es) 2009-07-29
SA04250297B1 (ar) 2008-11-18
NZ545785A (en) 2010-03-26
ATE428701T1 (de) 2009-05-15
AR045628A1 (es) 2005-11-02
EP1663989B1 (en) 2009-04-15
MXPA06002761A (es) 2006-12-14
PL1663989T3 (pl) 2009-08-31
TW200526595A (en) 2005-08-16
US20100222373A1 (en) 2010-09-02
US20130225622A1 (en) 2013-08-29
DE602004020640D1 (de) 2009-05-28
CN1878760B (zh) 2011-11-09
CN1878760A (zh) 2006-12-13
HK1090361A1 (en) 2006-12-22
DK1663989T3 (da) 2009-07-06
IL174073A (en) 2014-03-31
AU2004270467A1 (en) 2005-03-17
JP2007505090A (ja) 2007-03-08
HRP20090335T1 (en) 2009-07-31
CA2537962A1 (en) 2005-03-17
AU2004270467B8 (en) 2008-09-18
SI1663989T1 (sl) 2009-08-31
US20060293355A1 (en) 2006-12-28
IL174073A0 (en) 2006-08-01
UA85062C2 (uk) 2008-12-25
EP1663989A1 (en) 2006-06-07

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