DK1663989T3 - Krystallisk form af bis(E)-7-[4(4-fluorphenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidin-5-yl(3R,5S))-3-5-dihydroxyhept-6-ensyrecalciumsalt - Google Patents

Krystallisk form af bis(E)-7-[4(4-fluorphenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidin-5-yl(3R,5S))-3-5-dihydroxyhept-6-ensyrecalciumsalt

Info

Publication number
DK1663989T3
DK1663989T3 DK04768376T DK04768376T DK1663989T3 DK 1663989 T3 DK1663989 T3 DK 1663989T3 DK 04768376 T DK04768376 T DK 04768376T DK 04768376 T DK04768376 T DK 04768376T DK 1663989 T3 DK1663989 T3 DK 1663989T3
Authority
DK
Denmark
Prior art keywords
dihydroxyhept
aminopyrimidin
methylsulfonyl
fluorophenyl
isopropyl
Prior art date
Application number
DK04768376T
Other languages
Danish (da)
English (en)
Inventor
Rebecca Jane Booth
Peter Anthony Cittern
Jeffrey Norman Crabb
John Horbury
David Wyn Calvert Jones
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34276833&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1663989(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0321127A external-priority patent/GB0321127D0/en
Priority claimed from GB0404859A external-priority patent/GB0404859D0/en
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Application granted granted Critical
Publication of DK1663989T3 publication Critical patent/DK1663989T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
DK04768376T 2003-09-10 2004-09-08 Krystallisk form af bis(E)-7-[4(4-fluorphenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidin-5-yl(3R,5S))-3-5-dihydroxyhept-6-ensyrecalciumsalt DK1663989T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0321127A GB0321127D0 (en) 2003-09-10 2003-09-10 Chemical compounds
GB0404859A GB0404859D0 (en) 2004-03-04 2004-03-04 Chemical compound
PCT/GB2004/003829 WO2005023779A1 (en) 2003-09-10 2004-09-08 Crystalline form of bis [(e)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6 -enoicacid] calcium salt

Publications (1)

Publication Number Publication Date
DK1663989T3 true DK1663989T3 (da) 2009-07-06

Family

ID=34276833

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04768376T DK1663989T3 (da) 2003-09-10 2004-09-08 Krystallisk form af bis(E)-7-[4(4-fluorphenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidin-5-yl(3R,5S))-3-5-dihydroxyhept-6-ensyrecalciumsalt

Country Status (32)

Country Link
US (4) US20060293355A1 (el)
EP (1) EP1663989B1 (el)
JP (1) JP2007505090A (el)
KR (1) KR20070019943A (el)
CN (1) CN1878760B (el)
AR (1) AR045628A1 (el)
AT (1) ATE428701T1 (el)
AU (1) AU2004270467B8 (el)
BR (1) BRPI0414236A (el)
CA (1) CA2537962C (el)
CO (1) CO5670355A2 (el)
CY (1) CY1109173T1 (el)
DE (1) DE602004020640D1 (el)
DK (1) DK1663989T3 (el)
ES (1) ES2324042T3 (el)
HK (1) HK1090361A1 (el)
HR (1) HRP20090335T1 (el)
IL (1) IL174073A (el)
IS (1) IS2689B (el)
MX (1) MXPA06002761A (el)
MY (1) MY142615A (el)
NO (1) NO336358B1 (el)
NZ (1) NZ545785A (el)
PL (1) PL1663989T3 (el)
PT (1) PT1663989E (el)
RU (1) RU2363697C2 (el)
SA (1) SA04250297B1 (el)
SI (1) SI1663989T1 (el)
TW (1) TWI370817B (el)
UA (1) UA85062C2 (el)
UY (1) UY28501A1 (el)
WO (1) WO2005023779A1 (el)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
DK1417180T3 (da) 2001-07-13 2007-04-10 Astrazeneca Uk Ltd Fremstilling af aminopyrimidinforbindelser
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
KR101060215B1 (ko) 2002-12-16 2011-08-29 아스트라제네카 유케이 리미티드 피리미딘 화합물의 제조 방법
GB0312896D0 (en) * 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
JP2008539278A (ja) * 2006-09-18 2008-11-13 テバ ファーマシューティカル インダストリーズ リミティド 結晶性ロスバスタチンカルシウム
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
EP2752407B1 (en) * 2009-01-14 2015-09-23 Krka Tovarna Zdravil, D.D., Novo Mesto Crystalline rosuvastatin calcium trihydrate
MX2011007478A (es) * 2009-01-15 2011-09-15 Sag Egis Gyogyszergyar Nylvanosan Muekoedoe Reszvenytarsa Proceso para la preparacion de sales de rosuvastatina.
HUP0900285A2 (en) 2009-05-07 2011-01-28 Egis Gyogyszergyar Nyilvanosan Mukoedoe Reszvenytarsasag Rosuvastatin salts and preparation thereof
WO2011074016A1 (en) 2009-12-17 2011-06-23 Matrix Laboratories Ltd Novel polymorphic forms of rosuvastatin calcium and process for preparation of the same
HU230737B1 (hu) 2010-11-16 2018-01-29 EGIS Gyógyszergyár Nyrt Eljárás rosuvastatin só előállítására
EP2643305A1 (en) 2010-11-22 2013-10-02 Basf Se Multicomponent system of rosuvastatin calcium salt and sorbitol
CA2832343A1 (en) 2011-04-18 2012-10-26 Basf Se Multicomponent crystalline system of rosuvastatin calcium salt and vanillin
WO2014050874A1 (ja) * 2012-09-27 2014-04-03 東和薬品株式会社 ロスバスタチンカルシウムの新規結晶形態およびその製造方法
RO129060B1 (ro) 2013-04-25 2014-11-28 Antibiotice S.A. Compoziţie farmaceutică stabilă cu rosuvastatină calcică amorfă
EP3103878A4 (en) 2014-02-06 2017-08-16 API Corporation Rosuvastatin calcium and process for producing intermediate thereof
HUE061878T2 (hu) * 2016-04-18 2023-08-28 Morepen Laboratories Ltd A kristályos rozuvasztatin kalcium új polimorf formája és új eljárások a kristályos és amorf rozuvasztatin kalcium elõállítására
CN105837516B (zh) * 2016-05-16 2018-07-10 山东新时代药业有限公司 一种瑞舒伐他汀钙晶型及其制备方法
US11446757B2 (en) 2017-09-13 2022-09-20 Jfe Steel Corporation Double-sided friction stir welding method for metal sheets and double-sided friction stir welding device

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4645858A (en) * 1982-03-22 1987-02-24 G. D. Searle & Co. Pentanedioic acid derivatives
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
EP0367895A1 (en) 1988-10-06 1990-05-16 Sandoz Ag Pyrimidinyl-substituted hydroxyacids, lactones and esters and pharmaceutical compositions containing them
US5026698A (en) * 1988-11-02 1991-06-25 Nissan Chemical Industries, Ltd. Thienopyridine type mevalonolactones
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
WO1993008823A1 (en) 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
DE59307409D1 (de) * 1992-07-02 1997-10-30 Hoechst Ag Verfahren zur Herstellung von (3R,5S)6-Hydroxy-3,5-0-isopropyliden-3,5-dihydroxy-hexansäure-tert.-butylester
BR9609872A (pt) 1995-07-17 1999-03-23 Warner Lambert Co Hemi sal de cálcio de ácido (R-(R*R*)]-2-(4-fluorfenil-)-beta delta-diidróxi-5-(1-metiletil)-3-fenil-4- [(fenilamino) carbonil]-1H- pirrol-1heptanóico (atorvasta-tina)c ristalino
FR2741620B1 (fr) 1995-11-28 1997-12-26 Oreal Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline
US6278001B1 (en) * 1995-11-28 2001-08-21 L'oréal Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping
ES2194202T3 (es) 1996-06-24 2003-11-16 Novartis Ag Compuestos polimorfos.
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
JP4440476B2 (ja) * 1998-12-10 2010-03-24 株式会社カネカ シンバスタチンの製造方法
GB9900339D0 (en) * 1999-01-09 1999-02-24 Zeneca Ltd Chemical compounds
GB9903472D0 (en) * 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
AU7717500A (en) 1999-09-30 2001-04-30 Merck & Co., Inc. Anti-hypercholesterolemic drug combination
ATE288893T1 (de) 1999-11-17 2005-02-15 Teva Pharma Polymorphe form von atorvastatin-calcium
GB0001621D0 (en) 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
AU2000254249A1 (en) 2000-03-28 2001-10-08 Biocon India Limited Synthesis of (r-(r*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
GB0011163D0 (en) 2000-05-10 2000-06-28 Astrazeneca Ab Chemical compound
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
JP3737801B2 (ja) 2000-10-05 2006-01-25 テバ ジョジセルジャール レースベニュタールシャシャーグ プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウム、並びにそれを含む組成物
KR100877165B1 (ko) 2000-11-16 2009-01-07 테바 파마슈티컬 인더스트리즈 리미티드 수산화 칼슘을 이용한[Ｒ(Ｒ*,Ｒ*)]-2-(4-플루오로페닐)-β,δ-디하이드록시-5-(1-메틸에틸)-3-페닐-4-[(페닐아미노)카보닐]-1Ｈ-피롤-1-헵탄산 에스테르의 가수분해
US6777552B2 (en) * 2001-08-16 2004-08-17 Teva Pharmaceutical Industries, Ltd. Processes for preparing calcium salt forms of statins
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
NL1017548C2 (nl) 2001-03-09 2002-09-10 Synthon Bv Een lactonisatie proces.
IN190564B (el) 2001-04-11 2003-08-09 Cadila Heathcare Ltd
TR200400600T3 (tr) * 2001-06-06 2004-06-21 Bristol-Myers Squibb Company Kiral diol sülfonlar ve dihidroksi asit HMG COA redüktaz inhibitörlerinin hazırlanmsı için işlem
DK1417180T3 (da) * 2001-07-13 2007-04-10 Astrazeneca Uk Ltd Fremstilling af aminopyrimidinforbindelser
CA2450820C (en) 2001-08-16 2011-03-15 Teva Pharmaceutical Industries Ltd. Processes for preparing calcium salt forms of statins
JP2005503393A (ja) 2001-08-22 2005-02-03 チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド インドール誘導体の製造方法
US7407772B2 (en) 2001-09-24 2008-08-05 Merck & Co., Inc. Screening and selection methods for statin drug combinations
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
KR100511533B1 (ko) 2002-04-09 2005-08-31 임광민 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법
BR0311195A (pt) 2002-05-21 2005-02-22 Ranbaxy Lab Ltd Processo de preparação de rosuvastatina
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
DE10228103A1 (de) 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
KR101060215B1 (ko) 2002-12-16 2011-08-29 아스트라제네카 유케이 리미티드 피리미딘 화합물의 제조 방법
GB0312896D0 (en) * 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) * 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
DE10352659B4 (de) 2003-11-11 2007-09-13 Ratiopharm Gmbh Verfahren zur Herstellung von Statinen und Tetrahydropyranonderivate zur Verwendung in dem Verfahren
WO2005054207A1 (en) * 2003-12-04 2005-06-16 Glenmark Pharmaceuticals Limited Process for the preparation of pyrimidine derivatives
US7241800B2 (en) * 2004-03-17 2007-07-10 Mai De Ltd. Anhydrous amorphous form of fluvastatin sodium
US7161004B2 (en) * 2004-06-21 2007-01-09 Dr. Reddy's Laboratories Limited Processes to produce intermediates for rosuvastatin
WO2006000020A1 (en) 2004-06-29 2006-01-05 European Nickel Plc Improved leaching of base metals
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
JP5058991B2 (ja) 2005-06-29 2012-10-24 コンプメディクス リミテッド 導電ブリッジを備えるセンサ・アセンブリ
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process

Also Published As

Publication number Publication date
US20120059022A1 (en) 2012-03-08
IS2689B (is) 2010-10-15
AU2004270467B2 (en) 2008-08-21
US20130225622A1 (en) 2013-08-29
ES2324042T3 (es) 2009-07-29
PL1663989T3 (pl) 2009-08-31
JP2007505090A (ja) 2007-03-08
PT1663989E (pt) 2009-06-09
SI1663989T1 (sl) 2009-08-31
US20060293355A1 (en) 2006-12-28
KR20070019943A (ko) 2007-02-16
AR045628A1 (es) 2005-11-02
RU2006111354A (ru) 2007-10-27
TW200526595A (en) 2005-08-16
IL174073A0 (en) 2006-08-01
NO20061181L (no) 2006-03-29
HRP20090335T1 (en) 2009-07-31
CO5670355A2 (es) 2006-08-31
UA85062C2 (uk) 2008-12-25
US20100222373A1 (en) 2010-09-02
WO2005023779A1 (en) 2005-03-17
DE602004020640D1 (de) 2009-05-28
AU2004270467A1 (en) 2005-03-17
CN1878760A (zh) 2006-12-13
CA2537962C (en) 2012-10-23
CY1109173T1 (el) 2014-07-02
BRPI0414236A (pt) 2006-10-31
RU2363697C2 (ru) 2009-08-10
AU2004270467B8 (en) 2008-09-18
HK1090361A1 (en) 2006-12-22
IL174073A (en) 2014-03-31
SA04250297B1 (ar) 2008-11-18
TWI370817B (en) 2012-08-21
CA2537962A1 (en) 2005-03-17
MY142615A (en) 2010-12-15
EP1663989B1 (en) 2009-04-15
MXPA06002761A (es) 2006-12-14
EP1663989A1 (en) 2006-06-07
UY28501A1 (es) 2005-04-29
CN1878760B (zh) 2011-11-09
ATE428701T1 (de) 2009-05-15
IS8385A (is) 2006-03-30
NZ545785A (en) 2010-03-26
NO336358B1 (no) 2015-08-03
US8436167B2 (en) 2013-05-07

Similar Documents

Publication Publication Date Title
DK1663989T3 (da) Krystallisk form af bis(E)-7-[4(4-fluorphenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidin-5-yl(3R,5S))-3-5-dihydroxyhept-6-ensyrecalciumsalt
DK1263739T3 (da) Krystallinske salte af 7-[4-(4-fluorphenyl)-6-isopropyl-2-methyl(methylsulfonyl) aminopyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoinsyre
DK1682536T3 (da) Fremgangsmåde til fremstilling af calciumsaltet af rosuvastatin (e)-7-[4-(4-fluorphenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-ensyre og krystallinske mellemprodukter deraf
DK1539711T3 (da) Fremgangsmåde til fremstilling af calciumsaltet af rosuvastatin
IS8217A (is) Bætt framleiðsla rósúvastatínkalsíumsalts
DK1817301T3 (da) Forstærkere af glutamat-receptorer
ME01992B (me) Jedinjenje diarilhidantoina
DK1897546T3 (da) Kombinerede sammensætninger omfattende (E)-7-[4-(4-fluorphenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3r,5s]-3,5-dihydroxyhept-6-enoinsyre
DK1505998T3 (da) Forbedret anvendelse af hop-syrer som antimikrobielle midler
DK1417180T3 (da) Fremstilling af aminopyrimidinforbindelser
DK1827483T3 (da) Terapeutiske formuleringer af keratinocyt-vækstfaktor
DK1622612T3 (da) Farmaceutisk formulering af natriumsaltet af telmitarsan
DK1600441T3 (da) Krystallinsk form af elrcanidipinhydrochlorid til anvendelse som et antihypertensivt middel
DK1578731T3 (da) Fremgangsmåde til fremstilling af pyrimidinforbindelser
ATE517623T1 (de) Verwendung von methylphenidat-derivaten
DK1513806T3 (da) Sulfonsyresalte af sulfonsyrederivater
DE60220993D1 (de) Kristalline zusammensetzungen von dotiertem aluminiumphosphat
DK1656358T3 (da) Stabil polymorf af bifeprunox-mesilat
DK1497290T3 (da) Fremgangsmåde til fremstilling af syresalte af gemifloxacin
DK1515959T3 (da) Farmaceutiske salte af reboxetin
ITMI20030018A1 (it) Procedimento per la preparazione di composti mono-
ATE497497T1 (de) 1,2,4-triazolderivat, verfahren zu dessenherstellung, und dieses enthaltende pharmazeutische zusammensetzung
DK1622629T3 (da) Strontiumsaltsammensætning med kontrolleret frisætning
ATE556047T1 (de) Kristalline feste form der (2s-5z)-2-amino-7-