US20140345631A1 - Nicotine salt formulations for aerosol devices and methods thereof - Google Patents
Nicotine salt formulations for aerosol devices and methods thereof Download PDFInfo
- Publication number
- US20140345631A1 US20140345631A1 US14/271,071 US201414271071A US2014345631A1 US 20140345631 A1 US20140345631 A1 US 20140345631A1 US 201414271071 A US201414271071 A US 201414271071A US 2014345631 A1 US2014345631 A1 US 2014345631A1
- Authority
- US
- United States
- Prior art keywords
- acid
- nicotine
- nicotine salt
- electronic cigarette
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical class CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 1296
- 239000000443 aerosol Substances 0.000 title claims abstract description 162
- 239000000203 mixture Substances 0.000 title claims description 546
- 238000009472 formulation Methods 0.000 title claims description 424
- 238000000034 method Methods 0.000 title claims description 155
- 229960002715 nicotine Drugs 0.000 claims abstract description 451
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 447
- 239000003571 electronic cigarette Substances 0.000 claims abstract description 423
- 239000012669 liquid formulation Substances 0.000 claims abstract description 342
- 239000002253 acid Substances 0.000 claims description 330
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 294
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 153
- 239000007788 liquid Substances 0.000 claims description 151
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 142
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 108
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims description 104
- 238000009835 boiling Methods 0.000 claims description 102
- 238000002844 melting Methods 0.000 claims description 102
- 230000008018 melting Effects 0.000 claims description 102
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims description 89
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 88
- 239000012458 free base Substances 0.000 claims description 74
- 235000011187 glycerol Nutrition 0.000 claims description 63
- 235000010233 benzoic acid Nutrition 0.000 claims description 61
- 239000005711 Benzoic acid Substances 0.000 claims description 60
- 235000019504 cigarettes Nutrition 0.000 claims description 56
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 54
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 53
- 229940107700 pyruvic acid Drugs 0.000 claims description 52
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 51
- 229940040102 levulinic acid Drugs 0.000 claims description 50
- 238000010438 heat treatment Methods 0.000 claims description 49
- 150000007524 organic acids Chemical class 0.000 claims description 46
- 235000013311 vegetables Nutrition 0.000 claims description 45
- 239000005639 Lauric acid Substances 0.000 claims description 44
- 229940075582 sorbic acid Drugs 0.000 claims description 43
- 239000004334 sorbic acid Substances 0.000 claims description 43
- 235000010199 sorbic acid Nutrition 0.000 claims description 43
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 35
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 32
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 32
- JOOXCMJARBKPKM-UHFFFAOYSA-M 4-oxopentanoate Chemical compound CC(=O)CCC([O-])=O JOOXCMJARBKPKM-UHFFFAOYSA-M 0.000 claims description 30
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 30
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 30
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 30
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 30
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 30
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 30
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 30
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 30
- 229940058352 levulinate Drugs 0.000 claims description 30
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 30
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 30
- MMOPGICOOYBFJU-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;2-oxopropanoic acid Chemical compound CC(=O)C(O)=O.CN1CCCC1C1=CC=CN=C1 MMOPGICOOYBFJU-UHFFFAOYSA-N 0.000 claims description 27
- VAUQRLHPXWYZRZ-PPHPATTJSA-N benzoic acid 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)c1ccccc1.CN1CCC[C@H]1c1cccnc1 VAUQRLHPXWYZRZ-PPHPATTJSA-N 0.000 claims description 23
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 22
- 239000002245 particle Substances 0.000 claims description 22
- AIBWPBUAKCMKNS-PPHPATTJSA-N 2-hydroxybenzoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C1=CC=CC=C1O.CN1CCC[C@H]1C1=CC=CN=C1 AIBWPBUAKCMKNS-PPHPATTJSA-N 0.000 claims description 21
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 21
- 235000011090 malic acid Nutrition 0.000 claims description 19
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 18
- 150000004715 keto acids Chemical class 0.000 claims description 18
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 17
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 17
- 235000011054 acetic acid Nutrition 0.000 claims description 17
- 239000011975 tartaric acid Substances 0.000 claims description 17
- 235000002906 tartaric acid Nutrition 0.000 claims description 17
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 16
- GJMKJBHRQDGHMT-UHFFFAOYSA-N C(C=CC=CC)(=O)O.N1=CC=CC(=C1)C1N(C)CCC1 Chemical compound C(C=CC=CC)(=O)O.N1=CC=CC(=C1)C1N(C)CCC1 GJMKJBHRQDGHMT-UHFFFAOYSA-N 0.000 claims description 16
- ZDBSZLXHLZRTGL-UHFFFAOYSA-N dodecanoic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CN1CCCC1C1=CC=CN=C1.CCCCCCCCCCCC(O)=O ZDBSZLXHLZRTGL-UHFFFAOYSA-N 0.000 claims description 16
- 235000019253 formic acid Nutrition 0.000 claims description 16
- 239000001630 malic acid Substances 0.000 claims description 16
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims description 15
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 15
- NAOLWIGVYRIGTP-UHFFFAOYSA-N 1,3,5-trihydroxyanthracene-9,10-dione Chemical compound C1=CC(O)=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1 NAOLWIGVYRIGTP-UHFFFAOYSA-N 0.000 claims description 15
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 claims description 15
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 15
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 15
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 15
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 15
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 15
- 239000005642 Oleic acid Substances 0.000 claims description 15
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 15
- 235000021314 Palmitic acid Nutrition 0.000 claims description 15
- 235000021355 Stearic acid Nutrition 0.000 claims description 15
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 15
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 15
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 15
- 239000001530 fumaric acid Substances 0.000 claims description 15
- 239000000174 gluconic acid Substances 0.000 claims description 15
- 235000012208 gluconic acid Nutrition 0.000 claims description 15
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 15
- 239000004310 lactic acid Substances 0.000 claims description 15
- 235000014655 lactic acid Nutrition 0.000 claims description 15
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 15
- 229960004488 linolenic acid Drugs 0.000 claims description 15
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 claims description 15
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 15
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 15
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 15
- 229960002446 octanoic acid Drugs 0.000 claims description 15
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 15
- 235000021313 oleic acid Nutrition 0.000 claims description 15
- 235000019260 propionic acid Nutrition 0.000 claims description 15
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 15
- 239000008117 stearic acid Substances 0.000 claims description 15
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims description 15
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 15
- 229940005605 valeric acid Drugs 0.000 claims description 15
- 239000012530 fluid Substances 0.000 description 88
- 239000000243 solution Substances 0.000 description 78
- 229960004365 benzoic acid Drugs 0.000 description 56
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 52
- 229960004889 salicylic acid Drugs 0.000 description 52
- 238000012360 testing method Methods 0.000 description 47
- 210000002381 plasma Anatomy 0.000 description 40
- 210000004369 blood Anatomy 0.000 description 37
- 239000008280 blood Substances 0.000 description 37
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 36
- 230000009972 noncorrosive effect Effects 0.000 description 26
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 24
- 239000000126 substance Substances 0.000 description 20
- 150000007513 acids Chemical class 0.000 description 19
- 229940050390 benzoate Drugs 0.000 description 18
- 239000000796 flavoring agent Substances 0.000 description 17
- 235000019634 flavors Nutrition 0.000 description 17
- 229940033355 lauric acid Drugs 0.000 description 17
- 230000001007 puffing effect Effects 0.000 description 17
- 229940049920 malate Drugs 0.000 description 16
- 150000003839 salts Chemical class 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 231100000252 nontoxic Toxicity 0.000 description 15
- 230000003000 nontoxic effect Effects 0.000 description 15
- -1 acetoacetic acid Chemical class 0.000 description 13
- VAUQRLHPXWYZRZ-UHFFFAOYSA-N benzoic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound OC(=O)C1=CC=CC=C1.CN1CCCC1C1=CC=CN=C1 VAUQRLHPXWYZRZ-UHFFFAOYSA-N 0.000 description 13
- 238000005755 formation reaction Methods 0.000 description 13
- 238000009834 vaporization Methods 0.000 description 13
- 230000008016 vaporization Effects 0.000 description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 12
- 230000015572 biosynthetic process Effects 0.000 description 12
- 229940099690 malic acid Drugs 0.000 description 12
- 125000005523 4-oxopentanoic acid group Chemical group 0.000 description 11
- 238000010521 absorption reaction Methods 0.000 description 11
- 229960001860 salicylate Drugs 0.000 description 11
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 11
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 11
- 238000012546 transfer Methods 0.000 description 11
- 230000005588 protonation Effects 0.000 description 10
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 10
- 241000208125 Nicotiana Species 0.000 description 9
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 238000004891 communication Methods 0.000 description 8
- AIBWPBUAKCMKNS-UHFFFAOYSA-N 2-carboxyphenolate;3-(1-methylpyrrolidin-2-yl)pyridin-1-ium Chemical compound OC(=O)C1=CC=CC=C1O.CN1CCCC1C1=CC=CN=C1 AIBWPBUAKCMKNS-UHFFFAOYSA-N 0.000 description 7
- SDVKWBNZJFWIMO-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CN1CCCC1C1=CC=CN=C1.OC(=O)CC(O)(C(O)=O)CC(O)=O SDVKWBNZJFWIMO-UHFFFAOYSA-N 0.000 description 7
- JDIZODRSTZHAFD-UHFFFAOYSA-N butanedioic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound OC(=O)CCC(O)=O.CN1CCCC1C1=CC=CN=C1 JDIZODRSTZHAFD-UHFFFAOYSA-N 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000000470 constituent Substances 0.000 description 6
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 5
- 241000282412 Homo Species 0.000 description 5
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 5
- 230000037058 blood plasma level Effects 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 5
- 229940070765 laurate Drugs 0.000 description 5
- 229940076788 pyruvate Drugs 0.000 description 5
- 229940075554 sorbate Drugs 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 230000003466 anti-cipated effect Effects 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 150000001735 carboxylic acids Chemical class 0.000 description 4
- 230000002996 emotional effect Effects 0.000 description 4
- 125000000468 ketone group Chemical group 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 229930182840 (S)-nicotine Natural products 0.000 description 3
- 150000004716 alpha keto acids Chemical class 0.000 description 3
- 150000004718 beta keto acids Chemical class 0.000 description 3
- 125000002843 carboxylic acid group Chemical group 0.000 description 3
- 150000004721 gamma keto acids Chemical class 0.000 description 3
- 238000009532 heart rate measurement Methods 0.000 description 3
- 229940116298 l- malic acid Drugs 0.000 description 3
- 230000000391 smoking effect Effects 0.000 description 3
- 239000001384 succinic acid Substances 0.000 description 3
- AQCRXZYYMOXFAN-UHFFFAOYSA-N 2-(1-methyl-2-pyrrolidinyl)-pyridine Chemical compound CN1CCCC1C1=CC=CC=N1 AQCRXZYYMOXFAN-UHFFFAOYSA-N 0.000 description 2
- WDJHALXBUFZDSR-UHFFFAOYSA-N Acetoacetic acid Natural products CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- CPCNAMNNSLASDC-UHFFFAOYSA-N acetic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CC(O)=O.CN1CCCC1C1=CC=CN=C1 CPCNAMNNSLASDC-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- WOWBFOBYOAGEEA-UHFFFAOYSA-N diafenthiuron Chemical compound CC(C)C1=C(NC(=S)NC(C)(C)C)C(C(C)C)=CC(OC=2C=CC=CC=2)=C1 WOWBFOBYOAGEEA-UHFFFAOYSA-N 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000006193 liquid solution Substances 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 150000002763 monocarboxylic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 239000000779 smoke Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- SNICXCGAKADSCV-SNVBAGLBSA-N (+)-nicotine Chemical compound CN1CCC[C@@H]1C1=CC=CN=C1 SNICXCGAKADSCV-SNVBAGLBSA-N 0.000 description 1
- 229930182841 (R)-nicotine Natural products 0.000 description 1
- VWTHFJXLFGINSW-PPHPATTJSA-N 2-hydroxypropanoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound CC(O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 VWTHFJXLFGINSW-PPHPATTJSA-N 0.000 description 1
- DKLWVGJFLYEGDR-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;2-phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1.CN1CCCC1C1=CC=CN=C1 DKLWVGJFLYEGDR-UHFFFAOYSA-N 0.000 description 1
- XPGVXOLNUCRXLA-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;oxalic acid Chemical compound OC(=O)C(O)=O.CN1CCCC1C1=CC=CN=C1 XPGVXOLNUCRXLA-UHFFFAOYSA-N 0.000 description 1
- GPDPQNUEHLJMGV-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;tetradecanoic acid Chemical compound CN1CCCC1C1=CC=CN=C1.CCCCCCCCCCCCCC(O)=O GPDPQNUEHLJMGV-UHFFFAOYSA-N 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 1
- 229930194542 Keto Natural products 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- WXBLLCUINBKULX-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1 WXBLLCUINBKULX-UHFFFAOYSA-N 0.000 description 1
- 150000001559 benzoic acids Chemical class 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- GSYUXYXARXLYDO-UHFFFAOYSA-N butanedioic acid;2-hydroxybenzoic acid Chemical compound OC(=O)CCC(O)=O.OC(=O)C1=CC=CC=C1O GSYUXYXARXLYDO-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 229940001468 citrate Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 229940013688 formic acid Drugs 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 231100000324 minimal toxicity Toxicity 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 229940087730 nicorette Drugs 0.000 description 1
- LDMPZNTVIGIREC-ZGPNLCEMSA-N nicotine bitartrate Chemical compound O.O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 LDMPZNTVIGIREC-ZGPNLCEMSA-N 0.000 description 1
- 229940069688 nicotine bitartrate Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F47/00—Smokers' requisites not otherwise provided for
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/243—Nicotine
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
-
- A24F47/004—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- a method of delivering nicotine to a user comprising operating an electronic cigarette to a user wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C., and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.
- a method of delivering nicotine to a user comprising operating an electronic cigarette to a user wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C., and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.
- a method of delivering nicotine to a user comprising operating an electronic cigarette wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point, and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.
- a method of delivering nicotine to a user comprising providing an electronic cigarette to a user wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point, and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.
- a method of delivering nicotine to the blood of a user comprising providing an aerosol that is inhaled by the user from an electronic cigarette that comprises a nicotine salt formulation wherein providing the aerosol comprises the electronic cigarette heating the formulation thereby generating the aerosol, wherein the aerosol is effective in delivering a level of nicotine in the blood of the user that is at least 5 ng/mL at about 1.5 minutes after a first puff of ten puffs of the aerosol, each puff taken at 30 second intervals.
- a nicotine salt liquid formulation in an electronic cigarette for generating an inhalable aerosol upon heating in the electronic cigarette, the formulation in the cigarette comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C.
- a nicotine salt liquid formulation in an electronic cigarette for generating an inhalable aerosol upon heating in the electronic cigarette
- the formulation in the cigarette comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C.
- a nicotine salt liquid formulation in an electronic cigarette for generating an inhalable aerosol upon heating in the electronic cigarette
- the formulation in the cigarette comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point.
- a nicotine salt liquid formulation in an electronic cigarette for generating an inhalable aerosol upon heating in the electronic cigarette
- the formulation in the cigarette comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point.
- a nicotine salt liquid formulation for generating an inhalable aerosol upon heating in the electronic cigarette
- the nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C.
- a nicotine salt liquid formulation for generating an inhalable aerosol upon heating in the electronic cigarette
- the nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C.
- a nicotine salt liquid formulation for generating an inhalable aerosol upon heating in the electronic cigarette
- the nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point.
- a nicotine salt liquid formulation for generating an inhalable aerosol upon heating in the electronic cigarette
- the nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point.
- a nicotine salt liquid formulation for use in an electronic cigarette the nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C.
- a nicotine salt liquid formulation for use in an electronic cigarette the nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C.
- a nicotine salt liquid formulation for use in an electronic cigarette the nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point.
- a nicotine salt liquid formulation for use in an electronic cigarette the nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point.
- a nicotine salt formulation for delivery of nicotine to a user from an electronic cigarette
- the nicotine salt formulation comprises a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C., and the nicotine salt formulation is heated by the electronic cigarette to generate an aerosol inhalable by the user.
- a nicotine salt formulation for delivery of nicotine to a user from an electronic cigarette
- the nicotine salt formulation comprises a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C., and the nicotine salt formulation is heated by the electronic cigarette to generate an aerosol inhalable by the user.
- a nicotine salt formulation for delivery of nicotine to a user from an electronic cigarette
- the nicotine salt formulation comprises a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point, and the nicotine salt formulation is heated by the electronic cigarette to generate an aerosol inhalable by the user.
- a nicotine salt formulation for delivery of nicotine to the blood of a user from an electronic cigarette, wherein the nicotine salt formulation in the electronic cigarette is heated to form an aerosol which delivers a level of nicotine in the blood of the user that is at least 5 ng/mL at about 1.5 minutes after a first puff of ten puffs of the aerosol, each puff taken at 30 second intervals.
- a nicotine salt formulation for delivery of nicotine to a user from an electronic cigarette
- the nicotine salt formulation comprises a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point, and the nicotine salt formulation is heated by the electronic cigarette to generate an aerosol inhalable by the user.
- a cartomizer for an electronic cigarette comprising:
- a cartomizer for an electronic cigarette comprising:
- a cartomizer for an electronic cigarette comprising:
- a cartomizer for an electronic cigarette comprising:
- an electronic cigarette for generating an inhalable aerosol comprising:
- an electronic cigarette for generating an inhalable aerosol comprising:
- an electronic cigarette for generating an inhalable aerosol comprising:
- an electronic cigarette for generating an inhalable aerosol comprising:
- a cartridge in an electronic cigarette comprising a fluid storage compartment, wherein the fluid storage compartment stores a nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C.
- a cartridge in an electronic cigarette comprising a fluid storage compartment, wherein the fluid storage compartment stores a nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C.
- a cartridge in an electronic cigarette comprising a fluid storage compartment, wherein the fluid storage compartment stores a nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point.
- a cartridge in an electronic cigarette comprising a fluid storage compartment, wherein the fluid storage compartment stores a nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point.
- kit comprising:
- kit comprising:
- kit comprising:
- kit comprising:
- FIG. 1 illustrates results of heart rate data measured for six minutes from start of puffing.
- Y-axis is heart rate (bpm) and X-axis represent duration of the test ( ⁇ 60 to 180 seconds);
- FIG. 2 illustrates results of heart rate data measured for ten minutes from start of puffing.
- Y-axis is heart rate (bpm) and X-axis represents duration of the test (0 to 10 minutes);
- FIG. 3 illustrates the calculated vapor pressures of various acids relative to nicotine
- FIG. 4 illustrates the pharmacokinetic profiles for eight test articles in a blood plasma study
- FIG. 5 illustrates the comparison of C max and T max for eight test articles in a blood plasma study
- FIG. 6 illustrates the comparison of C max and AUC for eight test articles in a blood plasma study
- FIG. 7 depicts an example embodiment of an electronic cigarette having a fluid storage compartment comprising an embodiment nicotine salt formulation described herein;
- FIG. 8 depicts an example embodiment of an electronic cigarette cartomizer having a fluid storage compartment, a heater, and comprising an embodiment nicotine salt formulation described herein.
- Nicotine is a chemical stimulant and increases heart rate and blood pressure when provided to an individual or animal. Nicotine transfer to an individual is associated with a feeling of physical and/or emotional satisfaction.
- Conflicting reports have been published regarding the transfer efficiency of free base nicotine in comparison to mono- or di-protonated nicotine salts. Studies on the transfer efficiency of free base nicotine and nicotine salts are complex and have yielded unpredictable results. Further, such transfer efficiency studies have been performed under extremely high temperature conditions, comparable to smoking; therefore, they offer scant guidance on the transfer efficiency of free base nicotine and nicotine salts under low-temperature vaporization conditions. Some reports have posited that nicotine free base should give rise to a greater satisfaction in a user than any corresponding nicotine salt.
- certain nicotine salt formulations provide satisfaction in an individual superior to that of free base nicotine, and more comparable to the satisfaction in an individual smoking a traditional cigarette.
- the satisfaction effect is consistent with an efficient transfer of nicotine to the lungs of an individual and a rapid rise of nicotine absorption in the plasma as shown, for non-limiting example, in Example 8, at least.
- certain nicotine salt formulations provide greater satisfaction than other nicotine salt formulations, and such effect has been shown in blood plasma levels of example nicotine salt formulations herein, for non-limiting example, in Example 8, at least.
- kits and methods that are used to inhale an aerosol generated from a nicotine salt liquid formulation through the mouth or nose as described herein or as would be obvious to one of skill in the art upon reading the disclosure herein.
- freebase nicotine compositions' delivery of nicotine to blood when inhaled using is not necessarily comparable in blood plasma levels (C max and T max ) to a traditional cigarette's nicotine delivery to blood when inhaled.
- Freebase nicotine compositions' delivery of nicotine to blood when inhaled using is not necessarily comparable in blood plasma levels (C max and T max ) to nicotine salt formulations' nicotine delivery to blood when inhaled.
- Freebase nicotine compositions' delivery of nicotine to blood when inhaled using is not necessarily comparable in blood plasma levels when measuring the rate of nicotine uptake in the blood within the first 0-5 minutes to a traditional cigarette's nicotine delivery to blood when inhaled.
- Freebase nicotine compositions' delivery of nicotine to blood when inhaled using necessarily is not comparable in blood plasma levels when measuring the rate of nicotine uptake in the blood within the first 0-5 minutes to nicotine salt formulations' nicotine delivery to blood when inhaled.
- the rate of nicotine uptake in the plasma of blood of users is higher in certain nicotine salt formulations than that of the traditional cigarette.
- the nicotine salt formulations which demonstrate the quickest rate of nicotine uptake in the plasma were more preferred in satisfaction evaluations, and were rated more equivalent to cigarette satisfaction than the nicotine salt formulations showing the slowest rates of rise of nicotine in the subjects' blood plasma.
- doubling the concentration of the nicotine salt in the formulation may not necessarily impact the rate of absorption of nicotine in the blood (see, for non-limiting example Example 8, nicotine benzoate tested in 4% and 2% concentrations).
- nicotine salt formulations delivered using an e-cigarette appear comparable in C max and T max values (measuring blood plasma nicotine levels), however, not all nicotine salts perform similarly to each other or to a traditional cigarette with respect to the rate of nicotine uptake in the blood at early time periods (0-1.5 minutes). These results are unexpected.
- Nicotine salt formulations made using acids having a Vapor Pressure between 20-300 mmHg @ 200° C., or Vapor Pressure >20 mmHg @ 200° C., or a Vapor Pressure from 20 to 300 mmHg @ 200° C., or a Vapor Pressure from 20 to 200 mmHg @ 200° C., a Vapor Pressure between 20 and 300 mmHg @ 200° C.
- acids that meet one or more criteria of the prior sentence include salicylic acid, sorbic acid, benzoic acid, lauric acid, and levulinic acid. Nicotine salt formulations made using acids that have a difference between boiling point and melting point of at least 50° C., and a boiling point greater than 160° C., and a melting point less than 160° C.
- acids that meet the criteria of the prior sentence include salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid. Nicotine salt formulations made using acids that have a difference between boiling point and melting point of at least 50° C., and a boiling point at most 40° C.
- Operating temperature can be 100° C. to 300° C., or about 200° C., about 150° C. to about 250° C., 180° C. to 220° C., about 180° C. to about 220° C., 185° C. to 215° C., about 185° C.
- acids that meet the criteria of the prior sentence include salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid. Combinations of these criteria for preference of certain nicotine salt formulations are contemplated herein.
- an acid may be inappropriate for use with the device materials (corrosive or otherwise incompatible).
- Sulfuric acid is an example of this, which may be inappropriate for the e-cigarette device.
- An acid may be inappropriate for use in inhalation or for toxicity reasons—thus not be compatible for human consumption, ingestion, or inhalation.
- Sulfuric acid again is an example of this, which may be inappropriate for a user of an e-cigarette device, depending on the embodiment of the composition.
- An acid that is bitter or otherwise bad-tasting may also provide a reason for exclusion, such as acetic acid in some embodiments.
- Acids that oxidize at room temperature or at operating temperature may be inappropriate for certain embodiments, for example, sorbic acid, as this indicates a decomposition or reaction or instability that may be undesirable in the formulation.
- Decomposition of acids at room or operating temperatures may also indicate that the acid is inappropriate for use in the embodiment formulations.
- citric acid decomposes at 175° C.
- malic acid decomposes at 140° C., thus for a device operating at 200° C., these acids may not be appropriate.
- Acids that have poor solubility in the composition constituents may be inappropriate for use in certain embodiments of the compositions herein.
- nicotine bitartrate with a composition of nicotine and tartaric acid as 1:2 molar ratio will not produce a solution at a concentration of 0.5%(w/w) nicotine or higher and 0.9%(w/w) tartaric acid or higher in propylene glycol (PG) or vegetable glycerin (VG) or any mixture of PG and VG at ambient conditions.
- PG propylene glycol
- VG vegetable glycerin
- weight percentage refers to the weight of the individual component over the weight of the total formulation.
- organic acid refers to an organic compound with acidic properties (e.g., by Br ⁇ nsted-Lowry definition, or Lewis definition).
- a common organic acid is the carboxylic acids, whose acidity is associated with their carboxyl group —COOH.
- a dicarboxylic acid possesses two carboxylic acid groups. The relative acidity of an organic is measured by its pK a value and one of skill in the art knows how to determine the acidity of an organic acid based on its given pKa value.
- keto acid refers to organic compounds that contain a carboxylic acid group and a ketone group.
- keto acids include alpha-keto acids, or 2 -oxoacids, such as pyruvic acid or oxaloacetic acid, having the keto group adjacent to the carboxylic acid; beta-keto acids, or 3 -oxoacids, such as acetoacetic acid, having the ketone group at the second carbon from the carboxylic acid; gamma-keto acids, or 4 -oxoacids, such as levulinic acid, having the ketone group at the third carbon from the carboxylic acid.
- an electronic cigarette refers to an electronic inhaler that vaporizes a liquid solution into an aerosol mist, simulating the act of tobacco smoking.
- the liquid solution comprises a formulation comprising nicotine.
- electronic cigarettes which do not resemble conventional cigarettes at all. The amount of nicotine contained can be chosen by the user via the inhalation.
- an electronic cigarette contains three essential components: a plastic cartridge that serves as a mouthpiece and a reservoir for liquid, an “atomizer” that vaporizes the liquid, and a battery.
- Other embodiment electronic cigarettes include a combined atomizer and reservoir, called a “cartomizer” that may or may not be disposable, a mouthpiece that may be integrated with the cartomizer or not, and a battery.
- the term “about” refers to variations of 1%, 2%, 3%, 4%, 5%, 10%, 15%, or 25%, depending on the embodiment.
- Suitable carriers for the nicotine salts described herein include a medium in which a nicotine salt is soluble at ambient conditions, such that the nicotine salt does not form a solid precipitate.
- examples include, but are not limited to, glycerol, propylene glycol, trimethylene glycol, water, ethanol and the like, as well as combinations thereof.
- the liquid carrier comprises 0% to 100% of propylene glycol and 100% to 0% of vegetable glycerin.
- the liquid carrier comprises 10% to 70% of propylene glycol and 90% to 30% of vegetable glycerin.
- the liquid carrier comprises 20% to 50% of propylene glycol and 80% to 50% of vegetable glycerin.
- the liquid carrier comprises 30% propylene glycol and 70% vegetable glycerin.
- the formulations described herein vary in concentration. In some formulations, a dilute concentration of the nicotine salt in the carrier is utilized. In some formulations, a less dilute concentration of the nicotine salt in the carrier is utilized. In some formulations the concentration of nicotine in the nicotine salt formulation is about 1% (w/w) to about 25% (w/w). In some formulations the concentration of nicotine in the nicotine salt formulation is about 1% (w/w) to about 20% (w/w). In some formulations the concentration of nicotine in the nicotine salt formulation is about 1% (w/w) to about 18% (w/w). In some embodiments the concentration of nicotine in the nicotine salt formulation is about 1% (w/w) to about 15% (w/w).
- the concentration of nicotine in the nicotine salt formulation is about 4% (w/w) to about 12% (w/w). In some formulations the concentration of nicotine in the nicotine salt formulation is about 4% (w/w). In some embodiments the concentration of nicotine in the nicotine salt formulation is about 2% (w/w). In some formulations the concentration of nicotine in the nicotine salt formulation is 1% (w/w) to 25% (w/w). In some formulations the concentration of nicotine in the nicotine salt formulation is 1% (w/w) to 20% (w/w). In some formulations the concentration of nicotine in the nicotine salt formulation is 1% (w/w) to 18% (w/w). In some formulations the concentration of nicotine in the nicotine salt formulation is 1% (w/w) to 15% (w/w).
- the concentration of nicotine in the nicotine salt formulation is 4% (w/w) to 12% (w/w). In some formulations the concentration of nicotine in the nicotine salt formulation is 4% (w/w). In some formulations the concentration of nicotine in the nicotine salt formulation is 2% (w/w). In some formulations, a less dilute concentration of one nicotine salt is used in conjunction with a more dilute concentration of a second nicotine salt. In some formulations, the concentration of nicotine in the first nicotine salt formulation is about 1% to about 20%, and is combined with a second nicotine salt formulation having a concentration of nicotine therein from about 1% to about 20% or any range or concentration therein.
- the concentration of nicotine in the first nicotine salt formulation is 1% to 20%, and is combined with a second nicotine salt formulation having a concentration of nicotine therein from 1% to 20% or any range or concentration therein.
- concentrations of nicotine in the nicotine salt formulations the term “about” refers to ranges of 0.05% (i.e. if the concentration is about 2%, the range is 1.95%-2.05%), 0.1 (i.e. if the concentration is about 2%, the range is 1.9%-2.1%), 0.25 (i.e. if the concentration is about 2%, the range is 1.75%-2.25%), 0.5 (i.e. if the concentration is about 2%, the range is 1.5%-2.5%), or 1 (i.e. if the concentration is about 4%, the range is 3%-5%), depending on the embodiment.
- Nicotine salts are formed by the addition of a suitable acid, including organic or inorganic acids.
- suitable organic acids are carboxylic acids.
- suitable organic carboxylic acids are monocarboxylic acids, dicarboxylic acids (organic acid containing two carboxylic acid groups), carboxylic acids containing an aromatic group such as benzoic acids, hydroxycarboxylic acids, heterocyclic carboxylic acids, terpenoid acids, sugar acids; such as the pectic acids, amino acids, cycloaliphatic acids, aliphatic carboxylic acids, keto carboxylic acids, and the like.
- the organic acids used herein are monocarboxylic acids.
- Nicotine salts are formed from the addition of a suitable acid to nicotine.
- the stoichiometric ratios of the nicotine to acid are 1:1, 1:2, 1:3, 1:4, 2:3, 2:5, 2:7, 3:4, 3:5, 3:7, 3:8, 3:10, 3:11, 4:5, 4:7, 4:9, 4:10, 4:11, 4:13, 4:14, 4:15, 5:6, 5:7, 5:8, 5:9, 5:11, 5:12, 5:13, 5:14, 5:16, 5:17, 5:18, or 5:19.
- the stoichiometric ratios of the nicotine to acid are 1:1, 1:2, 1:3, or 1:4 (nicotine:acid).
- Nicotine is an alkaloid molecule that comprises two basic nitrogens. It may occur in different states of protonation. For example, if no protonation exists, nicotine is referred to as the “free base.” If one nitrogen is protonated, then the nicotine would be “mono-protonated.”
- Nicotine salt formulations may be formed by adding a suitable acid to nicotine, stiffing the neat mixture at ambient temperature or at elevated temperature, and then diluting the neat mixture with a carrier mixture, such as a mixture of propylene glycol and glycerin.
- a carrier mixture such as a mixture of propylene glycol and glycerin.
- the suitable acid is completely dissolved by the nicotine prior to dilution.
- the suitable acid may not completely dissolved by the nicotine prior to dilution.
- the addition of the suitable acid to the nicotine to form a neat mixture may cause an exothermic reaction.
- the addition of the suitable acid to the nicotine to form a neat mixture may be conducted at 55° C.
- the addition of the suitable acid to the nicotine to form a neat mixture may be conducted at 90° C.
- the neat mixture may be cooled to ambient temperature prior to dilution.
- the dilution may be carried out at elevated temperature.
- Nicotine salt formulations may be prepared by combining nicotine and a suitable acid in a carrier mixture, such as a mixture of propylene glycol and glycerin.
- a carrier mixture such as a mixture of propylene glycol and glycerin.
- the mixture of nicotine and a first carrier mixture is combined with a mixture of a suitable acid in a second carrier mixture.
- the first and second carrier mixtures are identical in composition.
- the first and second carrier mixtures are not identical in composition.
- heating of nicotine/acid/carrier mixture is required to facilitate complete dissolution.
- nicotine salt formulations may be prepared and added to a solution of 3:7 ratio by weight of propylene glycol (PG)/vegetable glycerin (VG), and mixed thoroughly. While described herein as producing 10 g of each of the formulations, all procedures noted infra are scalable. Other manners of formulation may also be employed form the formulations noted infra, without departing from the disclosure herein, and as would be known to one of skill in the art upon reading the disclosure herein.
- PG propylene glycol
- VG vegetable glycerin
- the optimal nicotine salt formulation may be determined by the vapor pressure of the constituent acid.
- the nicotine salt formulations comprise an acid with a vapor pressure that is similar to the vapor pressure of free base nicotine.
- the nicotine salt formulations are formed from an acid with a vapor pressure that is similar to the vapor pressure of free base nicotine at the heating temperature of the device.
- FIG. 3 illustrates this trend. Nicotine salts formed from nicotine and benzoic acid; nicotine and salicylic acid; or nicotine and levulinic acid are salts that produce a satisfaction in an individual user consistent with efficient transfer of nicotine and a rapid rise in nicotine plasma levels. This pattern may be due to the mechanism of action during heating of the nicotine salt formulation.
- the nicotine salt may disassociate at, or just below, the heating temperature of the device, resulting in a mixture of free base nicotine and the individual acid. At that point, if both the nicotine and acid have similar vapor pressures, they may aerosolize at the same time, giving rise to a transfer of both free base nicotine and the constituent acid to the user.
- the nicotine salt liquid formulation for generating an inhalable aerosol upon heating in an electronic cigarette may comprise a nicotine salt in a biologically acceptable liquid carrier; wherein the acid used to form said nicotine salt is characterized by a vapor pressure between 20-4000 mmHg at 200° C. In some embodiments, the acid used to form the nicotine salt is characterized by vapor pressure between 20-2000 mmHg at 200° C. In some embodiments, the acid used to form the nicotine salt is characterized by vapor pressure between 100-300 mmHg at 200° C.
- the extent of protonation of the nicotine salt affected satisfaction, such that more protonation was less satisfying as compared to less protonation.
- the nicotine salt formed may be monoprotonated.
- the nicotine salt formed may be diprotonated.
- the nicotine salt may exist in more than one protonation state, e.g., an equilibrium of mono-protonated and di-protonated nicotine salts.
- the extent of protonation of the nicotine molecule may be dependent upon the stoichiometric ratio of nicotine:acid used in the salt formation reaction.
- the extent of protonation of the nicotine molecule may be dependent upon the solvent.
- the extent of protonation of the nicotine molecule may be unknown.
- monoprotonated nicotine salts produced a high degree of satisfaction in the user.
- nicotine benzoate and nicotine salicylate are mono-protonated nicotine salts and all produce a high degree of satisfaction in the user.
- the reason for this trend may be explained by a mechanism of action wherein the nicotine is first deprotonated prior to transfer to the vapor with the constituent acid and then retained and stabilized after re-protonated by the acid going down stream to the lungs of the user. It may be easier to remove one proton versus two protons, thus resulting in better transfer efficiency.
- the lack of satisfaction of free base nicotine indicates that a second factor may be important.
- a nicotine salt may be best performing when it is at its optimal extent of protonation, depending on the salt.
- nicotine pyruvate is a nicotine salt with 1:2 nicotine:acid ratio.
- the formulation containing nicotine pyruvate (1:2) may deliver more satisfaction to the user than the one containing same amount of nicotine but only half amount of pyruvic acid, i.e. nicotine pyruvate (1:1). This may be explained as 1 mole of nicotine produces a salt with 2 moles of pyruvic acid. When there is not enough pyruvic acid to associate with all nicotine molecules, the free base nicotine left unprotonated in the formulation may reduce the satisfaction the formulation provides.
- the flavor of the constituent acid used in the salt formation may be a consideration in choosing the acid.
- a suitable acid may have minimal or no toxicity to humans in the concentrations used.
- a suitable acid may be compatible with the electronic cigarette components it contacts or could contact at the concentrations used. That is, such acid does not degrade or otherwise react with the electronic cigarette components it contacts or could contact.
- the odor of the constituent acid used in the salt formation may be a consideration in choosing a suitable acid.
- the concentration of the nicotine salt in the carrier may affect the satisfaction in the individual user.
- the flavor of the formulation is adjusted by changing the acid.
- the flavor of the formulation is adjusted by adding exogenous flavorants.
- an unpleasant tasting or smelling acid is used in minimal quantities to mitigate such characteristics.
- exogenous pleasant smelling or tasting acid is added to the formulation.
- salts which can provide flavor and aroma to the mainstream aerosol at certain levels include nicotine acetate, nicotine oxalate, nicotine malate, nicotine isovalerate, nicotine lactate, nicotine citrate, nicotine phenylacetate and nicotine myristate.
- Nicotine salt formulations may generate an inhalable aerosol upon heating in an electronic cigarette.
- the amount of nicotine or nicotine salt aerosol inhaled may be user-determined.
- the user may, for example, modify the amount of nicotine or nicotine salt inhaled by adjusting his inhalation strength.
- Formulations are described herein comprising two or more nicotine salts. In some embodiments, wherein a formulation comprises two or more nicotine salts, each individual nicotine salt is formed as described herein.
- Nicotine salt formulations refer to a single or mixture of nicotine salts with other suitable chemical components used for e-cigarette, such as carriers, stabilizers, diluents, dispersing agents, suspending agents, thickening agents, and/or excipients.
- the nicotine salt formulation is stirred at ambient conditions for 20 minutes.
- the nicotine salt formulation is heated and stirred at 55 C for 20 minutes.
- the nicotine salt formulation is heated and stirred at 90 C for 60 minutes.
- the formulation facilitates administration of nicotine to an organism (e.g., lung).
- the nicotine of nicotine salt formulations provided herein is either naturally occurring nicotine (e.g., from extract of nicotineous species such as tobacco), or synthetic nicotine.
- the nicotine is ( ⁇ )-nicotine, (+)-nicotine, or a mixture thereof.
- the nicotine is employed in relatively pure form (e.g., greater than about 80% pure, 85% pure, 90% pure, 95% pure, or 99% pure).
- the nicotine for nicotine salt formulation provided herein is “water clear” in appearance in order to avoid or minimize the formation of tarry residues during the subsequent salt formation steps.
- Nicotine salt formulations used for e-cigarettes described herein have a nicotine concentration of about 0.5% (w/w) to about 20% (w/w), wherein the concentration is of nicotine weight to total solution weight, i.e. (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 1% (w/w) to about 20% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 1% (w/w) to about 18% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 1% (w/w) to about 15% (w/w).
- nicotine salt formulations provided herein have a nicotine concentration of about 4% (w/w) to about 12% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 1% (w/w) to about 18% (w/w), about 3% (w/w) to about 15% (w/w), or about 4% (w/w) to about 12% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 0.5% (w/w) to about 10% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 0.5% (w/w) to about 5% (w/w).
- nicotine salt formulations provided herein have a nicotine concentration of about 0.5% (w/w) to about 4% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 0.5% (w/w) to about 3% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 0.5% (w/w) to about 2% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 0.5% (w/w) to about 1% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 1% (w/w) to about 10% (w/w).
- nicotine salt formulations provided herein have a nicotine concentration of about 1% (w/w) to about 5% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 1% (w/w) to about 4% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 1% (w/w) to about 3% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 1% (w/w) to about 2% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 2% (w/w) to about 10% (w/w).
- nicotine salt formulations provided herein have a nicotine concentration of about 2% (w/w) to about 5% (w/w). In certain embodiments, nicotine salt formulations provided herein have a nicotine concentration of about 2% (w/w) to about 4% (w/w).
- Certain embodiments provide a nicotine salt formulation having a nicotine concentration of about 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.5%, 5.0%, 5.5%, 6.0%, 6.5%, 7.0%, 7.5%, 8.0%, 8.5%, 9.0%, 9.5%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, or 20% (w/w), or more, including any increments therein.
- Certain embodiments provide a nicotine salt formulation having a nicotine concentration of about 5% (w/w). Certain embodiments provide a nicotine salt formulation having a nicotine concentration of about 4% (w/w). Certain embodiments provide a nicotine salt formulation having a nicotine concentration of about 3% (w/w). Certain embodiments provide a nicotine salt formulation having a nicotine concentration of about 2% (w/w). Certain embodiments provide a nicotine salt formulation having a nicotine concentration of about 1% (w/w). Certain embodiments provide a nicotine salt formulation having a nicotine concentration of about 0.5% (w/w).
- the formulation further may comprise one or more flavorants.
- Thee suitable acid for the nicotine salt formulation may have a vapor pressure >20 mmHg at 200° C. and is non-corrosive to the electronic cigarette or is non-toxic to humans.
- the suitable acid for nicotine salt formation is selected from the group consisting of salicylic acid, formic acid, sorbic acid, acetic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid.
- Thee suitable acid for the nicotine salt formulation may have a vapor pressure of about 20 to 200 mmHg at 200° C. and is non-corrosive to the electronic cigarette or is non-toxic to humans.
- the suitable acid for nicotine salt formation is selected from the group consisting of salicylic acid, benzoic acid, lauric acid, and levulinic acid.
- Thee suitable acid for the nicotine salt formulation may have a melting point ⁇ 160° C., a boiling point >160° C., at least a 50-degree difference between the melting point and the boiling point, and is non-corrosive to the electronic cigarette or is non-toxic to humans.
- the suitable acid for nicotine salt formation has a melting point at least 40 degrees lower than the operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, at least a 50-degree difference between the melting point and the boiling point, and is non-corrosive to the electronic cigarette or is non-toxic to humans; wherein the operating temperature is 200° C.
- the suitable acid for nicotine salt formation is selected from the group consisting of salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid.
- Thee suitable acid for the nicotine salt formulation does not decompose at the operating temperature of the electronic cigarette. In some embodiments, the suitable acid for nicotine salt formation does not oxidize at the operating temperature of the electronic cigarette. In some embodiments, the suitable acid for nicotine salt formation does not oxidize at room temperature. In some embodiments, the suitable acid for nicotine salt formation does not provide an unpleasant taste. In some embodiments, the suitable acid for nicotine salt formation has good solubility in a liquid formulation for use in an electronic cigarette.
- an electronic cigarette 2 having a fluid storage compartment 4 comprising an embodiment nicotine salt formulation of any embodiment described herein within the fluid storage compartment described herein.
- An embodiment is shown in FIG. 7 .
- the electronic cigarette 2 of FIG. 7 includes a mouth end 6 , and a charging end 8 .
- the mouth-end 6 includes a mouthpiece 10 .
- the charging end 8 may connect to a battery or a charger or both, wherein the battery is within a body of the electronic cigarette, and the charger is separate from the battery and couples to the body or the battery to charge the battery.
- the electronic cigarette comprises a rechargeable battery within a body 14 of the electronic cigarette and the charge end 8 comprises a connection 12 for charging the rechargeable battery.
- the electronic cigarette comprises a cartomizer that comprises the fluid storage compartment and an atomizer.
- the atomizer comprises a heater.
- the fluid storage compartment 4 is separable from an atomizer.
- the fluid storage compartment 4 is replaceable as part of a replaceable cartridge.
- the fluid storage compartment 4 is refillable.
- the mouthpiece 10 is replaceable.
- a cartomizer 18 for an electronic cigarette 2 having a fluid storage compartment 4 comprising an embodiment nicotine salt formulation of any embodiment described herein within the fluid storage compartment described herein.
- the cartomizer 18 embodiment of FIG. 8 includes a mouth end 6 , and a connection end 16 .
- the connection end 16 in the embodiment of FIG. 8 couples the cartomizer 14 to a body of an electronic cigarette, or to a battery of the electronic cigarette, or both.
- the mouth end 6 includes a mouthpiece 10 .
- the cartomizer does not include a mouthpiece, and in such embodiments, the cartomizer can be coupled to a mouthpiece of an electronic cigarette, or the cartomizer can be coupled to a battery or body of an electronic cigarette, while the mouthpiece is also coupled to the battery or the body of the electronic cigarette. In some embodiments, the mouthpiece is integral with the body of the electronic cigarette.
- the cartomizer 18 comprises the fluid storage compartment 4 and an atomizer (not shown). In some embodiments, the atomizer comprises a heater (not shown)
- compositions comprising different nicotine salts can be prepared similarly, or different concentrations of the above-noted nicotine formulations or other nicotine salt formulations can be prepared as one of skill in the art would know to do upon reading the disclosure herein.
- Various formulations comprising two or more nicotine salts can be prepared similarly in a solution of 3:7 ratio of propylene glycol (PG)/vegetable glycerin (VG).
- PG propylene glycol
- VG vegetable glycerin
- 0.43 g (2.5% w/w nicotine) of nicotine levulinate salt and 0.34 g (2.5% w/w nicotine) of nicotine acetate salt are added to 9.23 g of PG/VG solution, to achieve a 5% w/w nicotine formulation.
- 0.23 g (1.33% w/w nicotine) of nicotine benzoate salt (molar ratio 1:1 nicotine/benzoic acid), 0.25 g (1.33% w/w nicotine) of nicotine salicylate salt (molar ratio 1:1 nicotine/salicylic acid) and 0.28 g (1.34% w/w nicotine) of nicotine pyruvate salt (molar ratio 1:2 nicotine/pyruvic acid) are added to 9.25 g of PG/VG solution, to achieve a 5% w/w nicotine formulation.
- Exemplary formulations of nicotine levulinate, nicotine benzoate, nicotine succinate, nicotine salicylate, nicotine malate, nicotine pyruvate, nicotine citrate, nicotine freebase, and a control of propylene glycol were prepared as noted in Example 1 in 3% w/w solutions and were administered in the same fashion by an electronic cigarette to the same human subject.
- About 0.5 mL of each solution was loaded into an “eRoll” cartridge atomizer (joyetech.com) to be used in the study. The atomizer was then attached to an “eRoll” e-cigarette (same manufacturer).
- the operating temperature was from about 150° C. to about 250° C., or from about 180° C. to about 220° C.
- Heart rate measurements were taken for 6 minutes; from 1 minute before start of puffing, for 3 minutes during puffing, and continuing until 2 minutes after end of puffing. The test participant took 10 puffs over 3 minutes in each case.
- the base heart rate was the average heart rate over the first 1 minute before start of puffing. Heart rate after puffing started was averaged over 20-second intervals. Puffing (inhalation) occurred every 20 seconds for a total of 3 minutes.
- Normalized heart rate was defined as the ratio between individual heart rate data point and the base heart rate. Final results were presented as normalized heart rate, shown for the first 4 minutes in FIG. 1 .
- FIG. 1 summarizes results from heart rate measurements taken for a variety of nicotine salt formulations.
- the nicotine formulations are as follows: nicotine salicylate formulation, nicotine malate formulation, nicotine levulinate formulation (nearly identical to nicotine malate formulation at 180 seconds, thus, as a second reference point: the nicotine malate formulation curve is lower than the nicotine levulinate formulation curve at the 160-second time point), nicotine pyruvate formulation, nicotine benzoate formulation, nicotine citrate formulation, nicotine succinate formulation, and nicotine free base formulation.
- the bottom curve (lowest normalized heart rate) at the 180-second timepoint is associated with the placebo (100% propylene glycol).
- the test formulations comprising a nicotine salt cause a faster and more significant rise in heart rate than the placebo.
- the test formulations comprising a nicotine salt also cause faster and more significant rise when compared with a nicotine freebase formulation with the same amount of nicotine by weight.
- the nicotine salts e.g., nicotine benzoate and nicotine pyruvate
- the acids having calculated vapor pressures between 20-200 mmHg at 200° C. benzoic acid (171.66 mmHg), with the exception of pyruvic acid (having a boiling point of 165 C), respectively
- the nicotine salts (e.g., nicotine levulinate, nicotine benzoate, and nicotine salicylate) prepared from the acids (benzoic acid, levulinic acid and salicylic acid, respectively) also cause a more significant heart rate increase.
- other suitable nicotine salts formed by the acids with the similar vapor pressure and/or similar boiling point may be used in accordance with the practice of the present invention.
- This experience of increased heart rate theoretically approaching or theoretically comparable to that of a traditional burned cigarette has not been demonstrated or identified in other electronic cigarette devices.
- nicotine formulations (using 3% w/w nicotine formulations as described in Example 1) were used to conduct a satisfaction study in a single test participant.
- the test participant an e-cigarette and/or traditional cigarette user, was required to have no nicotine intake for at least 12 hours before the test.
- the participant took 10 puffs using an e-cigarette (same as used in Example 2) over 3 minutes in each case, and then was asked to rate the level of physical and emotional satisfaction he or she felt on a scale of 0-10, with 0 being no physical or emotional satisfaction.
- the nicotine salts formulations with acids having vapor pressure ranges between >20 mmHg @ 200° C., or 20-200 mmHg @ 200° C., or 100-300 mmHg @ 200° C. provide more satisfaction than the rest (except the pyruvic acid which has boiling point of 165° C.).
- salicylic acid has a vapor pressure of about 135.7 mmHg @ 200° C.
- benzoic acid has a vapor pressure of about 171.7 mmHg @ 200° C.
- lauric acid has a vapor pressure of about 38 mmHg @ 200° C.
- levulinic acid has a 149 mmHg @ 200° C.
- L-Nicotine has a molar mass of 162.2 g, and levulinic acid molar mass is 116.1 g.
- a solution of free base nicotine in glycerol comprising 0.40 g (4.00% w/w) of L-nicotine was dissolved in 9.60 g (96.0% w/w) of glycerol and mixed thoroughly.
- Both formulations (TF1 and TF2) were administered in the same fashion by an electronic cigarette to the same human subject: about 0.6 mL of each solution was loaded into “eGo-C” cartridge atomizer (joyetech.com). The atomizer was then attached to an “eVic” e-cigarette (same manufacturer). This model of e-cigarette allows for adjustable voltage, and therefore wattage, through the atomizer.
- the operating temperature of the e-cigarette is from about 150° C. to about 250° C., or from about 180° C. to about 220° C.
- Heart rate was measured in a 30-second interval for ten minutes from start of puffing. Test participants took 10 puffs over 3 minutes in each case (solid line (2 nd highest peak): cigarette, dark dotted line (highest peak): test formulation 1 (TF1-nicotine salt formulation), light dotted line: test formulation 2 (TF2—nicotine formulation). Comparison between cigarette, TF1, and TF2 is shown in FIG. 2 .
- TF1 nicotine levulinate
- TF2 just nicotine
- TF1 more closely resembles the rate of increase for a cigarette.
- Other salts were tried and also found to increase heart rate relative to a pure nicotine solution.
- suitable nicotine salts that cause the similar effect may be used in accordance with the practice of the present invention.
- keto acids alpha-keto acids, beta-keto acids, gamma-keto acids, and the like
- pyruvic acid oxaloacetic acid
- acetoacetic acid acetoacetic acid
- the nicotine salts formulations with acids having vapor pressures between 20-300 mmHg @ 200° C. provide more satisfaction than the rest, with the exception of the nicotine salt formulation made with pyruvic acid, which has a boiling point of 165° C., as noted in FIG. 3 . Based on the findings herein, it was anticipated that these nicotine salt formulations having either:
- T max Time to maximum blood concentration: Based on the results established herein, a user of an e-cigarette comprising the nicotine salt formulation will experience a comparable rate of physical and emotional satisfaction from using a formulation comprising a mixture of nicotine salts prepared with an appropriate acid at least 1.2 ⁇ to 3 ⁇ faster than using a formulation comprising a freebase nicotine. As illustrated in FIG.
- Nicotine from a nicotine salts formulation appears to generate a heartbeat that is nearly 1.2 times that of a normal heart rate for an individual approximately 40 seconds after the commencement of puffing; whereas the nicotine from a nicotine freebase formulation appears to generate a heartbeat that is nearly 1.2 times that of a normal heart rate for an individual approximately 110 seconds after the commencement of puffing; a 2.75 ⁇ difference in time to achieve a comparable initial satisfaction level.
- the approximate slope of those nicotine salt formulations that exceeded the freebase nicotine formulation range between 0.0054 hr n /sec and 0.0025 hr n /sec.
- the slope of the line for the freebase nicotine formulation is about 0.002. This would suggest that the concentration of available nicotine will be delivered to the user at a rate that is between 1.25 and 2.7 times faster than a freebase formulation.
- C max Maximum blood nicotine concentration
- Example 8 presents data for multiple salt formulations consistent with these predictions which were made based on the findings and tests noted herein, and unexpected compared to the art available to date.
- Exemplary formulations of nicotine levulinate, nicotine benzoate, nicotine succinate, nicotine salicylate, nicotine malate, nicotine pyruvate, nicotine citrate, nicotine sorbate, nicotine laurate, nicotine freebase, and a control of propylene glycol are prepared as noted in Example 1 and are administered in the same fashion by an electronic cigarette to the same human subject.
- About 0.5 mL of each solution is loaded into an “eRoll” cartridge atomizer (joyetech.com) to be used in the study.
- the atomizer is then attached to an “eRoll” e-cigarette (same manufacturer).
- the operating temperature of the e-cigarette is from about 150° C. to about 250° C., or from about 180° C. to about 220° C.
- Heart rate measurements are taken for 6 minutes; from 1 minute before start of puffing, for 3 minutes during puffing, and continuing until 2 minutes after end of puffing.
- the test participant takes 10 puffs over 3 minutes in each case.
- the base heart rate is the average heart rate over the first 1 minute before start of puffing.
- Heart rate after puffing started is averaged over 20-second intervals.
- Normalized heart rate is defined as the ratio between individual heart rate data point and the base heart rate. Final results are presented as normalized heart rate.
- the seven blends were liquid formulations prepared as described in Example 1.
- the concentration of nicotine in each of the formulations was confirmed using UV spectrophotometer (Cary 60, manufactured by Agilent).
- the sample solutions for UV analysis were made by dissolving 20 mg of each of the formulations in 20 mL 0.3% HCl in water.
- the sample solutions were then scanned in UV spectrophotometer and the characteristic nicotine peak at 259 nm was used to quantify nicotine in the sample against a standard solution of 19.8 ⁇ g/mL nicotine in the same diluent.
- the standard solution was prepared by first dissolving 19.8 mg nicotine in 10 mL 0.3% HCl in water followed by a 1:100 dilution with 0.3% HCl in water. Nicotine concentrations reported for all formulations were within the range of 95%-105% of the claimed concentrations
- Tables 1 & 2 present the amount of nicotine detected (as an average of all users) for each formulation and the Pall Mall, presented in ng/mL, along with C max and T max and AUC. Data from these tables, along with the raw data therefore, was used to generate FIGS. 4 , 5 , and 6 .
- Rates of nicotine uptake in the blood of the users of each sample within the first 90 seconds are shown in Table 3.
- the rates of nicotine absorption within the first 90 seconds differed among the test articles.
- four blends (2% salicylate, 2% benzoate, 4% benzoate, and 2% citrate) showed markedly higher rates of absorption within the first 90 seconds compared to the other blends and with the reference cigarette.
- These four blends contain salts (salicylate, benzoate, and citrate) which performed well in the Satisfaction Study of Example 3.
- 2% benzoate and 4% benzoate had comparable rates of absorption, suggesting that a lower concentration of nicotinic salt may not adversely impact the rate of absorption.
- the reference cigarette is Pall Mall (New Zealand).
- the operating temperature of the e-cigarette is from about 150° C. to about 250° C., or from about 180° C. to about 220° C.
- Ten blends are tested: 2% free base, 2% benzoate, 2% sorbate, 2% pyruvate, 2% laurate, 2% levulinate, 2% citrate, 2% malate, 2% salicylate, and 2% succinate.
- the ten blends are liquid formulations prepared according to protocols similar to that described infra and in Example 1.
- the reference cigarette is Pall Mall (New Zealand).
- the operating temperature of the e-cigarette is from about 150° C. to about 250° C., or from about 180° C. to about 220° C.
- the reference cigarette is Pall Mall (New Zealand).
- the operating temperature of the e-cigarette is from about 150° C. to about 250° C., or from about 180° C. to about 220° C.
- the twenty blends are tested: 2% free base, 1% free base, 2% benzoate, 1% benzoate, 2% sorbate, 1% sorbate, 2% pyruvate, 1% pyruvate, 2% laurate, 1% laurate, 2% levulinate, 1% levulinate, 2% citrate, 1% citrate, 2% malate, 1% malate, 2% salicylate, 1% salicylate, 2% succinate, and 1% succinate.
- the twenty blends are liquid formulations prepared according to protocols similar to that described infra and in Example 1.
- a method of delivering nicotine to a user comprising operating an electronic cigarette to a user wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C., and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.
- a method of delivering nicotine to a user comprising operating an electronic cigarette to a user wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C., and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.
- a method of delivering nicotine to a user comprising operating an electronic cigarette wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point, and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.
- a method of delivering nicotine to a user comprising providing an electronic cigarette to a user wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point, and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.
- liquid carrier comprises glycerol, propylene glycol, trimethylene glycol, water, ethanol or combinations thereof.
- liquid carrier comprises propylene glycol and vegetable glycerin.
- liquid carrier comprises 20% to 50% of propylene glycol and 80% to 50% of vegetable glycerin.
- liquid carrier comprises 30% propylene glycol and 70% vegetable glycerin.
- a second acid used to form the additional nicotine salt is selected from the group consisting of salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid.
- a method of delivering nicotine to the blood of a user comprising providing an aerosol that is inhaled by the user from an electronic cigarette that comprises a nicotine salt formulation wherein providing the aerosol comprises the electronic cigarette heating the formulation thereby generating the aerosol, wherein the aerosol is effective in delivering a level of nicotine in the blood of the user that is at least 5 ng/mL at about 1.5 minutes after a first puff of ten puffs of the aerosol, each puff taken at 30 second intervals.
- the nicotine salt formulation comprises a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C.
- the nicotine salt formulation comprises a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C.
- the nicotine salt formulation comprises a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point.
- the nicotine salt formulation comprises a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than the operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point; and the operating temperature is 200° C.
- organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, phenylacetic acid, benzoic acid, pyruvic acid, levulinic acid, tartaric acid, lactic acid, malonic acid, succinic acid, fumaric acid, finnaric acid, gluconic acid, saccharic acid, salicylic acid, sorbic acid, malonic acid, or malic acid.
- the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid,
- liquid carrier comprises glycerol, propylene glycol, trimethylene glycol, water, ethanol or combinations thereof.
- liquid carrier comprises propylene glycol and vegetable glycerin.
- liquid carrier comprises 20% to 50% of propylene glycol and 80% to 50% of vegetable glycerin.
- liquid carrier comprises 30% propylene glycol and 70% vegetable glycerin.
- a second acid used to form the additional nicotine salt is selected from the group consisting of salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid.
- a nicotine salt liquid formulation in an electronic cigarette for generating an inhalable aerosol upon heating in the electronic cigarette comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C.
- a nicotine salt liquid formulation in an electronic cigarette for generating an inhalable aerosol upon heating in the electronic cigarette comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C.
- a nicotine salt liquid formulation in an electronic cigarette for generating an inhalable aerosol upon heating in the electronic cigarette comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point.
- a nicotine salt liquid formulation in an electronic cigarette for generating an inhalable aerosol upon heating in the electronic cigarette comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point.
- the nicotine salt liquid formulation in the electronic cigarette of embodiment 125, wherein the operating temperature is from 150° C. to 250° C.
- the nicotine salt liquid formulation in the electronic cigarette of embodiment 125, wherein the operating temperature is from 180° C. to 220° C.
- the nicotine salt liquid formulation in the electronic cigarette of embodiment 133 wherein the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, phenylacetic acid, benzoic acid, pyruvic acid, levulinic acid, tartaric acid, lactic acid, malonic acid, succinic acid, fumaric acid, finnaric acid, gluconic acid, saccharic acid, salicylic acid, sorbic acid, malonic acid, or malic acid.
- the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stea
- the nicotine salt liquid formulation in the electronic cigarette of any one of embodiments 122-167 further comprising one or more additional nicotine salts in a biologically acceptable liquid carrier suitable for generating the inhalable aerosol upon heating.
- a second acid used to form the additional nicotine salt is selected from the group consisting of salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid.
- a nicotine salt liquid formulation for generating an inhalable aerosol upon heating in the electronic cigarette comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C.
- a nicotine salt liquid formulation for generating an inhalable aerosol upon heating in the electronic cigarette comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C.
- a nicotine salt liquid formulation for generating an inhalable aerosol upon heating in the electronic cigarette comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point.
- a nicotine salt liquid formulation for generating an inhalable aerosol upon heating in the electronic cigarette comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point.
- the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, ole
- the nicotine salt liquid formulation of embodiment 216, wherein a second acid used to form the additional nicotine salt is selected from the group consisting of salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid.
- a nicotine salt liquid formulation for use in an electronic cigarette the nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C.
- a nicotine salt liquid formulation for use in an electronic cigarette the nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C.
- a nicotine salt liquid formulation for use in an electronic cigarette the nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point.
- a nicotine salt liquid formulation for use in an electronic cigarette the nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point.
- the nicotine salt liquid formulation of embodiment 229 wherein the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, phenylacetic acid, benzoic acid, pyruvic acid, levulinic acid, tartaric acid, lactic acid, malonic acid, succinic acid, fumaric acid, finnaric acid, gluconic acid, saccharic acid, salicylic acid, sorbic acid, malonic acid, or malic acid.
- the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, o
- a second acid used to form the additional nicotine salt is selected from the group consisting of salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid.
- a nicotine salt formulation for delivery of nicotine to a user from an electronic cigarette wherein the nicotine salt formulation comprises a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C., and the nicotine salt formulation is heated by the electronic cigarette to generate an aerosol inhalable by the user.
- a nicotine salt formulation for delivery of nicotine to a user from an electronic cigarette wherein the nicotine salt formulation comprises a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C., and the nicotine salt formulation is heated by the electronic cigarette to generate an aerosol inhalable by the user.
- a nicotine salt formulation for delivery of nicotine to a user from an electronic cigarette wherein the nicotine salt formulation comprises a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point, and the nicotine salt formulation is heated by the electronic cigarette to generate an aerosol inhalable by the user.
- a nicotine salt formulation for delivery of nicotine to the blood of a user from an electronic cigarette, wherein the nicotine salt formulation in the electronic cigarette is heated to form an aerosol which delivers a level of nicotine in the blood of the user that is at least 5 ng/mL at about 1.5 minutes after a first puff of ten puffs of the aerosol, each puff taken at 30 second intervals.
- a nicotine salt formulation for delivery of nicotine to a user from an electronic cigarette
- the nicotine salt formulation comprises a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point, and the nicotine salt formulation is heated by the electronic cigarette to generate an aerosol inhalable by the user.
- liquid carrier comprises glycerol, propylene glycol, trimethylene glycol, water, ethanol or combinations thereof.
- liquid carrier comprises propylene glycol and vegetable glycerin.
- liquid carrier comprises 20% to 50% of propylene glycol and 80% to 50% of vegetable glycerin.
- liquid carrier comprises 30% propylene glycol and 70% vegetable glycerin.
- a second acid used to form the additional nicotine salt is selected from the group consisting of salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid
- a cartomizer for an electronic cigarette comprising:
- a cartomizer for an electronic cigarette comprising:
- a cartomizer for an electronic cigarette comprising:
- a cartomizer for an electronic cigarette comprising:
- the cartomizer of embodiment 335 wherein the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, phenylacetic acid, benzoic acid, pyruvic acid, levulinic acid, tartaric acid, lactic acid, malonic acid, succinic acid, fumaric acid, finnaric acid, gluconic acid, saccharic acid, salicylic acid, sorbic acid, malonic acid, or malic acid.
- the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, o
- liquid carrier comprises glycerol, propylene glycol, trimethylene glycol, water, ethanol or combinations thereof.
- liquid carrier comprises propylene glycol and vegetable glycerin.
- liquid carrier comprises 20% to 50% of propylene glycol and 80% to 50% of vegetable glycerin.
- liquid carrier comprises 30% propylene glycol and 70% vegetable glycerin.
- a second acid used to form the additional nicotine salt is selected from the group consisting of salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid.
- An electronic cigarette for generating an inhalable aerosol comprising
- An electronic cigarette for generating an inhalable aerosol comprising
- An electronic cigarette for generating an inhalable aerosol comprising
- An electronic cigarette for generating an inhalable aerosol comprising
- thermoelectric cigarette of any one of embodiments 381-384, wherein the heater comprises a heater chamber, a fluid wick, and a resistive heating element in contact with the fluid wick.
- organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, phenylacetic acid, benzoic acid, pyruvic acid, levulinic acid, tartaric acid, lactic acid, malonic acid, succinic acid, fumaric acid, finnaric acid, gluconic acid, saccharic acid, salicylic acid, sorbic acid, malonic acid, or malic acid.
- the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid,
- liquid carrier comprises glycerol, propylene glycol, trimethylene glycol, water, ethanol or combinations thereof.
- liquid carrier comprises propylene glycol and vegetable glycerin.
- liquid carrier comprises 20% to 50% of propylene glycol and 80% to 50% of vegetable glycerin.
- liquid carrier comprises 30% propylene glycol and 70% vegetable glycerin.
- a second acid used to form the additional nicotine salt is selected from the group consisting of salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid.
- a cartridge in an electronic cigarette comprising a fluid storage compartment, wherein the fluid storage compartment stores a nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C.
- a cartridge in an electronic cigarette comprising a fluid storage compartment, wherein the fluid storage compartment stores a nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C.
- a cartridge in an electronic cigarette comprising a fluid storage compartment, wherein the fluid storage compartment stores a nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point.
- a cartridge in an electronic cigarette comprising a fluid storage compartment, wherein the fluid storage compartment stores a nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point.
- the cartridge of embodiment 447, wherein the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, phenylacetic acid, benzoic acid, pyruvic acid, levulinic acid, tartaric acid, lactic acid, malonic acid, succinic acid, fumaric acid, finnaric acid, gluconic acid, saccharic acid, salicylic acid, sorbic acid, malonic acid, or malic acid.
- the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic
- liquid carrier comprises glycerol, propylene glycol, trimethylene glycol, water, ethanol or combinations thereof.
- liquid carrier comprises propylene glycol and vegetable glycerin.
- liquid carrier comprises 20% to 50% of propylene glycol and 80% to 50% of vegetable glycerin.
- a second acid used to form the additional nicotine salt is selected from the group consisting of salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid.
- a kit comprising:
- a kit comprising:
- a kit comprising:
- a kit comprising:
- kits of embodiment 487 wherein the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, phenylacetic acid, benzoic acid, pyruvic acid, levulinic acid, tartaric acid, lactic acid, malonic acid, succinic acid, fumaric acid, finnaric acid, gluconic acid, saccharic acid, salicylic acid, sorbic acid, malonic acid, or malic acid.
- the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid,
- kits of any one of embodiments 482-485, wherein the acid used to form the nicotine salt is salicylic acid.
- kit of any one of embodiments 482-485, wherein the acid used to form the nicotine salt is pyruvic acid.
- kit of any one of embodiments 482-485, wherein the acid used to form the nicotine salt is sorbic acid.
- kits of any one of embodiments 482-501, wherein the liquid carrier comprises glycerol, propylene glycol, trimethylene glycol, water, ethanol or combinations thereof.
- kits of embodiment 520, wherein a second acid used to form the additional nicotine salt is selected from the group consisting of salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid.
- a cartridge comprising a fluid storage compartment, wherein the fluid storage compartment stores a nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C.
- a cartridge comprising a fluid storage compartment, wherein the fluid storage compartment stores a nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure of about 20 to 200 mmHg at 200° C.
- a cartridge comprising a fluid storage compartment, wherein the fluid storage compartment stores a nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point ⁇ 160° C., a boiling point >160° C., and at least a 50-degree difference between the melting point and the boiling point.
- a cartridge comprising a fluid storage compartment, wherein the fluid storage compartment stores a nicotine salt liquid formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is further characterized by a melting point at least 40 degrees lower than an operating temperature of the electronic cigarette, a boiling point no more than 40 degrees lower than the operating temperature of the electronic cigarette, and at least a 50-degree difference between the melting point and the boiling point.
- the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, phenylacetic acid, benzoic acid, pyruvic acid, levulinic acid, tartaric acid, lactic acid, malonic acid, succinic acid, fumaric acid, finnaric acid, gluconic acid, saccharic acid, salicylic acid, sorbic acid, malonic acid, or malic acid.
- the organic acid is formic acid, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, caprylic acid, capric acid, citric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid
- liquid carrier comprises glycerol, propylene glycol, trimethylene glycol, water, ethanol or combinations thereof.
- liquid carrier comprises propylene glycol and vegetable glycerin.
- liquid carrier comprises 20% to 50% of propylene glycol and 80% to 50% of vegetable glycerin.
- liquid carrier comprises 30% propylene glycol and 70% vegetable glycerin.
- a second acid used to form the additional nicotine salt is selected from the group consisting of salicylic acid, sorbic acid, benzoic acid, pyruvic acid, lauric acid, and levulinic acid.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Manufacture Of Tobacco Products (AREA)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/271,071 US20140345631A1 (en) | 2013-05-06 | 2014-05-06 | Nicotine salt formulations for aerosol devices and methods thereof |
US14/512,311 US9215895B2 (en) | 2013-05-06 | 2014-10-10 | Nicotine salt formulations for aerosol devices and methods thereof |
US14/925,961 US10952468B2 (en) | 2013-05-06 | 2015-10-28 | Nicotine salt formulations for aerosol devices and methods thereof |
US14/925,968 US20160044968A1 (en) | 2013-05-06 | 2015-10-28 | Nicotine salt formulations for aerosol devices and methods thereof |
US15/430,317 US10130123B2 (en) | 2013-03-15 | 2017-02-10 | Vaporizer devices with blow discrimination |
US15/430,284 US10279934B2 (en) | 2013-03-15 | 2017-02-10 | Fillable vaporizer cartridge and method of filling |
US15/430,357 US10638792B2 (en) | 2013-03-15 | 2017-02-10 | Securely attaching cartridges for vaporizer devices |
US17/171,976 US20210186082A1 (en) | 2013-05-06 | 2021-02-09 | Nicotine salt formulations for aerosol devices and methods thereof |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361820128P | 2013-05-06 | 2013-05-06 | |
US201361912507P | 2013-12-05 | 2013-12-05 | |
US14/271,071 US20140345631A1 (en) | 2013-05-06 | 2014-05-06 | Nicotine salt formulations for aerosol devices and methods thereof |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/512,311 Continuation US9215895B2 (en) | 2013-05-06 | 2014-10-10 | Nicotine salt formulations for aerosol devices and methods thereof |
US14/925,961 Continuation US10952468B2 (en) | 2013-05-06 | 2015-10-28 | Nicotine salt formulations for aerosol devices and methods thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
US20140345631A1 true US20140345631A1 (en) | 2014-11-27 |
Family
ID=51867698
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/271,071 Abandoned US20140345631A1 (en) | 2013-03-15 | 2014-05-06 | Nicotine salt formulations for aerosol devices and methods thereof |
US14/512,311 Active US9215895B2 (en) | 2013-05-06 | 2014-10-10 | Nicotine salt formulations for aerosol devices and methods thereof |
US14/925,968 Abandoned US20160044968A1 (en) | 2013-05-06 | 2015-10-28 | Nicotine salt formulations for aerosol devices and methods thereof |
US14/925,961 Active US10952468B2 (en) | 2013-05-06 | 2015-10-28 | Nicotine salt formulations for aerosol devices and methods thereof |
US17/171,976 Pending US20210186082A1 (en) | 2013-05-06 | 2021-02-09 | Nicotine salt formulations for aerosol devices and methods thereof |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/512,311 Active US9215895B2 (en) | 2013-05-06 | 2014-10-10 | Nicotine salt formulations for aerosol devices and methods thereof |
US14/925,968 Abandoned US20160044968A1 (en) | 2013-05-06 | 2015-10-28 | Nicotine salt formulations for aerosol devices and methods thereof |
US14/925,961 Active US10952468B2 (en) | 2013-05-06 | 2015-10-28 | Nicotine salt formulations for aerosol devices and methods thereof |
US17/171,976 Pending US20210186082A1 (en) | 2013-05-06 | 2021-02-09 | Nicotine salt formulations for aerosol devices and methods thereof |
Country Status (14)
Country | Link |
---|---|
US (5) | US20140345631A1 (es) |
EP (2) | EP2993999B1 (es) |
JP (4) | JP6400678B2 (es) |
KR (3) | KR20230013165A (es) |
CN (4) | CN114223928A (es) |
AU (4) | AU2014262808B2 (es) |
CA (3) | CA2909967C (es) |
ES (1) | ES2856448T3 (es) |
HK (1) | HK1222516A1 (es) |
IL (5) | IL297399B2 (es) |
MX (3) | MX2015015175A (es) |
RU (1) | RU2659887C2 (es) |
UA (1) | UA119323C2 (es) |
WO (1) | WO2014182736A1 (es) |
Cited By (137)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9215895B2 (en) | 2013-05-06 | 2015-12-22 | Pax Labs, Inc. | Nicotine salt formulations for aerosol devices and methods thereof |
USD758650S1 (en) * | 2014-10-16 | 2016-06-07 | Shenzhen Smaco Technology Limited | Electronic cigarette device |
US9408416B2 (en) | 2011-08-16 | 2016-08-09 | Pax Labs, Inc. | Low temperature electronic vaporization device and methods |
US9549573B2 (en) | 2013-12-23 | 2017-01-24 | Pax Labs, Inc. | Vaporization device systems and methods |
US20170112182A1 (en) * | 2015-10-23 | 2017-04-27 | Next Generation Labs, LLC | Nicotine composition for vaping devices and vaping devices employing the same |
WO2017139675A1 (en) * | 2016-02-11 | 2017-08-17 | Pax Labs, Inc. | Securely attaching cartridges for vaporizer devices |
US9801416B2 (en) | 2006-10-18 | 2017-10-31 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
WO2017203689A1 (ja) | 2016-05-27 | 2017-11-30 | 日本たばこ産業株式会社 | 非燃焼型加熱喫煙物品用のたばこ充填物 |
WO2017203686A1 (ja) * | 2016-05-27 | 2017-11-30 | 日本たばこ産業株式会社 | 非燃焼型加熱喫煙物品用のたばこ充填物 |
US9864947B1 (en) | 2016-11-15 | 2018-01-09 | Rai Strategic Holdings, Inc. | Near field communication for a tobacco-based article or package therefor |
US20180027876A1 (en) * | 2016-07-28 | 2018-02-01 | Rai Strategic Holdings, Inc. | Aerosol delivery devices including a selector and related methods |
US20180042306A1 (en) * | 2016-08-05 | 2018-02-15 | Juul Labs, Inc. | Anemometric-assisted control of a vaporizer |
US20180084821A1 (en) * | 2016-09-27 | 2018-03-29 | BOND STREET MANUFACTURING LLC (a Florida LLC) | Vaporizable Tobacco Wax Compositions |
US9936733B2 (en) | 2016-03-09 | 2018-04-10 | Rai Strategic Holdings, Inc. | Accessory configured to charge an aerosol delivery device and related method |
US9955733B2 (en) | 2015-12-07 | 2018-05-01 | Rai Strategic Holdings, Inc. | Camera for an aerosol delivery device |
US9980516B2 (en) | 2015-03-09 | 2018-05-29 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a wave guide and related method |
US10015987B2 (en) | 2015-07-24 | 2018-07-10 | Rai Strategic Holdings Inc. | Trigger-based wireless broadcasting for aerosol delivery devices |
US10015989B2 (en) | 2016-01-27 | 2018-07-10 | Rai Strategic Holdings, Inc. | One-way valve for refilling an aerosol delivery device |
US10028534B2 (en) | 2016-04-20 | 2018-07-24 | Rai Strategic Holdings, Inc. | Aerosol delivery device, and associated apparatus and method of formation thereof |
USD825102S1 (en) | 2016-07-28 | 2018-08-07 | Juul Labs, Inc. | Vaporizer device with cartridge |
US10045567B2 (en) | 2013-12-23 | 2018-08-14 | Juul Labs, Inc. | Vaporization device systems and methods |
US10045568B2 (en) | 2013-12-23 | 2018-08-14 | Juul Labs, Inc. | Vaporization device systems and methods |
US10051891B2 (en) | 2016-01-05 | 2018-08-21 | Rai Strategic Holdings, Inc. | Capacitive sensing input device for an aerosol delivery device |
US10058130B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
US10080387B2 (en) | 2016-09-23 | 2018-09-25 | Rai Strategic Holdings, Inc. | Aerosol delivery device with replaceable wick and heater assembly |
US10085485B2 (en) | 2016-07-06 | 2018-10-02 | Rai Strategic Holdings, Inc. | Aerosol delivery device with a reservoir housing and a vaporizer assembly |
US10092036B2 (en) | 2015-12-28 | 2018-10-09 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a housing and a coupler |
US20180289062A1 (en) * | 2017-03-30 | 2018-10-11 | Markham Biotech Inc. | Cannabinoid Formulations for Aerosol Devices and Methods Thereof |
US10104912B2 (en) | 2016-01-20 | 2018-10-23 | Rai Strategic Holdings, Inc. | Control for an induction-based aerosol delivery device |
US10111470B2 (en) | 2013-12-23 | 2018-10-30 | Juul Labs, Inc. | Vaporizer apparatus |
US20180338905A1 (en) * | 2017-05-26 | 2018-11-29 | Inhale Health, LLC | Bioavailable aerosolized supplement formulations |
USD836541S1 (en) | 2016-06-23 | 2018-12-25 | Pax Labs, Inc. | Charging device |
WO2019005889A1 (en) * | 2017-06-26 | 2019-01-03 | Nude Nicotine, Inc. | NICOTINE SALTS AND METHODS FOR PREPARING AND USING SAME |
US10172392B2 (en) | 2016-11-18 | 2019-01-08 | Rai Strategic Holdings, Inc. | Humidity sensing for an aerosol delivery device |
US10172388B2 (en) | 2015-03-10 | 2019-01-08 | Rai Strategic Holdings, Inc. | Aerosol delivery device with microfluidic delivery component |
US10194694B2 (en) | 2016-01-05 | 2019-02-05 | Rai Strategic Holdings, Inc. | Aerosol delivery device with improved fluid transport |
US10201187B2 (en) | 2015-11-02 | 2019-02-12 | Rai Strategic Holdings, Inc. | User interface for an aerosol delivery device |
US10206431B2 (en) | 2016-11-18 | 2019-02-19 | Rai Strategic Holdings, Inc. | Charger for an aerosol delivery device |
US10206429B2 (en) | 2015-07-24 | 2019-02-19 | Rai Strategic Holdings, Inc. | Aerosol delivery device with radiant heating |
USD842536S1 (en) | 2016-07-28 | 2019-03-05 | Juul Labs, Inc. | Vaporizer cartridge |
US10231484B2 (en) | 2007-12-18 | 2019-03-19 | Juul Labs, Inc. | Aerosol devices and methods for inhaling a substance and uses thereof |
US10231485B2 (en) | 2016-07-08 | 2019-03-19 | Rai Strategic Holdings, Inc. | Radio frequency to direct current converter for an aerosol delivery device |
US10238145B2 (en) | 2015-05-19 | 2019-03-26 | Rai Strategic Holdings, Inc. | Assembly substation for assembling a cartridge for a smoking article |
US10244793B2 (en) | 2005-07-19 | 2019-04-02 | Juul Labs, Inc. | Devices for vaporization of a substance |
US10258086B2 (en) | 2016-01-12 | 2019-04-16 | Rai Strategic Holdings, Inc. | Hall effect current sensor for an aerosol delivery device |
US10274539B2 (en) | 2013-03-07 | 2019-04-30 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
USD848057S1 (en) | 2016-06-23 | 2019-05-07 | Pax Labs, Inc. | Lid for a vaporizer |
US10279934B2 (en) | 2013-03-15 | 2019-05-07 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
US10300225B2 (en) | 2010-05-15 | 2019-05-28 | Rai Strategic Holdings, Inc. | Atomizer for a personal vaporizing unit |
USD849996S1 (en) | 2016-06-16 | 2019-05-28 | Pax Labs, Inc. | Vaporizer cartridge |
EP3488715A2 (en) | 2017-11-24 | 2019-05-29 | Juul Labs, Inc. | Puff sensing and power circuitry for vaporizer devices |
US10314340B2 (en) | 2017-04-21 | 2019-06-11 | Rai Strategic Holdings, Inc. | Refillable aerosol delivery device and related method |
USD851830S1 (en) | 2016-06-23 | 2019-06-18 | Pax Labs, Inc. | Combined vaporizer tamp and pick tool |
US10327472B2 (en) | 2015-09-25 | 2019-06-25 | Altria Client Services Llc | Pre-vaporization formulation for controlling acidity in an e-vaping device |
US10333339B2 (en) | 2016-04-12 | 2019-06-25 | Rai Strategic Holdings, Inc. | Charger for an aerosol delivery device |
US10334880B2 (en) | 2016-03-25 | 2019-07-02 | Rai Strategic Holdings, Inc. | Aerosol delivery device including connector comprising extension and receptacle |
US10349674B2 (en) | 2017-07-17 | 2019-07-16 | Rai Strategic Holdings, Inc. | No-heat, no-burn smoking article |
US10349684B2 (en) | 2015-09-15 | 2019-07-16 | Rai Strategic Holdings, Inc. | Reservoir for aerosol delivery devices |
US10362809B2 (en) | 2011-08-09 | 2019-07-30 | Rai Strategic Holdings, Inc. | Smoking articles and use thereof for yielding inhalation materials |
US10405581B2 (en) | 2016-07-08 | 2019-09-10 | Rai Strategic Holdings, Inc. | Gas sensing for an aerosol delivery device |
US10405579B2 (en) | 2016-04-29 | 2019-09-10 | Rai Strategic Holdings, Inc. | Methods for assembling a cartridge for an aerosol delivery device, and associated systems and apparatuses |
US10405582B2 (en) | 2016-03-10 | 2019-09-10 | Pax Labs, Inc. | Vaporization device with lip sensing |
US10426200B2 (en) | 2013-03-15 | 2019-10-01 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
US20190307176A1 (en) * | 2016-12-27 | 2019-10-10 | Japan Tobacco Inc. | Heating-type flavor inhaler |
US10440992B2 (en) | 2015-12-07 | 2019-10-15 | Rai Strategic Holdings, Inc. | Motion sensing for an aerosol delivery device |
US10463078B2 (en) | 2016-07-08 | 2019-11-05 | Rai Strategic Holdings, Inc. | Aerosol delivery device with condensing and non-condensing vaporization |
US10463069B2 (en) | 2013-12-05 | 2019-11-05 | Juul Labs, Inc. | Nicotine liquid formulations for aerosol devices and methods thereof |
US10470495B2 (en) | 2015-10-21 | 2019-11-12 | Rai Strategic Holdings, Inc. | Lithium-ion battery with linear regulation for an aerosol delivery device |
US10477896B2 (en) | 2016-10-12 | 2019-11-19 | Rai Strategic Holdings, Inc. | Photodetector for measuring aerosol precursor composition in an aerosol delivery device |
US10492530B2 (en) | 2016-11-15 | 2019-12-03 | Rai Strategic Holdings, Inc. | Two-wire authentication system for an aerosol delivery device |
US10505383B2 (en) | 2017-09-19 | 2019-12-10 | Rai Strategic Holdings, Inc. | Intelligent charger for an aerosol delivery device |
US10512282B2 (en) | 2014-12-05 | 2019-12-24 | Juul Labs, Inc. | Calibrated dose control |
US10517530B2 (en) | 2012-08-28 | 2019-12-31 | Juul Labs, Inc. | Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances |
US10517332B2 (en) | 2017-10-31 | 2019-12-31 | Rai Strategic Holdings, Inc. | Induction heated aerosol delivery device |
US10517326B2 (en) | 2017-01-27 | 2019-12-31 | Rai Strategic Holdings, Inc. | Secondary battery for an aerosol delivery device |
US10517330B2 (en) * | 2017-05-23 | 2019-12-31 | RAI Stategic Holdings, Inc. | Heart rate monitor for an aerosol delivery device |
US10524508B2 (en) | 2016-11-15 | 2020-01-07 | Rai Strategic Holdings, Inc. | Induction-based aerosol delivery device |
US10524509B2 (en) | 2016-11-18 | 2020-01-07 | Rai Strategic Holdings, Inc. | Pressure sensing for an aerosol delivery device |
US10531691B2 (en) | 2012-10-08 | 2020-01-14 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
US10537137B2 (en) | 2016-11-22 | 2020-01-21 | Rai Strategic Holdings, Inc. | Rechargeable lithium-ion battery for an aerosol delivery device |
US10555558B2 (en) | 2017-12-29 | 2020-02-11 | Rai Strategic Holdings, Inc. | Aerosol delivery device providing flavor control |
US10561178B2 (en) | 2014-05-23 | 2020-02-18 | Rai Strategic Holdings, Inc. | Sealed cartridge for an aerosol delivery device and related assembly method |
US10582726B2 (en) | 2015-10-21 | 2020-03-10 | Rai Strategic Holdings, Inc. | Induction charging for an aerosol delivery device |
US10602775B2 (en) | 2016-07-21 | 2020-03-31 | Rai Strategic Holdings, Inc. | Aerosol delivery device with a unitary reservoir and liquid transport element comprising a porous monolith and related method |
US10610526B2 (en) | 2015-12-30 | 2020-04-07 | Next Generation Labs, LLC | Nicotine replacement therapy products comprising synthetic nicotine |
US10617151B2 (en) | 2016-07-21 | 2020-04-14 | Rai Strategic Holdings, Inc. | Aerosol delivery device with a liquid transport element comprising a porous monolith and related method |
US10653180B2 (en) | 2013-06-14 | 2020-05-19 | Juul Labs, Inc. | Multiple heating elements with separate vaporizable materials in an electric vaporization device |
US10653186B2 (en) | 2013-11-12 | 2020-05-19 | VMR Products, LLC | Vaporizer, charger and methods of use |
US10653183B2 (en) | 2016-11-18 | 2020-05-19 | Rai Strategic Holdings, Inc. | Power source for an aerosol delivery device |
US10660365B2 (en) * | 2013-07-19 | 2020-05-26 | Altria Client Services Llc | Liquid aerosol formulation of an electronic smoking article |
US10660370B2 (en) | 2017-10-12 | 2020-05-26 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a control body, an atomizer body, and a cartridge and related methods |
USD887632S1 (en) | 2017-09-14 | 2020-06-16 | Pax Labs, Inc. | Vaporizer cartridge |
US10709173B2 (en) | 2014-02-06 | 2020-07-14 | Juul Labs, Inc. | Vaporizer apparatus |
US10750778B2 (en) | 2014-08-21 | 2020-08-25 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a moveable cartridge and related assembly method |
US10765146B2 (en) | 2016-08-08 | 2020-09-08 | Rai Strategic Holdings, Inc. | Boost converter for an aerosol delivery device |
US10765144B2 (en) | 2014-08-21 | 2020-09-08 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a moveable cartridge and related assembly method |
US10806181B2 (en) | 2017-12-08 | 2020-10-20 | Rai Strategic Holdings, Inc. | Quasi-resonant flyback converter for an induction-based aerosol delivery device |
US10820630B2 (en) | 2015-11-06 | 2020-11-03 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a wirelessly-heated atomizer and related method |
US10827783B2 (en) | 2017-02-27 | 2020-11-10 | Rai Strategic Holdings, Inc. | Digital compass for an aerosol delivery device |
US10834964B2 (en) | 2005-07-19 | 2020-11-17 | Juul Labs, Inc. | Method and system for vaporization of a substance |
US10842197B2 (en) | 2017-07-12 | 2020-11-24 | Rai Strategic Holdings, Inc. | Detachable container for aerosol delivery having pierceable membrane |
US10865001B2 (en) | 2016-02-11 | 2020-12-15 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
US10912333B2 (en) | 2016-02-25 | 2021-02-09 | Juul Labs, Inc. | Vaporization device control systems and methods |
US10918134B2 (en) | 2015-10-21 | 2021-02-16 | Rai Strategic Holdings, Inc. | Power supply for an aerosol delivery device |
US10939706B2 (en) | 2015-10-13 | 2021-03-09 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a moveable cartridge and related assembly method |
US10945462B2 (en) | 2016-04-12 | 2021-03-16 | Rai Strategic Holdings, Inc. | Detachable power source for an aerosol delivery device |
US10959458B2 (en) | 2016-06-20 | 2021-03-30 | Rai Strategic Holdings, Inc. | Aerosol delivery device including an electrical generator assembly |
US10966460B2 (en) | 2015-07-17 | 2021-04-06 | Rai Strategic Holdings, Inc. | Load-based detection of an aerosol delivery device in an assembled arrangement |
US11000069B2 (en) | 2015-05-15 | 2021-05-11 | Rai Strategic Holdings, Inc. | Aerosol delivery device and methods of formation thereof |
US11019685B2 (en) | 2014-02-06 | 2021-05-25 | Juul Labs, Inc. | Vaporization device systems and methods |
US11013266B2 (en) | 2016-12-09 | 2021-05-25 | Rai Strategic Holdings, Inc. | Aerosol delivery device sensory system including an infrared sensor and related method |
US11019850B2 (en) | 2018-02-26 | 2021-06-01 | Rai Strategic Holdings, Inc. | Heat conducting substrate for electrically heated aerosol delivery device |
US11033054B2 (en) | 2015-07-24 | 2021-06-15 | Rai Strategic Holdings, Inc. | Radio-frequency identification (RFID) authentication system for aerosol delivery devices |
US11039645B2 (en) | 2017-09-19 | 2021-06-22 | Rai Strategic Holdings, Inc. | Differential pressure sensor for an aerosol delivery device |
US11044950B2 (en) | 2012-09-04 | 2021-06-29 | Rai Strategic Holdings, Inc. | Electronic smoking article comprising one or more microheaters |
US11103012B2 (en) | 2016-11-17 | 2021-08-31 | Rai Strategic Holdings, Inc. | Satellite navigation for an aerosol delivery device |
US11134544B2 (en) | 2015-07-24 | 2021-09-28 | Rai Strategic Holdings, Inc. | Aerosol delivery device with radiant heating |
CN113784634A (zh) * | 2019-03-08 | 2021-12-10 | 莱战略控股公司 | 用于气溶胶递送装置的乳酸水解方法 |
US11207478B2 (en) | 2016-03-25 | 2021-12-28 | Rai Strategic Holdings, Inc. | Aerosol production assembly including surface with micro-pattern |
US11291252B2 (en) | 2015-12-18 | 2022-04-05 | Rai Strategic Holdings, Inc. | Proximity sensing for an aerosol delivery device |
US11297876B2 (en) | 2017-05-17 | 2022-04-12 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
US11337456B2 (en) | 2017-07-17 | 2022-05-24 | Rai Strategic Holdings, Inc. | Video analytics camera system for an aerosol delivery device |
US11344683B2 (en) | 2010-05-15 | 2022-05-31 | Rai Strategic Holdings, Inc. | Vaporizer related systems, methods, and apparatus |
WO2022152529A1 (en) * | 2021-01-12 | 2022-07-21 | Ventus Medical Limited | Aerosolizable nicotine-containing formulations |
US11412781B2 (en) | 2016-02-12 | 2022-08-16 | Rai Strategic Holdings, Inc. | Adapters for refilling an aerosol delivery device |
WO2022180491A1 (en) * | 2021-02-24 | 2022-09-01 | Rai Strategic Holdings, Inc. | Aerosol precursor formulations |
US11458093B2 (en) | 2016-06-30 | 2022-10-04 | Philip Morris Products S.A. | Nicotine particles |
US11478021B2 (en) | 2014-05-16 | 2022-10-25 | Juul Labs, Inc. | Systems and methods for aerosolizing a vaporizable material |
US11504489B2 (en) | 2015-07-17 | 2022-11-22 | Rai Strategic Holdings, Inc. | Contained liquid system for refilling aerosol delivery devices |
US11589621B2 (en) * | 2017-05-23 | 2023-02-28 | Rai Strategic Holdings, Inc. | Heart rate monitor for an aerosol delivery device |
CN115918952A (zh) * | 2023-01-04 | 2023-04-07 | 东莞市吉纯生物技术有限公司 | 一种烟草味专用烟碱盐及其制备方法及其应用 |
US11660403B2 (en) | 2016-09-22 | 2023-05-30 | Juul Labs, Inc. | Leak-resistant vaporizer device |
US11659868B2 (en) | 2014-02-28 | 2023-05-30 | Rai Strategic Holdings, Inc. | Control body for an electronic smoking article |
US11937647B2 (en) | 2016-09-09 | 2024-03-26 | Rai Strategic Holdings, Inc. | Fluidic control for an aerosol delivery device |
US11992038B2 (en) | 2018-12-31 | 2024-05-28 | Philip Morris Products S.A. | Liquid nicotine formulation comprising partially water-soluble solvent |
US12048762B2 (en) | 2016-06-30 | 2024-07-30 | Philip Morris Products S.A. | Nicotine particles |
Families Citing this family (174)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1993724B (zh) * | 2004-07-29 | 2010-10-27 | 皇家飞利浦电子股份有限公司 | 利用极性反转图案来驱动显示器 |
US11247003B2 (en) | 2010-08-23 | 2022-02-15 | Darren Rubin | Systems and methods of aerosol delivery with airflow regulation |
ITBO20130706A1 (it) * | 2013-12-20 | 2015-06-21 | Sino Business Ltd | Composizione per sigarette elettroniche |
EP3073846B1 (en) | 2013-05-22 | 2023-07-05 | Njoy, Inc. | Compositions, devices, and methods for nicotine aerosol delivery |
FR3015186A1 (fr) * | 2014-03-11 | 2015-06-26 | Antoine Piccirilli | Utilisation d'une composition renfermant du 1,3-propanediol comme e-liquide |
US9896429B2 (en) | 2014-05-27 | 2018-02-20 | R.J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
CN113754634A (zh) | 2014-05-27 | 2021-12-07 | R.J.雷诺兹烟草公司 | 烟碱盐、共晶体和盐共晶体络合物 |
US10508096B2 (en) | 2014-05-27 | 2019-12-17 | R.J. Reynolds Tobacco Company | Nicotine salts, co-crystals, and salt co-crystal complexes |
GB2535427A (en) * | 2014-11-07 | 2016-08-24 | Nicoventures Holdings Ltd | Solution |
GB2532062A (en) | 2014-11-07 | 2016-05-11 | Nicoventures Holdings Ltd | Container |
CN104473322A (zh) * | 2014-12-02 | 2015-04-01 | 河南中烟工业有限责任公司 | 一种含烟碱和有机酸的电子烟烟液 |
USD792957S1 (en) | 2015-02-10 | 2017-07-25 | Blake Starkenburg | Vaporizing device outer lid and basket assembly |
US10611505B2 (en) | 2015-05-04 | 2020-04-07 | Rai Strategic Holdings, Inc. | Dispensing machine for aerosol precursor |
US20170059554A1 (en) | 2015-09-02 | 2017-03-02 | R. J. Reynolds Tobacco Company | Method for monitoring use of a tobacco product |
EP3155909B1 (en) * | 2015-10-16 | 2018-03-21 | Fontem Holdings 1 B.V. | Slide-on attachment for electronic smoking devices |
US20170119052A1 (en) | 2015-10-30 | 2017-05-04 | R.J. Reynolds Tobacco Company | Application specific integrated circuit (asic) for an aerosol delivery device |
DK3379952T3 (da) * | 2015-11-25 | 2024-01-08 | Reynolds Tobacco Co R | Nikotinsalte, co-krystaller og salt-co-krystalkomplekser |
US20170172204A1 (en) | 2015-12-18 | 2017-06-22 | Altria Client Services Llc | Strength enhancers and method of achieving strength enhancement in an electronic vapor device |
US20170251724A1 (en) | 2016-03-04 | 2017-09-07 | Rai Strategic Holdings, Inc. | Flexible display for an aerosol delivery device |
CN118319066A (zh) * | 2016-04-22 | 2024-07-12 | 尤尔实验室有限公司 | 具有间隔材料的气雾剂装置 |
US10405580B2 (en) | 2016-07-07 | 2019-09-10 | Altria Client Services Llc | Mechanically-adjustable e-vaping device flavor assembly |
CN106063583A (zh) * | 2016-07-14 | 2016-11-02 | 深圳昱朋科技有限公司 | 烟油添加剂的制备方法及烟油 |
DE102016114718B4 (de) | 2016-08-09 | 2021-02-25 | Hauni Maschinenbau Gmbh | Inhalator |
US20180070633A1 (en) | 2016-09-09 | 2018-03-15 | Rai Strategic Holdings, Inc. | Power source for an aerosol delivery device |
US20180070634A1 (en) | 2016-09-09 | 2018-03-15 | Rai Strategic Holdings, Inc. | Analog control component for an aerosol delivery device |
US20180084823A1 (en) | 2016-09-27 | 2018-03-29 | BOND STREET MANUFACTURING LLC (a Florida LLC) | Vaporizable Tobacco Wax Compositions and Container thereof |
US20180103680A1 (en) * | 2016-10-18 | 2018-04-19 | Altria Client Services Llc | Methods and systems for improving stability of the pre-vapor formulation of an e-vaping device |
US20180132526A1 (en) | 2016-11-11 | 2018-05-17 | Rai Strategic Holdings, Inc. | Real-time temperature control for an aerosol delivery device |
US20180132529A1 (en) | 2016-11-14 | 2018-05-17 | Rai Strategic Holdings, Inc. | Aerosol delivery device with integrated wireless connectivity for temperature monitoring |
US20180132528A1 (en) | 2016-11-14 | 2018-05-17 | Rai Strategic Holdings, Inc. | Photoelectric proximity sensor for gesture-based control of an aerosol delivery device |
WO2018100495A1 (en) | 2016-12-01 | 2018-06-07 | Rai Strategic Holdings, Inc. | Rechargeable lithium-ion capacitor for an aerosol delivery device |
CN110036551A (zh) | 2016-12-02 | 2019-07-19 | 莱战略控股公司 | 用于气溶胶递送设备的感应充电 |
JP2020513742A (ja) | 2016-12-30 | 2020-05-21 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチン含有シート |
EP3562328A1 (en) * | 2016-12-30 | 2019-11-06 | Philip Morris Products S.a.s. | Nicotine and binder containing sheet |
MX2019007464A (es) | 2016-12-30 | 2019-09-09 | Philip Morris Products Sa | Lamina que contiene nicotina y celulosa. |
US10759554B2 (en) | 2017-02-02 | 2020-09-01 | Rai Strategic Holdings, Inc. | Dispenser unit for aerosol precursor |
US10440995B2 (en) | 2017-03-29 | 2019-10-15 | Rai Strategic Holdings, Inc. | Aerosol delivery device including substrate with improved absorbency properties |
US10674765B2 (en) | 2017-03-29 | 2020-06-09 | Rai Strategic Holdings, Inc. | Aerosol delivery device with improved atomizer |
US10285444B2 (en) | 2017-04-27 | 2019-05-14 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a ceramic wicking element |
US10383369B2 (en) | 2017-06-07 | 2019-08-20 | Rai Strategic Holdings, Inc. | Fibrous filtration material for electronic smoking article |
US10791761B2 (en) | 2017-08-17 | 2020-10-06 | Rai Strategic Holdings, Inc. | Microtextured liquid transport element for aerosol delivery device |
WO2019049049A1 (en) | 2017-09-05 | 2019-03-14 | R. J. Reynolds Tobacco Company | SALTS, CO-CRYSTALS, AND CO-CRYSTAL COMPLEXES OF NICOTINE SALTS |
CN107536099A (zh) * | 2017-09-14 | 2018-01-05 | 昌宁德康生物科技(深圳)有限公司 | 一种尼古丁盐及其制备方法 |
GB2604314A (en) | 2017-09-22 | 2022-09-07 | Nerudia Ltd | Device, system and method |
US20190116863A1 (en) | 2017-10-24 | 2019-04-25 | Rai Strategic Holdings, Inc. | Method for formulating aerosol precursor for aerosol delivery device |
CN107812005A (zh) * | 2017-10-26 | 2018-03-20 | 广州和慧思生物科技有限公司 | 一种复合烟碱盐及其制备方法 |
US10786010B2 (en) | 2017-12-15 | 2020-09-29 | Rai Strategic Holdings, Inc. | Aerosol delivery device with multiple aerosol delivery pathways |
CN108208915B (zh) * | 2017-12-29 | 2021-06-08 | 深圳睿思奇科技开发有限公司 | 一种烟油降刺柔顺剂的制备方法及用该方法制备的烟油降刺柔顺剂 |
US10813385B2 (en) | 2018-03-09 | 2020-10-27 | Rai Strategic Holdings, Inc. | Buck regulator with operational amplifier feedback for an aerosol delivery device |
US10945465B2 (en) | 2018-03-15 | 2021-03-16 | Rai Strategic Holdings, Inc. | Induction heated susceptor and aerosol delivery device |
US11206864B2 (en) | 2018-03-26 | 2021-12-28 | Rai Strategic Holdings, Inc. | Aerosol delivery device providing flavor control |
GB201807305D0 (en) * | 2018-05-03 | 2018-06-20 | Nicoventures Trading Ltd | Vaporisable formulation |
US10932490B2 (en) | 2018-05-16 | 2021-03-02 | Rai Strategic Holdings, Inc. | Atomizer and aerosol delivery device |
US10959459B2 (en) | 2018-05-16 | 2021-03-30 | Rai Strategic Holdings, Inc. | Voltage regulator for an aerosol delivery device |
EP3574902A1 (en) * | 2018-06-01 | 2019-12-04 | Yatzz Limited | Nicotine formulation and mode of delivery |
US11191298B2 (en) | 2018-06-22 | 2021-12-07 | Rai Strategic Holdings, Inc. | Aerosol source member having combined susceptor and aerosol precursor material |
WO2020002585A1 (en) * | 2018-06-29 | 2020-01-02 | Nerudia Limited | A method for manufacturing reconstituted plant material |
EP3826705B1 (en) | 2018-07-23 | 2022-09-14 | Juul Labs, Inc. | Airflow management for vaporizer device |
WO2020023540A1 (en) | 2018-07-23 | 2020-01-30 | Juul Labs, Inc. | Cartridge for vaporizer device |
GB201812496D0 (en) * | 2018-07-31 | 2018-09-12 | Nicoventures Holdings Ltd | Aerosol generation |
US11094993B2 (en) | 2018-08-10 | 2021-08-17 | Rai Strategic Holdings, Inc. | Charge circuitry for an aerosol delivery device |
US11517685B2 (en) | 2019-01-18 | 2022-12-06 | Qnovia, Inc. | Electronic device for producing an aerosol for inhalation by a person |
US11690963B2 (en) | 2018-08-22 | 2023-07-04 | Qnovia, Inc. | Electronic device for producing an aerosol for inhalation by a person |
US10939707B2 (en) | 2018-08-23 | 2021-03-09 | Rai Strategic Holdings, Inc. | Aerosol delivery device with segmented electrical heater |
CN109007981A (zh) * | 2018-09-10 | 2018-12-18 | 深圳市新宜康科技股份有限公司 | 一种液态尼古丁盐及其制备方法 |
CN109171010A (zh) * | 2018-09-10 | 2019-01-11 | 深圳市新宜康科技股份有限公司 | 液态尼古丁盐及其制备方法 |
US20200077703A1 (en) | 2018-09-11 | 2020-03-12 | Rai Strategic Holdings, Inc. | Wicking element for aerosol delivery device |
US11291249B2 (en) | 2018-10-12 | 2022-04-05 | Rai Strategic Holdings, Inc. | Aerosol delivery device with visible indicator |
US20200113240A1 (en) | 2018-10-12 | 2020-04-16 | Rai Strategic Holdings, Inc. | Vaporization system |
US10791767B2 (en) | 2018-10-12 | 2020-10-06 | Rai Strategic Holdings, Inc. | Connectors for forming electrical and mechanical connections between interchangeable units in an aerosol delivery system |
US11588287B2 (en) | 2018-10-12 | 2023-02-21 | Rai Strategic Holdings, Inc. | Aerosol delivery device with improved connectivity, airflow, and aerosol paths |
US20200113243A1 (en) | 2018-10-12 | 2020-04-16 | Rai Strategic Holdings, Inc. | Heater and liquid transport for an aerosol delivery system |
CN109288115A (zh) * | 2018-10-16 | 2019-02-01 | 云南拓宝科技有限公司 | 一种无溶剂法制备的烟碱盐及其制备方法 |
CN109288117B (zh) * | 2018-10-22 | 2022-06-17 | 福建中烟工业有限责任公司 | 一种组合物及其在卷烟中的应用 |
FI3840596T3 (fi) | 2018-10-24 | 2023-04-26 | Zanoprima Lifesciences Ltd | Koostumus |
GB201817859D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
GB201817861D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Gel and crystalline powder |
GB201817867D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
US11592793B2 (en) | 2018-11-19 | 2023-02-28 | Rai Strategic Holdings, Inc. | Power control for an aerosol delivery device |
US11372153B2 (en) | 2018-11-19 | 2022-06-28 | Rai Strategic Holdings, Inc. | Cartridge orientation for selection of a control function in a vaporization system |
US11614720B2 (en) | 2018-11-19 | 2023-03-28 | Rai Strategic Holdings, Inc. | Temperature control in an aerosol delivery device |
US20200154779A1 (en) | 2018-11-19 | 2020-05-21 | Rai Strategic Holdings, Inc. | Charging control for an aerosol delivery device |
US11753750B2 (en) | 2018-11-20 | 2023-09-12 | R.J. Reynolds Tobacco Company | Conductive aerosol generating composite substrate for aerosol source member |
US11547816B2 (en) | 2018-11-28 | 2023-01-10 | Rai Strategic Holdings, Inc. | Micropump for an aerosol delivery device |
CA185291S (en) | 2018-12-17 | 2019-12-13 | Green Tank Tech Corp | Vaporizer |
JP7410956B2 (ja) * | 2019-01-24 | 2024-01-10 | イノ-アイティー・カンパニー・リミテッド | 電気加熱式喫煙物品内に挿入可能なゲル状エアロゾル発生基材カートリッジ、これを含む電気加熱式喫煙物品、並びに、このためのエアロゾル発生装置及びシステム |
US11096419B2 (en) | 2019-01-29 | 2021-08-24 | Rai Strategic Holdings, Inc. | Air pressure sensor for an aerosol delivery device |
US20200237018A1 (en) | 2019-01-29 | 2020-07-30 | Rai Strategic Holdings, Inc. | Susceptor arrangement for induction-heated aerosol delivery device |
US20200245696A1 (en) | 2019-02-06 | 2020-08-06 | Rai Strategic Holdings, Inc. | Buck-boost regulator circuit for an aerosol delivery device |
US11456480B2 (en) | 2019-02-07 | 2022-09-27 | Rai Strategic Holdings, Inc. | Non-inverting amplifier circuit for an aerosol delivery device |
US20200278707A1 (en) | 2019-03-01 | 2020-09-03 | Rai Strategic Holdings, Inc. | Temperature control circuitry for an aerosol delivery device |
FR3093405B1 (fr) * | 2019-03-05 | 2022-07-29 | V F P France | Compositions de vapotage |
US11324249B2 (en) | 2019-03-06 | 2022-05-10 | R.J. Reynolds Tobacco Company | Aerosol delivery device with nanocellulose substrate |
US11602164B2 (en) | 2019-03-14 | 2023-03-14 | Rai Strategic Holdings, Inc. | Aerosol delivery device with graded porosity from inner to outer wall surfaces |
US11140918B2 (en) | 2019-03-15 | 2021-10-12 | Flair Products Llc | Personal vaporizer |
EP3714876A1 (de) * | 2019-03-29 | 2020-09-30 | VitaSalts AG | Verdampfungszusammensetzungen zum inhalieren |
US11200770B2 (en) | 2019-04-02 | 2021-12-14 | Rai Strategic Holdings, Inc. | Functional control and age verification of electronic devices through visual communication |
US11935350B2 (en) | 2019-04-02 | 2024-03-19 | Rai Strategic Holdings, Inc. | Functional control and age verification of electronic devices through speaker communication |
US11676438B2 (en) | 2019-04-02 | 2023-06-13 | Rai Strategic Holdings, Inc. | Authentication and age verification for an aerosol delivery device |
WO2020200773A1 (en) | 2019-04-04 | 2020-10-08 | Ventus Medical Limited | A heater assembly |
US11783395B2 (en) | 2019-04-24 | 2023-10-10 | Rai Strategic Holdings, Inc. | Decentralized identity storage for tobacco products |
US11690405B2 (en) | 2019-04-25 | 2023-07-04 | Rai Strategic Holdings, Inc. | Artificial intelligence in an aerosol delivery device |
US11517688B2 (en) | 2019-05-10 | 2022-12-06 | Rai Strategic Holdings, Inc. | Flavor article for an aerosol delivery device |
US20200359703A1 (en) | 2019-05-17 | 2020-11-19 | Rai Strategic Holdings, Inc. | Age verification with registered cartridges for an aerosol delivery device |
US20200367553A1 (en) | 2019-05-22 | 2020-11-26 | Rai Strategic Holdings, Inc. | Reservoir configuration for aerosol delivery device |
US11589425B2 (en) | 2019-05-24 | 2023-02-21 | Rai Strategic Holdings, Inc. | Shape memory material for controlled liquid delivery in an aerosol delivery device |
KR20220014875A (ko) | 2019-05-31 | 2022-02-07 | 제이티 인터내셔널 소시에떼 아노님 | 니코틴 액제 |
CN113905625A (zh) * | 2019-06-25 | 2022-01-07 | 菲利普莫里斯生产公司 | 包含尼古丁和水不混溶性溶剂的筒 |
US12022859B2 (en) | 2019-07-18 | 2024-07-02 | R.J. Reynolds Tobacco Company | Thermal energy absorbers for tobacco heating products |
US11207711B2 (en) | 2019-08-19 | 2021-12-28 | Rai Strategic Holdings, Inc. | Detachable atomization assembly for aerosol delivery device |
CA3149463A1 (en) | 2019-08-29 | 2021-03-04 | Vahid Hejazi | Dual-chamber aerosol dispenser |
CN110452219B (zh) * | 2019-09-05 | 2020-06-12 | 深圳市真味生物科技有限公司 | 一种尼古丁盐及其制备方法、设备 |
US11889861B2 (en) | 2019-09-23 | 2024-02-06 | Rai Strategic Holdings, Inc. | Arrangement of atomization assemblies for aerosol delivery device |
US11785991B2 (en) | 2019-10-04 | 2023-10-17 | Rai Strategic Holdings, Inc. | Use of infrared temperature detection in an aerosol delivery device |
US10721973B1 (en) | 2019-10-09 | 2020-07-28 | Cegnum LLC | Electronic smoking device with an indicator assembly for providing visual output based on operation of plural atomizers |
US10842189B1 (en) | 2019-10-09 | 2020-11-24 | Cegnum LLC | Electronic smoking device including terminals arranged to provide for selective energizing of heating elements |
US20210112882A1 (en) | 2019-10-18 | 2021-04-22 | Rai Strategic Holdings, Inc. | Surface acoustic wave atomizer for aerosol delivery device |
US11304451B2 (en) | 2019-10-18 | 2022-04-19 | Rai Strategic Holdings, Inc. | Aerosol delivery device with dual reservoir |
EP3811789A1 (en) | 2019-10-24 | 2021-04-28 | Nerudia Limited | Smoking substitute system |
US11470689B2 (en) | 2019-10-25 | 2022-10-11 | Rai Strategic Holdings, Inc. | Soft switching in an aerosol delivery device |
KR20220100946A (ko) | 2019-11-18 | 2022-07-18 | 레이 스트라티직 홀딩스, 인크. | 보안 태그 |
US11730191B2 (en) | 2019-12-15 | 2023-08-22 | Shaheen Innovations Holding Limited | Hookah device |
IL294000B (en) | 2019-12-15 | 2022-09-01 | Shaheen Innovations Holding Ltd | Steam inhaler devices |
US11589610B2 (en) | 2019-12-15 | 2023-02-28 | Shaheen Innovations Holding Limited | Nicotine delivery device having a mist generator device and a driver device |
US11666713B2 (en) | 2019-12-15 | 2023-06-06 | Shaheen Innovations Holding Limited | Mist inhaler devices |
US20240148053A9 (en) | 2019-12-15 | 2024-05-09 | Shaheen Innovations Holding Limited | Hookah device |
WO2021123869A1 (en) | 2019-12-15 | 2021-06-24 | Shaheen Innovations Holding Limited | Ultrasonic mist inhaler |
US11730193B2 (en) | 2019-12-15 | 2023-08-22 | Shaheen Innovations Holding Limited | Hookah device |
WO2021123867A1 (en) | 2019-12-15 | 2021-06-24 | Shaheen Innovations Holding Limited | Ultrasonic mist inhaler |
EP3860696B1 (en) | 2019-12-15 | 2024-04-10 | Shaheen Innovations Holding Limited | Ultrasonic mist inhaler |
CN111072631A (zh) * | 2019-12-23 | 2020-04-28 | 华宝香精股份有限公司 | 一种无色苯甲酸烟碱盐的制备方法 |
CA3163451A1 (en) | 2019-12-30 | 2021-07-08 | Rai Strategic Holdings Inc | A heart rate monitor for an aerosol delivery device |
US11607511B2 (en) | 2020-01-08 | 2023-03-21 | Nicoventures Trading Limited | Inductively-heated substrate tablet for aerosol delivery device |
US11457665B2 (en) | 2020-01-16 | 2022-10-04 | Nicoventures Trading Limited | Susceptor arrangement for an inductively-heated aerosol delivery device |
JP2021122237A (ja) * | 2020-02-05 | 2021-08-30 | 日本たばこ産業株式会社 | 液体加熱式の加熱型香味吸引器用の液体組成物 |
KR102653443B1 (ko) * | 2020-03-25 | 2024-03-29 | 선전 필라이프 라이프 사이언스 컴퍼니., 리미티드. | 인공 합성 라세미 니코틴 염의 제조 방법 |
CN113951546A (zh) * | 2020-03-27 | 2022-01-21 | 深圳市水槟榔生物科技有限公司 | 槟榔碱盐及其制备方法、制品 |
MA65146B1 (fr) * | 2020-04-06 | 2024-05-31 | Shaheen Innovations Holding Ltd | Dispositifs d'inhalateur de brouillard |
US20210321655A1 (en) | 2020-04-16 | 2021-10-21 | R.J. Reynolds Tobacco Company | Aerosol delivery device including a segregated substrate |
US20210321674A1 (en) | 2020-04-21 | 2021-10-21 | Rai Strategic Holdings, Inc. | Pressure-sensing user interface for an aerosol delivery device |
US11839240B2 (en) | 2020-04-29 | 2023-12-12 | Rai Strategic Holdings, Inc. | Piezo sensor for a power source |
US20230225403A1 (en) | 2020-05-29 | 2023-07-20 | Nicoventures Trading Limited | Aerosol delivery device |
WO2021245391A1 (en) | 2020-06-01 | 2021-12-09 | Shaheen Innovations Holding Limited | An infectious disease screening device |
CA3180786A1 (en) | 2020-06-01 | 2021-05-28 | Imad Lahoud | An infectious disease screening system |
US20220000178A1 (en) | 2020-07-01 | 2022-01-06 | Nicoventures Trading Limited | 3d-printed substrate for aerosol delivery device |
US11771132B2 (en) | 2020-08-27 | 2023-10-03 | Rai Strategic Holdings, Inc. | Atomization nozzle for aerosol delivery device |
US11707088B2 (en) | 2020-09-25 | 2023-07-25 | Rai Strategic Holdings, Inc. | Aroma delivery system for aerosol delivery device |
US11771136B2 (en) | 2020-09-28 | 2023-10-03 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
AU2021359804A1 (en) * | 2020-10-16 | 2023-06-01 | Philip Morris Products S.A. | Liquid nicotine formulation and cartridge for an aerosol-generating system |
US11856986B2 (en) | 2020-10-19 | 2024-01-02 | Rai Strategic Holdings, Inc. | Customizable panel for aerosol delivery device |
KR102647379B1 (ko) * | 2020-10-19 | 2024-03-13 | 주식회사 케이티앤지 | 유기 산을 포함하는 에어로졸 생성 물품 |
WO2022094358A1 (en) * | 2020-11-01 | 2022-05-05 | Respira Technologies, Inc. | Aqueous formulation for aerosolizing and inhaling using electronic devices |
US20220168514A1 (en) | 2020-12-01 | 2022-06-02 | Rai Strategic Holdings, Inc. | Microchannel Feed System for an Aerosol Delivery Device |
US11969545B2 (en) | 2020-12-01 | 2024-04-30 | Rai Strategic Holdings, Inc. | Liquid feed systems for an aerosol delivery device |
WO2022121451A1 (zh) * | 2020-12-07 | 2022-06-16 | 深圳雾芯科技有限公司 | 电子烟液及包含其的雾化装置 |
CN114587008B (zh) * | 2020-12-07 | 2023-09-05 | 深圳雾芯科技有限公司 | 电子烟液及包含其的雾化装置 |
WO2022121452A1 (zh) * | 2020-12-07 | 2022-06-16 | 深圳雾芯科技有限公司 | 电子烟液及包含其的雾化装置 |
US20220183389A1 (en) | 2020-12-11 | 2022-06-16 | Rai Strategic Holdings, Inc. | Sleeve for smoking article |
US11382861B1 (en) * | 2020-12-17 | 2022-07-12 | Nirajkumar Karneshbhai Patel | Nicotine pouch |
KR102573819B1 (ko) | 2020-12-22 | 2023-08-31 | 주식회사 케이티앤지 | 에어로졸 생성 물질 가열 장치 및 시스템 |
KR102508689B1 (ko) | 2020-12-22 | 2023-03-10 | 주식회사 케이티앤지 | 에어로졸 생성 장치 및 시스템 |
CN114983001A (zh) * | 2021-03-02 | 2022-09-02 | 深圳雾灵科技有限公司 | 一种烟草产品的添加剂及其制备方法和应用 |
CN113115976B (zh) * | 2021-03-11 | 2022-07-19 | 浙江中烟工业有限责任公司 | 一种烟碱盐的批量制备方法及其在电子烟中的应用 |
US20220304378A1 (en) | 2021-03-24 | 2022-09-29 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
CZ309812B6 (cs) * | 2021-05-25 | 2023-11-01 | Consumer Brands International s.r.o | Směs pro výrobu nikotinových sáčků a způsob její výroby |
CN113907398B (zh) * | 2021-09-28 | 2023-06-27 | 深圳市真味生物科技有限公司 | 一种具有防漏液功能的电子雾化液 |
US20230105080A1 (en) | 2021-10-01 | 2023-04-06 | Rai Strategic Holdings, Inc. | Absorbent containing mouthpiece for aerosol delivery device |
US20230107943A1 (en) | 2021-10-01 | 2023-04-06 | Rai Strategic Holdings, Inc. | Mouthpiece for aerosol delivery device |
US20230188901A1 (en) | 2021-12-15 | 2023-06-15 | Shaheen Innovations Holding Limited | Apparatus for transmitting ultrasonic waves |
WO2023161465A1 (en) | 2022-02-28 | 2023-08-31 | Jt International S.A. | Provision of high nicotine aerosol |
CN114868955B (zh) * | 2022-05-09 | 2023-08-18 | 东莞市吉纯生物技术有限公司 | 一种尼古丁盐制备方法、尼古丁盐以及气溶胶制品 |
CN114886144A (zh) * | 2022-05-16 | 2022-08-12 | 深圳昱朋科技有限公司 | 一种组合物及其制备方法和应用 |
US20240057691A1 (en) | 2022-08-19 | 2024-02-22 | Rai Strategic Holdings, Inc. | Pressurized aerosol delivery device |
WO2024073334A1 (en) | 2022-09-26 | 2024-04-04 | Rose Research Center, Llc | Combination for use in a method of preventing weight gain |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060018840A1 (en) * | 2004-06-28 | 2006-01-26 | Nektar Therapeutics | Aerosolizable formulation comprising nicotine |
US9215895B2 (en) * | 2013-05-06 | 2015-12-22 | Pax Labs, Inc. | Nicotine salt formulations for aerosol devices and methods thereof |
Family Cites Families (653)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US576653A (en) | 1897-02-09 | Combined match | ||
US595070A (en) | 1897-12-07 | Ernest oldenbusch | ||
US374584A (en) | 1887-12-13 | Joseph cook | ||
US720007A (en) | 1902-05-28 | 1903-02-10 | Edwin Grant Dexter | Tobacco cartridge. |
US799844A (en) | 1903-02-18 | 1905-09-19 | Mergott J E Co | Match-box or other receptacle. |
US968160A (en) | 1904-11-29 | 1910-08-23 | Edward Hibberd Johnson | Tobacco-pipe. |
US969076A (en) | 1907-03-11 | 1910-08-30 | Gorham Mfg Company | Match-box. |
US1067531A (en) | 1911-04-17 | 1913-07-15 | Peter Macgregor | Detachable tab. |
US1163183A (en) | 1914-10-22 | 1915-12-07 | David Stoll | Cigarette-box. |
US1299162A (en) | 1918-02-13 | 1919-04-01 | Marathon Company | Cigarette-case. |
US1552877A (en) | 1923-01-25 | 1925-09-08 | Ralph S Phillipps | Container for tobacco and other products |
US1505748A (en) | 1924-03-26 | 1924-08-19 | Schanfein & Tamis | Cigarette case |
US1632335A (en) | 1925-04-27 | 1927-06-14 | J E Mergott Co | Articulated case for smokers' requisites |
US1706244A (en) | 1927-11-01 | 1929-03-19 | Meyerson Louis | Combination cigarette holder and ash receptacle |
US1845340A (en) | 1928-11-02 | 1932-02-16 | Woller Oliver C Ritz | Combination cigarette case and lighter |
US1972118A (en) | 1932-01-07 | 1934-09-04 | Rex D Mcdill | Medicated stick |
US2039559A (en) | 1933-03-17 | 1936-05-05 | Hyman R Segal | Cigarette case |
US1998683A (en) | 1934-02-16 | 1935-04-23 | Fred H Montgomery | Device for treating cigarettes |
US2031363A (en) | 1935-01-28 | 1936-02-18 | Erikson Erik Elof | Combination vanity case |
US2104266A (en) | 1935-09-23 | 1938-01-04 | William J Mccormick | Means for the production and inhalation of tobacco fumes |
US2177636A (en) | 1936-12-17 | 1939-10-31 | Coffelt | Combined cigarette holder, smoker, and ash-retainer |
US2159698A (en) | 1937-01-08 | 1939-05-23 | Harris Julius | Stem |
US2195260A (en) | 1937-12-29 | 1940-03-26 | Walter H Rasener | Smoker's pipe |
US2231909A (en) | 1939-06-29 | 1941-02-18 | Edwin G Hempel | Spring hinge |
US2327120A (en) | 1940-11-12 | 1943-08-17 | Trijex Corp | Cigarette case |
US2483304A (en) | 1945-12-11 | 1949-09-27 | Vogel Rudolf | Container |
US2460427A (en) | 1946-01-26 | 1949-02-01 | Henry E Musselman | Combined cigarette case and lighter |
US2502561A (en) | 1947-02-25 | 1950-04-04 | Einson Freeman Co Inc | Package deivce for shipping and displaying articles, and display mantle therefor |
US2830597A (en) | 1953-05-21 | 1958-04-15 | Kummli Jakob | Smoking device |
US2765949A (en) | 1953-10-23 | 1956-10-09 | Hillman Swan | Container |
US2860638A (en) | 1956-02-21 | 1958-11-18 | Bartolomeo Frank | Smoking device |
US2935987A (en) | 1956-03-21 | 1960-05-10 | Johnstown Res Associates Inc | Tobacco pellet for pipes |
US2897958A (en) | 1957-04-04 | 1959-08-04 | Black Starr & Gorham | Cigarette case |
US3271719A (en) | 1961-06-21 | 1966-09-06 | Energy Conversion Devices Inc | Resistance switches and the like |
US3146937A (en) | 1962-12-13 | 1964-09-01 | Crown Zellerbach Canada Ltd | Extendable handle carton |
US3258015A (en) | 1964-02-04 | 1966-06-28 | Battelle Memorial Institute | Smoking device |
GB1025630A (en) | 1964-03-19 | 1966-04-14 | British American Tobacco Co | Improvements relating to tobacco charges for pipes |
US3292634A (en) | 1964-03-20 | 1966-12-20 | Stephen Nester | Tobacco holding cartridge |
GB1065678A (en) | 1964-11-10 | 1967-04-19 | Super Temp Corp | Smoking elements and devices |
US3373915A (en) | 1965-06-28 | 1968-03-19 | Riegel Paper Corp | Moldable pouch material |
US3443827A (en) | 1966-10-21 | 1969-05-13 | William L Acker | Connector assembly for axially connecting rods and tubing |
US3456645A (en) | 1967-01-19 | 1969-07-22 | Dart Ind Inc | Inhalation-actuated aerosol dispensing device |
US3420360A (en) | 1967-06-30 | 1969-01-07 | Willie C Young | Split pack of cigarettes |
US3479561A (en) | 1967-09-25 | 1969-11-18 | John L Janning | Breath operated device |
US3567014A (en) | 1969-05-09 | 1971-03-02 | Churchill Co Inc The | Tray for shipping and displaying merchandise |
US3675661A (en) | 1970-03-18 | 1972-07-11 | William R Weaver | Smoking pipe |
US3707017A (en) | 1970-11-20 | 1972-12-26 | Bjorksten Research Lab Inc | Magnetic hinge |
US3792704A (en) | 1971-05-12 | 1974-02-19 | M Parker | Pipe tobacco smoking system |
US3815597A (en) | 1972-11-24 | 1974-06-11 | W Goettelman | Pipe inhaler |
US3861523A (en) | 1973-02-09 | 1975-01-21 | Mary Fountain | Case for cigarettes and cigarette substitute |
US3941300A (en) | 1974-07-19 | 1976-03-02 | Pamark, Inc. | Folded plastic container with snap lid |
US4020853A (en) | 1975-10-02 | 1977-05-03 | Nuttall Richard T | Smoking pipe |
US4049005A (en) | 1976-05-17 | 1977-09-20 | Hernandez Armando C | Filtering apparatus for cigarette smokers |
US4066088A (en) | 1976-08-26 | 1978-01-03 | Ensor John E | Smoke reducer for cigarette smokers |
NL165639C (nl) | 1977-03-02 | 1981-05-15 | Evert Jacob Sybren Bron | Pijp voor sigaretten, sigaren en andere tabaksartikelen waarbij in het rookkanaal een gloeidraad als nabrander is aangebracht. |
US4219032A (en) | 1977-11-30 | 1980-08-26 | Reiner Steven H | Smoking device |
US4207976A (en) | 1979-04-09 | 1980-06-17 | Herman Rodney W | Cigarette package |
US4312367A (en) | 1980-05-08 | 1982-01-26 | Philip Morris Incorporated | Smoking compositions |
DE3022465A1 (de) | 1980-06-14 | 1982-01-07 | Robert Finke Kunststoff-Spritzguss-Werk, 5950 Finnentrop | Sicherheitsschraubverschluss |
US4303083A (en) | 1980-10-10 | 1981-12-01 | Burruss Jr Robert P | Device for evaporation and inhalation of volatile compounds and medications |
US4519319A (en) | 1982-05-20 | 1985-05-28 | Container Corporation Of America | Tubular paperboard display stand |
GB8301659D0 (en) | 1983-01-21 | 1983-02-23 | Leo Ab | Smoking substitutes |
US4506683A (en) | 1983-05-09 | 1985-03-26 | Brown & Williamson Tobacco Corporation | Ventilated mouthpiece for a smoking article |
IL73912A0 (en) | 1984-01-09 | 1985-03-31 | Advanced Tobacco Prod | Nicotine preparation |
US4595024A (en) | 1984-08-31 | 1986-06-17 | R. J. Reynolds Tobacco Company | Segmented cigarette |
US5020548A (en) | 1985-08-26 | 1991-06-04 | R. J. Reynolds Tobacco Company | Smoking article with improved fuel element |
US5042509A (en) | 1984-09-14 | 1991-08-27 | R. J. Reynolds Tobacco Company | Method for making aerosol generating cartridge |
US4793365A (en) | 1984-09-14 | 1988-12-27 | R. J. Reynolds Tobacco Company | Smoking article |
SE8405479D0 (sv) | 1984-11-01 | 1984-11-01 | Nilsson Sven Erik | Sett att administrera flyktiga, fysiologiskt, aktiva emnen och anordning for detta |
US4648393A (en) | 1984-11-02 | 1987-03-10 | Ackrad Laboratories, Inc. | Breath activated medication spray |
CN1024996C (zh) | 1984-12-21 | 1994-06-15 | 美国J·R瑞诺兹烟草公司 | 吸烟制品 |
US4597961A (en) | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
CN85100146B (zh) | 1985-04-01 | 1987-06-10 | 清华大学 | 热--湿--气多功能敏感陶瓷元件及其制造方法 |
US5105831A (en) | 1985-10-23 | 1992-04-21 | R. J. Reynolds Tobacco Company | Smoking article with conductive aerosol chamber |
US4708151A (en) | 1986-03-14 | 1987-11-24 | R. J. Reynolds Tobacco Company | Pipe with replaceable cartridge |
US5076297A (en) | 1986-03-14 | 1991-12-31 | R. J. Reynolds Tobacco Company | Method for preparing carbon fuel for smoking articles and product produced thereby |
US4846199A (en) | 1986-03-17 | 1989-07-11 | The Regents Of The University Of California | Smoking of regenerated tobacco smoke |
JPS62271868A (ja) | 1986-05-20 | 1987-11-26 | プラチナ万年筆株式会社 | 物品収納容器 |
JPS62278975A (ja) | 1986-05-26 | 1987-12-03 | 渡部 勇 | 嗜好品を加熱気化させて吸喫する方法とその吸喫器具 |
US4893639A (en) | 1986-07-22 | 1990-01-16 | R. J. Reynolds Tobacco Company | Densified particulate materials for smoking products and process for preparing the same |
US4735217A (en) | 1986-08-21 | 1988-04-05 | The Procter & Gamble Company | Dosing device to provide vaporized medicament to the lungs as a fine aerosol |
IE873108L (en) | 1986-12-12 | 1988-06-12 | Huels Chemische Werke Ag | Impact modifying agent for use with smoking articles |
US4771796A (en) | 1987-01-07 | 1988-09-20 | Fritz Myer | Electrically operated simulated cigarette |
US4819665A (en) | 1987-01-23 | 1989-04-11 | R. J. Reynolds Tobacco Company | Aerosol delivery article |
US4830028A (en) | 1987-02-10 | 1989-05-16 | R. J. Reynolds Tobacco Company | Salts provided from nicotine and organic acid as cigarette additives |
EP0283672B1 (en) | 1987-02-10 | 1993-09-22 | R.J. Reynolds Tobacco Company | Cigarette |
GB8713645D0 (en) | 1987-06-11 | 1987-07-15 | Imp Tobacco Ltd | Smoking device |
US4813536A (en) | 1987-07-13 | 1989-03-21 | Willis William T | Preassembled display stand and container |
US4870748A (en) | 1987-07-17 | 1989-10-03 | R. J. Reynolds Tobacco Co. | Apparatus for assembling elements of a smoking article |
SE8703827D0 (sv) | 1987-10-05 | 1987-10-05 | Svenska Tobaks Ab | Tobaksportion |
FR2624100B1 (fr) | 1987-12-02 | 1990-06-01 | Bouche Alain | Boite a verrouillage |
US4848563A (en) | 1987-12-17 | 1989-07-18 | Robbins Sports | Display package and method of manufacture |
GB8819291D0 (en) | 1988-08-12 | 1988-09-14 | British American Tobacco Co | Improvements relating to smoking articles |
US4947874A (en) | 1988-09-08 | 1990-08-14 | R. J. Reynolds Tobacco Company | Smoking articles utilizing electrical energy |
US4947875A (en) | 1988-09-08 | 1990-08-14 | R. J. Reynolds Tobacco Company | Flavor delivery articles utilizing electrical energy |
US4896683A (en) | 1988-10-17 | 1990-01-30 | Hercules Incorporated | Selective delivery and retention of nicotine by-product from cigarette smoke |
EP0399252A3 (en) | 1989-05-22 | 1992-04-15 | R.J. Reynolds Tobacco Company | Smoking article with improved insulating material |
US4955397A (en) | 1989-07-10 | 1990-09-11 | Brown & Williamson Tobacco Corporation | Cigarette |
US4941483A (en) | 1989-09-18 | 1990-07-17 | R. J. Reynolds Tobacco Company | Aerosol delivery article |
EP0419975A3 (en) | 1989-09-29 | 1991-08-07 | R.J. Reynolds Tobacco Company | Cigarette and smokable filler material therefor |
US5060671A (en) | 1989-12-01 | 1991-10-29 | Philip Morris Incorporated | Flavor generating article |
US5224498A (en) | 1989-12-01 | 1993-07-06 | Philip Morris Incorporated | Electrically-powered heating element |
US5144962A (en) | 1989-12-01 | 1992-09-08 | Philip Morris Incorporated | Flavor-delivery article |
US5269327A (en) | 1989-12-01 | 1993-12-14 | Philip Morris Incorporated | Electrical smoking article |
US5152456A (en) | 1989-12-12 | 1992-10-06 | Bespak, Plc | Dispensing apparatus having a perforate outlet member and a vibrating device |
US5031646A (en) | 1990-01-16 | 1991-07-16 | R. J. Reynolds Tobacco Company | Cigarette |
US5183062A (en) | 1990-02-27 | 1993-02-02 | R. J. Reynolds Tobacco Company | Cigarette |
US5324498A (en) | 1990-03-30 | 1994-06-28 | Bandgap Chemical Corporation | Purification of tungsten hexafluoride |
AU6867891A (en) | 1990-07-20 | 1992-01-23 | S.B. Kollasch | Self-refilling tobacco pipe |
US5065776A (en) | 1990-08-29 | 1991-11-19 | R. J. Reynolds Tobacco Company | Cigarette with tobacco/glass fuel wrapper |
US5105838A (en) | 1990-10-23 | 1992-04-21 | R.J. Reynolds Tobacco Company | Cigarette |
US5746587A (en) | 1990-12-17 | 1998-05-05 | Racine, Deceased; Roland | Lighter attachable to a cigarette packet |
US5141004A (en) | 1991-01-18 | 1992-08-25 | Brown & Williamson Tobacco Corporation | Smoking article |
NZ237288A (en) | 1991-03-01 | 1994-11-25 | Massey University Substituted | Seed sower with rotatable ground-slitting blade and scraper therefor: sub-surface tine forms horizontal slot for seed deposition |
ATE121909T1 (de) | 1991-03-11 | 1995-05-15 | Philip Morris Prod | Aromaerzeugende artikel. |
US5591368A (en) | 1991-03-11 | 1997-01-07 | Philip Morris Incorporated | Heater for use in an electrical smoking system |
US5249586A (en) | 1991-03-11 | 1993-10-05 | Philip Morris Incorporated | Electrical smoking |
US5505214A (en) | 1991-03-11 | 1996-04-09 | Philip Morris Incorporated | Electrical smoking article and method for making same |
US5261424A (en) | 1991-05-31 | 1993-11-16 | Philip Morris Incorporated | Control device for flavor-generating article |
GB2259082A (en) | 1991-09-05 | 1993-03-03 | Lee Kuen Yi | Cigarette and pastille container |
EP0532194A1 (en) | 1991-09-10 | 1993-03-17 | Philip Morris Products Inc. | Thermally-regulated flavor generator |
CA2079495A1 (en) | 1991-10-03 | 1993-04-04 | John H. Kolts | Smoking article with co oxidation catalyst |
US5240012A (en) | 1991-11-13 | 1993-08-31 | Philip Morris Incorporated | Carbon heat smoking article with reusable body |
US5322075A (en) | 1992-09-10 | 1994-06-21 | Philip Morris Incorporated | Heater for an electric flavor-generating article |
TW245766B (es) | 1992-09-11 | 1995-04-21 | Philip Morris Prod | |
SK139993A3 (en) | 1992-12-17 | 1994-09-07 | Philip Morris Prod | Method of impregnation and expanding of tobacco and device for its performing |
US5372148A (en) | 1993-02-24 | 1994-12-13 | Philip Morris Incorporated | Method and apparatus for controlling the supply of energy to a heating load in a smoking article |
GB9307710D0 (en) | 1993-04-14 | 1993-06-02 | Rothmans Benson & Hedges | Smoking apparatus-l |
US5666977A (en) | 1993-06-10 | 1997-09-16 | Philip Morris Incorporated | Electrical smoking article using liquid tobacco flavor medium delivery system |
PT706352E (pt) | 1993-06-29 | 2002-07-31 | Ponwell Entpr Ltd | Distribuidor |
US5388574A (en) | 1993-07-29 | 1995-02-14 | Ingebrethsen; Bradley J. | Aerosol delivery article |
DE4328243C1 (de) | 1993-08-19 | 1995-03-09 | Sven Mielordt | Rauch- oder Inhalationsvorrichtung |
DE4422710C1 (de) | 1994-06-29 | 1995-09-14 | Boehringer Ingelheim Kg | Inhalationsgerät mit einem Elektronikmodul zur Funktionsüberwachung |
US5845649A (en) | 1994-01-26 | 1998-12-08 | Japan Tobacco Inc. | Flavor-tasting article |
CN1131676C (zh) | 1994-02-25 | 2003-12-24 | 菲利普莫里斯生产公司 | 传送烟香的电吸烟系统和烟卷 |
ATE246909T1 (de) | 1994-03-07 | 2003-08-15 | Theratech Inc | Medikament enthaltende, adhesive, zusammenbaubare,transdermale abgabevorrichtung |
US6102036A (en) | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
US5529078A (en) | 1994-05-09 | 1996-06-25 | Truce, Inc. | Smoker's box |
US5449078A (en) | 1994-07-08 | 1995-09-12 | Thermar Corporation | Combination of a container and a safety cap therefor |
US5605226A (en) | 1995-02-13 | 1997-02-25 | Hernlein; William J. | Caddy |
CA2146954C (en) | 1995-04-12 | 2008-06-17 | Arthur Slutsky | Breath activated nicotine inhalers |
JP3606950B2 (ja) | 1995-05-31 | 2005-01-05 | ダイセル化学工業株式会社 | たばこフィルターおよびその製造方法 |
JPH0975058A (ja) | 1995-09-18 | 1997-03-25 | Masaya Nagai | ニコチン喫気器 |
US5579934A (en) | 1995-10-12 | 1996-12-03 | Van Blarcom Closures, Inc. | Convertible child resistant closure |
JP2845225B2 (ja) | 1995-12-11 | 1999-01-13 | 日本電気株式会社 | 高分子化合物、それを用いた感光性樹脂組成物およびパターン形成方法 |
US5810164A (en) | 1995-12-20 | 1998-09-22 | Rennecamp; Bryan | Cigarette box insert |
US5641064A (en) | 1995-12-29 | 1997-06-24 | Goserud; J. Thomas | Storage container having changeable identifying indicia |
ES2118034B1 (es) | 1996-02-23 | 1999-04-16 | Nugar Bobinajes Sl | Dispositivo para evaporar o sublimar productos balsamicos, odorificos o similares. |
US5730118A (en) | 1996-02-27 | 1998-03-24 | Hermanson; Susan Thomas | Carrier for asthma inhaler |
US6381739B1 (en) | 1996-05-15 | 2002-04-30 | Motorola Inc. | Method and apparatus for hierarchical restructuring of computer code |
DE69719719T2 (de) | 1996-06-17 | 2004-03-25 | Japan Tobacco Inc. | Aromaerzeugende artikel und aromaerzeugendes gerät |
US6089857A (en) | 1996-06-21 | 2000-07-18 | Japan Tobacco, Inc. | Heater for generating flavor and flavor generation appliance |
US5931828A (en) | 1996-09-04 | 1999-08-03 | The West Company, Incorporated | Reclosable vial closure |
US5934289A (en) | 1996-10-22 | 1999-08-10 | Philip Morris Incorporated | Electronic smoking system |
US5878752A (en) | 1996-11-25 | 1999-03-09 | Philip Morris Incorporated | Method and apparatus for using, cleaning, and maintaining electrical heat sources and lighters useful in smoking systems and other apparatuses |
US5944025A (en) | 1996-12-30 | 1999-08-31 | Brown & Williamson Tobacco Company | Smokeless method and article utilizing catalytic heat source for controlling products of combustion |
US5881884A (en) | 1997-03-13 | 1999-03-16 | Avery Dennison Corporation | Shipping and display carton and blank therefor |
CA2202717A1 (en) | 1997-04-15 | 1998-10-15 | Rothmans, Benson & Hedges Inc. | Cigarette or tobacco package with re-usable aroma releasent for multiple package openings |
US6324261B1 (en) | 1997-05-05 | 2001-11-27 | Donald A. Merte | Door answering machine |
KR100289448B1 (ko) | 1997-07-23 | 2001-05-02 | 미즈노 마사루 | 향미발생장치 |
SE9703458D0 (sv) * | 1997-09-25 | 1997-09-25 | Pharmacia & Upjohn Ab | Nicotine compositions and methods of formulation thereof |
US5954979A (en) | 1997-10-16 | 1999-09-21 | Philip Morris Incorporated | Heater fixture of an electrical smoking system |
JPH11178563A (ja) | 1997-12-19 | 1999-07-06 | Japan Tobacco Inc | 非燃焼型香味生成品用ヒータユニット |
US5996589A (en) | 1998-03-03 | 1999-12-07 | Brown & Williamson Tobacco Corporation | Aerosol-delivery smoking article |
EP1066074A1 (en) | 1998-03-16 | 2001-01-10 | Inhale Therapeutic Systems, Inc. | Aerosolized active agent delivery |
US5975415A (en) | 1998-04-09 | 1999-11-02 | Hewlett-Packard Co. | Reclosable carton |
US6211194B1 (en) | 1998-04-30 | 2001-04-03 | Duke University | Solution containing nicotine |
US5967310A (en) | 1998-05-06 | 1999-10-19 | Hill; Chrisjon | Container system for smoking components |
US6164287A (en) | 1998-06-10 | 2000-12-26 | R. J. Reynolds Tobacco Company | Smoking method |
US6095153A (en) | 1998-06-19 | 2000-08-01 | Kessler; Stephen B. | Vaporization of volatile materials |
ITPD980192A1 (it) | 1998-08-05 | 2000-02-05 | Giorgio Polacco | Contenitore-espositore pallettizzato in cartone. |
US6234169B1 (en) | 1998-08-14 | 2001-05-22 | Arthur Slutsky | Inhaler |
US6344222B1 (en) | 1998-09-03 | 2002-02-05 | Jsr Llc | Medicated chewing gum delivery system for nicotine |
DE19847968A1 (de) | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen |
DE19854005C2 (de) | 1998-11-12 | 2001-05-17 | Reemtsma H F & Ph | System zur Bereitstellung eines inhalierbaren Aerosols |
DE19854012C2 (de) | 1998-11-12 | 2001-05-10 | Reemtsma H F & Ph | System zur Bereitstellung eines inhalierbaren Aerosols |
DE19854009C2 (de) | 1998-11-12 | 2001-04-26 | Reemtsma H F & Ph | System zur Bereitstellung eines inhalierbaren Aerosols |
JP2000203639A (ja) | 1999-01-14 | 2000-07-25 | S & B Foods Inc | 包装材 |
JP2000236865A (ja) | 1999-02-22 | 2000-09-05 | Seiko Kogyo Kk | 喫煙用具 |
US6053176A (en) | 1999-02-23 | 2000-04-25 | Philip Morris Incorporated | Heater and method for efficiently generating an aerosol from an indexing substrate |
US6196232B1 (en) | 1999-03-01 | 2001-03-06 | Gocha Chkadua | Magnetic smoking pipe |
US6799576B2 (en) | 1999-07-16 | 2004-10-05 | Aradigm Corporation | System for effecting smoking cessation |
US20080138398A1 (en) | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
US8256433B2 (en) * | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
US7066321B2 (en) | 1999-07-29 | 2006-06-27 | Kao Corporation | Paper container |
JP2001165437A (ja) | 1999-09-22 | 2001-06-22 | Tsubota Pearl Co Ltd | ライターケース |
US6446793B1 (en) | 1999-11-12 | 2002-09-10 | John M. Layshock | Container for cigarettes and cigarette lighter |
PE20010720A1 (es) | 1999-12-11 | 2001-07-26 | Glaxo Group Ltd | Distribuidor de medicamento |
US6672762B1 (en) | 2000-02-08 | 2004-01-06 | Sara Lee Corporation | Package with arcuate top having integral latch and hanger |
DE10007485A1 (de) | 2000-02-18 | 2001-08-23 | Hauni Maschinenbau Ag | Verfahren und Vorrichtung zur Verwertung von Tabakstaub |
US6971513B2 (en) | 2000-02-22 | 2005-12-06 | Newfrey Llc | Packaging system for door hardware |
DE10013712A1 (de) * | 2000-03-20 | 2001-09-27 | Nutrinova Gmbh | Nikotinsalze mit verbessertem Geschmack, Verfahren zu ihrer Herstellung und ihre Verwendung |
ES2329546T3 (es) | 2000-03-23 | 2009-11-27 | Pmpi Llc | Sistema y metodo para fumar electrico. |
US6349728B1 (en) | 2000-05-03 | 2002-02-26 | Philip Morris Incorporated | Portable cigarette smoking apparatus |
US6386371B1 (en) | 2000-05-08 | 2002-05-14 | Armament Systems And Procedures, Inc. | Display device |
US6510982B2 (en) | 2000-06-14 | 2003-01-28 | Colgate-Palmolive Company | Shipper and display carton |
US6431363B1 (en) | 2000-07-24 | 2002-08-13 | One Source Industries, Inc. | Shipping carton and display tray |
US6269966B1 (en) | 2000-10-04 | 2001-08-07 | John D. Brush & Co., Inc. | Blow-molded snapped-together hinge for double-walled body and lid |
WO2002038208A2 (en) | 2000-11-03 | 2002-05-16 | Recovery Pharmaceuticals, Inc. | Device and method for the cessation of smoking |
EP1205199A1 (en) | 2000-11-13 | 2002-05-15 | The Technology Partnership Public Limited Company | Aerosol drug-dispensing device with membrane for controlling vacuum during dispensing |
US6536442B2 (en) | 2000-12-11 | 2003-03-25 | Brown & Williamson Tobacco Corporation | Lighter integral with a smoking article |
US7077130B2 (en) | 2000-12-22 | 2006-07-18 | Chrysalis Technologies Incorporated | Disposable inhaler system |
EP1249163A1 (en) | 2001-04-09 | 2002-10-16 | Zelnova, S.A. | Thermal vaporizer for a liquid formulation comprising a volatile active |
US20030051728A1 (en) | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
US6612404B2 (en) | 2001-05-25 | 2003-09-02 | Thyssen Elevator Capital Corp. | Contactless hall effect push button switch |
US6923338B2 (en) | 2001-05-25 | 2005-08-02 | Fort James Corporation | Food container with interchangeable lid—base seal design |
US20060157072A1 (en) | 2001-06-08 | 2006-07-20 | Anthony Albino | Method of reducing the harmful effects of orally or transdermally delivered nicotine |
US6726006B1 (en) | 2001-06-26 | 2004-04-27 | Douglas Amon Funderburk | Flask-shaped cigarette container and method of packaging cigarettes |
US6606998B1 (en) | 2001-10-05 | 2003-08-19 | Ely Gold | Simple simulated cigarette |
US6532965B1 (en) | 2001-10-24 | 2003-03-18 | Brown & Williamson Tobacco Corporation | Smoking article using steam as an aerosol-generating source |
US6598607B2 (en) | 2001-10-24 | 2003-07-29 | Brown & Williamson Tobacco Corporation | Non-combustible smoking device and fuel element |
US6817365B2 (en) | 2001-11-15 | 2004-11-16 | Philip Morris Usa Inc. | Cigarette paper having heat-degradable filler particles, and cigarette comprising a cigarette paper wrapper having heat-degradable filler particles |
SE0104388D0 (sv) | 2001-12-27 | 2001-12-27 | Pharmacia Ab | New formulation and use and manufacture thereof |
AU2002360023A1 (en) | 2001-12-28 | 2003-07-24 | Japan Tobacco Inc. | Smoking implement |
US20030159702A1 (en) | 2002-01-21 | 2003-08-28 | Lindell Katarina E.A. | Formulation and use manufacture thereof |
US6772756B2 (en) | 2002-02-09 | 2004-08-10 | Advanced Inhalation Revolutions Inc. | Method and system for vaporization of a substance |
US6615840B1 (en) | 2002-02-15 | 2003-09-09 | Philip Morris Incorporated | Electrical smoking system and method |
US6622867B2 (en) | 2002-02-19 | 2003-09-23 | Cosmoda Concept Corporation | Package |
CA2478294C (en) | 2002-03-19 | 2013-09-03 | Plant Research International B.V. | Gntiii (udp-n-acetylglucosamine:beta-d mannoside beta (1,4)-n-acetylglucosaminyltransferase iii) expression in plants |
US7434584B2 (en) | 2002-03-22 | 2008-10-14 | Vaporgenie, Llc | Vaporization pipe with flame filter |
EP1489930A4 (en) | 2002-03-22 | 2008-03-26 | Dan A Steinberg | VAPORIZATION TUBE WITH FLAME FILTER |
WO2003094900A1 (en) | 2002-05-13 | 2003-11-20 | Alexza Molecular Delivery Corporation | Delivery of drug amines through an inhalation route |
EP1511399B1 (de) | 2002-05-13 | 2005-06-29 | Think Global B.V. | Inhalator |
SE0201669D0 (sv) * | 2002-06-03 | 2002-06-03 | Pharmacia Ab | New formulation and use thereof |
US7767698B2 (en) | 2002-06-03 | 2010-08-03 | Mcneil Ab | Formulation and use thereof |
US6803545B2 (en) | 2002-06-05 | 2004-10-12 | Philip Morris Incorporated | Electrically heated smoking system and methods for supplying electrical power from a lithium ion power source |
EP1509081B1 (en) | 2002-06-06 | 2008-04-02 | S.C. Johnson & Son, Inc. | Localized surface volatilization |
US7000775B2 (en) | 2002-06-06 | 2006-02-21 | Westvaco Packaging Group, Inc. | Product container with locking end cap |
US7025205B2 (en) * | 2002-06-26 | 2006-04-11 | Aventis Pharma Limited | Method and packaging for pressurized containers |
US20040002520A1 (en) | 2002-07-01 | 2004-01-01 | Soderlund Patrick L. | Composition and method for cessation of Nicotine cravings |
ATE372935T1 (de) | 2002-07-17 | 2007-09-15 | Meadwestvaco Corp | Produktbehälter mit verriegelbarer endkappe |
US7015796B2 (en) | 2002-09-06 | 2006-03-21 | Brady Development, Inc. | Device for weaning an addiction |
US6827573B2 (en) | 2002-10-25 | 2004-12-07 | Brown & Williamson Tobacco Corporation | Gas micro burner |
US7488171B2 (en) | 2002-10-25 | 2009-02-10 | R.J. Reynolds Tobacco Company | Gas micro burner |
US20050172976A1 (en) | 2002-10-31 | 2005-08-11 | Newman Deborah J. | Electrically heated cigarette including controlled-release flavoring |
US7025066B2 (en) | 2002-10-31 | 2006-04-11 | Jerry Wayne Lawson | Method of reducing the sucrose ester concentration of a tobacco mixture |
US6810883B2 (en) | 2002-11-08 | 2004-11-02 | Philip Morris Usa Inc. | Electrically heated cigarette smoking system with internal manifolding for puff detection |
US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
WO2004056363A2 (en) | 2002-12-20 | 2004-07-08 | Niconovum Ab | A physically and chemically stable nicotine-containing particulate material |
US6805545B2 (en) | 2002-12-23 | 2004-10-19 | Jeffrey K. Slaboden | Molding and packaging apparatus |
IL154075A0 (en) | 2003-01-21 | 2003-07-31 | Omry Netzer | Hookah-based smoking device and a method of using the same |
US6994096B2 (en) | 2003-01-30 | 2006-02-07 | Philip Morris Usa Inc. | Flow distributor of an electrically heated cigarette smoking system |
KR20040070612A (ko) | 2003-02-04 | 2004-08-11 | 이형 | 필터궐련 |
US6976588B2 (en) | 2003-02-05 | 2005-12-20 | Rock-Tenn Shared Services, Llc | Easy-open display shipping container |
US20040182403A1 (en) | 2003-02-28 | 2004-09-23 | Sven-Borje Andersson | Container comprising nicotine and the use and manufacture thereof |
SE0300520D0 (sv) | 2003-02-28 | 2003-02-28 | Pharmacia Ab | A container comprising nicotine and the use and manufacture thereof |
US20040173229A1 (en) | 2003-03-05 | 2004-09-09 | Crooks Evon Llewellyn | Smoking article comprising ultrafine particles |
CN100381082C (zh) | 2003-03-14 | 2008-04-16 | 韩力 | 一种非可燃性电子雾化香烟 |
CA2520759C (en) | 2003-04-01 | 2008-09-30 | Shusei Takano | Nicotine inhalation pipe and nicotine holder |
CN100381083C (zh) * | 2003-04-29 | 2008-04-16 | 韩力 | 一种非可燃性电子喷雾香烟 |
US20040237974A1 (en) | 2003-05-05 | 2004-12-02 | Min Wang Wei | Filtering cigarette holder |
US7100618B2 (en) | 2003-05-05 | 2006-09-05 | Armando Dominguez | Sensory smoking simulator |
WO2004104490A1 (en) | 2003-05-21 | 2004-12-02 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
US6954979B2 (en) | 2003-07-14 | 2005-10-18 | Curt Logan | Frame joiner press system |
JP2005034021A (ja) | 2003-07-17 | 2005-02-10 | Seiko Epson Corp | 電子タバコ |
US7290549B2 (en) | 2003-07-22 | 2007-11-06 | R. J. Reynolds Tobacco Company | Chemical heat source for use in smoking articles |
ATE470468T1 (de) | 2003-08-04 | 2010-06-15 | Alexza Pharmaceuticals Inc | Substrate für eine medikamentenverabreichungsvorrichtung und verfahren zur bereitung |
KR100598131B1 (ko) | 2003-09-01 | 2006-07-11 | 이승현 | 밀폐형 흡연장치 |
US7128222B2 (en) | 2003-09-24 | 2006-10-31 | Kraft Foods Holdings, Inc. | Hanger and backcard for packages |
BRPI0415741B1 (pt) | 2003-11-07 | 2013-07-23 | composições de tabaco e métodos de fabricação de uma composição de tabaco | |
US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
US7223096B2 (en) | 2003-11-28 | 2007-05-29 | Chi Lam Wong | Lighter |
DE10356925B4 (de) | 2003-12-05 | 2006-05-11 | Lts Lohmann Therapie-Systeme Ag | Inhalator für basische pharmazeutische Wirkstoffe sowie Verfahren für dessen Herstellung |
US7997280B2 (en) | 2004-01-30 | 2011-08-16 | Joshua Rosenthal | Portable vaporizer |
CN2719043Y (zh) | 2004-04-14 | 2005-08-24 | 韩力 | 雾化电子烟 |
US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
US20050145533A1 (en) | 2004-06-15 | 2005-07-07 | New England Pottery Co., Inc. | Packaging for decorative frangible ornaments |
US7428905B2 (en) | 2004-07-30 | 2008-09-30 | R.J. Reynolds Tobacco Company | Method of making smokeable tobacco substitute filler having an increased fill value |
US20100006092A1 (en) | 2004-08-12 | 2010-01-14 | Alexza Pharmaceuticals, Inc. | Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages |
WO2006020969A1 (en) | 2004-08-13 | 2006-02-23 | Rock-Tenn Shared Services, Inc. | Easy open container |
US7766018B2 (en) | 2004-09-30 | 2010-08-03 | Smoke-Break, Inc. | Device and composition for reducing the incidence of tobacco smoking |
GB0422927D0 (en) | 2004-10-15 | 2004-11-17 | Gamesman Ltd | Push button assembly |
UA88792C2 (ru) * | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
US20060102175A1 (en) | 2004-11-18 | 2006-05-18 | Nelson Stephen G | Inhaler |
US8322350B2 (en) | 2004-12-30 | 2012-12-04 | Philip Morris Usa Inc. | Aerosol generator |
AU2006211093B2 (en) | 2005-02-02 | 2012-08-09 | Oglesby & Butler Research & Development Limited | A device for vaporising vaporisable matter |
EP1885332A2 (en) * | 2005-03-22 | 2008-02-13 | NicoNovum AB | Use of an artificial sweetener to enhance absorption of nicotine |
EA012674B1 (ru) | 2005-04-29 | 2009-12-30 | Филип Моррис Продактс С.А. | Табачный продукт в пакетиках |
US20060254948A1 (en) | 2005-05-05 | 2006-11-16 | Herbert Curtis B | Nestable containers with folding coverings |
US20060255105A1 (en) | 2005-05-12 | 2006-11-16 | Frances Sweet | Carton having space saving feature |
US9648907B2 (en) | 2005-05-31 | 2017-05-16 | Philip Morris Usa Inc. | Virtual reality smoking system |
US9675109B2 (en) | 2005-07-19 | 2017-06-13 | J. T. International Sa | Method and system for vaporization of a substance |
US20070215167A1 (en) | 2006-03-16 | 2007-09-20 | Evon Llewellyn Crooks | Smoking article |
GB0517551D0 (en) | 2005-08-27 | 2005-10-05 | Acetate Products Ltd | Process for making filter tow |
US7186958B1 (en) | 2005-09-01 | 2007-03-06 | Zhao Wei, Llc | Inhaler |
US20070074734A1 (en) | 2005-09-30 | 2007-04-05 | Philip Morris Usa Inc. | Smokeless cigarette system |
US20070102013A1 (en) | 2005-09-30 | 2007-05-10 | Philip Morris Usa Inc. | Electrical smoking system |
US20070098148A1 (en) | 2005-10-14 | 2007-05-03 | Sherman Kenneth N | Aroma releasing patch on mobile telephones |
JP4717618B2 (ja) | 2005-12-08 | 2011-07-06 | 日東電工株式会社 | 通気フィルタ付き筐体部品の製造方法および通気フィルタ付き筐体の製造方法 |
WO2007078273A1 (en) | 2005-12-22 | 2007-07-12 | Augite Incorporation | No-tar electronic smoking utensils |
US7802569B2 (en) | 2005-12-22 | 2010-09-28 | Kaer Biotherapeutics Corporation | Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery |
FR2895644B1 (fr) | 2006-01-03 | 2008-05-16 | Didier Gerard Martzel | Substitut de cigarette |
US7815332B1 (en) | 2006-02-01 | 2010-10-19 | Dustin Smith | Lighting apparatus and associated method |
US20070267033A1 (en) | 2006-02-09 | 2007-11-22 | Philip Morris Usa Inc. | Gamma cyclodextrin flavoring-release additives |
US8371310B2 (en) | 2006-02-17 | 2013-02-12 | Jake Brenneise | Portable vaporizing device and method for inhalation and/or aromatherapy without combustion |
EP1998748B1 (en) | 2006-03-16 | 2015-01-14 | NicoNovum AB | Improved snuff composition |
US20070215164A1 (en) | 2006-03-20 | 2007-09-20 | Mya Saray Llc | Disposable hookah bowl |
UA92214C2 (ru) | 2006-03-31 | 2010-10-11 | Филип Моррис Продактс С.А. | Фильтровальный элемент, сигарета, которая включает его в себе, и способ изготовления фильтровального элемента |
US8991389B2 (en) | 2006-04-20 | 2015-03-31 | Ric Investments, Llc | Drug solution level sensor for an ultrasonic nebulizer |
US8657843B2 (en) | 2006-05-03 | 2014-02-25 | Applied Medical Resources Corporation | Shield lockout for bladed obturator and trocars |
USD556682S1 (en) | 2006-05-15 | 2007-12-04 | Sony Ericsson Mobile Communications Ab | Travel charger for mobile phones and accessories |
CN201067079Y (zh) | 2006-05-16 | 2008-06-04 | 韩力 | 仿真气溶胶吸入器 |
US7546703B2 (en) | 2006-05-24 | 2009-06-16 | Smurfit-Stone Container Corporation | Flip-up headers for point-of-purchase displays |
US20070280652A1 (en) | 2006-05-31 | 2007-12-06 | Williams Clayton J | Tobacco vaporizer and related water pipe system |
US7467948B2 (en) | 2006-06-08 | 2008-12-23 | Nokia Corporation | Magnetic connector for mobile electronic devices |
CN101522244B (zh) | 2006-08-01 | 2013-06-26 | 日本烟草产业株式会社 | 气雾吸引器 |
US20100024834A1 (en) | 2006-09-05 | 2010-02-04 | Oglesby & Butler Research & Development Limited | Container comprising vaporisable matter for use in a vaporising device for vaporising a vaporisable constituent thereof |
US7988034B2 (en) | 2006-10-02 | 2011-08-02 | Kellogg Company | Dual dispensing container |
US7726320B2 (en) | 2006-10-18 | 2010-06-01 | R. J. Reynolds Tobacco Company | Tobacco-containing smoking article |
US8251060B2 (en) | 2006-11-15 | 2012-08-28 | Perfetti and Perfetti, LLC | Device and method for delivering an aerosol drug |
US7801573B2 (en) | 2006-12-22 | 2010-09-21 | Vtech Telecommunications Limited | Magnetic holder for rechargeable devices |
WO2008077271A1 (fr) | 2006-12-25 | 2008-07-03 | Bernard Maas | Dispositif informatisé permettant de fumer sainement |
US7621403B2 (en) | 2007-01-23 | 2009-11-24 | Conopco, Inc. | Liquid cosmetic product retail unit |
EP2119375B1 (en) | 2007-02-02 | 2018-06-13 | Japan Tobacco Inc. | Smokers' article |
WO2008103983A1 (en) | 2007-02-23 | 2008-08-28 | Graphic Packaging International, Inc. | Reinforced carton and methods of making carton blanks |
ES2594867T3 (es) | 2007-03-09 | 2016-12-23 | Alexza Pharmaceuticals, Inc. | Unidad de calentamiento para usar en un dispositivo de administración de fármaco |
EP2134395B1 (en) | 2007-03-30 | 2020-03-18 | Philip Morris Products S.A. | Device for delivery of a medicament |
US20080257367A1 (en) | 2007-04-23 | 2008-10-23 | Greg Paterno | Electronic evaporable substance delivery device and method |
US20080286340A1 (en) | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered nicotine containing products |
US7530210B2 (en) | 2007-06-21 | 2009-05-12 | Xerox Corporation | Custom package wrap |
GB0712308D0 (en) * | 2007-06-25 | 2007-08-01 | Kind Group Ltd | An inhalable composition |
US8541401B2 (en) | 2007-07-25 | 2013-09-24 | Philip Morris Usa Inc. | Flavorant ester salts of polycarboxylic acids and methods for immobilizing and delivering flavorants containing hydroxyl groups |
US9155848B2 (en) | 2007-10-15 | 2015-10-13 | Vapir, Inc. | Method and system for vaporization of a substance |
EP2218760B1 (en) * | 2007-11-30 | 2015-09-02 | Japan Tobacco Inc. | Aerosol-generating solution for aerosol aspirator |
US8991402B2 (en) | 2007-12-18 | 2015-03-31 | Pax Labs, Inc. | Aerosol devices and methods for inhaling a substance and uses thereof |
GB2466758B (en) * | 2008-02-29 | 2011-09-07 | Yunqiang Xiu | Electronic simulated cigarette and atomizing liquid thereof, smoking set for electronic simulated cigarette and smoking liquid capsule thereof |
EP2100525A1 (en) | 2008-03-14 | 2009-09-16 | Philip Morris Products S.A. | Electrically heated aerosol generating system and method |
EP2110033A1 (en) | 2008-03-25 | 2009-10-21 | Philip Morris Products S.A. | Method for controlling the formation of smoke constituents in an electrical aerosol generating system |
FR2929597B1 (fr) | 2008-04-04 | 2010-05-14 | Otor Sa | Ensemble de decoupes en carton, boite et procede de formation de boite avec de telles decoupes |
US20090255534A1 (en) | 2008-04-11 | 2009-10-15 | Greg Paterno | Sealed Vaporization Cartridge and Vaporization Systems for Using |
EP2110034A1 (en) | 2008-04-17 | 2009-10-21 | Philip Morris Products S.A. | An electrically heated smoking system |
EP2113178A1 (en) | 2008-04-30 | 2009-11-04 | Philip Morris Products S.A. | An electrically heated smoking system having a liquid storage portion |
US20090283103A1 (en) | 2008-05-13 | 2009-11-19 | Nielsen Michael D | Electronic vaporizing devices and docking stations |
US8613284B2 (en) | 2008-05-21 | 2013-12-24 | R.J. Reynolds Tobacco Company | Cigarette filter comprising a degradable fiber |
US20090293892A1 (en) | 2008-05-30 | 2009-12-03 | Vapor For Life | Portable vaporizer for plant material |
USD590990S1 (en) | 2008-06-13 | 2009-04-21 | Lik Hon | Electronic cigarette |
USD590991S1 (en) | 2008-06-13 | 2009-04-21 | Lik Hon | Electronic cigarette |
WO2009155734A1 (zh) | 2008-06-27 | 2009-12-30 | Maas Bernard | 替代香烟 |
GB0813686D0 (en) | 2008-07-25 | 2008-09-03 | Gamucci Ltd | A method and apparatus relating to electronic smoking-substitute devices |
WO2010023561A1 (en) | 2008-09-01 | 2010-03-04 | Actavis Group Ptc Ehf | Process for preparing varenicline, varenicline intermediates, and pharmaceutically acceptable salts thereof |
GB0818476D0 (en) | 2008-10-09 | 2008-11-12 | Vectura Delivery Device Ltd | Inhaler |
AT507187B1 (de) * | 2008-10-23 | 2010-03-15 | Helmut Dr Buchberger | Inhalator |
ES2622582T3 (es) | 2008-10-31 | 2017-07-06 | University Of Mississippi | Proceso para la preparación de ésteres de delta-9-THC-aminoácido |
CA2641869A1 (en) | 2008-11-06 | 2010-05-06 | Hao Ran Xia | Environmental friendly, non-combustible, atomizing electronic cigarette having the function of a cigarette substitute |
GB0823436D0 (en) | 2008-12-23 | 2009-01-28 | Rhodes Mark | Inductively coupled memory transfer system |
GB0823491D0 (en) | 2008-12-23 | 2009-01-28 | Kind Consumer Ltd | A simulated cigarette device |
EP2201850A1 (en) | 2008-12-24 | 2010-06-30 | Philip Morris Products S.A. | An article including identification information for use in an electrically heated smoking system |
CN101756352A (zh) * | 2008-12-25 | 2010-06-30 | 中国科学院理化技术研究所 | 一种采用电容供电的电子烟 |
USD611409S1 (en) | 2009-01-09 | 2010-03-09 | Amazon Technologies Inc. | Power adapter |
US20100200008A1 (en) | 2009-02-09 | 2010-08-12 | Eli Taieb | E-Cigarette With Vitamin Infusion |
CN201379072Y (zh) | 2009-02-11 | 2010-01-13 | 韩力 | 一种改进的雾化电子烟 |
CN102316850A (zh) * | 2009-02-11 | 2012-01-11 | 海格兰德公司 | 一种用于戒烟的口腔吸收尼古丁组合物 |
GB2467971A (en) | 2009-02-24 | 2010-08-25 | British American Tobacco Co | Pack for tobacco industry products |
BRPI1012702B1 (pt) * | 2009-03-17 | 2021-07-06 | Philip Morris Products S.A. | Dispositivo para aplicar nicotina a um paciente, método de aplicação de nicotina em um paciente pela inalação e método de substituição do produto de tabaco |
CN101518361B (zh) | 2009-03-24 | 2010-10-06 | 北京格林世界科技发展有限公司 | 高仿真电子烟 |
US8851068B2 (en) | 2009-04-21 | 2014-10-07 | Aj Marketing Llc | Personal inhalation devices |
CN101869356A (zh) | 2009-04-23 | 2010-10-27 | 柳哲琦 | 仿真电子烟及其烟盒 |
EP2421507B1 (en) | 2009-04-24 | 2019-01-23 | Fertin Pharma A/S | Chewing gum and particulate material for controlled release of active ingredients |
US8342335B2 (en) | 2009-04-30 | 2013-01-01 | Rock-Tenn Shared Services, Llc | Shelf-ready shipper display system |
US20100307116A1 (en) | 2009-06-04 | 2010-12-09 | Thad Joseph Fisher | Multiple-Atmosphere, Nested Food Container |
WO2011006534A1 (en) | 2009-07-14 | 2011-01-20 | Nokia Siemens Networks Oy | Apparatus and method of providing end-to-end call services |
US8813747B2 (en) | 2009-08-07 | 2014-08-26 | Hexbg, Llc | Vaporizer system for delivery of inhalable substances |
US9254002B2 (en) | 2009-08-17 | 2016-02-09 | Chong Corporation | Tobacco solution for vaporized inhalation |
US8464726B2 (en) | 2009-08-24 | 2013-06-18 | R.J. Reynolds Tobacco Company | Segmented smoking article with insulation mat |
US8875702B2 (en) | 2009-08-28 | 2014-11-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Aerosol generator |
US9167849B2 (en) | 2009-08-28 | 2015-10-27 | Kelly J. Adamic | Smoke and odor elimination filters, devices and methods |
US8490629B1 (en) | 2009-08-31 | 2013-07-23 | Incredibowl Industries, Llc | Therapeutic smoking device |
IN2012DN02325A (es) * | 2009-09-16 | 2015-08-21 | Philip Morris Products Sa | |
EP2477514B2 (en) | 2009-09-18 | 2021-12-29 | Altria Client Services LLC | Electronic cigarette |
US20110070286A1 (en) | 2009-09-24 | 2011-03-24 | Andreas Hugerth | Process for the manufacture of nicotine-comprising chewing gum and nicotine-comprising chewing gum manufactured according to said process |
USD624238S1 (en) | 2009-10-26 | 2010-09-21 | Turner Jeffrey D | Delivery device |
USD642330S1 (en) | 2009-10-26 | 2011-07-26 | Jeffrey Turner | Delivery device |
EP2319334A1 (en) | 2009-10-27 | 2011-05-11 | Philip Morris Products S.A. | A smoking system having a liquid storage portion |
PL2325093T3 (pl) | 2009-11-20 | 2012-11-30 | Imperial Tobacco Ltd | Opakowanie do wyrobów tytoniowych |
EP2338361A1 (en) | 2009-12-23 | 2011-06-29 | Philip Morris Products S.A. | An elongate heater for an electrically heated aerosol-generating system |
EP2340729A1 (en) | 2009-12-30 | 2011-07-06 | Philip Morris Products S.A. | An improved heater for an electrically heated aerosol generating system |
US9386803B2 (en) | 2010-01-06 | 2016-07-12 | Celanese Acetate Llc | Tobacco smoke filter for smoking device with porous mass of active particulate |
DE102010000043A1 (de) | 2010-01-11 | 2011-07-14 | Lars 12587 Dähne | Inhalatorsystem für flüchtige Substanzen |
US8443534B2 (en) | 2010-01-20 | 2013-05-21 | Esselte Corporation | Two-position tab |
US8408390B2 (en) | 2010-01-28 | 2013-04-02 | Bryan R. Rennecamp | Smoking accessory |
GB2480122A (en) | 2010-03-01 | 2011-11-09 | Oglesby & Butler Res & Dev Ltd | A vaporising device with removable heat transfer element |
AT509046B1 (de) | 2010-03-10 | 2011-06-15 | Helmut Dr Buchberger | Flächiger verdampfer |
WO2011112218A1 (en) | 2010-03-12 | 2011-09-15 | Xiao Pei Tao | A system and method for providing a laser-based lighting system for smokable material |
GB201004861D0 (en) | 2010-03-23 | 2010-05-05 | Kind Consumer Ltd | A simulated cigarette |
CN102740716B (zh) | 2010-04-09 | 2016-02-03 | 惠州市吉瑞科技有限公司深圳分公司 | 一种电子烟雾化装置 |
CN202664228U (zh) | 2010-04-13 | 2013-01-16 | 刘秋明 | 一种电子烟 |
CN101822420B (zh) | 2010-04-22 | 2012-06-27 | 修运强 | 一种组合式多功能电子模拟香烟 |
US20110268809A1 (en) * | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
EP2563172B2 (en) | 2010-04-30 | 2022-05-04 | Fontem Holdings 4 B.V. | Electronic smoking device |
US20110274628A1 (en) | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
US20110277780A1 (en) | 2010-05-15 | 2011-11-17 | Nathan Andrew Terry | Personal vaporizing inhaler with mouthpiece cover |
US9095175B2 (en) | 2010-05-15 | 2015-08-04 | R. J. Reynolds Tobacco Company | Data logging personal vaporizing inhaler |
EP2571385B1 (en) | 2010-05-21 | 2017-01-11 | Hzat Llc. | Method for preparing tobacco extract for electronic smoking devices |
US8381946B2 (en) | 2010-06-24 | 2013-02-26 | Sussex Im, Inc. | Container having a pre-curved lid |
CA2712624A1 (fr) | 2010-08-19 | 2012-02-19 | Cogestor Inc. | Panier pharmaceutique |
RU2528945C1 (ru) | 2010-08-24 | 2014-09-20 | Джапан Тобакко Инк. | Ингалятор аромата ненагревающего типа и способ изготовления ароматического картриджа |
PL3508081T3 (pl) | 2010-08-24 | 2021-12-27 | Jt International S.A. | Urządzenie do wdychania zawierające środki kontroli użycia substancji |
USD644375S1 (en) | 2010-11-02 | 2011-08-30 | Xuewu Zhou | Electronic cigarette |
US9301547B2 (en) | 2010-11-19 | 2016-04-05 | Huizhou Kimree Technology Co., Ltd. Shenzhen Branch | Electronic cigarette, electronic cigarette smoke capsule and atomization device thereof |
US9315890B1 (en) | 2010-11-19 | 2016-04-19 | Markus Frick | System and method for volatilizing organic compounds |
US8978663B2 (en) | 2010-12-06 | 2015-03-17 | Kyle D. Newton | Charger package for electronic cigarette components |
US20120152265A1 (en) | 2010-12-17 | 2012-06-21 | R.J. Reynolds Tobacco Company | Tobacco-Derived Syrup Composition |
EP2468116A1 (en) | 2010-12-24 | 2012-06-27 | Philip Morris Products S.A. | An aerosol generating system having means for handling consumption of a liquid substrate |
US9107453B2 (en) | 2011-01-28 | 2015-08-18 | R.J. Reynolds Tobacco Company | Tobacco-derived casing composition |
US20120199146A1 (en) | 2011-02-09 | 2012-08-09 | Bill Marangos | Electronic cigarette |
KR20140063506A (ko) | 2011-02-09 | 2014-05-27 | 새미 카푸아노 | 가변전력제어 전자담배 |
AT510837B1 (de) | 2011-07-27 | 2012-07-15 | Helmut Dr Buchberger | Inhalatorkomponente |
PL2672847T3 (pl) | 2011-02-11 | 2015-10-30 | Batmark Ltd | Część składowa inhalatora |
DE102011011676B4 (de) | 2011-02-18 | 2015-02-19 | Severus Patent Ag | Rauchfreie Zigarette, Zigarre oder Pfeife |
US9399110B2 (en) | 2011-03-09 | 2016-07-26 | Chong Corporation | Medicant delivery system |
EP2683431B1 (en) | 2011-03-09 | 2017-01-18 | Chong Corporation | Medicant delivery system |
US20120267383A1 (en) | 2011-04-19 | 2012-10-25 | Diva V. | Tote bag with interchangeable ornamental securing mechanism and system therefore |
USD649932S1 (en) | 2011-04-22 | 2011-12-06 | Dominic Symons | Electrical device charger |
US20120291791A1 (en) * | 2011-05-19 | 2012-11-22 | Neurofocus, Inc. | Methods and apparatus for nicotine delivery reduction |
US20120325227A1 (en) | 2011-06-24 | 2012-12-27 | Alexander Robinson | Portable vaporizer |
US8528569B1 (en) | 2011-06-28 | 2013-09-10 | Kyle D. Newton | Electronic cigarette with liquid reservoir |
USD653803S1 (en) | 2011-06-29 | 2012-02-07 | Timmermans Ludovicus Josephine F | Electric cigarette and cigar |
WO2013016846A1 (en) | 2011-08-04 | 2013-02-07 | Ruyan Investment (Holdings) Limited | A capacitor sensor, devices employing the capacitor sensor and methods for their use |
USD686987S1 (en) | 2011-08-12 | 2013-07-30 | Advanced Bionics Ag | Single slot USB battery charger |
KR102177660B1 (ko) | 2011-08-16 | 2020-11-12 | 쥴 랩스, 인크. | 저온 전자 증발 장치 및 방법 |
UA67598U (en) | 2011-08-26 | 2012-02-27 | Дмитрий Юрьевич Рогов | Electronic cigarette |
CN202262413U (zh) | 2011-09-05 | 2012-06-06 | 李永海 | 一次性电子香烟 |
KR200456814Y1 (ko) | 2011-09-21 | 2011-11-21 | (주)잔티아시아 | 조립식 연소부를 갖는 전자담배 |
CN102499488B (zh) | 2011-09-28 | 2014-03-12 | 卓尔悦(常州)电子科技有限公司 | 电子烟 |
US9351522B2 (en) | 2011-09-29 | 2016-05-31 | Robert Safari | Cartomizer e-cigarette |
DK2760444T3 (da) | 2011-09-29 | 2020-07-27 | Thc Pharm Gmbh The Health Concept | Cannabinoidcarboxylsyrer, salte af cannabinoidcarboxylsyrer, fremstilling og anvendelse deraf |
UA111630C2 (uk) | 2011-10-06 | 2016-05-25 | Сіс Рісорсез Лтд. | Система для паління |
US8695794B2 (en) | 2011-10-17 | 2014-04-15 | Njoy, Inc. | Electronic cigarette container and method therefor |
US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
SG11201401738UA (en) | 2011-10-25 | 2014-05-29 | Philip Morris Products Sa | Aerosol generating device with heater assembly |
USD691324S1 (en) | 2011-10-28 | 2013-10-08 | Ashlynn Marketing Group, Inc. | Electronic cigarette |
US8820330B2 (en) | 2011-10-28 | 2014-09-02 | Evolv, Llc | Electronic vaporizer that simulates smoking with power control |
CN202385728U (zh) | 2011-11-25 | 2012-08-22 | 周学武 | 内置雾化器电子香烟 |
EP2599512B1 (de) | 2011-12-01 | 2016-05-11 | Stobi GmbH & Co. KG | Heißluftextraktionsinhalator mit kombinierter Luft- und Strahlungsheizung |
WO2013083635A1 (en) | 2011-12-07 | 2013-06-13 | Philip Morris Products S.A. | An aerosol generating device having airflow inlets |
UA113744C2 (xx) | 2011-12-08 | 2017-03-10 | Пристрій для утворення аерозолю з внутрішнім нагрівачем | |
US9498588B2 (en) | 2011-12-14 | 2016-11-22 | Atmos Nation, LLC | Portable pen sized electric herb vaporizer with ceramic heating chamber |
MY154105A (en) | 2011-12-15 | 2015-04-30 | Foo Kit Seng | An electronic vaporisation cigarette |
ITMI20112290A1 (it) | 2011-12-16 | 2013-06-17 | Dks Aromatic Srl | Composizione per sigarette elettroniche |
UA114903C2 (uk) | 2011-12-18 | 2017-08-28 | Сіс Рісорсез Лтд. | Електронна цигарка з підзарядкою |
SG11201403681WA (en) | 2011-12-30 | 2014-07-30 | Philip Morris Products Sa | Aerosol generating system with consumption monitoring and feedback |
EP2609821A1 (en) | 2011-12-30 | 2013-07-03 | Philip Morris Products S.A. | Method and apparatus for cleaning a heating element of aerosol-generating device |
CN103040090B (zh) | 2012-01-20 | 2016-03-30 | 奥驰亚客户服务公司 | 脱除烟草的口腔用产品 |
US9282772B2 (en) | 2012-01-31 | 2016-03-15 | Altria Client Services Llc | Electronic vaping device |
NZ628602A (en) | 2012-02-22 | 2016-10-28 | Altria Client Services Llc | Electronic smoking article and improved heater element |
US9427022B2 (en) | 2012-03-12 | 2016-08-30 | UpToke, LLC | Electronic vaporizing device and methods for use |
US20130247924A1 (en) | 2012-03-23 | 2013-09-26 | Mark Scatterday | Electronic cigarette having a flexible and soft configuration |
US20130248385A1 (en) | 2012-03-23 | 2013-09-26 | Njoy, Inc. | Electronic cigarette container |
US8596460B2 (en) | 2012-03-23 | 2013-12-03 | Njoy, Inc. | Combination box and display unit |
WO2013142678A1 (en) | 2012-03-23 | 2013-09-26 | Njoy, Inc. | Single-use electronic cigar |
US20130276802A1 (en) | 2012-03-23 | 2013-10-24 | Njoy, Inc. | Electronic cigarette configured to simulate the filter of a traditional cigarette |
CN103764211A (zh) | 2012-03-23 | 2014-04-30 | 恩乔伊股份有限公司 | 被构造来模拟传统香烟的自然燃烧的电子香烟 |
US20130255702A1 (en) | 2012-03-28 | 2013-10-03 | R.J. Reynolds Tobacco Company | Smoking article incorporating a conductive substrate |
CN202618275U (zh) | 2012-04-01 | 2012-12-26 | 惠州市吉瑞科技有限公司 | 电子烟及其吸嘴 |
AU2012377326B2 (en) | 2012-04-18 | 2016-04-14 | Fontem Holdings 1 B.V. | Electronic cigarette |
US20130340775A1 (en) | 2012-04-25 | 2013-12-26 | Bernard Juster | Application development for a network with an electronic cigarette |
CA3147208A1 (en) | 2012-04-26 | 2013-10-31 | Fontem Holdings 1 B.V. | Electronic cigarette with sealed cartridge |
USD674748S1 (en) | 2012-05-03 | 2013-01-22 | Fka Distributing Co. | Portable power supply for a mobile device |
GB2502053B (en) | 2012-05-14 | 2014-09-24 | Nicoventures Holdings Ltd | Electronic smoking device |
GB2502055A (en) | 2012-05-14 | 2013-11-20 | Nicoventures Holdings Ltd | Modular electronic smoking device |
GB2502054A (en) | 2012-05-14 | 2013-11-20 | Nicoventures Holdings Ltd | Electronic smoking device |
US9271525B2 (en) | 2012-06-20 | 2016-03-01 | Huizhou Kimree Technology Co., Ltd., Shenzhen Branch | Electronic cigarette case |
WO2014032276A1 (zh) | 2012-08-31 | 2014-03-06 | Liu Qiuming | 多口味电子烟 |
US10004259B2 (en) * | 2012-06-28 | 2018-06-26 | Rai Strategic Holdings, Inc. | Reservoir and heater system for controllable delivery of multiple aerosolizable materials in an electronic smoking article |
US9386805B2 (en) | 2012-07-09 | 2016-07-12 | Huizhou Kimree Technology Co., Ltd., Shenzhen Branch | Electronic cigarette |
US9814262B2 (en) | 2012-07-11 | 2017-11-14 | Sis Resources, Ltd. | Hot-wire control for an electronic cigarette |
US9032968B2 (en) | 2012-07-12 | 2015-05-19 | Eco-Cigs, Inc. | Tip charging electronic cigarette and system and method for charging the same |
CN102754924B (zh) * | 2012-07-31 | 2014-09-10 | 龙功运 | 蒸发式电子香烟 |
US20140041655A1 (en) | 2012-08-11 | 2014-02-13 | Grenco Science, Inc | Portable Vaporizer |
US20140053856A1 (en) | 2012-08-21 | 2014-02-27 | Qiuming Liu | Electronic Cigarette Device |
GB2519731B (en) | 2012-08-24 | 2016-10-12 | Kimree Hi-Tech Inc | Electronic cigarette device |
US10517530B2 (en) | 2012-08-28 | 2019-12-31 | Juul Labs, Inc. | Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances |
US20140060552A1 (en) | 2012-08-28 | 2014-03-06 | Ploom, Inc. | Methods and devices for delivery and monitoring of tobacco, nicotine, or other substances |
US8881737B2 (en) | 2012-09-04 | 2014-11-11 | R.J. Reynolds Tobacco Company | Electronic smoking article comprising one or more microheaters |
PL2892370T3 (pl) | 2012-09-10 | 2017-05-31 | Ght Global Heating Technologies Ag | Urządzenie do odparowania płynu do inhalacji |
US9687025B2 (en) | 2012-09-10 | 2017-06-27 | Healthier Choices Managment Corp. | Electronic pipe |
DE102012108477A1 (de) | 2012-09-11 | 2014-03-13 | SNOKE GmbH & Co. KG | Mundstückverschluss für ein Mundstück einer elektrischen Zigarette |
NZ705806A (en) | 2012-09-11 | 2017-08-25 | Philip Morris Products Sa | Device and method for controlling an electrical heater to limit temperature |
US9308336B2 (en) | 2012-09-19 | 2016-04-12 | Kyle D. Newton | Refill diverter for electronic cigarette |
CA2886292A1 (en) | 2012-09-28 | 2014-04-03 | Kimree Hi-Tech Inc. | Electronic cigarette and electronic cigarette device thereof |
CN103960781A (zh) | 2013-09-29 | 2014-08-06 | 深圳市麦克韦尔科技有限公司 | 电子烟 |
US9854841B2 (en) | 2012-10-08 | 2018-01-02 | Rai Strategic Holdings, Inc. | Electronic smoking article and associated method |
US10117460B2 (en) | 2012-10-08 | 2018-11-06 | Rai Strategic Holdings, Inc. | Electronic smoking article and associated method |
GB2507103A (en) | 2012-10-19 | 2014-04-23 | Nicoventures Holdings Ltd | Electronic inhalation device |
GB2507104A (en) | 2012-10-19 | 2014-04-23 | Nicoventures Holdings Ltd | Electronic inhalation device |
GB2507102B (en) | 2012-10-19 | 2015-12-30 | Nicoventures Holdings Ltd | Electronic inhalation device |
KR200466757Y1 (ko) | 2012-11-01 | 2013-05-06 | (주)잔티아시아 | 다기능 제어수단을 갖는 스마트 전자담배 |
US9675114B2 (en) | 2012-11-08 | 2017-06-13 | Ludovicus Josephine Felicien Timmermans | Real time variable voltage programmable electronic cigarette and method |
US9226526B2 (en) | 2012-11-12 | 2016-01-05 | Huizhou Kimree Technology Co., Ltd., Shenzhen Branch | Electronic cigarette device, electronic cigarette and atomizing device thereof |
US10034988B2 (en) | 2012-11-28 | 2018-07-31 | Fontem Holdings I B.V. | Methods and devices for compound delivery |
USD707389S1 (en) | 2012-12-10 | 2014-06-17 | Shuigen Liu | Tobacco vaporizer |
USD695450S1 (en) | 2012-12-14 | 2013-12-10 | Atmos Technology, LLC | Portable pen sized herb vaporizer |
USD704629S1 (en) | 2012-12-14 | 2014-05-13 | Qiuming Liu | USB charger for electronic cigarette |
US20140166028A1 (en) | 2012-12-14 | 2014-06-19 | Richard C. Fuisz | Enhanced Delivery of Nicotine, THC, Tobacco, Cannabidiol or Base Alkaloid from an Electronic Cigarette or Other Vapor or Smoke Producing Device Through Use of an Absorption Conditioning Unit |
TW201427719A (zh) | 2012-12-18 | 2014-07-16 | Philip Morris Products Sa | 氣溶膠產生系統用之經封裝的揮發性液體源 |
US20140174459A1 (en) | 2012-12-21 | 2014-06-26 | Vapor Innovations, LLC | Smart Electronic Cigarette |
CN203015838U (zh) | 2012-12-28 | 2013-06-26 | 陈志平 | 一种电子雾化吸入装置 |
CN203152481U (zh) | 2013-01-05 | 2013-08-28 | 刘秋明 | 电子烟 |
US20150351456A1 (en) | 2013-01-08 | 2015-12-10 | L. Perrigo Company | Electronic cigarette |
EP2754361B1 (en) | 2013-01-10 | 2018-03-07 | Shenzhen First Union Technology Co., Ltd. | Atomizer and electronic cigarette having same |
US9185937B2 (en) | 2013-01-15 | 2015-11-17 | Huizhou Kimree Technology Co., Ltd., Shenzhen Branch | Electronic cigarette |
US8794245B1 (en) | 2013-01-17 | 2014-08-05 | Njoy, Inc. | Aroma pack for an electronic cigarette |
KR20160048024A (ko) | 2013-01-22 | 2016-05-03 | 에스아이에스 리소시즈, 엘티디. | 전자 담배에서 품질 관리를 위한 영상화 |
WO2014118286A2 (en) | 2013-01-30 | 2014-08-07 | Philip Morris Products S.A | Improved aerosol from tobacco |
US8910640B2 (en) | 2013-01-30 | 2014-12-16 | R.J. Reynolds Tobacco Company | Wick suitable for use in an electronic smoking article |
WO2014117397A1 (zh) | 2013-02-02 | 2014-08-07 | Liu Qiuming | 电子烟 |
US9271529B2 (en) | 2013-02-05 | 2016-03-01 | Atmos Nation Llc | Portable vaporization apparatus |
DK2767484T3 (en) | 2013-02-13 | 2015-11-02 | Swedish Match North Europe Ab | A container with a base and a lid |
US20140230835A1 (en) | 2013-02-21 | 2014-08-21 | Sarmad Saliman | Disposable electronic cigarette with power shut off protection |
US20140261486A1 (en) | 2013-03-12 | 2014-09-18 | R.J. Reynolds Tobacco Company | Electronic smoking article having a vapor-enhancing apparatus and associated method |
US20140261487A1 (en) | 2013-03-14 | 2014-09-18 | R. J. Reynolds Tobacco Company | Electronic smoking article with improved storage and transport of aerosol precursor compositions |
US9423152B2 (en) | 2013-03-15 | 2016-08-23 | R. J. Reynolds Tobacco Company | Heating control arrangement for an electronic smoking article and associated system and method |
US9220302B2 (en) | 2013-03-15 | 2015-12-29 | R.J. Reynolds Tobacco Company | Cartridge for an aerosol delivery device and method for assembling a cartridge for a smoking article |
US20140261474A1 (en) * | 2013-03-15 | 2014-09-18 | Aradigm Corporation | Methods for inhalation of smoke-free nicotine |
US10799548B2 (en) | 2013-03-15 | 2020-10-13 | Altria Client Services Llc | Modifying taste and sensory irritation of smokeless tobacco and non-tobacco products |
MY173182A (en) | 2013-03-15 | 2020-01-02 | Philip Morris Products Sa | Aerosol-generating system having a piercing element |
RU2666100C2 (ru) | 2013-03-15 | 2018-09-05 | Олтриа Клайент Сервисиз Ллк | Электронное курительное изделие |
PL2967135T3 (pl) | 2013-03-15 | 2017-09-29 | Philip Morris Products S.A. | Urządzenie do wytwarzania aerozolu zawierające wiele materiałów zmieniających fazę stało-ciekłą |
SG11201507442TA (en) | 2013-03-15 | 2015-10-29 | Philip Morris Products Sa | An aerosol-generating system with a replacable mouthpiece cover |
US10390563B2 (en) | 2013-03-22 | 2019-08-27 | Altria Client Services Llc | Electronic smoking article |
US9814266B2 (en) | 2013-03-26 | 2017-11-14 | Shenzhen Kimsen Technology Co., Ltd. | Electronic cigarette |
US20150181928A1 (en) | 2013-04-15 | 2015-07-02 | Kimree Hi-Tech Inc. | Electronic cigarette and mouthpiece cover thereof |
CN104106842B (zh) | 2013-04-16 | 2019-02-12 | 惠州市吉瑞科技有限公司 | 电子烟及处理电子烟吸烟数据的方法 |
WO2014172905A1 (zh) | 2013-04-27 | 2014-10-30 | 吉瑞高新科技股份有限公司 | 一种基于电子烟的身份识别方法及相应的电子烟 |
GB2513639A (en) | 2013-05-02 | 2014-11-05 | Nicoventures Holdings Ltd | Electronic cigarette |
GB2513637A (en) | 2013-05-02 | 2014-11-05 | Nicoventures Holdings Ltd | Electronic cigarette |
US20140338685A1 (en) | 2013-05-20 | 2014-11-20 | Sis Resources, Ltd. | Burning prediction and communications for an electronic cigarette |
SG11201508669UA (en) | 2013-05-21 | 2015-11-27 | Philip Morris Products Sa | Aerosol comprising distributing agent and a medicament source |
SG11201508686UA (en) | 2013-05-21 | 2015-11-27 | Philip Morris Products Sa | Electrically heated aerosol delivery system |
EP3073846B1 (en) * | 2013-05-22 | 2023-07-05 | Njoy, Inc. | Compositions, devices, and methods for nicotine aerosol delivery |
US20140355969A1 (en) | 2013-05-28 | 2014-12-04 | Sis Resources, Ltd. | One-way valve for atomizer section in electronic cigarettes |
GB2514893B (en) | 2013-06-04 | 2017-12-06 | Nicoventures Holdings Ltd | Container |
WO2014198071A1 (zh) | 2013-06-14 | 2014-12-18 | 吉瑞高新科技股份有限公司 | 电子烟 |
CN111642812A (zh) | 2013-06-14 | 2020-09-11 | 尤尔实验室有限公司 | 电子汽化设备中的具有单独的可汽化材料的多个加热元件 |
CN205196988U (zh) | 2013-06-17 | 2016-05-04 | 吉瑞高新科技股份有限公司 | 电子烟 |
RU2763434C2 (ru) | 2013-06-19 | 2021-12-29 | ФОНТЕМ ХОЛДИНГС 4 Би.Ви. | Устройство и способ измерения массового расхода воздуха |
CN103284319A (zh) | 2013-06-20 | 2013-09-11 | 昌宁德康生物科技有限公司 | 一种金雀花碱替代尼古丁口腔雾化液及其制备方法 |
WO2014205694A1 (zh) | 2013-06-26 | 2014-12-31 | 吉瑞高新科技股份有限公司 | 电子烟及电子烟恒定功率输出方法 |
CN203388263U (zh) | 2013-06-26 | 2014-01-15 | 刘秋明 | 电子烟、电子烟雾化器及电子烟吸嘴 |
USD725310S1 (en) | 2013-06-29 | 2015-03-24 | Vahan Eksouzian | Vaporizer |
JP6397493B2 (ja) | 2013-07-11 | 2018-09-26 | アレックザ ファーマシューティカルズ, インコーポレイテッド | メタ−サリチル酸とのニコチン塩 |
USD704634S1 (en) | 2013-07-15 | 2014-05-13 | Whistle Labs, Inc. | Charger device |
UA122320C2 (uk) | 2013-07-19 | 2020-10-26 | Олтріа Клайєнт Сервісиз Ллк | Рідка аерозольна композиція для електронного курильного виробу |
US11229239B2 (en) | 2013-07-19 | 2022-01-25 | Rai Strategic Holdings, Inc. | Electronic smoking article with haptic feedback |
US10251422B2 (en) | 2013-07-22 | 2019-04-09 | Altria Client Services Llc | Electronic smoking article |
US11901747B2 (en) | 2013-07-23 | 2024-02-13 | Altria Client Services Llc | Charger for an electronic cigarette |
CN105592734A (zh) | 2013-07-24 | 2016-05-18 | 奥驰亚客户服务有限责任公司 | 具有替代的气流路径的电子吸烟器具 |
US20150027468A1 (en) | 2013-07-25 | 2015-01-29 | Altria Client Services Inc. | Electronic smoking article |
US9629391B2 (en) | 2013-08-08 | 2017-04-25 | R.J. Reynolds Tobacco Company | Tobacco-derived pyrolysis oil |
CN203434223U (zh) | 2013-08-16 | 2014-02-12 | 刘秋明 | 一种电子烟套装、电子烟及其电池组件 |
GB201315499D0 (en) | 2013-08-30 | 2013-10-16 | British American Tobacco Co | A vending machine |
WO2015127591A1 (zh) | 2014-02-25 | 2015-09-03 | 吉瑞高新科技股份有限公司 | 电池组件、电子烟以及无线充电方法 |
CN203646498U (zh) | 2013-09-10 | 2014-06-18 | 刘秋明 | 电池组件、雾化组件及电子烟 |
WO2015040180A2 (en) | 2013-09-19 | 2015-03-26 | Philip Morris Products S.A. | Aerosol-generating system for generating nicotine salt particles |
US10194693B2 (en) | 2013-09-20 | 2019-02-05 | Fontem Holdings 1 B.V. | Aerosol generating device |
EP2856893B2 (en) | 2013-10-02 | 2023-10-04 | Fontem Holdings 1 B.V. | Electronic smoking device |
GB2519101A (en) | 2013-10-09 | 2015-04-15 | Nicoventures Holdings Ltd | Electronic vapour provision system |
US9820509B2 (en) | 2013-10-10 | 2017-11-21 | Kyle D. Newton | Electronic cigarette with encoded cartridge |
WO2015054861A1 (zh) | 2013-10-17 | 2015-04-23 | 吉瑞高新科技股份有限公司 | 电子烟及其电池杆组件与雾化器组件的匹配控制方法 |
WO2015058387A1 (zh) | 2013-10-24 | 2015-04-30 | 吉瑞高新科技股份有限公司 | 电池组件和电子烟 |
CN203536538U (zh) | 2013-10-25 | 2014-04-09 | 刘秋明 | 一种电子烟及其电池状态显示结构 |
WO2015063126A1 (en) | 2013-10-29 | 2015-05-07 | Choukroun Benjamin | Smoking cessation device |
US10292424B2 (en) | 2013-10-31 | 2019-05-21 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a pressure-based aerosol delivery mechanism |
US20150122252A1 (en) | 2013-11-01 | 2015-05-07 | Kevin FRIJA | Hand-held personal vaporizer |
US20150122274A1 (en) | 2013-11-06 | 2015-05-07 | Sis Resources, Ltd. | Electronic cigarette overheating protection |
US20150128967A1 (en) | 2013-11-08 | 2015-05-14 | NWT Holdings, LLC | Portable vaporizer and method for temperature control |
US20150305409A1 (en) | 2013-11-12 | 2015-10-29 | VMR Products, LLC | Vaporizer |
US10980273B2 (en) | 2013-11-12 | 2021-04-20 | VMR Products, LLC | Vaporizer, charger and methods of use |
CA2925018A1 (en) | 2013-11-15 | 2015-05-21 | Jj 206, Llc | Systems and methods for a vaporization device and product usage control and documentation |
WO2015073975A1 (en) | 2013-11-15 | 2015-05-21 | VMR Products, LLC | Vaporizer with cover sleeve |
US9345269B2 (en) | 2013-11-19 | 2016-05-24 | Tuanfang Liu | Electronic cigarette |
WO2015074189A1 (zh) | 2013-11-20 | 2015-05-28 | 吉瑞高新科技股份有限公司 | 电子烟雾化器、电子烟以及电子烟雾化器组装方法 |
CN111466616A (zh) | 2013-11-21 | 2020-07-31 | 方特慕控股第四私人有限公司 | 电子香烟和记录吸烟数据的方法 |
CN203633504U (zh) | 2013-11-25 | 2014-06-11 | 深圳市合元科技有限公司 | 电子烟用雾化器及电子烟 |
KR20240070710A (ko) | 2013-12-05 | 2024-05-21 | 쥴 랩스, 인크. | 에어로졸 장치를 위한 니코틴 액제 및 그 방법 |
EA030599B1 (ru) | 2013-12-05 | 2018-08-31 | Филип Моррис Продактс С.А. | Никотинсодержащее изделие, не содержащее табак |
GB2521148B (en) | 2013-12-10 | 2016-06-08 | Kind Consumer Ltd | Airflow testing apparatus |
USD700572S1 (en) | 2013-12-10 | 2014-03-04 | Premier Accessory Group LLC | Pivot charger |
CA2931738A1 (en) | 2013-12-11 | 2015-06-18 | Jt International S.A. | Heating system and method of heating for an inhaler device |
US20150164141A1 (en) | 2013-12-13 | 2015-06-18 | Kyle D. Newton | Electronic Cigarette with Dual Atomizer Cartridge Interface |
CN105899093B (zh) | 2013-12-16 | 2019-04-12 | 吉瑞高新科技股份有限公司 | 电子烟控制电路、电子烟以及电子烟的控制方法 |
WO2015095207A1 (en) | 2013-12-16 | 2015-06-25 | VMR Products, LLC | Cartridge for a vaporizer |
KR102378679B1 (ko) | 2013-12-19 | 2022-03-28 | 필립모리스 프로덕츠 에스.에이. | 니코틴 염 입자의 양을 발생시키고 제어하기 위한 에어로졸 발생 시스템 |
US9635886B2 (en) | 2013-12-20 | 2017-05-02 | POSiFA MICROSYSTEMS, INC. | Electronic cigarette with thermal flow sensor based controller |
PL3504989T3 (pl) | 2013-12-23 | 2021-11-08 | Juul Labs International Inc. | Systemy urządzeń do odparowywania |
US9549573B2 (en) | 2013-12-23 | 2017-01-24 | Pax Labs, Inc. | Vaporization device systems and methods |
SG11201605380WA (en) | 2013-12-31 | 2016-07-28 | Philip Morris Products Sa | An aerosol-generating device, and a capsule for use in an aerosol-generating device |
WO2015101651A1 (en) | 2014-01-02 | 2015-07-09 | Philip Morris Products S.A. | Aerosol-generating system comprising a cylindrical polymeric capsule |
WO2015106390A1 (zh) | 2014-01-14 | 2015-07-23 | 吉瑞高新科技股份有限公司 | 电子烟识别装置、电子烟盒及对电子烟进行识别的方法 |
CN105916397B (zh) | 2014-01-14 | 2019-05-17 | 吉瑞高新科技股份有限公司 | 电子烟雾化器以及电子烟 |
US20160338411A1 (en) | 2014-01-16 | 2016-11-24 | Kimree Hi-Tech Inc. | Battery stick and electronic cigarette having same |
PL3698832T3 (pl) | 2014-01-22 | 2023-01-30 | Fontem Ventures B.V. | Sposoby i urządzenia do łagodzenia potrzeby palenia |
CN203722296U (zh) | 2014-01-24 | 2014-07-16 | 惠州市吉瑞科技有限公司 | 一种电子烟的无线充电系统 |
US9980514B2 (en) | 2014-01-27 | 2018-05-29 | Sis Resources Ltd. | Wire communication in an e-vaping device |
ES2718075T3 (es) | 2014-01-29 | 2019-06-27 | Japan Tobacco Inc | Inhalador de aromas de tipo sin combustión |
US20150224268A1 (en) | 2014-02-07 | 2015-08-13 | R.J. Reynolds Tobacco Company | Charging Accessory Device for an Aerosol Delivery Device and Related System, Method, Apparatus, and Computer Program Product for Providing Interactive Services for Aerosol Delivery Devices |
US20150223521A1 (en) | 2014-02-07 | 2015-08-13 | Alan Menting | Flavor dial vapor device |
CN106133733A (zh) | 2014-02-07 | 2016-11-16 | 弗雷德哈钦森癌症研究中心 | 用于在接受和承诺疗法中使用的方法、系统、装置和软件 |
CN105917734B (zh) | 2014-02-10 | 2019-09-13 | 菲利普莫里斯生产公司 | 用于气溶胶生成系统的流体可渗透加热器组件和组装方法 |
JP6755180B2 (ja) | 2014-02-10 | 2020-09-16 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ヒーター組立品を持つエアロゾル発生システムおよび流体透過性ヒーター組立品を持つエアロゾル発生システム用のカートリッジ |
FR3017954B1 (fr) | 2014-02-21 | 2016-12-02 | Smokio | Cigarette electronique |
GB201413027D0 (en) | 2014-02-28 | 2014-09-03 | Beyond Twenty Ltd | Beyond 4 |
PL2915443T3 (pl) | 2014-03-03 | 2020-01-31 | Fontem Holdings 1 B.V. | Elektroniczne urządzenie do palenia |
US9597466B2 (en) | 2014-03-12 | 2017-03-21 | R. J. Reynolds Tobacco Company | Aerosol delivery system and related method, apparatus, and computer program product for providing control information to an aerosol delivery device via a cartridge |
US11696604B2 (en) | 2014-03-13 | 2023-07-11 | Rai Strategic Holdings, Inc. | Aerosol delivery device and related method and computer program product for controlling an aerosol delivery device based on input characteristics |
CN103798960A (zh) | 2014-03-18 | 2014-05-21 | 刘秋明 | 电子烟盒和信息获取的方法 |
US20150272220A1 (en) | 2014-03-25 | 2015-10-01 | Nicotech, LLC | Nicotine dosage sensor |
US20150272222A1 (en) | 2014-03-25 | 2015-10-01 | Nicotech, LLC | Inhalation sensor for alternative nicotine/thc delivery device |
WO2015148649A2 (en) | 2014-03-26 | 2015-10-01 | Basil Rigas | Systems and methods for ameliorating the effects of tobacco products |
US9642397B2 (en) | 2014-03-31 | 2017-05-09 | Westfield Limited (Ltd.) | Personal vaporizer with liquid supply by suction |
CN103859609B (zh) | 2014-04-03 | 2016-05-11 | 惠州市吉瑞科技有限公司 | 电子烟和电子烟雾化控制方法 |
US9877510B2 (en) | 2014-04-04 | 2018-01-30 | Rai Strategic Holdings, Inc. | Sensor for an aerosol delivery device |
WO2015157901A1 (zh) | 2014-04-14 | 2015-10-22 | 吉瑞高新科技股份有限公司 | 电子烟 |
WO2015157893A1 (zh) | 2014-04-14 | 2015-10-22 | 吉瑞高新科技股份有限公司 | 电子烟 |
EA201692191A1 (ru) | 2014-04-30 | 2017-03-31 | Олтриа Клайент Сервисиз Ллк | Жидкая рецептура аэрозоля электронного курительного изделия |
WO2015165067A1 (zh) | 2014-04-30 | 2015-11-05 | 吉瑞高新科技股份有限公司 | 一种电子烟 |
WO2015168828A1 (zh) | 2014-05-04 | 2015-11-12 | 吉瑞高新科技股份有限公司 | 电子烟及其雾化控制方法 |
CN203873004U (zh) | 2014-05-07 | 2014-10-15 | 林光榕 | 一种双电压电子烟控制组件 |
US20150320114A1 (en) | 2014-05-12 | 2015-11-12 | Hao Wu | Touch control electronic cigarette |
WO2015175979A1 (en) | 2014-05-16 | 2015-11-19 | Pax Labs, Inc. | Systems and methods for aerosolizing a smokeable material |
ES2833012T3 (es) | 2014-05-22 | 2021-06-14 | Nuryan Holdings Ltd | Dispositivo vaporizador de bolsillo |
US9955726B2 (en) | 2014-05-23 | 2018-05-01 | Rai Strategic Holdings, Inc. | Sealed cartridge for an aerosol delivery device and related assembly method |
GB2527349A (en) | 2014-06-19 | 2015-12-23 | Ciaran Oglesby | Improved vaporizer and vaporizing method |
US20150366265A1 (en) | 2014-06-19 | 2015-12-24 | Samuel Lansing | Electronic-cigarette filter |
CN104106844B (zh) | 2014-06-23 | 2017-10-10 | 深圳麦克韦尔股份有限公司 | 电子烟控制器及电子烟 |
CN106170214B (zh) | 2014-07-01 | 2019-05-14 | 惠州市吉瑞科技有限公司 | 一种电子烟及雾化方法 |
EP3171721B1 (en) | 2014-07-24 | 2021-03-31 | Altria Client Services LLC | Electronic vaping device and components thereof |
GB2528673B (en) | 2014-07-25 | 2020-07-01 | Nicoventures Holdings Ltd | Aerosol provision system |
CN105934165A (zh) | 2014-07-31 | 2016-09-07 | 惠州市吉瑞科技有限公司 | 一种电子烟及信息采集方法 |
GB201413835D0 (en) | 2014-08-05 | 2014-09-17 | Nicoventures Holdings Ltd | Electronic vapour provision system |
CN106998808B (zh) | 2014-08-22 | 2020-05-01 | 富特姆4有限公司 | 用于控制加热元件的方法、系统和装置 |
US11350669B2 (en) | 2014-08-22 | 2022-06-07 | Njoy, Llc | Heating control for vaporizing device |
GB2529629B (en) | 2014-08-26 | 2021-05-12 | Nicoventures Trading Ltd | Electronic aerosol provision system |
CN107847696B (zh) | 2014-09-10 | 2020-11-06 | 方特慕控股第一私人有限公司 | 用于调节递送装置中的气流的方法和装置 |
CN204444244U (zh) | 2014-09-15 | 2015-07-08 | 惠州市吉瑞科技有限公司 | 一种电子烟 |
WO2016041140A1 (zh) | 2014-09-16 | 2016-03-24 | 惠州市吉瑞科技有限公司 | 一种电子烟 |
PL3193643T5 (pl) | 2014-09-17 | 2024-01-29 | Fontem Holdings 4 B.V. | Urządzenie do przechowywania i odparowania ciekłych mediów |
US20160302486A1 (en) | 2014-09-17 | 2016-10-20 | Atmos Nation, LLC | Electric Heating Cartridge for a Dry Herb Vaporizer |
GB2530980A (en) | 2014-09-19 | 2016-04-13 | Kind Consumer Ltd | Simulated cigarette |
US20160081393A1 (en) | 2014-09-24 | 2016-03-24 | Alvin Black | Personal vaping device |
AU2015327893A1 (en) | 2014-10-02 | 2017-05-18 | Best Rider Global Limited | Disposable tank electronic cigarette, method of manufacture and method of use |
WO2016050247A1 (en) | 2014-10-03 | 2016-04-07 | Fertin Pharma A/S | Electronic nicotine delivery system |
EA201790835A1 (ru) | 2014-10-15 | 2017-08-31 | Олтриа Клайент Сервисиз Ллк | Электронное устройство для вейпинга и его компоненты |
US20170250552A1 (en) | 2014-10-17 | 2017-08-31 | Huizhou Kimree Technology Co., Ltd. | Battery assembly and charging method thereof, and electronic cigarette |
US20160106936A1 (en) | 2014-10-21 | 2016-04-21 | Breathe eCigs Corp. | Personal Vaporizer Having Controlled Usage |
GB201418817D0 (en) | 2014-10-22 | 2014-12-03 | British American Tobacco Co | Apparatus and method for generating an inhalable medium, and a cartridge for use therewith |
EP3207809B1 (en) | 2014-10-24 | 2021-01-06 | Japan Tobacco Inc. | Producing method of tobacco raw materials |
WO2016065606A1 (zh) | 2014-10-31 | 2016-05-06 | 惠州市吉瑞科技有限公司 | 一种雾化器以及电子烟 |
GB2535427A (en) | 2014-11-07 | 2016-08-24 | Nicoventures Holdings Ltd | Solution |
US10440991B2 (en) | 2014-11-05 | 2019-10-15 | Altria Client Services Llc | Reservoir filling system for an electronic vaping device |
US20160120228A1 (en) | 2014-11-05 | 2016-05-05 | Ali A. Rostami | Electronic vaping device |
GB2532062A (en) | 2014-11-07 | 2016-05-11 | Nicoventures Holdings Ltd | Container |
CN112155255A (zh) | 2014-12-05 | 2021-01-01 | 尤尔实验室有限公司 | 校正剂量控制 |
-
2014
- 2014-05-06 CN CN202210110566.4A patent/CN114223928A/zh active Pending
- 2014-05-06 RU RU2015146869A patent/RU2659887C2/ru active
- 2014-05-06 EP EP14794206.4A patent/EP2993999B1/en active Active
- 2014-05-06 KR KR1020237001550A patent/KR20230013165A/ko not_active Application Discontinuation
- 2014-05-06 KR KR1020217034525A patent/KR102490695B1/ko active IP Right Grant
- 2014-05-06 EP EP21153517.4A patent/EP3850957A1/en active Pending
- 2014-05-06 JP JP2016513030A patent/JP6400678B2/ja active Active
- 2014-05-06 IL IL297399A patent/IL297399B2/en unknown
- 2014-05-06 CA CA2909967A patent/CA2909967C/en active Active
- 2014-05-06 AU AU2014262808A patent/AU2014262808B2/en active Active
- 2014-05-06 CA CA3143647A patent/CA3143647C/en active Active
- 2014-05-06 CN CN201480025499.XA patent/CN105263345A/zh active Pending
- 2014-05-06 IL IL305842A patent/IL305842A/en unknown
- 2014-05-06 IL IL283581A patent/IL283581B2/en unknown
- 2014-05-06 US US14/271,071 patent/US20140345631A1/en not_active Abandoned
- 2014-05-06 MX MX2015015175A patent/MX2015015175A/es unknown
- 2014-05-06 WO PCT/US2014/037019 patent/WO2014182736A1/en active Application Filing
- 2014-05-06 CA CA3208137A patent/CA3208137A1/en active Pending
- 2014-05-06 CN CN202210110532.5A patent/CN114223927A/zh active Pending
- 2014-05-06 CN CN202311325831.1A patent/CN117137195A/zh active Pending
- 2014-05-06 KR KR1020157031919A patent/KR102320759B1/ko active IP Right Grant
- 2014-05-06 ES ES14794206T patent/ES2856448T3/es active Active
- 2014-06-05 UA UAA201510556A patent/UA119323C2/uk unknown
- 2014-10-10 US US14/512,311 patent/US9215895B2/en active Active
-
2015
- 2015-10-14 IL IL242070A patent/IL242070B/en active IP Right Grant
- 2015-10-28 US US14/925,968 patent/US20160044968A1/en not_active Abandoned
- 2015-10-28 US US14/925,961 patent/US10952468B2/en active Active
- 2015-10-30 MX MX2021008564A patent/MX2021008564A/es unknown
- 2015-10-30 MX MX2021002579A patent/MX2021002579A/es unknown
-
2016
- 2016-09-14 HK HK16110907.3A patent/HK1222516A1/zh unknown
-
2018
- 2018-09-05 JP JP2018166194A patent/JP7044670B2/ja active Active
-
2019
- 2019-03-13 AU AU2019201728A patent/AU2019201728B9/en active Active
-
2020
- 2020-07-08 IL IL275915A patent/IL275915B/en active IP Right Grant
- 2020-11-30 JP JP2020198563A patent/JP7473463B2/ja active Active
-
2021
- 2021-02-09 US US17/171,976 patent/US20210186082A1/en active Pending
- 2021-06-18 AU AU2021204112A patent/AU2021204112C1/en active Active
-
2023
- 2023-04-26 AU AU2023202508A patent/AU2023202508A1/en active Pending
-
2024
- 2024-04-11 JP JP2024064123A patent/JP2024088786A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060018840A1 (en) * | 2004-06-28 | 2006-01-26 | Nektar Therapeutics | Aerosolizable formulation comprising nicotine |
US9215895B2 (en) * | 2013-05-06 | 2015-12-22 | Pax Labs, Inc. | Nicotine salt formulations for aerosol devices and methods thereof |
Non-Patent Citations (1)
Title |
---|
Definition of "aerosol", Merriam-Webster Dictionary, [online], no date, retrieved from the Internet, [retrieved 6/8/2017], <URL: https://www.merriam-webster.com/dictionary/aerosol>. * |
Cited By (269)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10834964B2 (en) | 2005-07-19 | 2020-11-17 | Juul Labs, Inc. | Method and system for vaporization of a substance |
US10244793B2 (en) | 2005-07-19 | 2019-04-02 | Juul Labs, Inc. | Devices for vaporization of a substance |
US9901123B2 (en) | 2006-10-18 | 2018-02-27 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US11647781B2 (en) | 2006-10-18 | 2023-05-16 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US11980220B2 (en) | 2006-10-18 | 2024-05-14 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US10231488B2 (en) | 2006-10-18 | 2019-03-19 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US11758936B2 (en) | 2006-10-18 | 2023-09-19 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US9801416B2 (en) | 2006-10-18 | 2017-10-31 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US9814268B2 (en) | 2006-10-18 | 2017-11-14 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US10226079B2 (en) | 2006-10-18 | 2019-03-12 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US11805806B2 (en) | 2006-10-18 | 2023-11-07 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US10219548B2 (en) | 2006-10-18 | 2019-03-05 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US11641871B2 (en) | 2006-10-18 | 2023-05-09 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US11925202B2 (en) | 2006-10-18 | 2024-03-12 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US11785978B2 (en) | 2006-10-18 | 2023-10-17 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US11986009B2 (en) | 2006-10-18 | 2024-05-21 | Rai Strategic Holdings, Inc. | Tobacco-containing smoking article |
US11612702B2 (en) | 2007-12-18 | 2023-03-28 | Juul Labs, Inc. | Aerosol devices and methods for inhaling a substance and uses thereof |
US10231484B2 (en) | 2007-12-18 | 2019-03-19 | Juul Labs, Inc. | Aerosol devices and methods for inhaling a substance and uses thereof |
US10300225B2 (en) | 2010-05-15 | 2019-05-28 | Rai Strategic Holdings, Inc. | Atomizer for a personal vaporizing unit |
US11849772B2 (en) | 2010-05-15 | 2023-12-26 | Rai Strategic Holdings, Inc. | Cartridge housing and atomizer for a personal vaporizing unit |
US10744281B2 (en) | 2010-05-15 | 2020-08-18 | RAI Startegic Holdings, Inc. | Cartridge housing for a personal vaporizing unit |
US11344683B2 (en) | 2010-05-15 | 2022-05-31 | Rai Strategic Holdings, Inc. | Vaporizer related systems, methods, and apparatus |
US11779051B2 (en) | 2011-08-09 | 2023-10-10 | Rai Strategic Holdings, Inc. | Smoking articles and use thereof for yielding inhalation materials |
US10362809B2 (en) | 2011-08-09 | 2019-07-30 | Rai Strategic Holdings, Inc. | Smoking articles and use thereof for yielding inhalation materials |
US10588355B2 (en) | 2011-08-09 | 2020-03-17 | Rai Strategic Holdings, Inc. | Smoking articles and use thereof for yielding inhalation materials |
US12016384B2 (en) | 2011-08-09 | 2024-06-25 | Rai Strategic Holdings, Inc. | Smoking articles and use thereof for yielding inhalation materials |
US10492542B1 (en) | 2011-08-09 | 2019-12-03 | Rai Strategic Holdings, Inc. | Smoking articles and use thereof for yielding inhalation materials |
US9408416B2 (en) | 2011-08-16 | 2016-08-09 | Pax Labs, Inc. | Low temperature electronic vaporization device and methods |
US10517530B2 (en) | 2012-08-28 | 2019-12-31 | Juul Labs, Inc. | Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances |
US11044950B2 (en) | 2012-09-04 | 2021-06-29 | Rai Strategic Holdings, Inc. | Electronic smoking article comprising one or more microheaters |
US11825567B2 (en) | 2012-09-04 | 2023-11-21 | Rai Strategic Holdings, Inc. | Electronic smoking article comprising one or more microheaters |
US10531691B2 (en) | 2012-10-08 | 2020-01-14 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
US10881150B2 (en) | 2012-10-08 | 2021-01-05 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
US11856997B2 (en) | 2012-10-08 | 2024-01-02 | Rai Strategic Holdings, Inc. | Electronic smoking article and associated method |
US11019852B2 (en) | 2012-10-08 | 2021-06-01 | Rai Strategic Holdings, Inc. | Electronic smoking article and associated method |
US10274539B2 (en) | 2013-03-07 | 2019-04-30 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
US10753974B2 (en) | 2013-03-07 | 2020-08-25 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
US11428738B2 (en) | 2013-03-07 | 2022-08-30 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
US11871484B2 (en) | 2013-03-15 | 2024-01-09 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
US11000075B2 (en) | 2013-03-15 | 2021-05-11 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
US10279934B2 (en) | 2013-03-15 | 2019-05-07 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
US10426200B2 (en) | 2013-03-15 | 2019-10-01 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
US10638792B2 (en) | 2013-03-15 | 2020-05-05 | Juul Labs, Inc. | Securely attaching cartridges for vaporizer devices |
US9215895B2 (en) | 2013-05-06 | 2015-12-22 | Pax Labs, Inc. | Nicotine salt formulations for aerosol devices and methods thereof |
EP2993999B1 (en) | 2013-05-06 | 2021-01-27 | Juul Labs, Inc. | Nicotine salt formulations for electronic cigarettes and method of delivering nicotine |
US10952468B2 (en) | 2013-05-06 | 2021-03-23 | Juul Labs, Inc. | Nicotine salt formulations for aerosol devices and methods thereof |
US10653180B2 (en) | 2013-06-14 | 2020-05-19 | Juul Labs, Inc. | Multiple heating elements with separate vaporizable materials in an electric vaporization device |
US11337453B2 (en) | 2013-07-19 | 2022-05-24 | Altria Client Services Llc | Liquid aerosol formulation of an electronic smoking article |
US10660365B2 (en) * | 2013-07-19 | 2020-05-26 | Altria Client Services Llc | Liquid aerosol formulation of an electronic smoking article |
US10736360B2 (en) | 2013-11-12 | 2020-08-11 | Vmr Products Llc | Vaporizer, charger and methods of use |
US11606981B2 (en) | 2013-11-12 | 2023-03-21 | Vmr Products Llc | Vaporizer |
US10667561B2 (en) | 2013-11-12 | 2020-06-02 | Vmr Products Llc | Vaporizer |
US11051557B2 (en) | 2013-11-12 | 2021-07-06 | VMR Products, LLC | Vaporizer |
US11134722B2 (en) | 2013-11-12 | 2021-10-05 | Vmr Products Llc | Vaporizer |
US10980273B2 (en) | 2013-11-12 | 2021-04-20 | VMR Products, LLC | Vaporizer, charger and methods of use |
US10653186B2 (en) | 2013-11-12 | 2020-05-19 | VMR Products, LLC | Vaporizer, charger and methods of use |
US10463069B2 (en) | 2013-12-05 | 2019-11-05 | Juul Labs, Inc. | Nicotine liquid formulations for aerosol devices and methods thereof |
US11510433B2 (en) | 2013-12-05 | 2022-11-29 | Juul Labs, Inc. | Nicotine liquid formulations for aerosol devices and methods thereof |
US11744277B2 (en) | 2013-12-05 | 2023-09-05 | Juul Labs, Inc. | Nicotine liquid formulations for aerosol devices and methods thereof |
US10104915B2 (en) | 2013-12-23 | 2018-10-23 | Juul Labs, Inc. | Securely attaching cartridges for vaporizer devices |
US10667560B2 (en) | 2013-12-23 | 2020-06-02 | Juul Labs, Inc. | Vaporizer apparatus |
US10058124B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
US10912331B2 (en) | 2013-12-23 | 2021-02-09 | Juul Labs, Inc. | Vaporization device systems and methods |
US9549573B2 (en) | 2013-12-23 | 2017-01-24 | Pax Labs, Inc. | Vaporization device systems and methods |
US10986867B2 (en) | 2013-12-23 | 2021-04-27 | Juul Labs, Inc. | Vaporization device systems and methods |
US10993471B2 (en) | 2013-12-23 | 2021-05-04 | Juul Labs, Inc. | Vaporization device systems and methods |
US10264823B2 (en) | 2013-12-23 | 2019-04-23 | Juul Labs, Inc. | Vaporization device systems and methods |
US11752283B2 (en) | 2013-12-23 | 2023-09-12 | Juul Labs, Inc. | Vaporization device systems and methods |
US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
US10201190B2 (en) | 2013-12-23 | 2019-02-12 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
US10070669B2 (en) | 2013-12-23 | 2018-09-11 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
US10058130B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
US10159282B2 (en) | 2013-12-23 | 2018-12-25 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
US10045568B2 (en) | 2013-12-23 | 2018-08-14 | Juul Labs, Inc. | Vaporization device systems and methods |
US10045567B2 (en) | 2013-12-23 | 2018-08-14 | Juul Labs, Inc. | Vaporization device systems and methods |
US10701975B2 (en) | 2013-12-23 | 2020-07-07 | Juul Labs, Inc. | Vaporization device systems and methods |
US10111470B2 (en) | 2013-12-23 | 2018-10-30 | Juul Labs, Inc. | Vaporizer apparatus |
US10117466B2 (en) | 2013-12-23 | 2018-11-06 | Juul Labs, Inc. | Vaporization device systems and methods |
US10117465B2 (en) | 2013-12-23 | 2018-11-06 | Juul Labs, Inc. | Vaporization device systems and methods |
US11992044B2 (en) | 2013-12-23 | 2024-05-28 | Juul Labs, Inc. | Vaporization device systems and methods |
US10709173B2 (en) | 2014-02-06 | 2020-07-14 | Juul Labs, Inc. | Vaporizer apparatus |
US11452177B2 (en) | 2014-02-06 | 2022-09-20 | Juul Labs, Inc. | Vaporization device systems and methods |
US11019685B2 (en) | 2014-02-06 | 2021-05-25 | Juul Labs, Inc. | Vaporization device systems and methods |
US11659868B2 (en) | 2014-02-28 | 2023-05-30 | Rai Strategic Holdings, Inc. | Control body for an electronic smoking article |
US11864584B2 (en) | 2014-02-28 | 2024-01-09 | Rai Strategic Holdings, Inc. | Control body for an electronic smoking article |
US11478021B2 (en) | 2014-05-16 | 2022-10-25 | Juul Labs, Inc. | Systems and methods for aerosolizing a vaporizable material |
US10561178B2 (en) | 2014-05-23 | 2020-02-18 | Rai Strategic Holdings, Inc. | Sealed cartridge for an aerosol delivery device and related assembly method |
US10750778B2 (en) | 2014-08-21 | 2020-08-25 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a moveable cartridge and related assembly method |
US11291254B2 (en) | 2014-08-21 | 2022-04-05 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a moveable cartridge and related assembly method |
US10765144B2 (en) | 2014-08-21 | 2020-09-08 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a moveable cartridge and related assembly method |
USD758650S1 (en) * | 2014-10-16 | 2016-06-07 | Shenzhen Smaco Technology Limited | Electronic cigarette device |
US10512282B2 (en) | 2014-12-05 | 2019-12-24 | Juul Labs, Inc. | Calibrated dose control |
US10743588B2 (en) | 2015-03-09 | 2020-08-18 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a wave guide and related method |
US9980516B2 (en) | 2015-03-09 | 2018-05-29 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a wave guide and related method |
US11160939B2 (en) | 2015-03-10 | 2021-11-02 | Rai Strategic Holdings, Inc. | Aerosol delivery device with microfluidic delivery component |
US10172388B2 (en) | 2015-03-10 | 2019-01-08 | Rai Strategic Holdings, Inc. | Aerosol delivery device with microfluidic delivery component |
US11000069B2 (en) | 2015-05-15 | 2021-05-11 | Rai Strategic Holdings, Inc. | Aerosol delivery device and methods of formation thereof |
US20210220582A1 (en) * | 2015-05-15 | 2021-07-22 | Rai Strategic Holdings, Inc. | Aerosol delivery device and methods of formation thereof |
US11135690B2 (en) | 2015-05-19 | 2021-10-05 | Rai Strategic Holdings, Inc. | Method for assembling a cartridge for a smoking article |
US11607759B2 (en) | 2015-05-19 | 2023-03-21 | Rai Strategic Holdings, Inc. | Assembly substation for assembling a cartridge for a smoking article and related method |
US11065727B2 (en) | 2015-05-19 | 2021-07-20 | Rai Strategic Holdings, Inc. | System for assembling a cartridge for a smoking article and associated method |
US11006674B2 (en) | 2015-05-19 | 2021-05-18 | Rai Strategic Holdings, Inc. | Assembly substation for assembling a cartridge for a smoking article and related method |
US10238145B2 (en) | 2015-05-19 | 2019-03-26 | Rai Strategic Holdings, Inc. | Assembly substation for assembling a cartridge for a smoking article |
US11684732B2 (en) | 2015-07-17 | 2023-06-27 | Rai Strategic Holdings, Inc. | Load-based detection of an aerosol delivery device in an assembled arrangement |
US10966460B2 (en) | 2015-07-17 | 2021-04-06 | Rai Strategic Holdings, Inc. | Load-based detection of an aerosol delivery device in an assembled arrangement |
US11998686B2 (en) | 2015-07-17 | 2024-06-04 | Rai Strategic Holdings, Inc. | Contained liquid system for refilling aerosol delivery devices |
US11504489B2 (en) | 2015-07-17 | 2022-11-22 | Rai Strategic Holdings, Inc. | Contained liquid system for refilling aerosol delivery devices |
US11134544B2 (en) | 2015-07-24 | 2021-09-28 | Rai Strategic Holdings, Inc. | Aerosol delivery device with radiant heating |
US10015987B2 (en) | 2015-07-24 | 2018-07-10 | Rai Strategic Holdings Inc. | Trigger-based wireless broadcasting for aerosol delivery devices |
US11033054B2 (en) | 2015-07-24 | 2021-06-15 | Rai Strategic Holdings, Inc. | Radio-frequency identification (RFID) authentication system for aerosol delivery devices |
US10206429B2 (en) | 2015-07-24 | 2019-02-19 | Rai Strategic Holdings, Inc. | Aerosol delivery device with radiant heating |
US10349684B2 (en) | 2015-09-15 | 2019-07-16 | Rai Strategic Holdings, Inc. | Reservoir for aerosol delivery devices |
RU2717923C2 (ru) * | 2015-09-25 | 2020-03-26 | Филип Моррис Продактс С.А. | Готовый состав для испарения с возможностью управления кислотностью в электронном устройстве для парения |
US10327472B2 (en) | 2015-09-25 | 2019-06-25 | Altria Client Services Llc | Pre-vaporization formulation for controlling acidity in an e-vaping device |
US11992607B2 (en) | 2015-10-13 | 2024-05-28 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a moveable cartridge and related assembly method |
US10939706B2 (en) | 2015-10-13 | 2021-03-09 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a moveable cartridge and related assembly method |
US10470495B2 (en) | 2015-10-21 | 2019-11-12 | Rai Strategic Holdings, Inc. | Lithium-ion battery with linear regulation for an aerosol delivery device |
US10918134B2 (en) | 2015-10-21 | 2021-02-16 | Rai Strategic Holdings, Inc. | Power supply for an aerosol delivery device |
US10582726B2 (en) | 2015-10-21 | 2020-03-10 | Rai Strategic Holdings, Inc. | Induction charging for an aerosol delivery device |
US11806471B2 (en) | 2015-10-21 | 2023-11-07 | Rai Strategic Holdings, Inc. | Power supply for an aerosol delivery device |
EP3364951A4 (en) * | 2015-10-23 | 2019-04-17 | Next Generation Labs, LLC | NICOTINE COMPOSITION FOR VAPOTING DEVICES AND VAPOTING DEVICES USING THE SAME |
US20170112182A1 (en) * | 2015-10-23 | 2017-04-27 | Next Generation Labs, LLC | Nicotine composition for vaping devices and vaping devices employing the same |
WO2017070706A1 (en) * | 2015-10-23 | 2017-04-27 | Next Generation Labs, LLC | Nicotine composition for vaping devices and vaping devices employing the same |
CN108697643A (zh) * | 2015-10-23 | 2018-10-23 | 下代实验室有限责任公司 | 用于电子烟装置的尼古丁组合物以及使用该组合物的电子烟装置 |
US10729185B2 (en) | 2015-11-02 | 2020-08-04 | Rai Strategic Holdings, Inc. | User interface for an aerosol delivery device |
US11812790B2 (en) | 2015-11-02 | 2023-11-14 | R.J. Reynolds Tobacco Company | User interface for an aerosol delivery device |
US10201187B2 (en) | 2015-11-02 | 2019-02-12 | Rai Strategic Holdings, Inc. | User interface for an aerosol delivery device |
US11464259B2 (en) | 2015-11-02 | 2022-10-11 | R.J. Reynolds Tobacco Company | User interface for an aerosol delivery device |
US12011043B2 (en) | 2015-11-06 | 2024-06-18 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a wirelessly-heated atomizer and related method |
US10820630B2 (en) | 2015-11-06 | 2020-11-03 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a wirelessly-heated atomizer and related method |
US10440992B2 (en) | 2015-12-07 | 2019-10-15 | Rai Strategic Holdings, Inc. | Motion sensing for an aerosol delivery device |
US9955733B2 (en) | 2015-12-07 | 2018-05-01 | Rai Strategic Holdings, Inc. | Camera for an aerosol delivery device |
US11291252B2 (en) | 2015-12-18 | 2022-04-05 | Rai Strategic Holdings, Inc. | Proximity sensing for an aerosol delivery device |
US10092036B2 (en) | 2015-12-28 | 2018-10-09 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a housing and a coupler |
US11311688B2 (en) | 2015-12-28 | 2022-04-26 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a housing and a coupler |
US10610526B2 (en) | 2015-12-30 | 2020-04-07 | Next Generation Labs, LLC | Nicotine replacement therapy products comprising synthetic nicotine |
US10194694B2 (en) | 2016-01-05 | 2019-02-05 | Rai Strategic Holdings, Inc. | Aerosol delivery device with improved fluid transport |
US10051891B2 (en) | 2016-01-05 | 2018-08-21 | Rai Strategic Holdings, Inc. | Capacitive sensing input device for an aerosol delivery device |
US10258086B2 (en) | 2016-01-12 | 2019-04-16 | Rai Strategic Holdings, Inc. | Hall effect current sensor for an aerosol delivery device |
US10104912B2 (en) | 2016-01-20 | 2018-10-23 | Rai Strategic Holdings, Inc. | Control for an induction-based aerosol delivery device |
US10015989B2 (en) | 2016-01-27 | 2018-07-10 | Rai Strategic Holdings, Inc. | One-way valve for refilling an aerosol delivery device |
US11751605B2 (en) | 2016-02-11 | 2023-09-12 | Juul Labs, Inc. | Securely attaching cartridges for vaporizer devices |
WO2017139675A1 (en) * | 2016-02-11 | 2017-08-17 | Pax Labs, Inc. | Securely attaching cartridges for vaporizer devices |
EA039727B1 (ru) * | 2016-02-11 | 2022-03-04 | Джуул Лэбз, Инк. | Надежно прикрепляющиеся картриджи для испарительных устройств |
US10865001B2 (en) | 2016-02-11 | 2020-12-15 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
US11412781B2 (en) | 2016-02-12 | 2022-08-16 | Rai Strategic Holdings, Inc. | Adapters for refilling an aerosol delivery device |
US10912333B2 (en) | 2016-02-25 | 2021-02-09 | Juul Labs, Inc. | Vaporization device control systems and methods |
US9936733B2 (en) | 2016-03-09 | 2018-04-10 | Rai Strategic Holdings, Inc. | Accessory configured to charge an aerosol delivery device and related method |
US10405582B2 (en) | 2016-03-10 | 2019-09-10 | Pax Labs, Inc. | Vaporization device with lip sensing |
US10334880B2 (en) | 2016-03-25 | 2019-07-02 | Rai Strategic Holdings, Inc. | Aerosol delivery device including connector comprising extension and receptacle |
US11207478B2 (en) | 2016-03-25 | 2021-12-28 | Rai Strategic Holdings, Inc. | Aerosol production assembly including surface with micro-pattern |
US11911561B2 (en) | 2016-03-25 | 2024-02-27 | Rai Strategic Holdings, Inc. | Aerosol production assembly including surface with micro-pattern |
US10945462B2 (en) | 2016-04-12 | 2021-03-16 | Rai Strategic Holdings, Inc. | Detachable power source for an aerosol delivery device |
US10333339B2 (en) | 2016-04-12 | 2019-06-25 | Rai Strategic Holdings, Inc. | Charger for an aerosol delivery device |
US11844152B2 (en) | 2016-04-12 | 2023-12-12 | Rai Strategic Holdings, Inc. | Detachable power source for an aerosol delivery device |
US11589421B2 (en) | 2016-04-12 | 2023-02-21 | Rai Strategic Holdings, Inc. | Detachable power source for an aerosol delivery device |
US10028534B2 (en) | 2016-04-20 | 2018-07-24 | Rai Strategic Holdings, Inc. | Aerosol delivery device, and associated apparatus and method of formation thereof |
US10945457B2 (en) | 2016-04-20 | 2021-03-16 | Rai Strategic Holdings, Inc. | Aerosol delivery device, and associated apparatus and method of formation thereof |
US12035749B2 (en) | 2016-04-20 | 2024-07-16 | Rai Strategic Holdings, Inc. | Aerosol delivery device, and associated apparatus and method of formation thereof |
US10405579B2 (en) | 2016-04-29 | 2019-09-10 | Rai Strategic Holdings, Inc. | Methods for assembling a cartridge for an aerosol delivery device, and associated systems and apparatuses |
US11278686B2 (en) | 2016-04-29 | 2022-03-22 | Rai Strategic Holdings, Inc. | Methods for assembling a cartridge for an aerosol delivery device, and associated systems and apparatuses |
US12005184B2 (en) | 2016-04-29 | 2024-06-11 | Rai Strategic Holdings, Inc. | Methods for assembling a cartridge for an aerosol delivery device, and associated systems and apparatuses |
KR20180135021A (ko) | 2016-05-27 | 2018-12-19 | 니뽄 다바코 산교 가부시키가이샤 | 비연소형 가열 흡연 물품용의 담배 충전물 |
JPWO2017203689A1 (ja) * | 2016-05-27 | 2019-03-14 | 日本たばこ産業株式会社 | 非燃焼型加熱喫煙物品用のたばこ充填物 |
WO2017203686A1 (ja) * | 2016-05-27 | 2017-11-30 | 日本たばこ産業株式会社 | 非燃焼型加熱喫煙物品用のたばこ充填物 |
WO2017203689A1 (ja) | 2016-05-27 | 2017-11-30 | 日本たばこ産業株式会社 | 非燃焼型加熱喫煙物品用のたばこ充填物 |
KR20210158861A (ko) | 2016-05-27 | 2021-12-31 | 니뽄 다바코 산교 가부시키가이샤 | 비연소형 가열 흡연 물품용의 담배 충전물 |
USD929036S1 (en) | 2016-06-16 | 2021-08-24 | Pax Labs, Inc. | Vaporizer cartridge and device assembly |
USD913583S1 (en) | 2016-06-16 | 2021-03-16 | Pax Labs, Inc. | Vaporizer device |
USD849996S1 (en) | 2016-06-16 | 2019-05-28 | Pax Labs, Inc. | Vaporizer cartridge |
US10959458B2 (en) | 2016-06-20 | 2021-03-30 | Rai Strategic Holdings, Inc. | Aerosol delivery device including an electrical generator assembly |
US11682946B2 (en) | 2016-06-20 | 2023-06-20 | Rai Strategic Holdings, Inc. | Aerosol delivery device including an electrical generator assembly |
USD851830S1 (en) | 2016-06-23 | 2019-06-18 | Pax Labs, Inc. | Combined vaporizer tamp and pick tool |
USD848057S1 (en) | 2016-06-23 | 2019-05-07 | Pax Labs, Inc. | Lid for a vaporizer |
USD836541S1 (en) | 2016-06-23 | 2018-12-25 | Pax Labs, Inc. | Charging device |
US11458093B2 (en) | 2016-06-30 | 2022-10-04 | Philip Morris Products S.A. | Nicotine particles |
US12048762B2 (en) | 2016-06-30 | 2024-07-30 | Philip Morris Products S.A. | Nicotine particles |
US11759584B2 (en) | 2016-07-06 | 2023-09-19 | Rai Strategic Holdings, Inc. | Aerosol delivery device with a reservoir housing and a vaporizer assembly |
US10798974B2 (en) | 2016-07-06 | 2020-10-13 | Rai Strategic Holdings, Inc. | Aerosol delivery device with a reservoir housing and a vaporizer assembly |
US10085485B2 (en) | 2016-07-06 | 2018-10-02 | Rai Strategic Holdings, Inc. | Aerosol delivery device with a reservoir housing and a vaporizer assembly |
US11684731B2 (en) | 2016-07-06 | 2023-06-27 | Rai Strategic Holdings, Inc. | Aerosol delivery device with a reservoir housing and a vaporizer assembly |
US10405581B2 (en) | 2016-07-08 | 2019-09-10 | Rai Strategic Holdings, Inc. | Gas sensing for an aerosol delivery device |
US10463078B2 (en) | 2016-07-08 | 2019-11-05 | Rai Strategic Holdings, Inc. | Aerosol delivery device with condensing and non-condensing vaporization |
US10231485B2 (en) | 2016-07-08 | 2019-03-19 | Rai Strategic Holdings, Inc. | Radio frequency to direct current converter for an aerosol delivery device |
US10602775B2 (en) | 2016-07-21 | 2020-03-31 | Rai Strategic Holdings, Inc. | Aerosol delivery device with a unitary reservoir and liquid transport element comprising a porous monolith and related method |
US10617151B2 (en) | 2016-07-21 | 2020-04-14 | Rai Strategic Holdings, Inc. | Aerosol delivery device with a liquid transport element comprising a porous monolith and related method |
US11964098B2 (en) | 2016-07-21 | 2024-04-23 | Rai Strategic Holdings, Inc. | Aerosol delivery device with a liquid transport element comprising a porous monolith and related method |
USD825102S1 (en) | 2016-07-28 | 2018-08-07 | Juul Labs, Inc. | Vaporizer device with cartridge |
US11019847B2 (en) * | 2016-07-28 | 2021-06-01 | Rai Strategic Holdings, Inc. | Aerosol delivery devices including a selector and related methods |
US20180027876A1 (en) * | 2016-07-28 | 2018-02-01 | Rai Strategic Holdings, Inc. | Aerosol delivery devices including a selector and related methods |
USD842536S1 (en) | 2016-07-28 | 2019-03-05 | Juul Labs, Inc. | Vaporizer cartridge |
US10729179B2 (en) * | 2016-08-05 | 2020-08-04 | Juul Labs, Inc. | Anemometric-assisted control of a vaporizer |
US20180116292A1 (en) * | 2016-08-05 | 2018-05-03 | Juul Labs, Inc. | Anenometric-assisted control of a vaporizer |
US10779574B2 (en) * | 2016-08-05 | 2020-09-22 | Juul Labs, Inc. | Anemometric-assisted control of a vaporizer |
US20180042306A1 (en) * | 2016-08-05 | 2018-02-15 | Juul Labs, Inc. | Anemometric-assisted control of a vaporizer |
US10765146B2 (en) | 2016-08-08 | 2020-09-08 | Rai Strategic Holdings, Inc. | Boost converter for an aerosol delivery device |
US11937647B2 (en) | 2016-09-09 | 2024-03-26 | Rai Strategic Holdings, Inc. | Fluidic control for an aerosol delivery device |
US11660403B2 (en) | 2016-09-22 | 2023-05-30 | Juul Labs, Inc. | Leak-resistant vaporizer device |
US10080387B2 (en) | 2016-09-23 | 2018-09-25 | Rai Strategic Holdings, Inc. | Aerosol delivery device with replaceable wick and heater assembly |
US20180084821A1 (en) * | 2016-09-27 | 2018-03-29 | BOND STREET MANUFACTURING LLC (a Florida LLC) | Vaporizable Tobacco Wax Compositions |
US10709165B2 (en) * | 2016-09-27 | 2020-07-14 | Bond Street Manufacturing Llc | Vaporizable tobacco wax compositions |
US10477896B2 (en) | 2016-10-12 | 2019-11-19 | Rai Strategic Holdings, Inc. | Photodetector for measuring aerosol precursor composition in an aerosol delivery device |
US11484066B2 (en) | 2016-11-15 | 2022-11-01 | Rai Strategic Holdings, Inc. | Two-wire authentication system for an aerosol delivery device |
US9864947B1 (en) | 2016-11-15 | 2018-01-09 | Rai Strategic Holdings, Inc. | Near field communication for a tobacco-based article or package therefor |
US12027879B2 (en) | 2016-11-15 | 2024-07-02 | Rai Strategic Holdings, Inc. | Induction-based aerosol delivery device |
US12004572B2 (en) | 2016-11-15 | 2024-06-11 | Rai Strategic Holdings, Inc. | Two-wire authentication system for an aerosol delivery device |
US10524508B2 (en) | 2016-11-15 | 2020-01-07 | Rai Strategic Holdings, Inc. | Induction-based aerosol delivery device |
US11588350B2 (en) | 2016-11-15 | 2023-02-21 | Rai Strategic Holdings, Inc. | Induction-based aerosol delivery device |
US10492530B2 (en) | 2016-11-15 | 2019-12-03 | Rai Strategic Holdings, Inc. | Two-wire authentication system for an aerosol delivery device |
US11103012B2 (en) | 2016-11-17 | 2021-08-31 | Rai Strategic Holdings, Inc. | Satellite navigation for an aerosol delivery device |
US11517053B2 (en) | 2016-11-18 | 2022-12-06 | Rai Strategic Holdings, Inc. | Pressure sensing for an aerosol delivery device |
US10524509B2 (en) | 2016-11-18 | 2020-01-07 | Rai Strategic Holdings, Inc. | Pressure sensing for an aerosol delivery device |
US10172392B2 (en) | 2016-11-18 | 2019-01-08 | Rai Strategic Holdings, Inc. | Humidity sensing for an aerosol delivery device |
US10206431B2 (en) | 2016-11-18 | 2019-02-19 | Rai Strategic Holdings, Inc. | Charger for an aerosol delivery device |
US10653183B2 (en) | 2016-11-18 | 2020-05-19 | Rai Strategic Holdings, Inc. | Power source for an aerosol delivery device |
US10537137B2 (en) | 2016-11-22 | 2020-01-21 | Rai Strategic Holdings, Inc. | Rechargeable lithium-ion battery for an aerosol delivery device |
US11013266B2 (en) | 2016-12-09 | 2021-05-25 | Rai Strategic Holdings, Inc. | Aerosol delivery device sensory system including an infrared sensor and related method |
US20190307176A1 (en) * | 2016-12-27 | 2019-10-10 | Japan Tobacco Inc. | Heating-type flavor inhaler |
US10517326B2 (en) | 2017-01-27 | 2019-12-31 | Rai Strategic Holdings, Inc. | Secondary battery for an aerosol delivery device |
US10827783B2 (en) | 2017-02-27 | 2020-11-10 | Rai Strategic Holdings, Inc. | Digital compass for an aerosol delivery device |
US20180289062A1 (en) * | 2017-03-30 | 2018-10-11 | Markham Biotech Inc. | Cannabinoid Formulations for Aerosol Devices and Methods Thereof |
US20210337856A1 (en) * | 2017-03-30 | 2021-11-04 | Markham Biotech Inc. | Cannabinoid Formulations for Aerosol Devices and Methods Thereof |
US11659857B2 (en) * | 2017-03-30 | 2023-05-30 | Markham Biotech, Inc. | Cannabinoid formulations for aerosol devices and methods thereof |
US10932497B2 (en) * | 2017-03-30 | 2021-03-02 | Markham Biotech Inc. | Cannabinoid formulations for aerosol devices and methods thereof |
US10806187B2 (en) | 2017-04-21 | 2020-10-20 | Rai Strategic Holdings, Inc. | Refillable aerosol delivery device and related method |
US10314340B2 (en) | 2017-04-21 | 2019-06-11 | Rai Strategic Holdings, Inc. | Refillable aerosol delivery device and related method |
US11297876B2 (en) | 2017-05-17 | 2022-04-12 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
US11992061B2 (en) * | 2017-05-23 | 2024-05-28 | Rai Strategic Holdings, Inc. | Heart rate monitor for an aerosol delivery device |
US20230180845A1 (en) * | 2017-05-23 | 2023-06-15 | Rai Strategic Holdings, Inc. | Heart rate monitor for an aerosol delivery device |
US10517330B2 (en) * | 2017-05-23 | 2019-12-31 | RAI Stategic Holdings, Inc. | Heart rate monitor for an aerosol delivery device |
US11589621B2 (en) * | 2017-05-23 | 2023-02-28 | Rai Strategic Holdings, Inc. | Heart rate monitor for an aerosol delivery device |
US20180338905A1 (en) * | 2017-05-26 | 2018-11-29 | Inhale Health, LLC | Bioavailable aerosolized supplement formulations |
WO2018218218A1 (en) * | 2017-05-26 | 2018-11-29 | Inhale Health Llc | Bioavailable aerosolized supplement formulations and methods thereof |
WO2019005889A1 (en) * | 2017-06-26 | 2019-01-03 | Nude Nicotine, Inc. | NICOTINE SALTS AND METHODS FOR PREPARING AND USING SAME |
US10842197B2 (en) | 2017-07-12 | 2020-11-24 | Rai Strategic Holdings, Inc. | Detachable container for aerosol delivery having pierceable membrane |
US10349674B2 (en) | 2017-07-17 | 2019-07-16 | Rai Strategic Holdings, Inc. | No-heat, no-burn smoking article |
US11883579B2 (en) | 2017-07-17 | 2024-01-30 | Rai Strategic Holdings, Inc. | No-heat, no-burn smoking article |
US11606971B2 (en) | 2017-07-17 | 2023-03-21 | Rai Strategic Holdings, Inc. | Video analytics camera system for an aerosol delivery device |
US10548349B2 (en) | 2017-07-17 | 2020-02-04 | Rai Strategic Holdings, Inc. | No heat, no-burn smoking article |
US11337456B2 (en) | 2017-07-17 | 2022-05-24 | Rai Strategic Holdings, Inc. | Video analytics camera system for an aerosol delivery device |
US10856572B2 (en) | 2017-07-17 | 2020-12-08 | Rai Strategic Holdings, Inc. | No-heat, no-burn smoking article |
USD927061S1 (en) | 2017-09-14 | 2021-08-03 | Pax Labs, Inc. | Vaporizer cartridge |
USD887632S1 (en) | 2017-09-14 | 2020-06-16 | Pax Labs, Inc. | Vaporizer cartridge |
US11039645B2 (en) | 2017-09-19 | 2021-06-22 | Rai Strategic Holdings, Inc. | Differential pressure sensor for an aerosol delivery device |
US10505383B2 (en) | 2017-09-19 | 2019-12-10 | Rai Strategic Holdings, Inc. | Intelligent charger for an aerosol delivery device |
US11819609B2 (en) | 2017-09-19 | 2023-11-21 | Rai Strategic Holdings, Inc. | Differential pressure sensor for an aerosol delivery device |
US11266178B2 (en) | 2017-10-12 | 2022-03-08 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a control body, an atomizer body, and a cartridge and related methods |
US11986012B2 (en) | 2017-10-12 | 2024-05-21 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a control body, an atomizer body, and a cartridge and related methods |
US10660370B2 (en) | 2017-10-12 | 2020-05-26 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a control body, an atomizer body, and a cartridge and related methods |
US11553562B2 (en) | 2017-10-31 | 2023-01-10 | Rai Strategic Holdings, Inc. | Aerosol delivery device having a resonant transmitter |
US11265970B2 (en) | 2017-10-31 | 2022-03-01 | Rai Strategic Holdings, Inc. | Aerosol delivery device having a resonant transmitter |
US10517332B2 (en) | 2017-10-31 | 2019-12-31 | Rai Strategic Holdings, Inc. | Induction heated aerosol delivery device |
EP3488715A2 (en) | 2017-11-24 | 2019-05-29 | Juul Labs, Inc. | Puff sensing and power circuitry for vaporizer devices |
US11825877B2 (en) | 2017-11-24 | 2023-11-28 | Juul Labs, Inc. | Puff sensing and power circuitry for vaporizer devices |
WO2019104277A1 (en) | 2017-11-24 | 2019-05-31 | Juul Labs, Inc. | Puff sensing and power circuitry for vaporizer devices |
EP3824748A1 (en) | 2017-11-24 | 2021-05-26 | Juul Labs, Inc. | Puff sensing and power circuitry for vaporizer devices |
US10806181B2 (en) | 2017-12-08 | 2020-10-20 | Rai Strategic Holdings, Inc. | Quasi-resonant flyback converter for an induction-based aerosol delivery device |
US11764687B2 (en) | 2017-12-08 | 2023-09-19 | Rai Strategic Holdings, Inc. | Quasi-resonant flyback converter for an induction-based aerosol delivery device |
US11264912B2 (en) | 2017-12-08 | 2022-03-01 | Rai Strategic Holdings, Inc. | Quasi-resonant flyback converter for an induction-based aerosol delivery device |
US10791769B2 (en) | 2017-12-29 | 2020-10-06 | Rai Strategic Holdings, Inc. | Aerosol delivery device providing flavor control |
US10555558B2 (en) | 2017-12-29 | 2020-02-11 | Rai Strategic Holdings, Inc. | Aerosol delivery device providing flavor control |
US11882867B2 (en) | 2018-02-26 | 2024-01-30 | Rai Strategic Holdings, Inc. | Heat conducting substrate for electrically heated aerosol delivery device |
US11019850B2 (en) | 2018-02-26 | 2021-06-01 | Rai Strategic Holdings, Inc. | Heat conducting substrate for electrically heated aerosol delivery device |
US11992038B2 (en) | 2018-12-31 | 2024-05-28 | Philip Morris Products S.A. | Liquid nicotine formulation comprising partially water-soluble solvent |
CN113784634A (zh) * | 2019-03-08 | 2021-12-10 | 莱战略控股公司 | 用于气溶胶递送装置的乳酸水解方法 |
WO2022152529A1 (en) * | 2021-01-12 | 2022-07-21 | Ventus Medical Limited | Aerosolizable nicotine-containing formulations |
WO2022180491A1 (en) * | 2021-02-24 | 2022-09-01 | Rai Strategic Holdings, Inc. | Aerosol precursor formulations |
CN115918952A (zh) * | 2023-01-04 | 2023-04-07 | 东莞市吉纯生物技术有限公司 | 一种烟草味专用烟碱盐及其制备方法及其应用 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20210186082A1 (en) | Nicotine salt formulations for aerosol devices and methods thereof | |
US11744277B2 (en) | Nicotine liquid formulations for aerosol devices and methods thereof | |
RU2782007C1 (ru) | Составы на основе солей никотина для аэрозольных устройств и способы их применения |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: PLOOM, INC., CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BOWEN, ADAM;XING, CHENYUE;REEL/FRAME:033367/0718 Effective date: 20140514 |
|
AS | Assignment |
Owner name: PAX LABS, INC., CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PLOOM, INC.;REEL/FRAME:035121/0328 Effective date: 20150211 |
|
AS | Assignment |
Owner name: JUUL LABS, INC., CALIFORNIA Free format text: CHANGE OF NAME;ASSIGNOR:PAX LABS, INC.;REEL/FRAME:043544/0004 Effective date: 20170613 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |
|
AS | Assignment |
Owner name: JUUL LABS, INC., CALIFORNIA Free format text: CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNOR EXECUTION DATE PREVIOUSLY RECORDED AT REEL: 043544 FRAME: 0004. ASSIGNOR(S) HEREBY CONFIRMS THE CHANGE OF NAME;ASSIGNOR:PAX LABS, INC.;REEL/FRAME:046732/0847 Effective date: 20170630 |