Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C317/00—Sulfones; Sulfoxides
  • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
  • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
  • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
  • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
  • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
  • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
  • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
  • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Definitions

• the present invention relates generally to a new process for preparing oxazolidine protected aminodiol compounds. These compounds are useful intermediates in the process for making Florfenicol.
• Florfenicol is a broad spectrum antibiotic of Formula I
• Florfenicol is also known as [R—(R*,S*)]-2,2-Dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide.
• the present invention addresses these shortcomings and provides alternative methods of preparing useful intermediates included in the synthesis of Florfenicol.
• the present invention includes a process for preparing an oxazolidine protected aminodiol compound of Formula V:
• R 1 is hydrogen, methylthio, methylsulfoxy, methylsulfonyl, fluoromethylthio, fluoromethylsulfoxy, fluoromethylsulfonyl, nitro, fluoro, bromo, chloro, acetyl, benzyl, phenyl, halo substituted phenyl, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 aralkyl, C 2-6 aralkenyl, or C 2-6 heterocyclic group;
• R 2 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 aralkyl, C 2-6 aralkenyl, aryl, or C 2-6 heterocyclic group;
• R 3 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 aralkyl, C 2-6 aralkenyl, aryl or C 2-6 heterocyclic group; and
• R 4 is hydrogen, OH, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, benzyl, phenyl or C 1-6 phenylalkyl group, where the phenyl ring may be substituted by one or two halogens, C 1-6 alkyl, or C 1-6 alkoxy.
• the present invention includes a process for preparing an oxazolidine protected aminodiol compound of Formula XII:
• R 1 , R 2 and R 3 are as defined above;
• R 7 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 dihaloalkyl, C 1-6 trihaloalkyl, C 3-8 cycloalkyl, C 3-8 cyclohaloalkyl, C 3-8 cyclodihaloalkyl, C 3-8 cyclotrihaloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 aralkyl, C 2-6 aralkenyl, C 2-6 heterocyclic, benzyl, phenyl or phenyl alkyl where the phenyl ring may be substituted by one or two halogens, C 1-6 alkyl or C 1-6 alkoxy.
• R 7 is CH 2 Cl, CHCl 2 , CCl 3 , CH 2 Br, CHBr 2 , CBr 3 , CH 2 F, CHF 2 , or CF 3 .
• the process includes the steps of:
• R 1 is as defined above and R 5 is hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl, benzyl, phenyl or C 1-6 phenylalkyl, in a vessel with a reducing agent in an alcoholic solvent to form an aminodiol compound of Formula VII:
• R 1 is as defined above;
• R 1 , R 2 and R 3 are as defined above;
• the process includes the steps of:
• R 1 , R 2 , R 3 and R 7 are as defined above;
• R 1 and R 7 are as defined above;
• esters of Formulas IV and VI generates the expensive free base starting material of Formula III in situ, thereby eliminating the need to isolate this difficult to isolate compound. Yield losses for the free base starting material of Formula III due to isolation are thus eliminated with resulting increased yield and lower cost for the oxazolidine protected aminodiol compound of Formula V, or specifically the compound of Formula II, or in the more preferred embodiment the oxazolidine protected aminodiol compound of Formula XII.
• Applicants have also found ways to utilize the compound of Formula IV with more efficient and cost-saving processes.
• the present invention thus has the advantage of being an efficient and economical process for preparing Florfenicol, its analogs and oxazolidine intermediates related thereto.
• alcoholic solvent includes C 1 to C 10 alcohols such as methanol and ethanol and mixtures thereof, C 2 to C 10 dialcohols such as ethylene glycol and C 1 to C 10 trialcohols such as glycerin.
• the alcoholic solvent can be admixed with any suitable cosolvent.
• Such cosolvents can include other solvents which are miscible with the alcoholic solvent such as C 4 to C 10 alkanes, aromatic solvents such as benzene, toluene, xylenes, halobenzenes such as chlorobenzene, and ethers such as diethylether, tert-butylmethylether, isopropylether and tetrahydrofuran, or mixtures of any of the above solvents or cosolvents.
• alcoholic solvent such as C 4 to C 10 alkanes
• aromatic solvents such as benzene, toluene, xylenes
• halobenzenes such as chlorobenzene
• ethers such as diethylether, tert-butylmethylether, isopropylether and tetrahydrofuran, or mixtures of any of the above solvents or cosolvents.
• alkyl means a straight or branched alkyl such as methyl, ethyl, propyl, or sec-butyl. Alternatively, the number of carbons in alkyl may be specified.
• C 1 to C 6 alkyl means an “alkyl” as described above containing 1 to 6 carbon atoms.
• Haloalkyl means an “alkyl” as described above wherein one or more hydrogens are replaced by halo.
• aryl means phenyl, or phenyl substituted by C 1 to C 6 alkyl or halo.
• Substituted benzyl means benzyl substituted by C 1 to C 6 alkyl or halo.
• halo means fluoro, chloro, bromo or iodo.
• halo aryl means phenyl substituted by halo.
• R 1 is hydrogen, methylthio, methylsulfoxy, methylsulfonyl, fluoromethylthio, fluoromethylsulfoxy, fluoromethylsulfonyl, nitro, fluoro, bromo, chloro, acetyl, benzyl, phenyl, halo substituted phenyl, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 aralkyl, C 2-6 aralkenyl, or C 2-6 heterocyclic group;
• R 2 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 aralkyl, C 2-6 aralkenyl, aryl, or C 2-6 heterocyclic group;
• R 3 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 aralkyl, C 2-6 aralkenyl, aryl or C 2-6 heterocyclic group; and
• R 4 is hydrogen, OH, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, benzyl, phenyl or C 1-6 phenylalkyl group, where the phenyl ring may be substituted by one or two halogens, C 1-6 alkyl or C 1-6 alkoxy.
• the compounds corresponding thereto are useful intermediates in the formation of Florfenicol and related compounds.
• One preferred process corresponding to the invention includes the steps of:
• R 1 is as defined above and R 5 is hydrogen, C 1-6 alkyl, C 3-8 cycloalkyl, benzyl, phenyl or C 1-6 alkylphenyl, in a vessel with a reducing agent in an alcoholic solvent to form an aminodiol compound of Formula VII:
• R 1 is as defined above;
• R 1 , R 2 , R 3 and R 4 are as defined above;
• R 1 , R 2 , R 3 and R 4 are as defined above.
• R 1 is methylthio, methylsulfoxy, or methylsulfonyl. More preferably, R 1 is methylsulfonyl;
• R 2 and R 3 are hydrogen, methyl, ethyl or propyl. More preferably, R 2 and R 3 are methyl;
• R 4 is a methyl, ethyl, propyl or isopropyl group. More preferably, R 4 is methyl; and
• R 5 is methyl, ethyl, n-propyl, isopropyl, butyl, t-butyl, or pentyl.
• the compound of Formula IV is commercially available.
• Alternative compounds corresponding to Formula VI can be prepared using standard organic synthetic techniques without undue experimentation.
• ester compound of Formula VI is N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl
• esters correspond to:
• R 5 is as defined above.
• the compound corresponding to Formula VI is the compound of Formula IV.
• reaction vessel shall be understood to mean a container known to those of ordinary skill which is capable of holding the reactants and allowing the reaction step to proceed to completion.
• the size and type of vessel will, of course, depend upon the size of the batch and the specific reactants selected.
• suitable reducing agents can be employed in carrying out the process of the invention.
• suitable reducing agents include NaBH 4 , KBH 4 , Ca(BH 4 ) 2 , and LiBH 4 and mixtures thereof when an alcoholic solvent is used.
• the alcoholic solvent can also be one of many art-recognized solvents but some preferred solvents include methanol, ethanol, propanol, isopropanol, butanol and pentanol and mixtures thereof.
• One preferred reducing agent is KBH 4 .
• the molar ratio of reducing agent, such as KBH 4 , to the compound of Formula IV is between about 1:1 and about 2:1.
• the reducing agent is KBH 4
• the molar ratio of KBH 4 to the compound of Formula IV is about 1.5:1 and the preferred solvent is methanol.
• This reduction can be carried out at a temperature of about 30° C. to about 80° C. in about 8 hours.
• the temperature is below 60° C. and the time for the reaction to reach completion is under 6 hours.
• the artisan can use reducing agents such as LiAlH 4 or NaAlH 4 when anhydrous conditions are desired.
• solvents like ether or tetrahydrofuran can be used.
• aminodiol compound corresponding to Formula VII is reacted, preferably in the same vessel (i.e., in situ), with an oxazolidine forming reagent such as formaldehyde, acetone, 2-methoxypropene, 2,2-dimethoxypropane, 2,2-diethoxypropane and mixtures thereof, under conditions such as those set forth in the examples to make a compound of Formula VIII.
• an oxazolidine forming reagent such as formaldehyde, acetone, 2-methoxypropene, 2,2-dimethoxypropane, 2,2-diethoxypropane and mixtures thereof.
• the compound corresponding to Formula VIII is the compound:
• the methanol solvent is removed by distillation and replaced with another solvent designated herein as an oxazolidine forming solvent such as toluene, xylene, hexane or a mixture thereof.
• the preferred oxazolidine forming solvent is toluene.
• the ratio of the oxazolidine forming solvent to methanol is about 0.5:1 to 3:1 with the preferred ratio of about 1:1.
• An oxazolidine forming reagent such as formaldehyde, acetone, 2-methoxypropene, 2,2-dimethoxypropane, 2,2-diethoxypropane and mixtures thereof is then added.
• One preferred oxazolidine forming reagent is acetone which is added in a ratio to toluene of about 0.5:1 to 3:1 with the preferred ratio of about 1:1.
• the reaction runs to completion to form the oxazolidine compound of Formula VIII over about 12-18 hours in the presence of a base designated herein as an oxazolidine promoting base such as potassium carbonate, sodium carbonate, trimethylamine or triethylamine.
• a preferred base is potassium carbonate or triethylamine.
• the oxazolidine forming reaction can be carried out at a temperature of about 65-85° C.
• the compound of Formula VIII remain in the same vessel after completion of the reaction step when the first N-acylating agent is added.
• the nomenclature “first,” “second” and “third” are used for describing the (1) N-acylating (first) agents so as to distinguish the agents used for making the oxazolidine protected aminodiol compounds of Formula V, from the (2) N-acylating agents (second) which are used in the formation of the compounds of Formula XI after the intermediate of Formula X has been formed, from the (3) N-acylating agents (third) used during the process to form the oxazolidine protected aminodiol compounds of Formula XII.
• some preferred first N-acylating compounds are of the formula R 6 COR 4
• R 4 is hydrogen, OH, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, benzyl, phenyl or C 1-6 phenylalkyl group, where the phenyl ring may be substituted by one or two halogens, C 1-6 alkyl or C 1-6 alkoxy; and
• R 6 is halo, or C 1-6 alkoxy.
• Some more preferred first acylating agents include acetyl chloride, acetyl bromide, propionyl chloride, propionyl bromide, butyl chloride, methyl chloroformate, ethyl chloroformate, propyl chloroformate and mixtures thereof.
• the compound corresponding to Formula V is the compound:
• a base such as potassium carbonate, sodium carbonate, trimethylamine or triethylamine is added in a molar equivalent ratio to the compound of Formula VII of about 1:1 to 1:3.
• the preferred base is potassium carbonate or triethylamine and the preferred molar equivalent ratio is about 1.1 to 1.
• the preferred first N-acylating agent acetyl chloride is added in a molar ratio to the compound of Formula VII of about 1:1 to 3:1 with the preferred ratio being 1.1:1.
• Reaction temperature is about 20-30° C. and the reaction completes in about 2-4 hours.
• R 1 , R 2 , R 3 and R 4 are as defined above.
• Suitable fluorinating agents include, without limitation, N-(2-chloro-1,1,2-trifluoroethyl)diethylamine, N-(2-chloro-1,1,2-trifluoroethyl)dimethylamine, N-(2-chloro-1,1,2-trifluoroethyl)dipropylamine, N-(2-chloro-1,1,2-trifluoroethyl)pyrrolidine, N-(2-chloro-1,1,2-trifluoroethyl)-2-methylpyrrolidine, N-(2-chloro-1,1,2-trifluoroethyl)-4-methylpiperazine, N-(2-chloro-1,1,2-trifluoroethyl)-morpholine, N-(2-chloro-1,1,2-trifluoroethyl)piperidine, 1,1,2,2-tetrafluoroethyl-N,N-dimethylamine, (Diethylamino)sulfur triflu
• the molar ratio of the fluorinating agent such as N,N-diethyl-1,1,2,3,3,3-hexafluoro-1-propanamine to the compound according to Formula V is between about 1:1 and about 2:1.
• the molar ratio of the N,N-diethyl-1,1,2,3,3,3-hexafluoro-1-propanamine to the compound of Formula V is about 1.5:1.
• the fluorinating step can be carried out at a temperature of from about 80° C. to about 110° C. and at a pressure of about 60 psi.
• the organic solvent used during the fluorinating step is preferably 1,2-dichloroethane, methylene chloride, chloroform, chlorobenzene, chlorinated hydrocarbons or mixtures thereof.
• a more preferred organic solvent is methylene chloride.
• R 1 is as defined above, preferably, R 1 is CH 3 SO 2 .
• the acid used in this part of the process can be an inorganic acid like aqueous hydrochloric acid, sulfuric acid, or phosphoric acid or an organic acid like methanesulfonic acid.
• the hydrolyzing step is preferably carried out by heating the compound of Formula IX with 6N aqueous hydrochloric acid at a temperature of from about 90° C. to about 105° C. for about 60 minutes. Other suitable hydrolyzing steps will be apparent to those of ordinary skill.
• R 1 is the same as above, preferably CH 3 SO 2 ;
• R 7 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 dihaloalkyl, C 1-6 trihaloalkyl, C 3-8 cycloalkyl, C 3-8 cyclohaloalkyl, C 3-8 cyclodihaloalkyl, C 3-8 cyclotrihaloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 aralkyl, C 2-6 aralkenyl, C 2-6 heterocyclic benzyl, phenyl or phenyl alkyl where the phenyl ring may be substituted by one or two halogens, C 1-6 alkyl or C 1-6 alkoxy.
• R 7 is CH 2 Cl, CHCl 2 , CCl 3 , CH 2 Br, CHBr 2 , CBr 3 , CH 2 F, CHF 2 , or CF 3 .
• one preferred compound of Formula XI is:
• R 7 is as defined above.
• the compound corresponding to Formula XI is the compound of Formula I:
• Suitable second N-acylating compounds are of the formula R 8 COR 7 , wherein R 7 is the same as that described above and R 8 is OH, halo or C 1-6 alkoxy.
• Some more preferred second N-acylating agents include dichloroacetic acid or a reactive derivative thereof.
• a non-limiting list includes reagents such as methyldichloroacetate, ethyldichloroacetate, or dichloroacetylchloride.
• the second N-acylation step is preferably carried out by reacting the compound of Formula X in methanol with methyldichloroacetate at a temperature of from about 20° C. to about 30° C. for about 12 hours.
• the compound of Formula XI can optionally be purified by heating in a mixture of an alkyl mono, di or tri alcohols and water.
• the alcohols in this part of the process can be C 1-10 monoalcohols, C 1-10 dialcohols and C 1-10 trialcohols and mixtures thereof.
• a non-limiting list of the C 1-10 monoalcohols includes methanol, ethanol, propanol, isopropanol, butanol, sec-butanol, t-butanol and pentanol.
• One preferred C 1-10 monoalcohol is isopropanol.
• C 1-10 dialcohols includes ethylene glycol, propylene glycol and butylene glycol of which propylene glycol is preferred. Glycerin is the preferred C 1-10 trialcohol. A C 1-10 monoalcohol is preferred for the purification. One most preferred C 1-10 monoalcohol is isopropanol.
• the ratio of alcohol, such as isopropanol, to water is between 1:5 and 5:1.
• the ratio of isopropanol to water is 1:1.
• the compound of Formula XI is dissolved in a 1:1 mixture of isopropanol and water heated to the reflux point of the mixture.
• the solution is clarified by filtration with active carbon and a filter aid, then cooled to about 10-30° C. and the purified compound of Formula XI crystallizes from solution.
• the solution is cooled to about 20-25° C. and the purified compound of Formula XI crystallizes from solution.
• the purified compound corresponding to Formula XI is the compound of Formula I.
• the process corresponding to the invention includes the steps of:
• R 1 , R 2 , R 3 and R 7 are as defined above.
• R 7 is CH 2 Cl, CHCl 2 , CCl 3 , CH 2 Br, CHBr 2 , CBr 3 , CH 2 F, CHF 2 , or CF 3 ;
• R 1 , R 2 , R 3 and R 7 are as defined above;
• One preferred aspect is that after the compound of Formula VIII is made it is reacted preferably in the same vessel (i.e., in situ) with a suitable third N-acylating compound.
• Some preferred third N-acylating compounds are of the formula R 6 COR 7 wherein R 6 and R 7 are as defined above.
• R 6 is Cl and R 7 is CH 2 Cl, CHCl 2 , CCl 3 , CH 2 Br, CHBr 2 , CBr 3 , CH 2 F, CHF 2 , or CF 3 .
• Some preferred third N-acylating agents include alkylhaloacetic acid derivatives.
• a non-limiting list includes reagents such as methyldichloroacetate, ethyldichloroacetate, dichloroacetylchloride, methylchloroacetate, ethylchloroacetate, chloroacetylchloride, methyltrichloroacetate, ethyltrichloroacetate, trichloroacetylchloride, methyldifluoroacetate, ethyldifluoroacetate, difluoroacetylchloride, methylfluoroacetate, ethylfluoroacetate, fluoroacetylchloride, methyltrifluoroacetate, ethyltrifluoroacetate, trifluoroacetylchloride, dichloroacetylbromide, difluoroacetylbromide, acet
• the compound corresponding to Formula XII is the compound of Formula XIIa:
• a base such as potassium carbonate, sodium carbonate, trimethylamine or triethylamine is added in a molar equivalent ratio to the compound of Formula VIIIa of about 1:1 to 1:3.
• the preferred base is potassium carbonate or triethylamine and the preferred molar equivalent ratio is about 1.1 to 1.
• the preferred N-acylating agent dichloroacetyl chloride is added in a molar ratio to the compound of Formula VIIIa of about 1:1 to 3:1 with the preferred ratio being 1.1:1.
• Reaction temperature is about 20-30° C. and the reaction completes in about 2-4 hours.
• R 1 , R 2 , R 3 and R 7 are as defined above, with a fluorinating agent, as previously defined, in the presence of an organic solvent, as previously defined, to obtain a compound of Formula XIII:
• R 1 , R 2 , R 3 and R 7 are as defined above.
• the compound corresponding to Formula XIII is specifically the compound of Formula XIIIa:
• a wide range of acid catalysts can be employed in carrying out the process of the invention.
• suitable acid catalysts include inorganic acids like dilute aqueous hydrochloric acid, sulfuric acid, or phosphoric acid or organic acids like methanesulfonic acid or p-toluene sulfonic acid.
• One preferred acid catalyst is p-toluene sulfonic acid.
• a wide range of basic catalysts can be employed in carrying out the process of the invention.
• a non-limiting list of suitable basic catalysts include inorganic bases such as LiOH, NaOH, KOH, Li 2 CO 3 , Na 2 CO 3 , K 2 CO 3 or organic bases such as sodium methoxide, sodium ethoxide, potassium methoxide and potassium ethoxide.
• One preferred basic catalyst is K 2 CO 3 .
• the selective hydrolyzing step is preferably carried out be heating the compound of Formula XIII with p-toluene sulfonic acid in a mixture of an organic solvent and water at a temperature below 80° C.
• One preferred organic solvent is methylene chloride.
• Other suitable selective hydrolyzing steps will be apparent to those of ordinary skill.
• the compound corresponding to Formula XI is the compound of Formula I:
• the compound of Formula XI After the compound of Formula XI is made and if necessary, it can optionally be purified by the process as described above.
• the purified compound corresponding to Formula XI is the compound of Formula I.

Landscapes

• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
• Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
• Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Priority Applications (1)

Applications Claiming Priority (2)

Publications (1)

Family

ID=37684114

Family Applications (3)

Family Applications After (2)

Country Status (19)

Cited By (4)

Families Citing this family (12)

Citations (3)

Family Cites Families (5)

• 2006
  • 2006-08-31 RU RU2008112952/04A patent/RU2008112952A/ru unknown
  • 2006-08-31 EP EP06802796A patent/EP1934190A2/en not_active Withdrawn
  • 2006-08-31 SI SI200631769T patent/SI1928820T1/sl unknown
  • 2006-08-31 RU RU2008112950/04A patent/RU2008112950A/ru not_active Application Discontinuation
  • 2006-08-31 JP JP2008530112A patent/JP2009507074A/ja not_active Withdrawn
  • 2006-08-31 US US11/515,278 patent/US20070055067A1/en not_active Abandoned
  • 2006-08-31 CA CA002621961A patent/CA2621961A1/en not_active Abandoned
  • 2006-08-31 CA CA002621971A patent/CA2621971A1/en not_active Abandoned
  • 2006-08-31 BR BRPI0615764-5A patent/BRPI0615764A2/pt not_active IP Right Cessation
  • 2006-08-31 WO PCT/US2006/034370 patent/WO2007030405A2/en active Application Filing
  • 2006-08-31 CN CNA2006800410847A patent/CN101300237A/zh active Pending
  • 2006-08-31 JP JP2008530111A patent/JP2009507842A/ja active Pending
  • 2006-08-31 AU AU2006287716A patent/AU2006287716A1/en not_active Abandoned
  • 2006-08-31 ES ES06824884.8T patent/ES2459205T3/es active Active
  • 2006-08-31 AU AU2006287697A patent/AU2006287697A1/en not_active Abandoned
  • 2006-08-31 TW TW095132192A patent/TWI331139B/zh not_active IP Right Cessation
  • 2006-08-31 US US11/514,741 patent/US20070055066A1/en not_active Abandoned
  • 2006-08-31 MX MX2008003187A patent/MX2008003187A/es unknown
  • 2006-08-31 EP EP06802794A patent/EP1934189A2/en not_active Withdrawn
  • 2006-08-31 AU AU2006287696A patent/AU2006287696A1/en not_active Abandoned
  • 2006-08-31 TW TW095132200A patent/TW200800924A/zh unknown
  • 2006-08-31 UA UAA200804362A patent/UA93212C2/ru unknown
  • 2006-08-31 TW TW095132185A patent/TW200804253A/zh unknown
  • 2006-08-31 RU RU2008112946/04A patent/RU2008112946A/ru not_active Application Discontinuation
  • 2006-08-31 US US11/515,135 patent/US7786329B2/en active Active
  • 2006-08-31 JP JP2008530125A patent/JP5113754B2/ja not_active Expired - Fee Related
  • 2006-08-31 WO PCT/US2006/034219 patent/WO2007030386A2/en active Application Filing
  • 2006-08-31 BR BRPI0615767-0A patent/BRPI0615767A2/pt not_active IP Right Cessation
  • 2006-08-31 EP EP06824884.8A patent/EP1928820B1/en active Active
  • 2006-08-31 CN CN2006800411958A patent/CN101300227B/zh active Active
  • 2006-08-31 CA CA002621987A patent/CA2621987A1/en not_active Abandoned
  • 2006-08-31 WO PCT/US2006/034217 patent/WO2007030385A2/en active Application Filing
  • 2006-08-31 KR KR1020087005954A patent/KR20080049040A/ko not_active Application Discontinuation
  • 2006-08-31 MX MX2008003188A patent/MX2008003188A/es unknown
  • 2006-08-31 KR KR1020087005920A patent/KR101408596B1/ko not_active IP Right Cessation
  • 2006-08-31 BR BRPI0615565-0A patent/BRPI0615565A2/pt not_active IP Right Cessation
  • 2006-08-31 MX MX2008003186A patent/MX2008003186A/es unknown
  • 2006-08-31 KR KR1020087005952A patent/KR20080049039A/ko not_active Application Discontinuation
  • 2006-08-31 CN CNA2006800412359A patent/CN101300238A/zh active Pending
• 2008
  • 2008-02-28 IL IL189829A patent/IL189829A0/en unknown
  • 2008-02-28 IL IL189828A patent/IL189828A0/en unknown
  • 2008-02-28 IL IL189830A patent/IL189830A0/en unknown
  • 2008-03-04 ZA ZA200802046A patent/ZA200802046B/xx unknown
  • 2008-03-04 ZA ZA200802047A patent/ZA200802047B/xx unknown
  • 2008-03-04 ZA ZA200802048A patent/ZA200802048B/xx unknown
  • 2008-03-13 EC EC2008008267A patent/ECSP088267A/es unknown
  • 2008-03-13 EC EC2008008266A patent/ECSP088266A/es unknown
  • 2008-03-13 EC EC2008008268A patent/ECSP088268A/es unknown
  • 2008-04-04 NO NO20081684A patent/NO20081684L/no not_active Application Discontinuation
  • 2008-04-04 NO NO20081686A patent/NO20081686L/no not_active Application Discontinuation
  • 2008-04-04 NO NO20081685A patent/NO20081685L/no not_active Application Discontinuation

Patent Citations (3)

Also Published As

Similar Documents

Legal Events