US20070027105A1 - Peroxide removal from drug delivery vehicle - Google Patents
Peroxide removal from drug delivery vehicle Download PDFInfo
- Publication number
- US20070027105A1 US20070027105A1 US11/492,153 US49215306A US2007027105A1 US 20070027105 A1 US20070027105 A1 US 20070027105A1 US 49215306 A US49215306 A US 49215306A US 2007027105 A1 US2007027105 A1 US 2007027105A1
- Authority
- US
- United States
- Prior art keywords
- drug delivery
- delivery vehicle
- formulation
- saib
- peroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
Definitions
- the present invention relates to methods for reducing peroxide levels in non-polymeric preparations and to compositions used in and prepared by such methods.
- SAIB Sucrose acetate isobutyrate
- SAIB is a hydrophobic liquid with limited water solubility. It is soluble in a large number of biocompatible solvents. SAIB has an unusual property—it undergoes a dramatic change in viscosity with small additions of heat or with the addition of solvents. It is a very viscous liquid, having a viscosity of approximately 3200 poise at 37° C. SAIB is produced by the controlled esterification of natural sugar (sucrose) with acetic and isobutyric anhydrides. SAIB metabolizes to sucrose, acetic acid and isobutyric acid.
- SAIB is orally non-toxic and is currently used to stabilize emulsions in the food industry.
- SAIB is commonly found in the beverage industry, where it is used as a weighting agent to help stabilize the final beverage formula.
- SAIB has been reported to be useful as a gelling system-type drug excipient that allows for sustained or controlled release of drugs.
- SAIB can be applied via injection or an aerosol spray.
- SAIB is compatible with cellulose esters and other polymers that can affect the rate of delivery of the substance.
- SAIB is the main ingredient for the SABER drug delivery system, which also consists of a pharmaceutically acceptable solvent.
- Drug delivery systems including SAIB delivery systems, are still confronted by various issues of drug instability, as such systems are considered for longer and longer drug delivery durations.
- Drug instability can occur via a number of factors, including denaturation, precipitation, oxidation, aggregation, and others.
- a number of excipients used to facilitate delivery and release of drugs have peroxides or are susceptible to the formation of peroxides, which may lead to oxidation of active ingredient in the formulation.
- the presence of peroxides is deleterious to a drug incorporated in an SAIB drug formulation as the drug is likely to undergo oxidative degradation.
- the peroxide levels must be reduced.
- An aspect of the present invention comprises methods of treating sucrose acetate isobutyrate (SAIB) formulations to be used as drug delivery vehicles comprising adding to the formulations an amount of bisulfite salt effective to substantially remove peroxides, the bisulfite salt comprising sodium metabisulfite, potassium metabisulfite, sodium bisulfite, or potassium bisulfite, or a mixture thereof.
- SAIB sucrose acetate isobutyrate
- drug delivery vehicles adapted to provide prolonged stability of a drug that is to be delivered in vivo comprising sucrose acetate isobutyrate having substantially reduced levels of peroxide, the drug delivery vehicle being treated with an amount of bisulfite salt effective to substantially reduce levels of peroxide in said drug delivery vehicle, the bisulfite salt comprising sodium metabisulfite, potassium metabisulfite, sodium bisulfite, or potassium bisulfite, or a combination thereof.
- FIG. 1 illustrates a bar graph of the results of Study I—Stability of omega-interferon in untreated SAIB.
- FIG. 2 illustrates a bar graph of the results of Study IIa—Stability of omega-interferon in alumina treated SAIB.
- FIG. 3 illustrates a bar graph of the results of Study IIb—Stability of omega-interferon in alumina treated SAIB.
- FIG. 4 illustrates a bar graph of the results of Study III—Stability of omega-interferon in untreated SAIB.
- FIG. 5 illustrates a bar graph of the results of Study VIb—Stability of omega-interferon in untreated SAIB.
- FIG. 6 illustrates a bar graph of the results of Study VIa—Stability of omega-interferon in sodium metabisulfite treated SAIB.
- FIG. 7 illustrates a bar graph that provides comparisons of oxidation of omega-IFN in sodium metabisulfite treated and untreated SAIB.
- FIG. 8 illustrates an osmotically pump-driven implantable device, Duros® being an example, that facilitates in vivo delivery of an active agent in an SAIB vehicle.
- sucrose acetate isobutyrate formulations that are to be used as drug delivery vehicles comprising adding an amount of a bisulfite salt effective for substantially removing peroxide from the formulations, the bisulfite salt comprising sodium metabisulfite, potassium metabisulfite, sodium bisulfite, or potassium bisulfite, or a combination thereof.
- the bisulfite salt is sodium metabisulfite.
- a ratio ranging from about 1:1 to about 1:4 (weight:volume) SAIB:aqueous solution of bisulfite salt (“aqueous bisulfite salt”) can be used.
- the bisulfite salt is a metabisulfite salt.
- the bisulfite salt is preferably sodium metabisulfite.
- the ratio of the aqueous bisulfite salt to SAIB is 1:1.
- a volume of sodium metabisulfite solution can be made up to 1 liter, and an approximate proportion of 1:1 of SAIB:aqueous sodium metabisulfite was used.
- the aqueous bisulfite salt in SAIB can be from about 0.1% weight to volume of water (w/v) to about 50% w/v; preferably, from about 0.5% w/v to about 30% w/v.
- the aqueous bisulfite salt is preferably from about 1% w/v to about 15% w/v.
- the aqueous bisulfite salt is about 5% w/v solution in water.
- the method removes peroxide to a level that is at least less than 50% of the levels before the method, or starting levels, and, preferably, less than 20% of the starting levels. In some embodiments, peroxide is removed to less than 10% of the starting levels. While in some embodiments, the method removes peroxide to a level that is less than 5% of the starting levels. Furthermore, the method can remove peroxide so that the resulting SAIB formulation contains peroxide in amounts less than 20 ppm, and, preferably, less than 10 ppm. In some embodiments, the method removes peroxide to result in an SAIB formulation containing less than 5 ppm.
- the resulting SAIB formulation from this method can serve as a drug delivery vehicle for use with a medical delivery device, including a drug eluting stent, a catheter, or other drug delivery implants.
- the SAIB formulation can be loaded into an osmotically pump-driven implantable device of the type disclosed in U.S. Pat. No. 6,395,292, for example.
- the osmotically pump-driven implantable device is a Duros® device (Alza Corporation, Mountain View, Calif.).
- the SAIB formulation can serve as a drug depot for drug delivery.
- the step of adding the bisulfite salt comprises mixing a solution of the bisulfite salt with the sucrose acetate isobutyrate formulation.
- the SAIB formulation can be further comprised of a cosolvent, which can be selected from a number of solvents including pharmaceutically acceptable solvents, e.g., hexane, ethyl acetate, ethanol, benzyl benzoate, N-methyl pyrrolidone, and iso-propyl alcohol, among others.
- the cosolvent is hexane or ethyl acetate.
- the methods further comprise vacuum treating the formulation to remove the cosolvent.
- some embodiments comprise the additional step of removing bisulfite salt from the formulation.
- This removal step comprises washing the formulation with water to remove the bisulfite salt.
- a further step of drying the formulation over magnesium sulfate can be utilized to remove the water.
- calcium chloride anhydrous, calcium sulfate anhydrous, activated silica gel, phosphorous pentoxide, or drying under vacuum, or a combination thereof can be used to also remove the water.
- glycerin can be used to wash the bisulfite-added formulation to remove the bisulfite salt. Afterwards, residual glycerin can be removed by washing with water and then drying to remove water.
- the methods of substantially removing peroxide from a sucrose acetate isobutyrate formulation comprising the steps of adding the aqueous bisulfite salt, washing the formulation, and drying the formulation are repeated at least once. The steps can be repeated to further reduce the levels of peroxide in the SAIB formulation.
- the present invention includes a drug delivery vehicle comprising SAIB that provides for prolonged stability of a drug that is to be delivered by maintaining substantially reduced levels of peroxide, the drug delivery vehicle being treated with sodium metabisulfite.
- the prolonged stability comprises reduced oxidation, deamidation, or aggregation, e.g., dimerization, of the drug over extended periods of time in which drug is within environment of delivery vehicle.
- the prolonged stability is reduced oxidation.
- the extended periods of time can be periods from about one week to a few months, and up to about a year.
- the prolonged stability is evidenced by significant improvements in oxidation, deamidation, or aggregation levels of the drug when the delivery vehicle has been treated with a bisulfite salt versus untreated delivery vehicle.
- the prolonged stability is characterized as about 50% less oxidation, about 33% less deamidation, or about 75% less dimerization as compared to untreated delivery vehicles.
- the drug can be selected from any known and desired biomolecular material that can act as therapeutics and other therapeutic active agents that are susceptible to oxidative degradation.
- biomolecular material refers to peptides, polypeptides, proteins, nucleic acids, viruses, antibodies, small molecules susceptible to oxidation, and any other naturally derived, synthetically produced, or recombinantly produced active agent that includes nucleic or amino acid.
- drugs can be selected from among the following: a steroid, NSAIDS, peptides, proteins such as growth factors or hormones, anti-tumor agents, antibiotics, analgesics, local anesthetics, antiviral agents, antipsychotics, anticoagulants, oligonucleotides for gene therapy, active small molecules, and others.
- the term “removing” and all variations thereof, refer to decreasing by any measurable degree the level of peroxide present in a drug formulation.
- the term “substantially removing” is used herein to describe a dramatic decrease in the level of peroxide present in a drug formulation, such as SAIB formulation. The dramatic decrease is at least 50% of original levels (levels before treatment) and in some instances is 10% of original levels. In preferred aspects of the present invention, the “substantial removal” describes a decrease to less than 5% of original levels.
- drug delivery vehicle or “delivery vehicle” refers to a formulation that is biocompatible and used to carry a drug without reacting with the same drug. Also, the vehicle does not alter or minimally alters the activity of the drug. Furthermore, the vehicle allows for the transport of the drug in vivo and eventual delivery of the drug to a biological site for therapeutic effect.
- Prolonged stability is used to refer to the stabilizing effect of the drug delivery vehicles of the present invention on the carried drug. Prolonged stability can be evidenced by significant improvements in oxidation, deamidation, or aggregation of the drug over extended periods of time.
- Each of the experiments involved protein particles consisting of omega-interferon, which were suspended in SAIB at a particle loading of either 4% or 10% by weight.
- the suspensions were prepared in a dry box under nitrogen at 45° C. The suspension was mixed for 15 minutes while maintaining the temperature. Suspension mixing was performed by hand. Aliquots from the prepared suspensions were transferred to clear crimp-top glass vials and sealed under nitrogen. Each aliquot contained at least six milligrams of protein to allow for stability testing in triplicate. These samples were stored in an oven at 40° C. Samples were withdrawn at regular intervals (as indicated in Table 1) and analyzed for omega-interferon content and purity was assessed using reverse phase HPLC and size exclusion chromatography.
- Size exclusion chromatography was used to monitor the omega-interferon content and purity in the formulations. The percentages of monomer and dimer in the formulation were quantified using SEC. The stability of omega-interferon was judged by using a stability indicating chromatographic technique based on reverse phase HPLC (rp-HPLC). This technique was used to monitor the oxidation, deamidation and formation of an unknown species of omega-interferon in the formulations. The peroxide content of the vehicle was determined using EP 2002, 2.5.5 (Method A with auto titration). See Extra Pharmacopoeia, 2002 Ed. Content and purity assay of omega-interferon by size exclusion chromatography (SEC).
- SEC Size exclusion chromatography
- omega-interferon The stability of omega-interferon was monitored in two different lots of untreated SAIB (as received) and in treated SAIB (removal of peroxides), when treatment was applied.
- Study IIa Treatment of SAIB (lot #TD1030507) with neutral alumina by heating and stability in this treated SAIB for 4 weeks
- Study VIa Treatment of SAIB (lot #TD2032663) with 5% aqueous solution of sodium metabisulfite and stability in treated SAIB for 8 weeks
- Study VIb Stability in untreated SAIB (lot #TD2032663) for 8 weeks TABLE 1 Details about stability studies of omega-interferon in SAIB SAIB Particle Time Study # (Lot #) Treatment loading points Tests I TD1030507 Untreated 4% 0, 4, 7, SEC, RP-HPLC 14 days IIa TD1030507 Treated with neutral 10% 0, 2, SEC, RP-HPLC alumina by heating 4 weeks IIb TD1030507 Treated with neutral 10% 0, 2, SEC, RP-HPLC alumina using ethanol 4 weeks III TD2032663 Untreated 10% 0, 1, SEC, RP-HPLC 2 weeks IV TD2032663 Treated with basic NA NA NA alumina by heating V TD2032663 Treated with 10% NA NA NA aqueous solution of methionine VIa TD2032663 Treated with hexane 10% 0, 1, 2, 4, SEC, RP-HPLC and 8 weeks sodium metabisulfite VIb TD2032663 Untreated 10% 0, 1, 2, 4, S
- SAIB was heated to 75° C. Alumina (15% w/w) was added to the heated SAIB. The mixture was stirred for 40 minutes and filtered though a 5.0 ⁇ m filter at 75° C. The treated SAIB was then collected, sampled for peroxide testing, and used for preparation of suspension for stability testing.
- SAIB was mixed with 15% absolute ethanol to reduce the viscosity.
- Basic alumina (15% w/w) was added to the SAIB containing ethanol.
- the resulting mixture was stirred for 1 hour and filtered though a 0.2 ⁇ m filter.
- the filtered SAIB was placed overnight under vacuum at 60° C. to remove the ethanol. This treated SAIB was then collected, sampled for peroxide testing, and used for preparation of suspension for stability testing.
- SAIB was heated to 90° C.
- Basic alumina (15% w/w) was added to the heated SAIB.
- Two different grades of alumina were used—Basic Super I and Basic Standard Activity I.
- the resulting mixture was stirred for 40 minutes.
- the mixture was then centrifuged at 4000 rpm while temperature was maintained at 75° C. After centrifugation, the supernatant was collected and sampled for peroxide analysis.
- SAIB was vigorously agitated with 4 parts of 10% aqueous solution of methionine at 80° C. for 45 minutes using a magnetic stirrer. (Evaporated water was replenished as necessary) Afterwards, the methionine solution was decanted. SAIB was then washed with 4 parts of water by agitating for 15 minutes at 70°-80° C. This washing step was carried out three times. SAIB was placed overnight in vacuum oven at 70° C. to remove residual water, and, afterwards, was sampled for peroxide analysis.
- SAIB was dissolved in two parts of hexane. The resulting solution was treated with a 5% aqueous solution of sodium metabisulfite by vigorous shaking. The aqueous layer was removed and the SAIB layer was washed with water. The SAIB layer was dried with MgSO 4 . Hexane was removed from SAIB by evaporation under vacuum at 50° C. The treated SAIB was sampled for peroxide analysis and used for preparation of suspension for stability testing.
- treatment with an aqueous solution of sodium metabisulfite was effective in significantly reducing peroxide levels from 115.9 ppm to 2.6 ppm—almost 45 times, or 45 fold decrease.
- treatment with neutral alumina either with heat or with ethanol, resulting in only a nominal change in peroxide levels—a 7% or 12% decrease, respectively.
- treatment with basic alumina with heat or 10% aqueous methionine only resulted in nominal change in peroxide levels—a 6% or 18% decrease, respectively.
- FIG. 8 illustrates an osmotically pump-driven implantable device for delivering an SAIB formulation acting as a drug delivery vehicle, active agent within.
- an osmotically pump-driven implantable device 10 shown comprising an impermeable reservoir 12 .
- the reservoir 12 is divided into two chambers by a piston 16 .
- the first chamber 18 is adapted to contain an SAIB formulation 19 containing an active agent 20 and the second chamber 21 is adapted to contain a fluid-imbibing agent.
- a back-diffusion regulating outlet 22 is inserted into the open end of the first chamber 18 and a semipermeable membrane 24 encloses the open end of the second chamber 21 .
- the piston 16 is driven towards the open end of the first chamber 18 by the osmotic pressure generated by the fluid-imbibing agent in the second chamber 21 .
- the pressure created by the piston 16 can force the contents of the first chamber 18 out the opening, i.e., the SAIB formulation 19 comprising active agents 20 .
- the release rate of the active agent can be governed by the osmotic pumping rate.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (34)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/492,153 US20070027105A1 (en) | 2005-07-26 | 2006-07-24 | Peroxide removal from drug delivery vehicle |
EA200800415A EA200800415A1 (ru) | 2005-07-26 | 2006-07-25 | Удаление пероксида из носителя для доставки лекарственного средства |
PT141782144T PT2810658E (pt) | 2005-07-26 | 2006-07-25 | Eliminação de peróxido de veículo de entrega de fármacos |
BRPI0614156-0A BRPI0614156A2 (pt) | 2005-07-26 | 2006-07-25 | veìculo de dispensação de droga, método para tratar uma formulação de isobutirato de acetato de sacarose, e, formulação de isobutirato de acetato de sacarose |
DK14178214.4T DK2810658T3 (en) | 2005-07-26 | 2006-07-25 | REMOVAL OF PEROXIDE FROM A vehicle for the administration of drug |
ES15181255.9T ES2632496T3 (es) | 2005-07-26 | 2006-07-25 | Eliminación de peróxido de un vehículo de administración de fármaco |
SI200631978T SI2810658T1 (sl) | 2005-07-26 | 2006-07-25 | Odstranitev peroksida iz naprave za dajanje zdravil |
AU2006275987A AU2006275987A1 (en) | 2005-07-26 | 2006-07-25 | Peroxide removal from drug delivery vehicle |
HUE14178214A HUE027925T2 (en) | 2005-07-26 | 2006-07-25 | Removal of peroxide from drug carrier |
JP2008524069A JP2009502930A (ja) | 2005-07-26 | 2006-07-25 | 薬物送達ビヒクルからの過酸化物の除去 |
PT151812559T PT2977061T (pt) | 2005-07-26 | 2006-07-25 | Eliminação de peróxido de veículo de entrega de fármacos |
EP14178214.4A EP2810658B1 (en) | 2005-07-26 | 2006-07-25 | Peroxide removal from drug delivery vehicle |
EP15181255.9A EP2977061B1 (en) | 2005-07-26 | 2006-07-25 | Peroxide removal from drug delivery vehicle |
EP17159693.5A EP3202422A1 (en) | 2005-07-26 | 2006-07-25 | Peroxide removal from drug delivery vehicle |
ES14178214.4T ES2554468T3 (es) | 2005-07-26 | 2006-07-25 | Eliminación de peróxido de un vehículo de administración de fármaco |
DK15181255.9T DK2977061T3 (da) | 2005-07-26 | 2006-07-25 | Fjernelse af peroxid fra vehikel til indgivelse af lægemiddel |
SI200632182T SI2977061T1 (sl) | 2005-07-26 | 2006-07-25 | Odstranitev peroksida iz naprave za dajanje zdravil |
MX2008001129A MX2008001129A (es) | 2005-07-26 | 2006-07-25 | Remocion de peroxido a partir de un vehiculo de suministro de farmaco. |
PL14178214T PL2810658T3 (pl) | 2005-07-26 | 2006-07-25 | Usuwanie nadtlenków z podłoża do dostarczania leków |
KR1020087004459A KR20080059149A (ko) | 2005-07-26 | 2006-07-25 | 약물 전달 비히클로부터의 과산화물 제거 |
PL15181255T PL2977061T3 (pl) | 2005-07-26 | 2006-07-25 | Usuwanie nadtlenków z podłoża do dostarczania leków |
LTEP15181255.9T LT2977061T (lt) | 2005-07-26 | 2006-07-25 | Peroksido pašalinimas iš vaisto įvedimo nešiklio |
CA002615688A CA2615688A1 (en) | 2005-07-26 | 2006-07-25 | Peroxide removal from drug delivery vehicle |
EP06788435.3A EP1917035B1 (en) | 2005-07-26 | 2006-07-25 | Peroxide removal from drug delivery vehicle |
PCT/US2006/028851 WO2007016093A2 (en) | 2005-07-26 | 2006-07-25 | Peroxide removal from drug delivery vehicle |
IL188991A IL188991A0 (en) | 2005-07-26 | 2008-01-24 | Peroxide removal from drug delivery vehicle |
US13/301,727 US20120330005A1 (en) | 2005-07-26 | 2011-11-21 | Peroxide removal from drug delivery vehicle |
HK15101703.9A HK1201185A1 (zh) | 2005-07-26 | 2015-02-16 | 從藥物遞送載體中去除過氧化氫 |
CY20151101018T CY1117052T1 (el) | 2005-07-26 | 2015-11-13 | Αφαιρεση υπεροξειδιου απο φορεα χορηγησης φαρμακου |
HK16108760.3A HK1221633A1 (zh) | 2005-07-26 | 2016-07-21 | 給藥載體中去除的過氧化物 |
US15/250,822 US20160361420A1 (en) | 2005-07-26 | 2016-08-29 | Peroxide removal from drug delivery vehicle |
CY20171100745T CY1119562T1 (el) | 2005-07-26 | 2017-07-13 | Αφαιρεση υπεροξειδιου απο φορεα χορηγησης φαρμακου |
US16/542,230 US11083796B2 (en) | 2005-07-26 | 2019-08-15 | Peroxide removal from drug delivery vehicle |
US17/364,519 US20220023424A1 (en) | 2005-07-26 | 2021-06-30 | Peroxide removal from drug delivery vehicle |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70254605P | 2005-07-26 | 2005-07-26 | |
US11/492,153 US20070027105A1 (en) | 2005-07-26 | 2006-07-24 | Peroxide removal from drug delivery vehicle |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/301,727 Continuation US20120330005A1 (en) | 2005-07-26 | 2011-11-21 | Peroxide removal from drug delivery vehicle |
Publications (1)
Publication Number | Publication Date |
---|---|
US20070027105A1 true US20070027105A1 (en) | 2007-02-01 |
Family
ID=37695158
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/492,153 Abandoned US20070027105A1 (en) | 2005-07-26 | 2006-07-24 | Peroxide removal from drug delivery vehicle |
US13/301,727 Abandoned US20120330005A1 (en) | 2005-07-26 | 2011-11-21 | Peroxide removal from drug delivery vehicle |
US15/250,822 Abandoned US20160361420A1 (en) | 2005-07-26 | 2016-08-29 | Peroxide removal from drug delivery vehicle |
US16/542,230 Active US11083796B2 (en) | 2005-07-26 | 2019-08-15 | Peroxide removal from drug delivery vehicle |
US17/364,519 Abandoned US20220023424A1 (en) | 2005-07-26 | 2021-06-30 | Peroxide removal from drug delivery vehicle |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/301,727 Abandoned US20120330005A1 (en) | 2005-07-26 | 2011-11-21 | Peroxide removal from drug delivery vehicle |
US15/250,822 Abandoned US20160361420A1 (en) | 2005-07-26 | 2016-08-29 | Peroxide removal from drug delivery vehicle |
US16/542,230 Active US11083796B2 (en) | 2005-07-26 | 2019-08-15 | Peroxide removal from drug delivery vehicle |
US17/364,519 Abandoned US20220023424A1 (en) | 2005-07-26 | 2021-06-30 | Peroxide removal from drug delivery vehicle |
Country Status (20)
Country | Link |
---|---|
US (5) | US20070027105A1 (ru) |
EP (4) | EP2977061B1 (ru) |
JP (1) | JP2009502930A (ru) |
KR (1) | KR20080059149A (ru) |
AU (1) | AU2006275987A1 (ru) |
BR (1) | BRPI0614156A2 (ru) |
CA (1) | CA2615688A1 (ru) |
CY (2) | CY1117052T1 (ru) |
DK (2) | DK2977061T3 (ru) |
EA (1) | EA200800415A1 (ru) |
ES (2) | ES2632496T3 (ru) |
HK (2) | HK1201185A1 (ru) |
HU (1) | HUE027925T2 (ru) |
IL (1) | IL188991A0 (ru) |
LT (1) | LT2977061T (ru) |
MX (1) | MX2008001129A (ru) |
PL (2) | PL2977061T3 (ru) |
PT (2) | PT2810658E (ru) |
SI (2) | SI2810658T1 (ru) |
WO (1) | WO2007016093A2 (ru) |
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050010196A1 (en) * | 2003-03-31 | 2005-01-13 | Fereira Pamela J. | Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems |
US20050101943A1 (en) * | 2003-11-06 | 2005-05-12 | Alza Corporation | Modular imbibition rate reducer for use with implantable osmotic pump |
US20050112188A1 (en) * | 2003-11-17 | 2005-05-26 | Eliaz Rom E. | Composition and dosage form comprising an amphiphilic molecule as a suspension vehicle |
US20060184158A1 (en) * | 2002-06-17 | 2006-08-17 | Fereira Pamela J | Osmotic delivery system with early zero order push power engine |
US20060193918A1 (en) * | 2005-02-03 | 2006-08-31 | Rohloff Catherine M | Solvent/polymer solutions as suspension vehicles |
US20060246138A1 (en) * | 2005-03-15 | 2006-11-02 | Rohloff Catherine M | Polyoxaester suspending vehicles for use with implantable delivery systems |
US20070191818A1 (en) * | 2003-03-31 | 2007-08-16 | Dionne Keith E | Osmotic pump with means for dissipating internal pressure |
US20080071253A1 (en) * | 1997-07-25 | 2008-03-20 | Alza Corporation | Osmotic Delivery System Flow Modulator Apparatus and Method |
US20080091176A1 (en) * | 2006-08-09 | 2008-04-17 | Alessi Thomas R | Osmotic delivery systems and piston assemblies for use therein |
US20080112994A1 (en) * | 2004-05-25 | 2008-05-15 | Intarcia Therapeutics, Inc. | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
US20080226689A1 (en) * | 1999-02-08 | 2008-09-18 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
US20080226625A1 (en) * | 1999-02-08 | 2008-09-18 | Intarcia Therapeutics, Inc. | Stable non- aqueous single phase viscous vehicles and formulations utlizing such vehicles |
US20080260840A1 (en) * | 2005-02-03 | 2008-10-23 | Alessi Thomas R | Suspension formulations of insulinotropic peptides and uses thereof |
US20080269726A1 (en) * | 2003-10-31 | 2008-10-30 | Intarcia Therapeutics, Inc. | Osmotic pump with self-retaining, fast-start membrane plug |
EP2067471A1 (en) | 2007-12-06 | 2009-06-10 | Durect Corporation | Oral pharmaceutical dosage forms |
US20090202608A1 (en) * | 2008-02-13 | 2009-08-13 | Alessi Thomas R | Devices, formulations, and methods for delivery of multiple beneficial agents |
US20100092566A1 (en) * | 2008-10-15 | 2010-04-15 | Alessi Thomas R | Highly concentrated drug particles, formulations, suspensions and uses thereof |
US20110076317A1 (en) * | 2009-09-28 | 2011-03-31 | Alessi Thomas R | Rapid establishment and/or termination of substantial steady-state drug delivery |
US8354124B2 (en) | 2002-12-13 | 2013-01-15 | Durect Corporation | Oral drug delivery system |
WO2014144984A1 (en) | 2013-03-15 | 2014-09-18 | Durect Corporation | Compositions with thixotropy and enhanced dissolution reproducibility and stability |
WO2014144975A1 (en) | 2013-03-15 | 2014-09-18 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
US9539200B2 (en) | 2005-02-03 | 2017-01-10 | Intarcia Therapeutics Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
US9616055B2 (en) | 2008-11-03 | 2017-04-11 | Durect Corporation | Oral pharmaceutical dosage forms |
WO2018009566A1 (en) | 2016-07-06 | 2018-01-11 | Durect Corporation | Oral dosage form with drug composition, barrier layer and drug layer |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
WO2018165462A1 (en) | 2017-03-08 | 2018-09-13 | Intarcia Therapeutics, Inc | Apparatus and methods for administration of a nauseogenic compound from a drug delivery device |
USD835783S1 (en) | 2016-06-02 | 2018-12-11 | Intarcia Therapeutics, Inc. | Implant placement guide |
US10159714B2 (en) | 2011-02-16 | 2018-12-25 | Intarcia Therapeutics, Inc. | Compositions, devices and methods of use thereof for the treatment of cancers |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
US10501517B2 (en) | 2016-05-16 | 2019-12-10 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
WO2020077129A1 (en) | 2018-10-11 | 2020-04-16 | Intarcia Therapeutics, Inc. | Human amylin analog polypeptides and methods of use |
US10835580B2 (en) | 2017-01-03 | 2020-11-17 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA124768C2 (uk) | 2016-06-30 | 2021-11-17 | Дьюрект Корпорейшн | Депо-препарат |
US10682340B2 (en) | 2016-06-30 | 2020-06-16 | Durect Corporation | Depot formulations |
EA201990127A1 (ru) | 2016-12-30 | 2020-08-18 | Дьюрект Корпорейшн | Депо-препарат |
US11273105B2 (en) * | 2017-06-16 | 2022-03-15 | Sorse Technology Corporation | Method for preparing solid forms of plant extract |
KR20220140711A (ko) | 2020-01-13 | 2022-10-18 | 듀렉트 코퍼레이션 | 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법 |
Citations (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3473949A (en) * | 1966-05-09 | 1969-10-21 | Gen Motors Corp | Method of forming acrylic resin surface coatings |
US3797492A (en) * | 1972-12-27 | 1974-03-19 | Alza Corp | Device for dispensing product with directional guidance member |
US3962162A (en) * | 1974-02-19 | 1976-06-08 | Minnesota Mining And Manufacturing Company | Rigidly bonded green ceramics and processes |
US3987790A (en) * | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
US4305927A (en) * | 1979-02-05 | 1981-12-15 | Alza Corporation | Method for the management of intraocular pressure |
US4865845A (en) * | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
US4874388A (en) * | 1987-06-25 | 1989-10-17 | Alza Corporation | Multi-layer delivery system |
US5034229A (en) * | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
US5057318A (en) * | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
US5059423A (en) * | 1988-12-13 | 1991-10-22 | Alza Corporation | Delivery system comprising biocompatible beneficial agent formulation |
US5110596A (en) * | 1988-12-13 | 1992-05-05 | Alza Corporation | Delivery system comprising means for delivering agent to livestock |
US5112614A (en) * | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
US5137727A (en) * | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
US5151093A (en) * | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
US5219572A (en) * | 1989-03-17 | 1993-06-15 | Pitman-Moore, Inc. | Controlled release delivery device for macromolecular proteins |
US5234693A (en) * | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
US5234692A (en) * | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
US5279608A (en) * | 1990-12-18 | 1994-01-18 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Osmotic pumps |
US5308348A (en) * | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
US5336057A (en) * | 1991-09-30 | 1994-08-09 | Nippon Densan Corporation | Micropump with liquid-absorptive polymer gel actuator |
US5368588A (en) * | 1993-02-26 | 1994-11-29 | Bettinger; David S. | Parenteral fluid medication reservoir pump |
US5511355A (en) * | 1991-11-15 | 1996-04-30 | Dingler; Gerhard | Construction element |
US5557318A (en) * | 1994-07-12 | 1996-09-17 | Koninklijke Ptt Nederland N.V. | Method and apparatus for permitting a viewer to scan through a plurality of video signals provided by a transmitter |
US5713847A (en) * | 1994-02-09 | 1998-02-03 | The University Of Iowa Research Foundation | Human drug delivery device for tinnitus |
US5728396A (en) * | 1996-02-02 | 1998-03-17 | Alza Corporation | Sustained delivery of leuprolide using an implantable system |
US5836935A (en) * | 1994-11-10 | 1998-11-17 | Ashton; Paul | Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body |
US5874388A (en) * | 1997-04-02 | 1999-02-23 | Dow Corning Corporation | Lubricant composition for disc brake caliper pin and a disc brake asembly containing the lubricant |
US5976109A (en) * | 1996-04-30 | 1999-11-02 | Medtronic, Inc. | Apparatus for drug infusion implanted within a living body |
US5997527A (en) * | 1997-03-24 | 1999-12-07 | Alza Corporation | Self adjustable exit port |
US5997902A (en) * | 1993-06-23 | 1999-12-07 | Alza Corporation | Ruminal drug delivery device |
US6113938A (en) * | 1997-12-30 | 2000-09-05 | Alza Corporation | Beneficial agent delivery system with membrane plug and method for controlling delivery of beneficial agents |
US6132420A (en) * | 1996-02-02 | 2000-10-17 | Alza Corporation | Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems |
US6156331A (en) * | 1996-02-02 | 2000-12-05 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
US6261584B1 (en) * | 1996-02-02 | 2001-07-17 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
US6270787B1 (en) * | 1997-12-29 | 2001-08-07 | Alza Corporation | Osmotic delivery system with membrane plug retention mechanism |
US6283949B1 (en) * | 1999-12-27 | 2001-09-04 | Advanced Cardiovascular Systems, Inc. | Refillable implantable drug delivery pump |
US6375978B1 (en) * | 1997-12-22 | 2002-04-23 | Alza Corporation | Rate controlling membranes for controlled drug delivery devices |
US6395292B2 (en) * | 1996-02-02 | 2002-05-28 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
US6508808B1 (en) * | 1999-12-21 | 2003-01-21 | Alza Corporation | Valve for osmotic devices |
US20030044467A1 (en) * | 1996-12-20 | 2003-03-06 | Brodbeck Kevin J. | Gel composition and methods |
US20030059376A1 (en) * | 1999-06-04 | 2003-03-27 | Libbey Miles A. | Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same |
US20030180364A1 (en) * | 2001-11-14 | 2003-09-25 | Guohua Chen | Catheter injectable depot compositions and uses thereof |
US20030215515A1 (en) * | 2002-04-11 | 2003-11-20 | Medimmune Vaccines, Inc. | Preservation of bioactive materials by spray drying |
US6840931B2 (en) * | 1997-07-25 | 2005-01-11 | Alza Corporation | Osmotic delivery system flow modulator apparatus and method |
US20050008661A1 (en) * | 2003-03-31 | 2005-01-13 | Fereira Pamela J. | Non-aqueous single phase vehicles and formulations utilizing such vehicles |
US20050095284A1 (en) * | 2003-10-31 | 2005-05-05 | Alza Corporation | Osmotic pump with self-retaining, fast-start membrane plug |
Family Cites Families (205)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2931802A (en) | 1958-04-30 | 1960-04-05 | Eastman Kodak Co | Mixed esters of glucose and sucrose |
US3215137A (en) | 1960-08-03 | 1965-11-02 | Kendall & Co | Immobilizing bandage and method of application |
GB1088992A (en) | 1963-09-19 | 1967-10-25 | Squibb & Sons Inc | Protective dressings |
US3346381A (en) * | 1964-07-30 | 1967-10-10 | Rca Corp | Electrostatic recording element |
US3755466A (en) * | 1968-11-04 | 1973-08-28 | Marathon Oil Co | Selective decomposition of hydroperoxides in the presence of polymeric peroxides and recovery of the polymeric peroxides |
US4069251A (en) | 1969-02-08 | 1978-01-17 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler | Continuous process for the manufacture of methionine |
US4411890A (en) | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US3743398A (en) | 1971-03-22 | 1973-07-03 | Eastman Kodak Co | Motion picture projector |
US3763018A (en) * | 1971-04-01 | 1973-10-02 | Basf Ag | Prevention of fouling in hydrocarbon separation |
NO139560C (no) | 1972-04-29 | 1979-04-04 | Takeda Chemical Industries Ltd | Analogifremgangsmaate til fremstilling av terapeutisk virksomme nonapeptidamid-derivater |
JPS5088069A (ru) | 1973-11-01 | 1975-07-15 | ||
DE2438350C3 (de) | 1974-08-09 | 1979-06-13 | Hoechst Ag, 6000 Frankfurt | Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
DE2438352A1 (de) | 1974-08-09 | 1976-02-26 | Hoechst Ag | Peptidcyclopropylamide mit lh-rh/fshrh-wirkung |
GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
JPS55154991A (en) | 1979-05-23 | 1980-12-02 | Hisamitsu Pharmaceut Co Inc | Beta-d-fructopyranoside derivative |
NZ194405A (en) | 1979-08-02 | 1982-05-25 | Dut Pty Ltd | Producing liquid hydrocarbon streams by hydrogenation of fossil-based feedstock |
US4692147A (en) | 1980-04-02 | 1987-09-08 | Medtronic, Inc. | Drug administration device |
US4304767A (en) | 1980-05-15 | 1981-12-08 | Sri International | Polymers of di- (and higher functionality) ketene acetals and polyols |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4562024A (en) | 1982-07-06 | 1985-12-31 | Sterling Drug Inc. | Process for preparing granulate containing poorly compressible medicinally active matter |
US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
DE3716302C2 (de) | 1987-05-15 | 1996-02-01 | Henkel Kgaa | Verbesserte resorbierbare Knochenwachse und ihre Verwendung |
US4906474A (en) | 1983-03-22 | 1990-03-06 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
JPS59210024A (ja) | 1983-05-13 | 1984-11-28 | Taiyo Kagaku Kk | トコフエロ−ル乳化物 |
US4622219A (en) | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
US4725442A (en) | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
US4891225A (en) | 1984-05-21 | 1990-01-02 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
US4630019A (en) | 1984-09-28 | 1986-12-16 | Westinghouse Electric Corp. | Molded case circuit breaker with calibration adjusting means for a bimetal |
US4725852A (en) | 1985-05-09 | 1988-02-16 | Burlington Industries, Inc. | Random artificially perturbed liquid apparatus and method |
JPS61260860A (ja) * | 1985-05-15 | 1986-11-19 | T Hasegawa Co Ltd | 酸性飲料に配合するための乳化組成物 |
JPS62419A (ja) | 1985-06-26 | 1987-01-06 | Shiseido Co Ltd | 脂溶性ビタミン含有水溶性剤 |
US4780320A (en) | 1986-04-29 | 1988-10-25 | Pharmetrix Corp. | Controlled release drug delivery system for the periodontal pocket |
JPH0657722B2 (ja) | 1986-05-27 | 1994-08-03 | 三菱化成株式会社 | 水溶性ポリマ−組成物 |
ATE107857T1 (de) | 1986-06-10 | 1994-07-15 | Euro Celtique Sa | Zusammensetzung mit kontrollierter freisetzung von dihydrocodein. |
DE3620685A1 (de) | 1986-06-20 | 1987-12-23 | Henkel Kgaa | Neue mittel zur abdeckung unverletzter und/oder verletzter bereiche menschlicher oder tierischer haut |
US4970075A (en) | 1986-07-18 | 1990-11-13 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
US4861598A (en) | 1986-07-18 | 1989-08-29 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
IT1198449B (it) | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
GB8626098D0 (en) | 1986-10-31 | 1986-12-03 | Euro Celtique Sa | Controlled release hydromorphone composition |
US5091171B2 (en) | 1986-12-23 | 1997-07-15 | Tristrata Inc | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use |
US5391381A (en) | 1987-06-25 | 1995-02-21 | Alza Corporation | Dispenser capable of delivering plurality of drug units |
US4795641A (en) | 1987-08-20 | 1989-01-03 | Eastman Kodak Company | Polymer blends having reverse phase morphology for controlled delivery of bioactive agents |
US5350741A (en) | 1988-07-30 | 1994-09-27 | Kanji Takada | Enteric formulations of physiologically active peptides and proteins |
JPH0296516A (ja) | 1988-09-29 | 1990-04-09 | Dainippon Pharmaceut Co Ltd | 粒剤およびその製造方法 |
US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US4987893A (en) | 1988-10-12 | 1991-01-29 | Rochal Industries, Inc. | Conformable bandage and coating material |
US5324520A (en) | 1988-12-19 | 1994-06-28 | Vipont Pharmaceutical, Inc. | Intragingival delivery systems for treatment of periodontal disease |
US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US5188837A (en) | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
GB8926612D0 (en) | 1989-11-24 | 1990-01-17 | Erba Farmitalia | Pharmaceutical compositions |
WO1991016929A1 (en) | 1990-05-10 | 1991-11-14 | Novo Nordisk A/S | A pharmaceutical preparation containing n-glycofurols and n-ethylene glycols |
IT1240643B (it) | 1990-05-11 | 1993-12-17 | Mediolanum Farmaceutici Spa | Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano |
US5110685A (en) | 1990-05-18 | 1992-05-05 | Exxon Chemical Patents, Inc. | Low friction, abrasion resistant polymer coating |
US5149543A (en) | 1990-10-05 | 1992-09-22 | Massachusetts Institute Of Technology | Ionically cross-linked polymeric microcapsules |
US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
JPH05508266A (ja) | 1991-04-03 | 1993-11-18 | イーストマン・コダック・カンパニー | GaAsをドライエッチングするための高耐久性マスク |
US5221698A (en) | 1991-06-27 | 1993-06-22 | The Regents Of The University Of Michigan | Bioactive composition |
JP3313124B2 (ja) | 1991-07-31 | 2002-08-12 | 森下仁丹株式会社 | 親水性物質を内容物とするシームレスカプセルおよびその製法 |
US5487898A (en) | 1991-08-26 | 1996-01-30 | Abbott Laboratories | Compositions and method for the sublingual or buccal administration therapeutic agents |
DE69231536T2 (de) | 1991-08-26 | 2001-06-13 | Abbott Lab | Verbindungen und methoden zur sublingualen oder buccalen verabreichung von therapeutischen agentien |
YU87892A (sh) | 1991-10-01 | 1995-12-04 | Eli Lilly And Company Lilly Corporate Center | Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu |
IL103275A0 (en) | 1991-10-01 | 1993-02-21 | Lilly Co Eli | Injectable extended release formulations and methods |
AU2605592A (en) | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
EP0609345B1 (en) | 1991-10-21 | 1999-09-22 | Peptech Limited | Biocompatible implant for the timing of ovulation in mares |
US5266331A (en) | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
US5656295A (en) | 1991-11-27 | 1997-08-12 | Euro-Celtique, S.A. | Controlled release oxycodone compositions |
DK0615438T3 (da) | 1991-12-05 | 1996-11-11 | Mallinckrodt Veterinary Inc | En carbohydratglasmatrix til langvarig frigivelse af et terapeutisk middel |
WO1993011754A1 (en) | 1991-12-11 | 1993-06-24 | The Procter & Gamble Company | Cetylpyridinium chloride and domiphen bromide in organic solvent |
US5478577A (en) | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US5192743A (en) | 1992-01-16 | 1993-03-09 | Genentech, Inc. | Reconstitutable lyophilized protein formulation |
US5456679A (en) | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
WO1993019739A1 (en) | 1992-03-30 | 1993-10-14 | Alza Corporation | Viscous suspensions of controlled-release drug particles |
DE69331387T2 (de) | 1992-09-10 | 2002-08-22 | Childrens Medical Center | Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika |
EP0678018B1 (en) | 1993-01-06 | 2003-04-09 | Kinerton Limited | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
US5340572A (en) | 1993-02-08 | 1994-08-23 | Insite Vision Incorporated | Alkaline ophthalmic suspensions |
AU679511B2 (en) | 1993-03-17 | 1997-07-03 | Minnesota Mining And Manufacturing Company | Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid |
EP0689423B1 (en) | 1993-03-17 | 1997-09-17 | Minnesota Mining And Manufacturing Company | Aerosol formulation containing a diol-diacid derived dispersing aid |
DK44193D0 (da) | 1993-04-20 | 1993-04-20 | Euromed I S | Saarforbinding og klaebemiddel til en saarforbinding eller lignende |
US5370864A (en) | 1993-06-29 | 1994-12-06 | The Procter & Gamble Company | Breath protection microcapsules |
IL110014A (en) | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
DE4322826A1 (de) | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmazeutisches Präparat |
US5442033A (en) | 1993-07-20 | 1995-08-15 | Ethicon, Inc. | Liquid copolymers of epsilon-caprolactone and lactide |
JP3257750B2 (ja) | 1993-07-20 | 2002-02-18 | エチコン・インコーポレーテツド | ε−カプロラクトンおよびラクチドの液状コポリマー |
US5879705A (en) | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
US5505922A (en) | 1993-08-13 | 1996-04-09 | University Of Maryland At Baltimore | Anesthetic pharmaceutical combination |
JPH0753356A (ja) | 1993-08-16 | 1995-02-28 | Morishita Jintan Kk | 酸化され易い油性物質を内容物とするシームレスカプセルおよびその製造方法 |
JPH07112940A (ja) | 1993-08-26 | 1995-05-02 | Takeda Chem Ind Ltd | 徐放性非経口投与製剤およびその製造方法 |
US5578137A (en) | 1993-08-31 | 1996-11-26 | E. I. Du Pont De Nemours And Company | Azeotropic or azeotrope-like compositions including 1,1,1,2,3,4,4,5,5,5-decafluoropentane |
AU5895994A (en) | 1993-10-04 | 1995-05-01 | Mark Chasin | Controlled release microspheres |
JPH07115901A (ja) | 1993-10-28 | 1995-05-09 | Fuji Bibaretsuji:Kk | ドコサヘキサエン酸高含有乳化組成物及び飲料 |
JPH09507233A (ja) | 1993-12-29 | 1997-07-22 | マトリクス ファーマスーティカル,インコーポレイティド | 細胞増殖性疾患に罹る宿主の治療方法及び治療のための組成物 |
ES2171186T3 (es) | 1994-04-08 | 2002-09-01 | Atrix Lab Inc | Composiciones liquidas de difusion. |
US5633000A (en) | 1994-06-23 | 1997-05-27 | Axxia Technologies | Subcutaneous implant |
AU695479B2 (en) | 1994-09-23 | 1998-08-13 | Darwin Discovery Limited | Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof |
US5599852A (en) | 1994-10-18 | 1997-02-04 | Ethicon, Inc. | Injectable microdispersions for soft tissue repair and augmentation |
ATE248148T1 (de) | 1994-10-25 | 2003-09-15 | Darwin Discovery Ltd | Verfahren zur herstellung von levobupivacaine und analoge |
US5994548A (en) | 1994-10-25 | 1999-11-30 | Darwin Discovery Ltd. | Crystallisation of levibupivacaine and analogues thereof |
GB9501071D0 (en) | 1995-01-18 | 1995-03-08 | Chiroscience Ltd | Racemisation |
US6384227B2 (en) | 1995-01-18 | 2002-05-07 | Darwin Discovery Ltd. | Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents |
DE19520237A1 (de) | 1995-06-02 | 1996-12-05 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen, enthaltend Oligomere oder Polymere von alpha-Hydroxycarbonsäuren |
US6413536B1 (en) | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
US5968542A (en) | 1995-06-07 | 1999-10-19 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system as a device |
US5747058A (en) * | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
US7833543B2 (en) | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
WO1996039995A1 (en) | 1995-06-07 | 1996-12-19 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
US5942241A (en) | 1995-06-09 | 1999-08-24 | Euro-Celtique, S.A. | Formulations and methods for providing prolonged local anesthesia |
US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
US6245351B1 (en) | 1996-03-07 | 2001-06-12 | Takeda Chemical Industries, Ltd. | Controlled-release composition |
AU733867B2 (en) | 1996-06-24 | 2001-05-31 | Euro-Celtique S.A. | Methods for providing safe local anesthesia |
DE69739165D1 (de) | 1996-07-08 | 2009-01-29 | Penwest Pharmaceuticals Co | Matrix mit verzögerter freisetzung für hochdosierte unlösliche arzneistoffe |
US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
US6046187A (en) | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
US5801012A (en) | 1996-09-17 | 1998-09-01 | Northwestern University | Methods and compositions for generating angiostatin |
US5747051A (en) | 1996-09-27 | 1998-05-05 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care compositions containing an amide of a hydroxy fatty acid and a retinoid |
US6479074B2 (en) | 1996-10-24 | 2002-11-12 | Pharmaceutical Applications Associates Llc | Methods and transdermal compositions for pain relief |
US6572880B2 (en) | 1996-10-24 | 2003-06-03 | Pharmaceutical Applications Associates Llc | Methods and transdermal compositions for pain relief |
US6203813B1 (en) | 1997-01-13 | 2001-03-20 | Lance L. Gooberman | Pharmaceutical delivery device and method of preparation therefor |
US6126919A (en) | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
DE19714765A1 (de) | 1997-04-10 | 1998-10-15 | Merck Patent Gmbh | Verwendung von niedermolekularen, oligomeren Estern von alpha-Hydroxysäuren und/oder aromatischen o-Hydroxysäuren in kosmetischen Formulierungen |
US5919473A (en) | 1997-05-12 | 1999-07-06 | Elkhoury; George F. | Methods and devices for delivering opioid analgesics to wounds via a subdermal implant |
US5840329A (en) | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
US6051558A (en) | 1997-05-28 | 2000-04-18 | Southern Biosystems, Inc. | Compositions suitable for controlled release of the hormone GnRH and its analogs |
DE69818675T2 (de) | 1997-07-29 | 2004-07-29 | Alcon Laboratories, Inc., Fort Worth | Galaktomannanpolymere und borat enthaltende augenarzneimittel |
BR9814883A (pt) | 1997-11-19 | 2000-10-03 | Darwin Discovery Ltd | Formulação anestésica |
US6241969B1 (en) | 1998-06-26 | 2001-06-05 | Elan Corporation Plc | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
MXPA00012767A (es) | 1998-06-29 | 2002-08-09 | Pharmaceuticals Applic Asociat | Metodos y composiciones transdermicas para el alivio del dolor. |
US6312717B1 (en) | 1998-07-07 | 2001-11-06 | Bristol-Myers Squibb Company | Method for treatment of anxiety and depression |
US6248112B1 (en) | 1998-09-30 | 2001-06-19 | C. R. Bard, Inc. | Implant delivery system |
WO2000033866A1 (en) | 1998-12-04 | 2000-06-15 | Provalis Uk Limited | Pharmaceutical compositions containing insulin |
DE19858891A1 (de) | 1998-12-19 | 2000-06-21 | Merck Patent Gmbh | Verbesserte Knochensiegel |
US6498153B1 (en) | 1998-12-31 | 2002-12-24 | Akzo Nobel N.V. | Extended release growth promoting two component composition |
US7258869B1 (en) | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
KR100858856B1 (ko) | 1999-02-08 | 2008-09-17 | 인타르시아 세라퓨틱스 인코포레이티드 | 안정한 비수성 단일상 점성 비히클 및 그 비히클을이용하는 제형물 |
US6541021B1 (en) | 1999-03-18 | 2003-04-01 | Durect Corporation | Devices and methods for pain management |
US6291013B1 (en) | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
AU5025300A (en) | 1999-06-18 | 2001-01-09 | Southern Biosystems, Inc. | Compositions for controlled release of the hormone gnrh and its analogs |
US6283948B1 (en) | 1999-07-13 | 2001-09-04 | Ethicon, Inc. | Trocar obturator having grooved passageway |
EP1220682B1 (en) | 1999-10-04 | 2006-11-22 | Novartis Vaccines and Diagnostics, Inc. | Stabilized liquid polypeptide-containing pharmaceutical compositions |
US6436091B1 (en) | 1999-11-16 | 2002-08-20 | Microsolutions, Inc. | Methods and implantable devices and systems for long term delivery of a pharmaceutical agent |
AU2979201A (en) | 1999-12-13 | 2001-06-18 | Pacmin Investments Limited | Method of digesting titanium containing material and products thereof |
AU2092701A (en) | 1999-12-17 | 2001-06-25 | Durect Corporation | Devices and methods in intracerebrospinal delivery of morphine-6-glucuronide |
AU2001900A (en) | 1999-12-29 | 2001-07-16 | Progen S.R.L. | Biocompatible hydrogel and method of its production |
DE10190041D2 (de) | 2000-01-11 | 2002-12-05 | Roland Bodmeier | Implantate, Partikel |
US6572890B2 (en) | 2000-01-13 | 2003-06-03 | Osmotica Corp. | Osmotic device containing venlafaxine and an anti-psychotic agent |
DE60125986T3 (de) | 2000-02-08 | 2011-07-28 | Allergan, Inc., 92612, Calif. | Pharmazeutische Zusammensetzungen mit Botulinum Toxin |
BR0002246A (pt) | 2000-04-06 | 2003-04-15 | Cristalia Prod Quimicos Farm | Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis |
US20010042590A1 (en) * | 2000-04-17 | 2001-11-22 | Neuburger Carl D. | Method and device for making a magnetically mountable substrate construction form a selected substrate |
AU2001259111B2 (en) | 2000-04-19 | 2005-12-08 | Durect Corporation | Sustained release formulations comprising growth hormone |
US20050042194A1 (en) | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
US6495534B2 (en) | 2000-05-15 | 2002-12-17 | Pharmacia & Upjohn Spa | Stabilized aqueous suspensions for parenteral use |
WO2002010436A2 (en) | 2000-07-28 | 2002-02-07 | The Brigham And Women's Hospital, Inc. | Prognostic classification of breast cancer |
FR2814308B1 (fr) | 2000-09-15 | 2003-03-14 | France Telecom | Procede de gestion de l'usage d'une ligne de telecommunication et systeme de mise en oeuvre |
CA2423431A1 (en) | 2000-10-06 | 2002-04-11 | Durect Corporation | Devices and methods for management of inflammation |
HU230686B1 (en) | 2000-10-30 | 2017-08-28 | Euro Celtique Sa | Controlled release hydrocodone compositions |
EP1335704A2 (en) | 2000-11-16 | 2003-08-20 | Durect Corporation | Implant dosage form and use thereof for the delivery of a cholesterol lowering agent |
JP4248236B2 (ja) | 2000-11-29 | 2009-04-02 | デュレクト コーポレイション | 薬物送達装置からの送達を制御するための装置および方法 |
JP2004521111A (ja) | 2001-01-25 | 2004-07-15 | ユーロ−セルティーク,エス.エイ. | 局所麻酔薬および使用法 |
JP4724354B2 (ja) | 2001-02-23 | 2011-07-13 | ジェネンテック, インコーポレイテッド | 注射用の崩壊性ポリマー |
DE10109861A1 (de) * | 2001-03-01 | 2002-09-05 | Bayer Ag | Neuartige seitenkettenhalogenierte Aminodicarbonsäurederivate |
US7318931B2 (en) | 2001-06-21 | 2008-01-15 | Genentech, Inc. | Sustained release formulation |
US20040142902A1 (en) | 2001-11-08 | 2004-07-22 | Struijker- Boudier Harry A.J. | Implant dosage form and use thereof for the delivery of a cholosterol lowering agent |
EP1446100B1 (en) | 2001-11-14 | 2011-05-04 | Durect Corporation | Injectable depot compositions and uses thereof |
GB2386066A (en) | 2002-02-28 | 2003-09-10 | Norbrook Lab Ltd | Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species |
FR2838349B1 (fr) | 2002-04-15 | 2004-06-25 | Laurence Paris | Compositions liquides pour capsules molle a liberation prolongee et leur procede de fabrication |
SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
EP1509182A4 (en) | 2002-05-31 | 2009-12-30 | Titan Pharmaceuticals Inc | IMPLANTABLE POLYMERS DEVICE FOR THE DELAYED RELEASE OF BUPRENORPHINE |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
US20040109893A1 (en) | 2002-06-25 | 2004-06-10 | Guohua Chen | Sustained release dosage forms of anesthetics for pain management |
JP4417039B2 (ja) | 2002-06-28 | 2010-02-17 | 太陽化学株式会社 | 水中油滴型乳化組成物 |
SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
WO2004011032A1 (ja) | 2002-07-26 | 2004-02-05 | Mikasa Seiyaku Co., Ltd. | 外用剤 |
IL166418A0 (en) | 2002-07-31 | 2006-01-15 | Alza Corp | Injectable depot compositions and uses thereof |
TW575722B (en) | 2002-09-02 | 2004-02-11 | Hannstar Display Corp | Planar light source device and liquid crystal display |
MXPA05002561A (es) | 2002-10-25 | 2005-05-05 | Pfizer Prod Inc | Nuevas formulaciones de liberacion prolongada inyectables. |
MXPA05004299A (es) | 2002-10-25 | 2005-08-03 | Pfizer Prod Inc | Formulacion de liberacion prolongada de agentes activos arilheterociclicos en forma de suspension. |
BR0315304A (pt) | 2002-11-06 | 2005-08-16 | Alza Corp | Formulações com depósito para liberação controlada |
EP1575569B1 (en) | 2002-12-13 | 2010-09-29 | Durect Corporation | Oral drug delivery system comprising high viscosity liquid carrier materials |
US20040224903A1 (en) * | 2002-12-19 | 2004-11-11 | Stephen Berry | Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device |
DE10312346A1 (de) | 2003-03-20 | 2004-09-30 | Bayer Healthcare Ag | Kontrolliertes Freisetzungssystem |
US7641643B2 (en) * | 2003-04-15 | 2010-01-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
DE10322469A1 (de) | 2003-05-19 | 2004-12-16 | Bayer Healthcare Ag | Heterocyclische Verbindungen |
US20050106304A1 (en) | 2003-11-14 | 2005-05-19 | Cook Phillip M. | Sucrose acetate isobutyrate formulation |
US20050281879A1 (en) | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
WO2005048742A1 (en) | 2003-11-14 | 2005-06-02 | Eastman Chemical Company | Sucrose acetate isobutyrate formulation |
US20050106214A1 (en) | 2003-11-14 | 2005-05-19 | Guohua Chen | Excipients in drug delivery vehicles |
US20050118206A1 (en) | 2003-11-14 | 2005-06-02 | Luk Andrew S. | Surfactant-based gel as an injectable, sustained drug delivery vehicle |
US20040224019A1 (en) | 2004-03-03 | 2004-11-11 | Adi Shefer | Oral controlled release system for targeted drug delivery into the cell and its nucleus for gene therapy, DNA vaccination, and administration of gene based drugs |
US20050232876A1 (en) | 2004-04-19 | 2005-10-20 | Robin Lynn Minga | Skin care compositions |
US20080023261A1 (en) | 2004-05-14 | 2008-01-31 | Yanmar Co., Ltd. | Noise Proof Structure of Cabin |
US20050266087A1 (en) | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
SI2767292T1 (sl) | 2004-09-17 | 2017-01-31 | Durect Corporation | Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem |
WO2006083950A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Method for reducing the level of peroxides in bopcompatible polymer preparations |
EP1877077A2 (en) | 2005-02-03 | 2008-01-16 | Intarcia Therapeutics, Inc. | An implantable interferon-containing device |
JP4531582B2 (ja) | 2005-02-10 | 2010-08-25 | アルパイン株式会社 | 地図更新処理用データ作成方法、地図更新方法及び装置 |
JP4501076B2 (ja) | 2006-01-06 | 2010-07-14 | ソニー株式会社 | 携帯無線通信端末 |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
DK2117521T3 (da) | 2006-11-03 | 2012-09-03 | Durect Corp | Transdermale indgivelsessystemer omfattende bupivacain |
CA2686137C (en) | 2007-05-18 | 2021-01-12 | Durect Corporation | Improved depot formulations |
US8415401B2 (en) | 2007-12-06 | 2013-04-09 | Durect Corporation | Oral pharmaceutical dosage forms |
SE531980C2 (sv) | 2008-01-17 | 2009-09-22 | Avtech Sweden Ab | Flygstyrningsförfarande samt datorprogram och datorprogramprodukt för att genomföra förfarandet |
US20140308352A1 (en) | 2013-03-11 | 2014-10-16 | Zogenix Inc. | Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material |
WO2014144984A1 (en) | 2013-03-15 | 2014-09-18 | Durect Corporation | Compositions with thixotropy and enhanced dissolution reproducibility and stability |
CN105120659A (zh) | 2013-03-15 | 2015-12-02 | 度瑞公司 | 用于降低溶解可变性的具有流变改性剂的组合物 |
-
2006
- 2006-07-24 US US11/492,153 patent/US20070027105A1/en not_active Abandoned
- 2006-07-25 PL PL15181255T patent/PL2977061T3/pl unknown
- 2006-07-25 PT PT141782144T patent/PT2810658E/pt unknown
- 2006-07-25 LT LTEP15181255.9T patent/LT2977061T/lt unknown
- 2006-07-25 SI SI200631978T patent/SI2810658T1/sl unknown
- 2006-07-25 EP EP15181255.9A patent/EP2977061B1/en not_active Not-in-force
- 2006-07-25 EP EP06788435.3A patent/EP1917035B1/en not_active Not-in-force
- 2006-07-25 PT PT151812559T patent/PT2977061T/pt unknown
- 2006-07-25 EA EA200800415A patent/EA200800415A1/ru unknown
- 2006-07-25 ES ES15181255.9T patent/ES2632496T3/es active Active
- 2006-07-25 PL PL14178214T patent/PL2810658T3/pl unknown
- 2006-07-25 KR KR1020087004459A patent/KR20080059149A/ko not_active Application Discontinuation
- 2006-07-25 SI SI200632182T patent/SI2977061T1/sl unknown
- 2006-07-25 CA CA002615688A patent/CA2615688A1/en not_active Abandoned
- 2006-07-25 WO PCT/US2006/028851 patent/WO2007016093A2/en active Application Filing
- 2006-07-25 AU AU2006275987A patent/AU2006275987A1/en not_active Abandoned
- 2006-07-25 HU HUE14178214A patent/HUE027925T2/en unknown
- 2006-07-25 JP JP2008524069A patent/JP2009502930A/ja active Pending
- 2006-07-25 EP EP14178214.4A patent/EP2810658B1/en active Active
- 2006-07-25 MX MX2008001129A patent/MX2008001129A/es active IP Right Grant
- 2006-07-25 EP EP17159693.5A patent/EP3202422A1/en not_active Withdrawn
- 2006-07-25 DK DK15181255.9T patent/DK2977061T3/da active
- 2006-07-25 BR BRPI0614156-0A patent/BRPI0614156A2/pt not_active IP Right Cessation
- 2006-07-25 ES ES14178214.4T patent/ES2554468T3/es active Active
- 2006-07-25 DK DK14178214.4T patent/DK2810658T3/en active
-
2008
- 2008-01-24 IL IL188991A patent/IL188991A0/en unknown
-
2011
- 2011-11-21 US US13/301,727 patent/US20120330005A1/en not_active Abandoned
-
2015
- 2015-02-16 HK HK15101703.9A patent/HK1201185A1/zh not_active IP Right Cessation
- 2015-11-13 CY CY20151101018T patent/CY1117052T1/el unknown
-
2016
- 2016-07-21 HK HK16108760.3A patent/HK1221633A1/zh not_active IP Right Cessation
- 2016-08-29 US US15/250,822 patent/US20160361420A1/en not_active Abandoned
-
2017
- 2017-07-13 CY CY20171100745T patent/CY1119562T1/el unknown
-
2019
- 2019-08-15 US US16/542,230 patent/US11083796B2/en active Active
-
2021
- 2021-06-30 US US17/364,519 patent/US20220023424A1/en not_active Abandoned
Patent Citations (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3473949A (en) * | 1966-05-09 | 1969-10-21 | Gen Motors Corp | Method of forming acrylic resin surface coatings |
US3797492A (en) * | 1972-12-27 | 1974-03-19 | Alza Corp | Device for dispensing product with directional guidance member |
US3962162A (en) * | 1974-02-19 | 1976-06-08 | Minnesota Mining And Manufacturing Company | Rigidly bonded green ceramics and processes |
US3987790A (en) * | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
US4305927A (en) * | 1979-02-05 | 1981-12-15 | Alza Corporation | Method for the management of intraocular pressure |
US4865845A (en) * | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
US4874388A (en) * | 1987-06-25 | 1989-10-17 | Alza Corporation | Multi-layer delivery system |
US5034229A (en) * | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
US5057318A (en) * | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
US5059423A (en) * | 1988-12-13 | 1991-10-22 | Alza Corporation | Delivery system comprising biocompatible beneficial agent formulation |
US5110596A (en) * | 1988-12-13 | 1992-05-05 | Alza Corporation | Delivery system comprising means for delivering agent to livestock |
US5219572A (en) * | 1989-03-17 | 1993-06-15 | Pitman-Moore, Inc. | Controlled release delivery device for macromolecular proteins |
US5112614A (en) * | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
US5234693A (en) * | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
US5234692A (en) * | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
US5151093A (en) * | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
US5312389A (en) * | 1990-10-29 | 1994-05-17 | Felix Theeuwes | Osmotically driven syringe with programmable agent delivery |
US5279608A (en) * | 1990-12-18 | 1994-01-18 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Osmotic pumps |
US5137727A (en) * | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
US5336057A (en) * | 1991-09-30 | 1994-08-09 | Nippon Densan Corporation | Micropump with liquid-absorptive polymer gel actuator |
US5511355A (en) * | 1991-11-15 | 1996-04-30 | Dingler; Gerhard | Construction element |
US5308348A (en) * | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
US5368588A (en) * | 1993-02-26 | 1994-11-29 | Bettinger; David S. | Parenteral fluid medication reservoir pump |
US5997902A (en) * | 1993-06-23 | 1999-12-07 | Alza Corporation | Ruminal drug delivery device |
US5713847A (en) * | 1994-02-09 | 1998-02-03 | The University Of Iowa Research Foundation | Human drug delivery device for tinnitus |
US5557318A (en) * | 1994-07-12 | 1996-09-17 | Koninklijke Ptt Nederland N.V. | Method and apparatus for permitting a viewer to scan through a plurality of video signals provided by a transmitter |
US5836935A (en) * | 1994-11-10 | 1998-11-17 | Ashton; Paul | Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body |
US6156331A (en) * | 1996-02-02 | 2000-12-05 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
US5985305A (en) * | 1996-02-02 | 1999-11-16 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
US6132420A (en) * | 1996-02-02 | 2000-10-17 | Alza Corporation | Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems |
US6395292B2 (en) * | 1996-02-02 | 2002-05-28 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
US6261584B1 (en) * | 1996-02-02 | 2001-07-17 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
US5728396A (en) * | 1996-02-02 | 1998-03-17 | Alza Corporation | Sustained delivery of leuprolide using an implantable system |
US5976109A (en) * | 1996-04-30 | 1999-11-02 | Medtronic, Inc. | Apparatus for drug infusion implanted within a living body |
US20030044467A1 (en) * | 1996-12-20 | 2003-03-06 | Brodbeck Kevin J. | Gel composition and methods |
US5997527A (en) * | 1997-03-24 | 1999-12-07 | Alza Corporation | Self adjustable exit port |
US6217906B1 (en) * | 1997-03-24 | 2001-04-17 | Alza Corporation | Self adjustable exit port |
US5874388A (en) * | 1997-04-02 | 1999-02-23 | Dow Corning Corporation | Lubricant composition for disc brake caliper pin and a disc brake asembly containing the lubricant |
US6840931B2 (en) * | 1997-07-25 | 2005-01-11 | Alza Corporation | Osmotic delivery system flow modulator apparatus and method |
US6375978B1 (en) * | 1997-12-22 | 2002-04-23 | Alza Corporation | Rate controlling membranes for controlled drug delivery devices |
US6270787B1 (en) * | 1997-12-29 | 2001-08-07 | Alza Corporation | Osmotic delivery system with membrane plug retention mechanism |
US6113938A (en) * | 1997-12-30 | 2000-09-05 | Alza Corporation | Beneficial agent delivery system with membrane plug and method for controlling delivery of beneficial agents |
US20030059376A1 (en) * | 1999-06-04 | 2003-03-27 | Libbey Miles A. | Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same |
US6508808B1 (en) * | 1999-12-21 | 2003-01-21 | Alza Corporation | Valve for osmotic devices |
US6283949B1 (en) * | 1999-12-27 | 2001-09-04 | Advanced Cardiovascular Systems, Inc. | Refillable implantable drug delivery pump |
US20030180364A1 (en) * | 2001-11-14 | 2003-09-25 | Guohua Chen | Catheter injectable depot compositions and uses thereof |
US20030215515A1 (en) * | 2002-04-11 | 2003-11-20 | Medimmune Vaccines, Inc. | Preservation of bioactive materials by spray drying |
US20050008661A1 (en) * | 2003-03-31 | 2005-01-13 | Fereira Pamela J. | Non-aqueous single phase vehicles and formulations utilizing such vehicles |
US20050276856A1 (en) * | 2003-03-31 | 2005-12-15 | Fereira Pamela J | Non-aqueous single phase vehicles and formulations utilizing such vehicles |
US20050095284A1 (en) * | 2003-10-31 | 2005-05-05 | Alza Corporation | Osmotic pump with self-retaining, fast-start membrane plug |
Cited By (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080071253A1 (en) * | 1997-07-25 | 2008-03-20 | Alza Corporation | Osmotic Delivery System Flow Modulator Apparatus and Method |
US8992961B2 (en) | 1999-02-08 | 2015-03-31 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
US8372424B2 (en) | 1999-02-08 | 2013-02-12 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
US8048438B2 (en) | 1999-02-08 | 2011-11-01 | Intarcia Therapeutics, Inc. | Stable non- aqueous single phase viscous vehicles and formulations utilizing such vehicles |
US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
US8268341B2 (en) | 1999-02-08 | 2012-09-18 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
US8173150B2 (en) | 1999-02-08 | 2012-05-08 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utlizing such vehicles |
US20080226625A1 (en) * | 1999-02-08 | 2008-09-18 | Intarcia Therapeutics, Inc. | Stable non- aqueous single phase viscous vehicles and formulations utlizing such vehicles |
US20080226689A1 (en) * | 1999-02-08 | 2008-09-18 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
US20060184158A1 (en) * | 2002-06-17 | 2006-08-17 | Fereira Pamela J | Osmotic delivery system with early zero order push power engine |
US8354124B2 (en) | 2002-12-13 | 2013-01-15 | Durect Corporation | Oral drug delivery system |
US9918982B2 (en) | 2002-12-13 | 2018-03-20 | Durect Corporation | Oral drug delivery system |
US9233160B2 (en) | 2002-12-13 | 2016-01-12 | Durect Corporation | Oral drug delivery system |
US9517271B2 (en) | 2002-12-13 | 2016-12-13 | Durect Corporation | Oral drug delivery system |
US8420120B2 (en) | 2002-12-13 | 2013-04-16 | Durect Corporation | Oral drug delivery system |
US8398967B2 (en) | 2002-12-19 | 2013-03-19 | Intarcia Therapeutics, Inc. | Particle formulations for use in pharmaceutical compositions |
US20110208168A1 (en) * | 2002-12-19 | 2011-08-25 | Intarcia Therapeutics, Inc. | Particle formulations for use in pharmaceutical compositions |
US20070191818A1 (en) * | 2003-03-31 | 2007-08-16 | Dionne Keith E | Osmotic pump with means for dissipating internal pressure |
US20050010196A1 (en) * | 2003-03-31 | 2005-01-13 | Fereira Pamela J. | Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems |
US20080269726A1 (en) * | 2003-10-31 | 2008-10-30 | Intarcia Therapeutics, Inc. | Osmotic pump with self-retaining, fast-start membrane plug |
US20050101943A1 (en) * | 2003-11-06 | 2005-05-12 | Alza Corporation | Modular imbibition rate reducer for use with implantable osmotic pump |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
US20050112188A1 (en) * | 2003-11-17 | 2005-05-26 | Eliaz Rom E. | Composition and dosage form comprising an amphiphilic molecule as a suspension vehicle |
US9724293B2 (en) | 2003-11-17 | 2017-08-08 | Intarcia Therapeutics, Inc. | Methods of manufacturing viscous liquid pharmaceutical formulations |
US8257691B2 (en) | 2003-11-17 | 2012-09-04 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising a particle formulation and suspending vehicle |
US7964183B2 (en) | 2003-11-17 | 2011-06-21 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising a particle formulation and suspending vehicle |
US20100112070A1 (en) * | 2003-11-17 | 2010-05-06 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising a particle formulation and suspending vehicle |
US20110195097A1 (en) * | 2003-11-17 | 2011-08-11 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising a particle formulation and suspending vehicle |
US20080112994A1 (en) * | 2004-05-25 | 2008-05-15 | Intarcia Therapeutics, Inc. | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
US8940316B2 (en) | 2005-02-03 | 2015-01-27 | Intarcia Therapeutics, Inc. | Osmotic delivery comprising an insulinotropic peptide and uses thereof |
US8299025B2 (en) | 2005-02-03 | 2012-10-30 | Intarcia Therapeutics, Inc. | Suspension formulations of insulinotropic peptides and uses thereof |
US8460694B2 (en) | 2005-02-03 | 2013-06-11 | Intarcia Therapeutics, Inc. | Solvent/polymer solutions as suspension vehicles |
US9539200B2 (en) | 2005-02-03 | 2017-01-10 | Intarcia Therapeutics Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
US8206745B2 (en) | 2005-02-03 | 2012-06-26 | Intarcia Therapeutics, Inc. | Solvent/polymer solutions as suspension vehicles |
US8211467B2 (en) | 2005-02-03 | 2012-07-03 | Intarcia Therapeutics, Inc. | Osmotic drug delivery devices containing suspension formulations comprising particles having active agents and nonaqueous single-phase vehicles |
US8440226B2 (en) | 2005-02-03 | 2013-05-14 | Intarcia Therapeutics, Inc. | Solvent/polymer solutions as suspension vehicles |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
US9526763B2 (en) | 2005-02-03 | 2016-12-27 | Intarcia Therapeutics Inc. | Solvent/polymer solutions as suspension vehicles |
US10363287B2 (en) | 2005-02-03 | 2019-07-30 | Intarcia Therapeutics, Inc. | Method of manufacturing an osmotic delivery device |
US8114437B2 (en) | 2005-02-03 | 2012-02-14 | Intarcia Therapeutics, Inc. | Solvent/polymer solutions as suspension vehicles |
US20080260840A1 (en) * | 2005-02-03 | 2008-10-23 | Alessi Thomas R | Suspension formulations of insulinotropic peptides and uses thereof |
US9095553B2 (en) | 2005-02-03 | 2015-08-04 | Intarcia Therapeutics Inc. | Solvent/polymer solutions as suspension vehicles |
US20060193918A1 (en) * | 2005-02-03 | 2006-08-31 | Rohloff Catherine M | Solvent/polymer solutions as suspension vehicles |
US9682127B2 (en) | 2005-02-03 | 2017-06-20 | Intarcia Therapeutics, Inc. | Osmotic delivery device comprising an insulinotropic peptide and uses thereof |
US7959938B2 (en) | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
US8114430B2 (en) | 2005-03-15 | 2012-02-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
US20060246138A1 (en) * | 2005-03-15 | 2006-11-02 | Rohloff Catherine M | Polyoxaester suspending vehicles for use with implantable delivery systems |
US10527170B2 (en) | 2006-08-09 | 2020-01-07 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies for use therein |
US8801700B2 (en) | 2006-08-09 | 2014-08-12 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies for use therein |
US7682356B2 (en) | 2006-08-09 | 2010-03-23 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies for use therein |
US20100185184A1 (en) * | 2006-08-09 | 2010-07-22 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies for use therein |
US7879028B2 (en) | 2006-08-09 | 2011-02-01 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies for use therein |
US20080091176A1 (en) * | 2006-08-09 | 2008-04-17 | Alessi Thomas R | Osmotic delivery systems and piston assemblies for use therein |
US20110166554A1 (en) * | 2006-08-09 | 2011-07-07 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies for use therein |
EP3326621A1 (en) | 2007-12-06 | 2018-05-30 | Durect Corporation | Oral pharmaceutical dosage forms |
EP2067471A1 (en) | 2007-12-06 | 2009-06-10 | Durect Corporation | Oral pharmaceutical dosage forms |
US10206883B2 (en) | 2007-12-06 | 2019-02-19 | Durect Corporation | Oral pharamaceutical dosage forms |
US9655861B2 (en) | 2007-12-06 | 2017-05-23 | Durect Corporation | Oral pharmaceutical dosage forms |
US9592204B2 (en) | 2007-12-06 | 2017-03-14 | Durect Corporation | Oral pharmaceutical dosage forms |
US8343140B2 (en) | 2008-02-13 | 2013-01-01 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
US9572889B2 (en) | 2008-02-13 | 2017-02-21 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
US20090202608A1 (en) * | 2008-02-13 | 2009-08-13 | Alessi Thomas R | Devices, formulations, and methods for delivery of multiple beneficial agents |
US8926595B2 (en) | 2008-02-13 | 2015-01-06 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
US10441528B2 (en) | 2008-02-13 | 2019-10-15 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
US20100092566A1 (en) * | 2008-10-15 | 2010-04-15 | Alessi Thomas R | Highly concentrated drug particles, formulations, suspensions and uses thereof |
US9616055B2 (en) | 2008-11-03 | 2017-04-11 | Durect Corporation | Oral pharmaceutical dosage forms |
US10328068B2 (en) | 2008-11-03 | 2019-06-25 | Durect Corporation | Oral pharmaceutical dosage forms |
US9884056B2 (en) | 2008-11-03 | 2018-02-06 | Durect Corporation | Oral pharmaceutical dosage forms |
EP3323423A1 (en) | 2009-09-28 | 2018-05-23 | Intarcia Therapeutics, Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
US10231923B2 (en) | 2009-09-28 | 2019-03-19 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
US10869830B2 (en) | 2009-09-28 | 2020-12-22 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
US8298561B2 (en) | 2009-09-28 | 2012-10-30 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
US20110076317A1 (en) * | 2009-09-28 | 2011-03-31 | Alessi Thomas R | Rapid establishment and/or termination of substantial steady-state drug delivery |
EP3735944A1 (en) | 2009-09-28 | 2020-11-11 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
US10159714B2 (en) | 2011-02-16 | 2018-12-25 | Intarcia Therapeutics, Inc. | Compositions, devices and methods of use thereof for the treatment of cancers |
US9572885B2 (en) | 2013-03-15 | 2017-02-21 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
US9907851B2 (en) | 2013-03-15 | 2018-03-06 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
US9855333B2 (en) | 2013-03-15 | 2018-01-02 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
US10300142B2 (en) | 2013-03-15 | 2019-05-28 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
US9555113B2 (en) | 2013-03-15 | 2017-01-31 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
WO2014144975A1 (en) | 2013-03-15 | 2014-09-18 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
WO2014144984A1 (en) | 2013-03-15 | 2014-09-18 | Durect Corporation | Compositions with thixotropy and enhanced dissolution reproducibility and stability |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
US10583080B2 (en) | 2014-09-30 | 2020-03-10 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
US11214607B2 (en) | 2016-05-16 | 2022-01-04 | Intarcia Therapeutics Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
US10501517B2 (en) | 2016-05-16 | 2019-12-10 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
US11840559B2 (en) | 2016-05-16 | 2023-12-12 | I2O Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
EP3733694A1 (en) | 2016-05-16 | 2020-11-04 | Intarcia Therapeutics, Inc | Glucagon-receptor selective polypeptides and methods of use thereof |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD912249S1 (en) | 2016-06-02 | 2021-03-02 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD835783S1 (en) | 2016-06-02 | 2018-12-11 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD962433S1 (en) | 2016-06-02 | 2022-08-30 | Intarcia Therapeutics, Inc. | Implant placement guide |
WO2018009566A1 (en) | 2016-07-06 | 2018-01-11 | Durect Corporation | Oral dosage form with drug composition, barrier layer and drug layer |
US10835580B2 (en) | 2017-01-03 | 2020-11-17 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
US11654183B2 (en) | 2017-01-03 | 2023-05-23 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of exenatide and co-administration of a drug |
WO2018165462A1 (en) | 2017-03-08 | 2018-09-13 | Intarcia Therapeutics, Inc | Apparatus and methods for administration of a nauseogenic compound from a drug delivery device |
WO2020077129A1 (en) | 2018-10-11 | 2020-04-16 | Intarcia Therapeutics, Inc. | Human amylin analog polypeptides and methods of use |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11083796B2 (en) | Peroxide removal from drug delivery vehicle | |
JP6837457B2 (ja) | 生分解性薬物送達組成物 | |
US5597897A (en) | Pharmaceutical formulations of osteogenic proteins | |
US6174856B1 (en) | Stabilized insulin compositions | |
WO1994008599A1 (en) | Ion-pairing of drugs for improved efficacy and delivery | |
WO1994008599A9 (en) | Ion-pairing of drugs for improved efficacy and delivery | |
US20140378370A1 (en) | Low viscosity highly concentrated suspensions | |
WO1993011785A1 (en) | Stabilized parathyroid hormone composition | |
JP7220664B2 (ja) | 液体医薬組成物 | |
EP4385517A2 (en) | Degarelix drug product | |
JP2022535555A (ja) | Glp1/2二重アゴニストの非経口医薬組成物 | |
JP2004536129A (ja) | セツキシマブおよびポリオキシエチレンソルビタン脂肪酸エステルを含む液体製剤 | |
JP3608802B2 (ja) | 安定なカルシトニン医薬組成物及びその製造法 | |
NZ223533A (en) | A dried protein product coated with an ionic surfactant whereby protein bioactivity and solubility is maintained and method of preparation | |
JP6965474B1 (ja) | テリパラチド又はその塩を含有するプレフィルドシリンジまたはカートリッジ製剤の振盪による白濁を抑制する方法 | |
US20160095904A1 (en) | Stabilized liquid formulation | |
JP2008528699A (ja) | Bop適合性ポリマー調製物中の過酸化物レベルを下げる方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: ALZA CORPORATION, CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:JUNNARKAR, GUNJAN;DESJARDIN, MICHAEL A.;CARR, JOHN PATRICK;REEL/FRAME:018180/0634;SIGNING DATES FROM 20060817 TO 20060824 |
|
AS | Assignment |
Owner name: DURECT CORPORATION, CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ALZA CORPORATION;REEL/FRAME:020036/0194 Effective date: 20071024 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |
|
AS | Assignment |
Owner name: ALZA, CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:JUNNARKAR, GUNJAN;DESJARDIN, MICHAEL A;CARR, JOHN PATRICK;SIGNING DATES FROM 20060817 TO 20060824;REEL/FRAME:032124/0777 |