UA82880C2 - Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer - Google Patents
Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer Download PDFInfo
- Publication number
- UA82880C2 UA82880C2 UAA200511386A UAA200511386A UA82880C2 UA 82880 C2 UA82880 C2 UA 82880C2 UA A200511386 A UAA200511386 A UA A200511386A UA A200511386 A UAA200511386 A UA A200511386A UA 82880 C2 UA82880 C2 UA 82880C2
- Authority
- UA
- Ukraine
- Prior art keywords
- component
- dosage form
- active substance
- substance
- transdermal administration
- Prior art date
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- 239000013543 active substance Substances 0.000 title claims abstract description 374
- 239000006211 transdermal dosage form Substances 0.000 title claims abstract description 6
- 239000003795 chemical substances by application Substances 0.000 title abstract description 48
- 230000002411 adverse Effects 0.000 title abstract description 4
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- 239000002552 dosage form Substances 0.000 claims description 247
- 239000000126 substance Substances 0.000 claims description 234
- -1 allylrhodine Chemical compound 0.000 claims description 182
- 230000004888 barrier function Effects 0.000 claims description 173
- 239000000203 mixture Substances 0.000 claims description 134
- 239000000463 material Substances 0.000 claims description 119
- 239000005557 antagonist Substances 0.000 claims description 81
- 238000000034 method Methods 0.000 claims description 76
- 239000002904 solvent Substances 0.000 claims description 76
- 150000003839 salts Chemical class 0.000 claims description 36
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 32
- 239000007787 solid Substances 0.000 claims description 32
- 238000009792 diffusion process Methods 0.000 claims description 31
- 239000012530 fluid Substances 0.000 claims description 30
- 239000007788 liquid Substances 0.000 claims description 27
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- 230000002093 peripheral effect Effects 0.000 claims description 16
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- 230000001070 adhesive effect Effects 0.000 claims description 13
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- 150000003180 prostaglandins Chemical class 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US46724303P | 2003-04-30 | 2003-04-30 | |
US46723503P | 2003-04-30 | 2003-04-30 |
Publications (1)
Publication Number | Publication Date |
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UA82880C2 true UA82880C2 (en) | 2008-05-26 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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UAA200511386A UA82880C2 (en) | 2003-04-30 | 2004-04-30 | Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer |
Country Status (22)
Country | Link |
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US (1) | US8778382B2 (es) |
EP (3) | EP2316440A1 (es) |
JP (1) | JP5048324B2 (es) |
KR (1) | KR101159828B1 (es) |
AR (1) | AR047936A1 (es) |
AU (1) | AU2004235794B8 (es) |
BR (1) | BRPI0409945A (es) |
CA (1) | CA2522529C (es) |
CL (1) | CL2004000927A1 (es) |
EA (1) | EA009623B1 (es) |
EC (1) | ECSP056191A (es) |
IS (1) | IS2935B (es) |
ME (1) | ME00276B (es) |
MX (1) | MXPA05011703A (es) |
MY (1) | MY141815A (es) |
NO (1) | NO332157B1 (es) |
NZ (1) | NZ542969A (es) |
PE (2) | PE20081297A1 (es) |
RS (1) | RS20050812A (es) |
TW (1) | TWI350186B (es) |
UA (1) | UA82880C2 (es) |
WO (1) | WO2004098567A2 (es) |
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US7182955B2 (en) * | 2003-04-30 | 2007-02-27 | 3M Innovative Properties Company | Abuse-resistant transdermal dosage form |
CA2522529C (en) | 2003-04-30 | 2015-10-20 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
US20040219195A1 (en) * | 2003-04-30 | 2004-11-04 | 3M Innovative Properties Company | Abuse-resistant transdermal dosage form |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DK2351555T3 (en) * | 2004-02-23 | 2017-01-23 | Euro Celtique Sa | Abuse-safe transdermal opioid delivery device |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102004039570B4 (de) * | 2004-08-14 | 2007-03-01 | Lts Lohmann Therapie-Systeme Ag | Überwachungssystem zum Sammeln und zur transdermalen Weiterdiffusion von Umweltkontaminantien enthaltender Luft und Verfahren hierzu |
KR20070053267A (ko) * | 2004-08-20 | 2007-05-23 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 반투명 보호 필름을 갖는 경피 약물 전달 장치 |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
TWI419717B (zh) * | 2005-06-17 | 2013-12-21 | Altea Therapeutics Corp | 滲透傳送系統及其使用方法 |
JP4704829B2 (ja) * | 2005-07-15 | 2011-06-22 | ニプロパッチ株式会社 | 貼付剤、及び貼付剤包装体 |
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WO2008007554A1 (fr) * | 2006-07-14 | 2008-01-17 | Hisamitsu Pharmaceutical Co., Inc. | Préparation d'adhésif |
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KR101690094B1 (ko) | 2008-05-09 | 2016-12-27 | 그뤼넨탈 게엠베하 | 분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법 |
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- 2004-04-30 PE PE2008000867A patent/PE20081297A1/es not_active Application Discontinuation
- 2004-04-30 EP EP10011794A patent/EP2316440A1/en not_active Withdrawn
- 2004-04-30 UA UAA200511386A patent/UA82880C2/uk unknown
- 2004-04-30 NZ NZ542969A patent/NZ542969A/en not_active IP Right Cessation
- 2004-04-30 PE PE2004000434A patent/PE20050146A1/es not_active Application Discontinuation
- 2004-04-30 EP EP10011795A patent/EP2319505A1/en not_active Withdrawn
- 2004-04-30 RS YUP-2005/0812A patent/RS20050812A/sr unknown
- 2004-04-30 EP EP04751268.6A patent/EP1641441B1/en not_active Expired - Lifetime
- 2004-04-30 BR BRPI0409945-1A patent/BRPI0409945A/pt not_active Application Discontinuation
- 2004-04-30 CL CL200400927A patent/CL2004000927A1/es unknown
- 2004-04-30 WO PCT/US2004/013810 patent/WO2004098567A2/en active Application Filing
- 2004-04-30 EA EA200501702A patent/EA009623B1/ru not_active IP Right Cessation
- 2004-04-30 US US10/835,535 patent/US8778382B2/en active Active
- 2004-04-30 AR ARP040101494A patent/AR047936A1/es not_active Application Discontinuation
- 2004-04-30 KR KR1020057020592A patent/KR101159828B1/ko active IP Right Grant
- 2004-04-30 JP JP2006514265A patent/JP5048324B2/ja not_active Expired - Lifetime
- 2004-04-30 ME MEP-2008-492A patent/ME00276B/me unknown
- 2004-04-30 TW TW093112241A patent/TWI350186B/zh not_active IP Right Cessation
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2005
- 2005-10-04 IS IS8060A patent/IS2935B/is unknown
- 2005-10-12 NO NO20054682A patent/NO332157B1/no not_active IP Right Cessation
- 2005-11-29 EC EC2005006191A patent/ECSP056191A/es unknown
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