UA81408C2 - Фармацевтична композиція для місцевого застосування та застосування її для виробництва медикаменту для лікування запальних станів шкіри та слизових оболонок - Google Patents
Фармацевтична композиція для місцевого застосування та застосування її для виробництва медикаменту для лікування запальних станів шкіри та слизових оболонок Download PDFInfo
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- UA81408C2 UA81408C2 UA20040907928A UA20040907928A UA81408C2 UA 81408 C2 UA81408 C2 UA 81408C2 UA 20040907928 A UA20040907928 A UA 20040907928A UA 20040907928 A UA20040907928 A UA 20040907928A UA 81408 C2 UA81408 C2 UA 81408C2
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IT2002MI000756A ITMI20020756A1 (it) | 2002-04-09 | 2002-04-09 | Composizioni farmaceutiche topiche per il trattamento delle dermatiti |
PCT/EP2003/003329 WO2003084553A1 (en) | 2002-04-09 | 2003-03-31 | Topical pharmaceutical compositions comprising proanthocyanidins for the treatment of dermatitis |
Publications (1)
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UA81408C2 true UA81408C2 (uk) | 2008-01-10 |
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UA20040907928A UA81408C2 (uk) | 2002-04-09 | 2003-03-31 | Фармацевтична композиція для місцевого застосування та застосування її для виробництва медикаменту для лікування запальних станів шкіри та слизових оболонок |
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EP (1) | EP1494692B1 (it) |
JP (1) | JP4861606B2 (it) |
KR (1) | KR101065645B1 (it) |
CN (1) | CN1646151B (it) |
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AT (1) | ATE361084T1 (it) |
AU (1) | AU2003226754B2 (it) |
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CA (1) | CA2481770C (it) |
CY (1) | CY1106628T1 (it) |
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DK (1) | DK1494692T3 (it) |
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GE (1) | GEP20074176B (it) |
HK (1) | HK1075617A1 (it) |
HR (1) | HRP20040917B1 (it) |
IL (1) | IL164434A (it) |
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UA (1) | UA81408C2 (it) |
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Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
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ITMI20020756A1 (it) * | 2002-04-09 | 2003-10-09 | Sinclair Pharma S R L | Composizioni farmaceutiche topiche per il trattamento delle dermatiti |
US20050031571A1 (en) * | 2003-05-16 | 2005-02-10 | Khaiat Alain V. | Topical treatment of ingrown hairs |
WO2004103321A2 (en) | 2003-05-16 | 2004-12-02 | Johnson & Johnson Consumer Companies, Inc. | Topical treatment of ingrown hairs |
GB0321996D0 (en) * | 2003-09-19 | 2003-10-22 | Novartis Nutrition Ag | Organic compounds |
ITMI20031941A1 (it) | 2003-10-09 | 2005-04-10 | Sinclair Pharmaceuticals Ltd | Composizioni farmaceutiche topiche per il trattamento delle dermatiti |
US20050260152A1 (en) * | 2004-05-03 | 2005-11-24 | Jaghab Khalil C | Hair growth composition |
JP2006022090A (ja) * | 2004-06-08 | 2006-01-26 | Ajinomoto Co Inc | ピロリドンカルボン酸亜鉛塩から成る炎症抑制剤 |
FR2871060B1 (fr) * | 2004-06-08 | 2008-07-11 | Ajinomoto Kk | Agent suppresseur pour l'inflammation et procede l'utilisant |
TW200744658A (en) * | 2005-10-12 | 2007-12-16 | Pentapharm Ag | Topical composition for use as a skin lightener |
US7897800B2 (en) * | 2006-02-03 | 2011-03-01 | Jr Chem, Llc | Chemical compositions and methods of making them |
US20080103103A1 (en) * | 2006-10-30 | 2008-05-01 | Bahram Memarzadeh | Reagents and methods to treat ocular diseases and infection |
JP5125122B2 (ja) * | 2007-01-31 | 2013-01-23 | 大正製薬株式会社 | アダパレン含有外用剤組成物 |
KR100823533B1 (ko) * | 2007-02-27 | 2008-04-30 | 바이오스펙트럼 주식회사 | 알파 비사볼올을 유효성분으로 포함하는 피부 상태 개선용조성물 |
JP4990352B2 (ja) * | 2007-03-01 | 2012-08-01 | 株式会社Tkバイオ研究所 | アレルギー疾患及び自己免疫疾患に有効な医薬 |
DE102007017851A1 (de) | 2007-04-16 | 2008-10-23 | Schülke & Mayr GmbH | Zusammensetzung auf Basis von Glycerinether/Polyol-Gemischen |
US20100323983A1 (en) * | 2007-05-11 | 2010-12-23 | Marc Moutet | Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof, and uses thereof |
US20100323985A1 (en) * | 2007-05-11 | 2010-12-23 | Marc Moutet | Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof and use of same |
WO2008139124A2 (fr) * | 2007-05-11 | 2008-11-20 | Galderma Research & Development | Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations |
EP2155149A2 (fr) * | 2007-05-11 | 2010-02-24 | Galderma Research & Development | Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations |
CN101496772B (zh) * | 2008-01-31 | 2013-04-24 | 姜宁 | 植物有效成分抗衰舒敏组合物 |
KR100823535B1 (ko) * | 2008-02-20 | 2008-04-21 | 바이오스펙트럼 주식회사 | 알파 비사볼올을 유효성분으로 포함하는 탈모 방지 또는발모 촉진용 조성물 |
US20100249060A1 (en) * | 2009-02-23 | 2010-09-30 | Smith Jan G | Topical formulation of low level clobetasol propionate for treating disorders of the skin and mucous membranes |
IT1397246B1 (it) * | 2009-05-14 | 2013-01-04 | Fidia Farmaceutici | Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica |
US8372382B2 (en) * | 2010-10-01 | 2013-02-12 | Mary Kay, Inc. | Skin moisturizer and age fighting formula |
JP5740666B2 (ja) * | 2011-02-10 | 2015-06-24 | 株式会社メニコンネクト | 眼科用組成物 |
CN102206242A (zh) * | 2011-03-28 | 2011-10-05 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | β体甘草酸及其衍生物在辐射防护中的用途 |
KR20140089340A (ko) * | 2011-08-16 | 2014-07-14 | 케이트 소머빌 스킨케어, 엘엘씨 | 피부 회춘 조성물 및 방법 |
KR101950662B1 (ko) * | 2011-09-28 | 2019-02-20 | 라이온 가부시키가이샤 | 구강용 조성물 |
ITMO20120036A1 (it) * | 2012-02-15 | 2013-08-16 | Drex Pharma S R L | Composizione coadiuvante per uso topico |
CN102614213A (zh) * | 2012-02-23 | 2012-08-01 | 武汉华纳联合药业有限公司 | 甘草酸、甘草次酸或其盐的用途及其凝胶组合物和制备方法 |
EP2829264B1 (en) * | 2012-03-22 | 2018-02-14 | FUJIFILM Corporation | Highly transparent emulsion composition and highly transparent cosmetic |
TW201412323A (zh) * | 2012-06-17 | 2014-04-01 | Kamedis Ltd | 用於治療慢性發炎皮膚病之局部用組成物 |
BR102012022291B8 (pt) * | 2012-09-04 | 2022-03-15 | Antonio Jose Trassi | Processo de fabricação de produto para tratamento da psoríase |
ES2506243T3 (es) * | 2012-09-05 | 2014-10-13 | Psoriasis+Creams Sweden Ab | Composición para tratar la psoriasis |
US9861645B2 (en) * | 2012-12-28 | 2018-01-09 | Rak Holdings Llc | Anti-itch scalp treatment compositions and combinations |
CN103908458A (zh) * | 2013-01-04 | 2014-07-09 | 厦门鹭佳生物科技有限公司 | 甘草次酸、甘草酸在制备预防或治疗放射性软组织损伤药物中的应用 |
CN103356438B (zh) * | 2013-07-11 | 2014-09-10 | 深圳市宜丽环保科技有限公司 | 一种专用于女性私处的护理液 |
ES2662854T3 (es) * | 2013-08-19 | 2018-04-10 | Rachid Ennamany | Composición dermatológica a partir de células madre vegetales y un derivado de ácido salicílico |
EP2907513A1 (en) | 2014-02-18 | 2015-08-19 | Bionoox Suisse SA | Compositions comprising dihydroquercetin for use in methods for alleviating the effects associated with skin inflammatory disorders |
CN103830303B (zh) * | 2014-03-11 | 2016-03-02 | 北京德默高科医药技术有限公司 | 一种预防褥疮的组合物 |
US11077087B2 (en) | 2015-03-18 | 2021-08-03 | Bionoox Suisse Sa | Compositions comprising dihydroquercetin for use in methods for treating herpes |
JP6606370B2 (ja) * | 2015-07-30 | 2019-11-13 | 章博 田井 | 抗アレルギー剤及びメディエーター遊離阻害剤 |
JP2018527401A (ja) * | 2015-09-17 | 2018-09-20 | ジューン ジェイコブス ラボラトリーズ, エルエルシー | 放射線皮膚炎の処置および予防のための組成物および方法 |
WO2017214497A1 (en) | 2016-06-10 | 2017-12-14 | Clarity Cosmetics Inc. | Non-comedogenic hair and scalp care formulations and method for use |
KR101839109B1 (ko) * | 2016-09-22 | 2018-03-15 | ㈜프론트바이오 | 퍼플콘 추출물을 함유하는 피부 질환의 예방 또는 치료용 약제학적 조성물 |
US20190321395A1 (en) * | 2018-04-20 | 2019-10-24 | Oread Therapeutics | Treatment of psoriasis, seborrheic dermatitis, and eczema of the head and neck |
IT201900013314A1 (it) * | 2019-07-30 | 2021-01-30 | Dermophisiologique S R L Soc Benefit | Composizioni per il trattamento della dermatite atopica |
WO2021074718A1 (pt) * | 2019-10-16 | 2021-04-22 | Tripod Maria | Creme para tratamento de acne e melasma |
IT202000004069A1 (it) * | 2020-02-27 | 2021-08-27 | Ricerfarma Srl | Composizioni topiche per il mantenimento e/o ripristino dell’integrità delle mucose e dell’epidermide lesa |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US487774A (en) * | 1892-12-13 | Sectional steam-boiler | ||
FR2509988B1 (fr) * | 1981-07-23 | 1986-05-30 | Oreal | Melange d'huiles vegetales a base d'huile de jojoba comme agent de stabilisation a l'oxydation et compositions cosmetiques le contenant |
IL64700A0 (en) * | 1982-01-01 | 1982-03-31 | Binderman Itzhak | Dental care compositions |
JPS60109519A (ja) * | 1983-11-17 | 1985-06-15 | Nippon Shinyaku Co Ltd | ニフェジピン坐剤 |
US4698360B1 (en) * | 1985-04-09 | 1997-11-04 | D Investigations Pharmacologiq | Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof |
US5422118A (en) * | 1986-11-07 | 1995-06-06 | Pure Pac, Inc. | Transdermal administration of amines with minimal irritation and high transdermal flux rate |
IT1201151B (it) * | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono |
IT1215469B (it) | 1987-05-08 | 1990-02-14 | Yason Srl | Composto ad attivita'mucoregolatrice e elastasi-inibitrice per la terapia dell'enfisema polmonare e della fibrosi polmonare. |
JPH0725660B2 (ja) * | 1990-05-29 | 1995-03-22 | サンスター株式会社 | 日焼けに対する消炎性を有する化粧料 |
IT1254321B (it) * | 1992-04-10 | 1995-09-14 | Kemiprogress S R L | Composizione farmaceutica per il trattamento e la prevenzione delle infiammazioni cutanee e della mucosa orale. |
US5650432A (en) * | 1995-03-24 | 1997-07-22 | Jlb, Inc. | Method of treating or preventing non-viral microbial infection |
JPH06336421A (ja) * | 1993-05-28 | 1994-12-06 | Kose Corp | 皮膚外用剤 |
IT1270999B (it) * | 1994-07-26 | 1997-05-26 | Indena Spa | Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico |
US5470874A (en) * | 1994-10-14 | 1995-11-28 | Lerner; Sheldon | Ascorbic acid and proanthocyanidine composition for topical application to human skin |
US5945409A (en) * | 1995-03-10 | 1999-08-31 | Wilson T. Crandall | Topical moisturizing composition and method |
JPH1059846A (ja) * | 1996-06-10 | 1998-03-03 | Kikkoman Corp | 白内障の予防または治療薬剤 |
US6471972B1 (en) * | 1996-11-07 | 2002-10-29 | Lvmh Recherche | Cosmetic treatment method for fighting against skin ageing effects |
US5811446A (en) * | 1997-04-18 | 1998-09-22 | Cytos Pharmaceuticals Llc | Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor |
WO1998052518A1 (en) * | 1997-07-02 | 1998-11-26 | Neutrogena Corporation | Methods for using compositions containing dichlorophenyl imidazoldioxolan to treat seborrheic dermatitis, dandruff, psoriasis, and acne, and compositions thereof |
EP0958833A1 (en) * | 1998-05-20 | 1999-11-24 | Erasmus Universiteit Rotterdam | Methods and means for preventing or treating inflammation |
IT1304183B1 (it) * | 1998-12-18 | 2001-03-08 | Indena Spa | Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici. |
JP2000212057A (ja) * | 1999-01-26 | 2000-08-02 | Kansai Koso Kk | 化粧料組成物 |
JP2001039844A (ja) * | 1999-07-29 | 2001-02-13 | Kikkoman Corp | 咽喉用うがい剤 |
US6274124B1 (en) * | 1999-08-20 | 2001-08-14 | Dragoco Gerberding & Co. Ag | Additive for improving the water resistance of cosmetic or dermatological formulations |
JP2001081021A (ja) * | 1999-09-09 | 2001-03-27 | Ichimaru Pharcos Co Ltd | 化粧料組成物 |
US6685970B1 (en) * | 1999-09-21 | 2004-02-03 | Kyowa Hakko Kogyo Co., Ltd. | Compositions containing proanthocyanidin and a vitamin B6 derivative or a salt thereof |
EP1226809B1 (en) * | 1999-10-29 | 2007-05-30 | Kyowa Hakko Kogyo Co., Ltd. | Skin texture-improving agents |
DE10131641A1 (de) * | 2000-12-22 | 2002-06-27 | Schwabe Willmar Gmbh & Co | Verbesserter und stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und Verwendung als topisches Arzneimittel |
EP1256335A1 (de) * | 2001-05-10 | 2002-11-13 | Cognis France S.A. | Verwendung von oligomeren Procyanolidinen |
ITMI20020756A1 (it) * | 2002-04-09 | 2003-10-09 | Sinclair Pharma S R L | Composizioni farmaceutiche topiche per il trattamento delle dermatiti |
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2002
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2003
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- 2003-03-31 WO PCT/EP2003/003329 patent/WO2003084553A1/en active IP Right Grant
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- 2003-03-31 MX MXPA04009755A patent/MXPA04009755A/es active IP Right Grant
- 2003-03-31 UA UA20040907928A patent/UA81408C2/uk unknown
- 2003-03-31 AT AT03745775T patent/ATE361084T1/de active
- 2003-03-31 EP EP03745775A patent/EP1494692B1/en not_active Expired - Lifetime
- 2003-03-31 NZ NZ535813A patent/NZ535813A/en not_active IP Right Cessation
- 2003-03-31 BR BRPI0309061-2A patent/BRPI0309061B1/pt unknown
- 2003-03-31 DK DK03745775T patent/DK1494692T3/da active
- 2003-03-31 AU AU2003226754A patent/AU2003226754B2/en not_active Ceased
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