IT1270999B - Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico - Google Patents
Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmeticoInfo
- Publication number
- IT1270999B IT1270999B ITMI941590A ITMI941590A IT1270999B IT 1270999 B IT1270999 B IT 1270999B IT MI941590 A ITMI941590 A IT MI941590A IT MI941590 A ITMI941590 A IT MI941590A IT 1270999 B IT1270999 B IT 1270999B
- Authority
- IT
- Italy
- Prior art keywords
- cumarines
- pharmaceutical
- formulations based
- cosmetic field
- coumarins
- Prior art date
Links
- 239000002537 cosmetic Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 abstract 2
- 229920002770 condensed tannin Polymers 0.000 abstract 2
- 235000001671 coumarin Nutrition 0.000 abstract 2
- 150000004775 coumarins Chemical class 0.000 abstract 2
- PLXMOAALOJOTIY-FPTXNFDTSA-N Aesculin Natural products OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1Oc2cc3C=CC(=O)Oc3cc2O PLXMOAALOJOTIY-FPTXNFDTSA-N 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 206010018852 Haematoma Diseases 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- QNHQEUFMIKRNTB-UHFFFAOYSA-N aesculetin Natural products C1CC(=O)OC2=C1C=C(O)C(O)=C2 QNHQEUFMIKRNTB-UHFFFAOYSA-N 0.000 abstract 1
- GUAFOGOEJLSQBT-UHFFFAOYSA-N aesculetin dimethyl ether Natural products C1=CC(=O)OC2=C1C=C(OC)C(OC)=C2 GUAFOGOEJLSQBT-UHFFFAOYSA-N 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- ILEDWLMCKZNDJK-UHFFFAOYSA-N esculetin Chemical compound C1=CC(=O)OC2=C1C=C(O)C(O)=C2 ILEDWLMCKZNDJK-UHFFFAOYSA-N 0.000 abstract 1
- XHCADAYNFIFUHF-TVKJYDDYSA-N esculin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC2=C1OC(=O)C=C2 XHCADAYNFIFUHF-TVKJYDDYSA-N 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 239000012049 topical pharmaceutical composition Substances 0.000 abstract 1
- 201000002282 venous insufficiency Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Birds (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invenzione riguarda l'uso di cumarine quali l'esculoside e l'esculetina, in associazione con proantocianidine dimeriche ed oligomeriche, in formulazioni per uso topico per il trattamento di vasculopatie periferiche, comprese le complicanze della stasi venosa cronica, o di inestetismi legati ad alterazioni dei capillari, o per migliorare l'andamento dei processi di cicatrizzazione. Queste cumarine, da sole o in associazione con proantocianidine, sono anche utili nelle dermatiti atopiche e nel trattamento degli ematomi.
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941590A IT1270999B (it) | 1994-07-26 | 1994-07-26 | Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico |
US08/498,867 US5665365A (en) | 1994-07-26 | 1995-07-06 | Formulations containing coumarins and the use thereof in the pharmaceutical and cosmetic fields |
DE69520173T DE69520173T2 (de) | 1994-07-26 | 1995-07-14 | Pharmazeutische oder kosmetische Zusammensetzungen, welche Cumarine und Proanthocyanidine enthalten |
DK95111054T DK0694305T3 (da) | 1994-07-26 | 1995-07-14 | Farmaceutiske eller kosmetiske formuleringer, som indeholder cumariner og proanthoxyanidiner |
ES95111054T ES2154308T3 (es) | 1994-07-26 | 1995-07-14 | Formulaciones farmaceuticas o cosmeticas que contienen cumarinas y proantocianidinas. |
EP95111054A EP0694305B1 (en) | 1994-07-26 | 1995-07-14 | Pharmaceutical or cosmetic formulations containing coumarins and proanthocyanidins |
PT95111054T PT694305E (pt) | 1994-07-26 | 1995-07-14 | Formulacoes farmaceuticas ou cosmeticas que contem cumarinas e proantocianidinas |
AT95111054T ATE199320T1 (de) | 1994-07-26 | 1995-07-14 | Pharmazeutische oder kosmetische zusammensetzungen, welche cumarine und proanthocyanidine enthalten |
AU27180/95A AU684963B2 (en) | 1994-07-26 | 1995-07-25 | Formulations Containing Cumarins And The Use Thereof In The Pharmaceutical And Cosmetic Fields |
KR1019950022175A KR100414310B1 (ko) | 1994-07-26 | 1995-07-25 | 쿠마린을포함하는국소용약제학적조성물 |
SG1995000943A SG30422A1 (en) | 1994-07-26 | 1995-07-25 | Formulations containing cumarins and the use thereof in the pharmaceutical and cosmetic fields |
CA002154601A CA2154601C (en) | 1994-07-26 | 1995-07-25 | Formulations containing coumarins and the use thereof in the pharmaceutical and cosmetic fields |
JP18932595A JP4611460B2 (ja) | 1994-07-26 | 1995-07-25 | クマリンを含む調製物および薬剤および美容分野におけるそれらの使用 |
HK98113940A HK1012569A1 (en) | 1994-07-26 | 1998-12-17 | Pharmaceutical or cosmetic formulations containing coumarins and proanthocyanidins |
GR20010400482T GR3035637T3 (en) | 1994-07-26 | 2001-03-26 | Pharmaceutical or cosmetic formulations containing coumarins and proanthocyanidinis |
KR1020020066070A KR100400963B1 (ko) | 1994-07-26 | 2002-10-29 | 쿠마린을 포함하는 미용 조성물 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941590A IT1270999B (it) | 1994-07-26 | 1994-07-26 | Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI941590A0 ITMI941590A0 (it) | 1994-07-26 |
ITMI941590A1 ITMI941590A1 (it) | 1996-01-26 |
IT1270999B true IT1270999B (it) | 1997-05-26 |
Family
ID=11369365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI941590A IT1270999B (it) | 1994-07-26 | 1994-07-26 | Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico |
Country Status (14)
Country | Link |
---|---|
US (1) | US5665365A (it) |
EP (1) | EP0694305B1 (it) |
JP (1) | JP4611460B2 (it) |
KR (2) | KR100414310B1 (it) |
AT (1) | ATE199320T1 (it) |
AU (1) | AU684963B2 (it) |
CA (1) | CA2154601C (it) |
DE (1) | DE69520173T2 (it) |
DK (1) | DK0694305T3 (it) |
ES (1) | ES2154308T3 (it) |
GR (1) | GR3035637T3 (it) |
HK (1) | HK1012569A1 (it) |
IT (1) | IT1270999B (it) |
PT (1) | PT694305E (it) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2773811B1 (fr) * | 1998-01-20 | 2001-11-09 | Jean Robert Grinda | Procede de stabilisation de substances polyphenoliques et les substances ainsi stabilisees |
IT1304183B1 (it) * | 1998-12-18 | 2001-03-08 | Indena Spa | Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici. |
US6485756B1 (en) * | 1999-04-06 | 2002-11-26 | Collaborative Technologies, Inc. | Stable, homogeneous natural product extracts containing polar and apolar fractions |
US6524626B2 (en) | 1999-04-23 | 2003-02-25 | E Excel International, Inc. | Ginseng berry topical products |
US6238672B1 (en) | 1999-04-23 | 2001-05-29 | E. Excel International Inc. | Dietary supplements containing dehydrated cactus fruit juice and ginseng berry juice |
US6210738B1 (en) | 1999-04-23 | 2001-04-03 | E Excel Internatioanal Inc. | Freeze-dried ginseng berry tea |
US6576286B1 (en) | 1999-04-23 | 2003-06-10 | E Excel International | Cactus fruit drinks and food products |
JP2001122791A (ja) | 1999-10-20 | 2001-05-08 | Boehringer Ingelheim Internatl Gmbh | 下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤 |
US6228387B1 (en) * | 2000-01-27 | 2001-05-08 | Murray Borod | Integrated comprehensive hemorrhoid treatment compositions and regimen |
US6576248B1 (en) * | 2000-09-11 | 2003-06-10 | Avon Products, Inc. | Pigmented vitamin C composition |
EP1256335A1 (de) * | 2001-05-10 | 2002-11-13 | Cognis France S.A. | Verwendung von oligomeren Procyanolidinen |
ITMI20020756A1 (it) * | 2002-04-09 | 2003-10-09 | Sinclair Pharma S R L | Composizioni farmaceutiche topiche per il trattamento delle dermatiti |
US20040009130A1 (en) * | 2002-07-08 | 2004-01-15 | Detore Donna Marie | Compositions for treating keratinous surfaces |
FR2842102B1 (fr) * | 2002-07-10 | 2005-10-28 | Cep | Utilisation d'un extrait de the pour controler la liberation d'il8, cytokine pro-inflammatoire et son incorporation dans des preparations cosmetiques et/ou dermatologiques |
US20050158409A1 (en) * | 2002-07-29 | 2005-07-21 | Kinya Takagaki | Food improving blood flow |
ITMI20031427A1 (it) * | 2003-07-11 | 2005-01-12 | Indena Spa | Combinazioni di agenti vasoattivi, loro uso in campo farmaceutico e cosmetico e formulazioni che li contengono |
DE10352602A1 (de) * | 2003-11-11 | 2005-06-02 | Rovi Gmbh & Co. Kosmetische Rohstoffe Kg | Kosmetisches oder therapeutisches Kombinationspräparat |
JP5456955B2 (ja) * | 2004-01-28 | 2014-04-02 | マース インコーポレーテッド | Aタイプのプロシアニジンを含有する組成物およびその使用方法 |
EP1718168A1 (en) * | 2004-02-19 | 2006-11-08 | Boehringer Ingelheim International Gmbh | Composition for the treatment of chronic venous insufficiencies comprising an extract of red vine leaves and an anti-inflammatory agent |
US7858115B2 (en) * | 2004-06-24 | 2010-12-28 | Idexx Laboratories | Phospholipid gel compositions for drug delivery and methods of treating conditions using same |
US20060013899A1 (en) * | 2004-07-14 | 2006-01-19 | Glen Lockhart | Topical compositions for treatment of skin disorders and methods of use thereof |
DE102004056838A1 (de) * | 2004-08-25 | 2006-03-02 | Gottfried Willmen | Mittel zur Behandlung von Pruritus ani und Haemorrhoidalleiden |
ITMI20042414A1 (it) * | 2004-12-17 | 2005-03-17 | Indena Spa | Formulazione per il trattamento di affezioni delle prime vie respiratorie |
US20060134235A1 (en) * | 2004-12-22 | 2006-06-22 | Toyo Shinyaku Co., Ltd. | External preparation for improving blood flow |
US20060293258A1 (en) * | 2005-06-23 | 2006-12-28 | Peter Rohdewald | Method and composition to treat skin ulcers |
EP1882473A1 (en) * | 2006-07-28 | 2008-01-30 | Indena S.P.A. | Use of anthocyanosides to prepare formulations for the treatment of mucositis induced by antitumoral drugs |
IT1398624B1 (it) | 2009-02-02 | 2013-03-08 | Dermogyn S R L | Uso cosmetico della proantocianidina a2 |
KR101324654B1 (ko) | 2011-09-30 | 2013-11-04 | 강원대학교산학협력단 | 에스쿨레틴을 유효성분으로 포함하는 주름 개선 및 항노화용 화장료 조성물 |
KR101322937B1 (ko) * | 2011-12-30 | 2013-10-28 | 한국식품연구원 | 어랩틴을 유효성분으로 함유하는 조직 재생용 조성물 |
TW201509928A (zh) * | 2013-09-02 | 2015-03-16 | 日本阿明諾化學有限公司 | 化合物、醫藥品、抗炎劑、化妝品、飲食品及化合物之製造方法 |
KR20190121932A (ko) | 2018-04-19 | 2019-10-29 | 경북대학교 산학협력단 | 에스쿨레틴을 포함하는 아토피 피부염의 예방 또는 치료용 조성물 |
AR127082A1 (es) * | 2019-11-22 | 2023-12-20 | Council Scient Ind Res | Compuestos antiinflamatorios para el tratamiento de trastornos cutáneos |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE589294C (de) * | 1932-07-31 | 1933-12-05 | Robert Bosch Akt Ges | Zuendkerze |
GB1589294A (en) * | 1976-09-08 | 1981-05-13 | Inverni Della Beffa Spa | Pharmaceutical compositions containing anthocyanidines |
FR2499405A1 (fr) * | 1981-02-10 | 1982-08-13 | Biotherm | Composition cosmetique amincissante et anti-cellulitique a base d'un extrait de plante contenant des saponines, un extrait d'arnica montana l. et d'un extrait de noix de cola et son procede d'application |
GB8518289D0 (en) * | 1985-07-19 | 1985-08-29 | Inverni Della Beffa Spa | Obtaining proanthocyanidine a2 |
IT1201151B (it) * | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono |
IT1219732B (it) * | 1988-06-28 | 1990-05-24 | Tecnofarmaci Spa | Frazioni oligomeriche procianidoliche,loro procedimento di preparazione e composizioni farmaceutiche che le contengono |
IT1231725B (it) * | 1989-08-11 | 1991-12-21 | Inverni Della Beffa Spa | Procedimento per la preparazione di estratti ad alto contenuto in antocianosidi. |
-
1994
- 1994-07-26 IT ITMI941590A patent/IT1270999B/it active IP Right Grant
-
1995
- 1995-07-06 US US08/498,867 patent/US5665365A/en not_active Expired - Lifetime
- 1995-07-14 PT PT95111054T patent/PT694305E/pt unknown
- 1995-07-14 AT AT95111054T patent/ATE199320T1/de not_active IP Right Cessation
- 1995-07-14 DK DK95111054T patent/DK0694305T3/da active
- 1995-07-14 DE DE69520173T patent/DE69520173T2/de not_active Expired - Lifetime
- 1995-07-14 EP EP95111054A patent/EP0694305B1/en not_active Expired - Lifetime
- 1995-07-14 ES ES95111054T patent/ES2154308T3/es not_active Expired - Lifetime
- 1995-07-25 AU AU27180/95A patent/AU684963B2/en not_active Ceased
- 1995-07-25 JP JP18932595A patent/JP4611460B2/ja not_active Expired - Fee Related
- 1995-07-25 KR KR1019950022175A patent/KR100414310B1/ko not_active IP Right Cessation
- 1995-07-25 CA CA002154601A patent/CA2154601C/en not_active Expired - Fee Related
-
1998
- 1998-12-17 HK HK98113940A patent/HK1012569A1/xx not_active IP Right Cessation
-
2001
- 2001-03-26 GR GR20010400482T patent/GR3035637T3/el unknown
-
2002
- 2002-10-29 KR KR1020020066070A patent/KR100400963B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0694305B1 (en) | 2001-02-28 |
KR100400963B1 (ko) | 2003-10-08 |
DE69520173D1 (de) | 2001-04-05 |
US5665365A (en) | 1997-09-09 |
KR100414310B1 (ko) | 2004-03-25 |
CA2154601A1 (en) | 1996-01-27 |
ITMI941590A1 (it) | 1996-01-26 |
ES2154308T3 (es) | 2001-04-01 |
HK1012569A1 (en) | 1999-08-06 |
GR3035637T3 (en) | 2001-06-29 |
CA2154601C (en) | 2006-09-19 |
DE69520173T2 (de) | 2001-07-19 |
AU684963B2 (en) | 1998-01-08 |
DK0694305T3 (da) | 2001-03-26 |
JP4611460B2 (ja) | 2011-01-12 |
ATE199320T1 (de) | 2001-03-15 |
PT694305E (pt) | 2001-07-31 |
EP0694305A1 (en) | 1996-01-31 |
ITMI941590A0 (it) | 1994-07-26 |
AU2718095A (en) | 1996-02-08 |
JPH0859463A (ja) | 1996-03-05 |
KR960003740A (ko) | 1996-02-23 |
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