WO2021074718A1 - Creme para tratamento de acne e melasma - Google Patents
Creme para tratamento de acne e melasma Download PDFInfo
- Publication number
- WO2021074718A1 WO2021074718A1 PCT/IB2020/058912 IB2020058912W WO2021074718A1 WO 2021074718 A1 WO2021074718 A1 WO 2021074718A1 IB 2020058912 W IB2020058912 W IB 2020058912W WO 2021074718 A1 WO2021074718 A1 WO 2021074718A1
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- skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Definitions
- the skin is the largest organ in the human body, it is responsible for the protection, temperature regulation and sensitivity of the organism. To keep the skin within healthy and aesthetic standards it is necessary to correct the imperfections and blemishes caused by acne and or melasma. For this treatment, the product proposed here, prepared with specific active ingredients, obtains the desired result and meets the patient's expectations.
- the product is prepared with synthetic active ingredients of organic origin in small quantities, water, biological emulsifier and in large part by phytotherapeutic actives.
- the active herbal ingredients used in the formula are products of plant origin and their benefits are proven by WHO (World Health Organization) through pharmacological studies. These assets have specific properties such as healing, antiseptic, anti-inflammatory, antioxidant, moisturizing and skin lightening properties.
- purpose of the formula is to combat fungi that lodge on the skin, using a substance that has the property of fungicide, to eliminate or reduce the excess pigmentation that causes melasma and to fight inflammation.
- Polawax Emulsifier and stabilizer. It is a wax of natural origin that keeps the product hydrated giving it shine and consistency in order to provide adequate viscosity to facilitate the application of the cream and assist in the absorption of the active principles by the skin.
- Ginko biloba Anti-inflammatory and antioxidant. It is a medicinal plant quite rich in flavonoids and terpenoids.
- Nettle or nettle anti-inflammatory and helps to reduce the oiliness of the skin avoiding the appearance of acne. It is a medicinal plant rich in vitamins and iron.
- Garnet or pomegranate Antiseptic. It is a fruit rich in mineral salts such as phosphorus, sodium, calcium and iron.
- Ginseng Anti-inflammatory, antioxidant and immune system stimulant. Ginseng contains vitamins Bl, B2 and B3, cobalt iron, polysaccharides, flavonoids, essential oils, magnesium, manganese, copper and calcium. Magnesium acts to recover damaged cells and helps fight acne. Manganese acts against free radicals responsible for premature skin aging. Copper helps in the absorption of iron aiding in the good healing of wounds maintaining the elasticity of the skin. Calcium stimulates collagen and is important for maintaining a firm and healthy skin. • Grape: antioxidant. It is rich in resveratrol and phenolic compounds that maintain cell development.
- Kójico acid antiseptic, antioxidant. Inhibits the formation of melanin, combating hyperpigmentation, reducing or eliminating spots, brightening the skin and preventing the appearance of new ones.
- Vitamin C antioxidant, aging, immunoprotective and anti-inflammatory, combats the action of free radicals, stimulates the formation of collagen, protects the skin from the effects of the sun and improves its elasticity.
- Hyaluronic acid moisturizes the skin. It assists in the production of collagen, prevents and controls sagging giving volume, firmness and elasticity to the skin. Helps in product viscosity.
- Dolomite alkaline, anti-inflammatory, analgesic, remineralizing, decongestant, toning and relaxing
- Clotrimazole broad spectrum fungicide, very effective in combating a wide range of fungi.
- Alpha arbutin acts to combat hyper pigmentation, eliminates or reduces skin blemishes.
- Caprylyl moisturizing and bactericidal preservative. Helps keep skin hydrated.
- Vitamin B3 anti-inflammatory and moisturizer. Prevents the appearance of spots and irritations, especially on sensitive skin. It acts to control the action of the sebaceous glands, preventing the appearance of acne.
- Palmiste the oil is made up of lauric acid and myristic acid.
- the lauric acid has anti-inflammatory, antibacterial and antifungal properties and the myristic acid helps in the absorption of the active principles by the skin.
- EDTA chelating agent. It gives stability to the product, preventing the change of color, smell and appearance.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
O produto é confecionado com princípios ativos fitoterápicos extraídos de raízes, caules e folhas de plantas medicinais, emulsificante biológico, ativos sintéticos de origem orgânica em pequena quantidade, minerais e água. O produto é feito nas fases oleosa, aquosa e seca seguindo as recomendações das Boas Práticas de Fabricação com. O objetivo de se obter um creme de boa qualidade para combater a acne e o melasma de maneira segura, rápida e eficaz. O crene é para tratamento de todos os tipos de pele, para ser aplicado na região lesionada ou afetada e tem as propriedades anti-inflamatória, antisséptica, antioxidante, cicatrizante, ante fungicida, hidratante e de clareamento da pele.
Description
DESCRIÇÃO
Creme para tratamento de acne e melasma Área técnica da invenção
• A pele é o maior órgão do corpo humano, é responsável pela proteção, regulação da temperatura e sensibilidade do organismo. Para manter a pele dentro de padrões saudáveis e estéticos é necessário corrigir as imperfeições e manchas causadas pela acne e ou melasma. Para esse tratamento, o produto aqui proposto, preparado com princípios ativos específicos, obtém o resultado desejado e atinge as expectativas do paciente.
• produto é preparado com princípios ativos sintéticos de origem orgânica em pequena quantidade, água, emulsificante biológico e em sua grande parte por ativos fitoterápicos.
• Os princípios ativos fitoterápicos utilizados na fórmula são produtos de origem vegetal e seus benefícios são comprovados pela OMS (Organização Mundial de Saúde) através de estudos farmacológicos. Esses ativos apresentam propriedades específicas como cicatrizantes, antissépticos, anti- inflamatórios, antioxidantes, hidratantes e de clareamento de pele.
• objetivo da fórmula é combater fungos que se alojam na pele, por meio de substância que tem a propriedade de fungicida, eliminar ou diminuir o excesso de pigmentação que causa o melasma e combater inflamações.
• Acnes são inflamações na pele que dependendo do grau da lesão podem deixar cicatrizes e manchas na região afetada causadas por fatores como:
• Hormonal
• Estresse
• Higiene geral do paciente
• Lesões antigas
• Exposição ao sol sem proteção
• Humidade da pele
• Oleosidade da pele
• Alimentação
• Efeito colateral de alguns medicamentos
• Outros
• Melasmas são manchas na pele devido ao aumento excessivo de melanina no organismo causados por fatores como:
• Hormonal
• Estresse
• Composição química da pele
• Higiene geral do paciente
• Lesões antigas na pele
• Exposição ao sol sem proteção
• Humidade da pele
• Alimentação
• Anticoncecionais
• Outros
Princípios ativos e suas propriedades
• Polawax: Emulsifícante e estabilizante. E uma cera de origem natural que mantém o produto hidratado dando brilho e consistência de modo a fornecer viscosidade adequada para facilitar a aplicação do creme e auxiliar na absorção dos princípios ativos pela pele.
• Ginko biloba: Anti-inflamatório e antioxidante. E uma planta medicinal bastante rica em flavonoides e terpenóides.
• Ortiga ou urtiga: anti-inflamatório e auxilia a diminuir a oleosidade da pele evitando o aparecimento de acne. E uma planta medicinal rica em vitaminas e ferro.
• Gayuba ou uva-ursina: antisséptico e anti-inflamatório. De uso tópico sobre feridas e ulcerações dérmicas. Contém glicosídeos, flavonoides e arbutina.
• Granada ou romã: Antisséptico. E uma fruta rica em sais minerais como fósforo, sódio cálcio e ferro.
• Ginseng: Anti-inflamatório, antioxidante e estimulante do sistema imunológico. O ginseng contém as vitaminas Bl, B2 e B3, ferro cobalto, polissacarídeos, flavonoides, óleos essenciais, magnésio, manganês, cobre e cálcio. O magnésio atua na recuperação das células danificadas e auxilia no combate a acne. O manganês age contra os radicais livres responsáveis pelo envelhecimento precoce da pele. O cobre ajuda na absorção do ferro auxiliando na boa cicatrização das feridas mantendo a elasticidade da pele. O cálcio estimula o colágeno e é importante para a manutenção de uma pele firme e saudável.
• Uva: antioxidante. É rica em resveratrol e compostos fenólicos que mantêm o desenvolvimento das células.
• Acido Kójico: antisséptico, antioxidante. Inibe a formação de melanina, combatendo a híperpigmentação, diminuindo ou eliminando as manchas, clareando a pele e prevenindo o aparecimento de novas.
• Vitamina C: antioxidante, ente envelhecimento, imunoprotetor e anti- inflamatório, combate a ação de radicais livres, estimula a formação de colágeno, protege a pele dos efeitos do sol e melhora a sua elasticidade.
• Acido hialurónico: hidrata a pele. Auxilia na produção de colágeno, previne e controla a flacidez dando volume, firmeza e elasticidade à pele. Ajuda na viscosidade do produto.
• Dolomita: alcalina, anti-inflamatório, analgésico, remineralizante, descongestionante, tonificante e relaxante
• Clotrimazol: fungicida de grande espectro, bastante eficaz no combate a grande gama de fungos.
• Alpha arbutina: atua no combate à híper-pigmentação, elimina ou reduz as manchas da pele.
• Caprylyl: conservante umectante e bactericida. Ajuda a manter a pele hidratada.
• Vitamina B3: anti-inflamatório e hidratante. Previne o aparecimento de manchas e irritações principalmente em peles sensíveis. Age no controle da ação das glândulas sebáceas evitando o surgimento da acne.
• Palmiste: o óleo é composto por ácido laurico e ácido mirístico. O acido láurico tem propriedades anti-inflamatória, antibacteriana e antifúngica e o ácido mirístico auxilia na absorção dos princípios ativos pela pele.
• EDTA: agente quelante. Dá estabilidade ao produto, impedindo a mudança de cor, cheiro e aparência.
Claims
1. Apresento pedido de patente.
2. Trata-se de invenção de produto com o objetivo de combater acnes e melasmas regenerando a saúde da pele.
3. Segue abaixo a formulação do produto e os procedimentos.
4. preparo segue cinco fases:
5. Fórmula para produção de 40 Gr.
Fase 1: oleosa
• Preparar a base oleosa, colocando o Polawax e o palmiste para derreter em fogo médio.
• Mistura a água com o EDTA
• Adicionar a misturada água com EDTA na base oleosa em banho maria mexendo sem parar
Fase 2: Extratos ativos (liquido)
• Misturar todos os ingredients:
Fase 3: Seca
• Misturar todos os ingredients:
Fase 4:
• Misturar a fase 2 com a fase 3
Fase 5:
• Misturar a fase 4 com a fase 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17/769,493 US20240225995A9 (en) | 2019-10-16 | 2020-09-24 | Cream for treating acne and melasma |
| BR112021025797A BR112021025797A2 (pt) | 2019-10-16 | 2020-09-24 | Creme para tratamento de acne e melasma |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT11585019 | 2019-10-16 | ||
| PT115850S | 2019-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2021074718A1 true WO2021074718A1 (pt) | 2021-04-22 |
Family
ID=75537142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2020/058912 WO2021074718A1 (pt) | 2019-10-16 | 2020-09-24 | Creme para tratamento de acne e melasma |
Country Status (2)
| Country | Link |
|---|---|
| BR (1) | BR112021025797A2 (pt) |
| WO (1) | WO2021074718A1 (pt) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050143324A1 (en) * | 2002-04-09 | 2005-06-30 | Sinclair Pharmaceuticals, Ltd. | Compositions and methods for the treatment of inflammatory conditions of mucosae, skin and the eye |
| US20070207110A1 (en) * | 2005-02-18 | 2007-09-06 | E.T. Brown Drug Co., Inc. | Topical cosmetic compositions containing alpha arbutin |
| CN102293733A (zh) * | 2011-08-25 | 2011-12-28 | 北京药谷传奇医药科技开发有限公司 | 全方位美白祛斑护肤产品 |
| CN103191037A (zh) * | 2013-03-30 | 2013-07-10 | 杭州师范大学 | 一种银杏美白祛痘霜 |
| EP2666469A1 (en) * | 2011-01-21 | 2013-11-27 | Jilin Zixin Pharmaceutical Research Institution LLC | Pharmaceutical composition for treating melasma and preparation method therefor |
-
2020
- 2020-09-24 WO PCT/IB2020/058912 patent/WO2021074718A1/pt active Application Filing
- 2020-09-24 BR BR112021025797A patent/BR112021025797A2/pt not_active IP Right Cessation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050143324A1 (en) * | 2002-04-09 | 2005-06-30 | Sinclair Pharmaceuticals, Ltd. | Compositions and methods for the treatment of inflammatory conditions of mucosae, skin and the eye |
| US20070207110A1 (en) * | 2005-02-18 | 2007-09-06 | E.T. Brown Drug Co., Inc. | Topical cosmetic compositions containing alpha arbutin |
| EP2666469A1 (en) * | 2011-01-21 | 2013-11-27 | Jilin Zixin Pharmaceutical Research Institution LLC | Pharmaceutical composition for treating melasma and preparation method therefor |
| CN102293733A (zh) * | 2011-08-25 | 2011-12-28 | 北京药谷传奇医药科技开发有限公司 | 全方位美白祛斑护肤产品 |
| CN103191037A (zh) * | 2013-03-30 | 2013-07-10 | 杭州师范大学 | 一种银杏美白祛痘霜 |
Non-Patent Citations (3)
| Title |
|---|
| LOZER PRISCILA ENDLICH, RENATA BOSCAINI DAVID: "Melasma: uma abordagem nutriciona", REV. BRAS. NUTR. CLIN, vol. 29, no. 1, 22 January 2014 (2014-01-22), pages 86 - 90, XP055817463 * |
| SONG, M. ET AL.: "Korean Red Ginseng Powder in the Treatment of Melasma: an uncontrolled observational study", J. GINSENG RES., vol. 35, no. 2, 2011, pages 170 - 175, XP053008439, DOI: 10.5142/jgr.2011.35.2.170 * |
| STEINER DENISE, CAMILA FEOLA, NEDIANA BIALESKI, FERNANDA AYRES DE MORAIS E SILVA: "Tratamento do Melasma: Revisao Sistematica", SURGICAL & COSMETIC DERMATOLOGY, vol. 1, no. 2, 2009, pages 87 - 94, XP055817466 * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021025797A2 (pt) | 2022-02-01 |
| US20240130959A1 (en) | 2024-04-25 |
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