UA78707C2 - Methods for treating or preventing diseases of animals caused by mycoplasma hyopneumoniae infection - Google Patents
Methods for treating or preventing diseases of animals caused by mycoplasma hyopneumoniae infection Download PDFInfo
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- UA78707C2 UA78707C2 UA20031213200A UA20031213200A UA78707C2 UA 78707 C2 UA78707 C2 UA 78707C2 UA 20031213200 A UA20031213200 A UA 20031213200A UA 20031213200 A UA20031213200 A UA 20031213200A UA 78707 C2 UA78707 C2 UA 78707C2
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- 239000002699 waste material Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/87—Mycoplasma
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30263601P | 2001-07-02 | 2001-07-02 | |
PCT/IB2002/002121 WO2003003941A2 (en) | 2001-07-02 | 2002-06-07 | One dose vaccination with mycoplasma hyopneumoniae |
Publications (1)
Publication Number | Publication Date |
---|---|
UA78707C2 true UA78707C2 (en) | 2007-04-25 |
Family
ID=23168589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA20031213200A UA78707C2 (en) | 2001-07-02 | 2002-07-06 | Methods for treating or preventing diseases of animals caused by mycoplasma hyopneumoniae infection |
Country Status (42)
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY129765A (en) * | 2000-12-19 | 2007-04-30 | Wyeth Corp | Improved mycoplasma hyopneumoniae bacterin vaccine |
WO2006056841A1 (en) * | 2004-11-24 | 2006-06-01 | Pharmacia & Upjohn Company Llc | Multiple-strain mycoplasma hyopneumoniae vaccines |
US7833707B2 (en) | 2004-12-30 | 2010-11-16 | Boehringer Ingelheim Vetmedica, Inc. | Methods of overexpression and recovery of porcine circovirus type 2 ORF2 |
UA95602C2 (ru) | 2004-12-30 | 2011-08-25 | Берингер Ингельхейм Ветмедика, Инк. | Иммуногенная композиция цвс2 и способы приготовления такой композиции |
US7700285B1 (en) | 2005-12-29 | 2010-04-20 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 immunogenic compositions and methods of producing such compositions |
US8834891B2 (en) | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
PL1968630T3 (pl) | 2005-12-29 | 2018-08-31 | Boehringer Ingelheim Vetmedica, Inc. | Multiwalentne immunogenne kompozycje PCV2 |
CN104383526B (zh) | 2005-12-29 | 2018-09-18 | 贝林格尔.英格海姆维特梅迪卡有限公司 | Pcv2免疫原性组合物用于减轻猪临床症状的用途 |
BRPI0708522A2 (pt) * | 2006-03-03 | 2011-05-31 | Merial Ltd | vacina de mycoplasma hyopneumoniae |
US20100136060A1 (en) * | 2006-11-22 | 2010-06-03 | Boehringer Ingelheim Vetmedica, Inc. | Methods of reducing porcine circovirus-associated disease outbreaks |
US20100129397A1 (en) * | 2006-12-11 | 2010-05-27 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
EP2094872B2 (de) | 2006-12-15 | 2020-02-19 | Boehringer Ingelheim Animal Health USA Inc. | Behandlung von anti-PCV2 Antikörper seropositiver Schweine mit PCV2 antigen |
EP1941903A1 (de) | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxe und Behandlung von PRDC |
EP1958644A1 (de) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Vorbeugung und Behandlung von subklinischer PCVD |
US7829274B2 (en) | 2007-09-04 | 2010-11-09 | Boehringer Ingelheim Vetmedica, Inc. | Reduction of concomitant infections in pigs by the use of PCV2 antigen |
MX2010005014A (es) * | 2007-11-06 | 2010-06-30 | Wyeth Llc | Vacuna viva avirulenta de mycoplasma hyopneumoniae con adyuvante. |
US20110020394A1 (en) * | 2007-12-31 | 2011-01-27 | Boehringer Ingelheim Vetmedica, Inc. | Pcv2 orf2 virus like particle with foreign amino acid insertion |
CN101236206B (zh) * | 2008-01-17 | 2014-10-15 | 中国兽医药品监察所 | 一种猪肺炎支原体重组抗原elisa检测试剂盒 |
EP2242511A4 (de) * | 2008-01-23 | 2012-10-24 | Boehringer Ingelheim Vetmed | Immunogene pcv2-zusammensetzungen gegen mycoplasma hyopneumoniae und verfahren zur herstellung solcher zusammensetzungen |
US8444989B1 (en) * | 2008-04-18 | 2013-05-21 | Boehringer Ingelheim Vetmedica Gmbh | One dose vaccination against mycoplasma infections of pigs |
NZ602945A (en) * | 2008-06-27 | 2014-05-30 | Zoetis Llc | Novel adjuvant compositions |
US9539209B2 (en) | 2009-06-04 | 2017-01-10 | National Institute Of Infectious Diseases | Vaccine for mycoplasma infection |
AR078253A1 (es) | 2009-09-02 | 2011-10-26 | Boehringer Ingelheim Vetmed | Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad |
EP3187585A1 (de) | 2010-03-25 | 2017-07-05 | Oregon Health&Science University | Cmv-glycoproteine und rekombinante vektoren |
DK2569007T3 (en) | 2010-05-11 | 2016-01-25 | Intervet Int Bv | VACCINE AGAINST Mycoplasma hyopneumoniae SUITABLE FOR ADMINISTRATION IN PRESENCE OF maternally derived antibodies |
DK2598165T3 (en) * | 2010-07-26 | 2017-10-16 | Qu Biologics Inc | IMMUNOGENIC ANTI-INFLAMMATORY COMPOSITIONS |
US8546149B2 (en) | 2010-08-27 | 2013-10-01 | Intervet Inc. | Potency test for vaccine formulations |
BR112013004594B1 (pt) * | 2010-08-27 | 2020-07-28 | Intervet International B. V. | método para a determinação de um conteúdo de antígeno |
DK2691530T3 (en) | 2011-06-10 | 2018-05-22 | Univ Oregon Health & Science | CMV GLYCOPROTEIN AND RECOMBINANT VECTORS |
MX362166B (es) * | 2012-03-07 | 2018-12-14 | Ceva Sante Animale | Nueva vacuna veterinaria. |
UA114503C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
US9120859B2 (en) * | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
EA038206B1 (ru) * | 2012-12-28 | 2021-07-23 | Бёрингер Ингельхайм Ветмедика Гмбх | Иммуногенная композиция, содержащая антигены микоплазм |
WO2014105672A1 (en) | 2012-12-28 | 2014-07-03 | Boehringer Ingelheim Vetmedica Gmbh | Method of making a mycoplasma vaccine |
KR101764750B1 (ko) * | 2013-02-05 | 2017-08-03 | 애그리컬쳐럴 테크놀로지 리서치 인스티튜트 | 항-마이코플라즈마 에스피피. 아단위 백신 |
CN104338125A (zh) * | 2013-07-29 | 2015-02-11 | 普莱柯生物工程股份有限公司 | 一种猪肺炎支原体抗原在预防和治疗猪呼吸道疾病综合征方面的应用 |
CN109675026A (zh) | 2013-09-19 | 2019-04-26 | 硕腾服务有限责任公司 | 油基佐剂 |
EA035265B1 (ru) | 2013-10-02 | 2020-05-21 | Бёрингер Ингельхайм Энимал Хелс Ю-Эс-Эй Инк. | Вариант белка opc2 pcv2 и содержащие его вирусоподобные частицы |
CN105792841B (zh) | 2013-11-21 | 2019-07-26 | 财团法人农业科技研究院 | 防治霉浆菌感染的组合物 |
CN105012948B (zh) * | 2014-04-18 | 2019-07-30 | 普莱柯生物工程股份有限公司 | 一种疫苗组合物及其应用 |
CN104248753B (zh) * | 2014-05-15 | 2017-07-28 | 普莱柯生物工程股份有限公司 | 一种疫苗组合物及其应用 |
BR102014014727B1 (pt) * | 2014-06-16 | 2018-04-03 | Ouro Fino Saúde Animal Ltda | COMPLEXO DE POLIPROTEÍNAS IMUNOGÊNICAS DE M. hyopneumoniae, GENE SINTÉTICO CODIFICANTE DO COMPLEXO DE POLIPROTEÍNAS IMUNOGÊNICAS DE M. hyopneumoniae, COMPOSIÇÃO ANTIGÊNICA, PROCESSO DE OBTENÇÃO DE UM COMPLEXO DE POLIPROTEÍNAS IMUNOGÊNICAS DE M. hyopneumoniae |
US9814769B2 (en) | 2014-09-30 | 2017-11-14 | Qatar University | Vaccines against pathogenic Escherichia coli and methods of using the same |
SI3244920T1 (sl) | 2015-01-16 | 2023-09-29 | The United States of America, represented by The Secretary of Agriculture, United States Department of Agriculture | Cepivo proti slinavki in parkljevki |
KR20160099223A (ko) * | 2015-02-12 | 2016-08-22 | 강원대학교산학협력단 | 마이코플라스마 하이오뉴모니애 박테린 백신 및 이의 제조방법 |
EP3498847A4 (de) * | 2016-08-12 | 2020-03-04 | Innovac | Impfstoffzusammensetzung zur vorbeugung von porcinen mycoplasma-infektionen mit rekombinantem protein |
RU2668799C1 (ru) * | 2017-09-08 | 2018-10-02 | Эгрикалчурал Текнолоджи Рисерч Инститьют | Субъединичная вакцина против mycoplasma spp. |
CN108101969A (zh) * | 2017-11-13 | 2018-06-01 | 南京大爻网络科技有限公司 | 一种与猪支原体肺炎相关的抗原及其应用 |
RU2695679C1 (ru) * | 2018-09-11 | 2019-07-25 | Эгрикалчурал Текнолоджи Рисерч Инститьют | Субъединичная вакцина против mycoplasma spp. |
RU2759427C2 (ru) * | 2019-07-08 | 2021-11-12 | Эгрикалчурал Текнолоджи Рисерч Инститьют | Субъединичная вакцина против mycoplasma spp |
CN117305192A (zh) * | 2023-12-01 | 2023-12-29 | 北京瑞阳瑞泰生物科技有限公司 | 一种猪肺炎支原体rt02株、疫苗组合物及其应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5252328A (en) * | 1987-03-26 | 1993-10-12 | Martin Marietta Energy Systems, Inc. | Mycoplasma hyopneumoniae antigen and uses therefor |
EP0283840A3 (de) * | 1987-03-26 | 1989-08-09 | Ml Technology Ventures, L.P. | Mycoplasma hyopneuminiae-Antigen und seine Vewendungen |
DE3881993T2 (de) | 1987-09-18 | 1993-09-30 | Akzo Nv | Mycoplasma-Impfstoff. |
EP0527771A4 (en) | 1990-04-02 | 1993-05-05 | Synergen, Inc. | Polypeptides useful in diagnosis of and treatment against mycoplasma infections in animals |
JP3187419B2 (ja) * | 1990-05-29 | 2001-07-11 | アメリカン・サイアナミド・カンパニー | ブタ肺炎ワクチンおよびその製造方法 |
US6113916A (en) * | 1990-05-29 | 2000-09-05 | American Cyanamid Company | Method of enhancing cell mediated immune responses |
US5565205A (en) | 1990-08-16 | 1996-10-15 | Solvay Animal Health, Inc. | Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof |
EP0475185A1 (de) | 1990-08-27 | 1992-03-18 | Nippon Flour Mills Co., Ltd. | DNA's, die für ein Oberflächenantigen von Mychoplasma hyopneumoniae kodidieren, DNA Fragmente für Primer, rekombinante antigene Peptide und diagnostische Methode für Mycoplasma Pneumoniae vom Schwein unter Nutzung derselben |
US5338543A (en) * | 1992-02-27 | 1994-08-16 | Ambico, Inc. | Thimerosal inactivated mycoplasma hyopneumoniae vaccine |
CA2145760A1 (en) * | 1992-09-28 | 1994-04-14 | Balbir S. Bhogal | Method of enhancing cell mediated immune responses |
US5530874A (en) | 1993-02-02 | 1996-06-25 | 3Com Corporation | Network adapter with an indication signal mask and an interrupt signal mask |
WO1995009870A1 (en) | 1993-10-07 | 1995-04-13 | Iowa State University Research Foundation, Inc. | Characterization of mycoplasma hyopneumoniae adhesins |
CA2189979C (en) | 1994-05-10 | 2011-04-19 | Hsien-Jue Chu | Improved modified live brsv vaccine |
US5788962A (en) | 1995-01-17 | 1998-08-04 | The Curators Of The University Of Missouri | DNA sequences coding for mycoplasma hyopneumoniae surface antigens, corresponding proteins and use in vaccines and diagnostic procedures |
AUPN178995A0 (en) | 1995-03-16 | 1995-04-13 | University Of Melbourne, The | Antigen composition |
CA2264810C (en) | 1996-09-30 | 2010-07-27 | Embrex, Inc. | Method of producing active immunity with vaccine conjugate |
EP0846468B1 (de) | 1996-12-05 | 2004-06-09 | Akzo Nobel N.V. | Nicht-virulentes Mycoplasma synoviae und Impfstoffe desselben |
EP1034004A1 (de) | 1997-11-26 | 2000-09-13 | Iowa State University Research Foundation, Inc. | Rekombinantes mycoplasma hyponeumoniae vakzin |
AU6128900A (en) * | 1999-09-29 | 2001-04-05 | Pfizer Products Inc. | Nucleic acids and proteins of the mycoplasma hyopneumoniae mph3 gene and uses thereof |
US6585981B1 (en) * | 2000-07-27 | 2003-07-01 | Regents Of The University Of Minnesota | Temperature-sensitive live vaccine for Mycoplasma hyopneumoniae |
UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
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2002
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2003
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- 2004-08-12 US US10/917,130 patent/US20050013823A1/en not_active Abandoned
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