UA73080C2 - Amino-terminally truncated rantes as chemokine antagonists - Google Patents
Amino-terminally truncated rantes as chemokine antagonists Download PDFInfo
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- UA73080C2 UA73080C2 UA2000042496A UA2000042496A UA73080C2 UA 73080 C2 UA73080 C2 UA 73080C2 UA 2000042496 A UA2000042496 A UA 2000042496A UA 2000042496 A UA2000042496 A UA 2000042496A UA 73080 C2 UA73080 C2 UA 73080C2
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Classifications
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97116863A EP0906954A1 (fr) | 1997-09-29 | 1997-09-29 | C-C chémokine tronquée à l'aminoterminus comme antagoniste de chémokines |
| EP98104216A EP0905241A1 (fr) | 1997-09-29 | 1998-03-10 | Amino-terminale tronquée C-C chemokine et d'un antagoniste de chemokin |
| PCT/EP1998/006143 WO1999016877A1 (fr) | 1997-09-29 | 1998-09-28 | Rantes tronques a acide amine terminal utilises comme antagonistes de la chemokine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA73080C2 true UA73080C2 (en) | 2005-06-15 |
Family
ID=8227408
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2000042496A UA73080C2 (en) | 1997-09-29 | 1998-09-28 | Amino-terminally truncated rantes as chemokine antagonists |
| UA2000042499A UA73081C2 (en) | 1997-09-29 | 1998-09-28 | Amino-terminally truncated mcp-2 as chemokine antagonists |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2000042499A UA73081C2 (en) | 1997-09-29 | 1998-09-28 | Amino-terminally truncated mcp-2 as chemokine antagonists |
Country Status (29)
| Country | Link |
|---|---|
| US (5) | US6905676B2 (fr) |
| EP (6) | EP0906954A1 (fr) |
| JP (2) | JP4230659B2 (fr) |
| KR (2) | KR100542934B1 (fr) |
| CN (3) | CN1233415C (fr) |
| AR (2) | AR013528A1 (fr) |
| AT (3) | ATE264390T1 (fr) |
| AU (2) | AU750341B2 (fr) |
| BG (2) | BG64679B1 (fr) |
| BR (2) | BR9812394A (fr) |
| CA (2) | CA2304827A1 (fr) |
| CY (1) | CY1110927T1 (fr) |
| CZ (2) | CZ299478B6 (fr) |
| DE (3) | DE69823218T2 (fr) |
| DK (3) | DK1021541T3 (fr) |
| EA (2) | EA003940B1 (fr) |
| EE (2) | EE200000152A (fr) |
| ES (3) | ES2287601T3 (fr) |
| HK (3) | HK1032426A1 (fr) |
| HU (2) | HU226414B1 (fr) |
| IL (2) | IL135351A (fr) |
| NO (2) | NO20001584D0 (fr) |
| NZ (3) | NZ503235A (fr) |
| PL (2) | PL196427B1 (fr) |
| PT (3) | PT1021541E (fr) |
| SK (2) | SK286495B6 (fr) |
| UA (2) | UA73080C2 (fr) |
| WO (2) | WO1999016877A1 (fr) |
| ZA (2) | ZA988676B (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6989435B2 (en) | 1997-09-11 | 2006-01-24 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| US7067117B1 (en) | 1997-09-11 | 2006-06-27 | Cambridge University Technical Services, Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| AU1616499A (en) | 1997-12-01 | 1999-06-16 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Chemokine variants and methods of use |
| US7238711B1 (en) | 1999-03-17 | 2007-07-03 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| AU1259501A (en) * | 1999-10-25 | 2001-05-08 | Euroscreen S.A. | Processed human chemokines phc-1 and phc-2 |
| EP1167527A1 (fr) * | 2000-06-22 | 2002-01-02 | Euroscreen S.A. | Chemokines humaines tronquées: PHC-1 et PHC-2 |
| AU2505601A (en) * | 1999-11-15 | 2001-05-30 | Wolf-Georg Forssmann | Novel use of hcc-2 |
| CA2316405A1 (fr) * | 2000-05-26 | 2001-11-26 | Ian Clark-Lewis | Modulation de l'inflammation a l'aide de produits du type protease |
| EP1176200A3 (fr) | 2000-06-20 | 2005-01-12 | Switch Biotech Aktiengesellschaft | Utilisation des polypeptides ou leurs acides nucléiques pour le diagnose ou traitement des maladies de la peau ou de la cicatrisation de blessures et leurs utilisations pour l'identification des substances pharmacologiquement actives |
| UA77950C2 (en) * | 2000-10-04 | 2007-02-15 | Applied Research Systems | Use of mutants of cc chemokines for treatment of multiple sclerosis |
| GB2373785A (en) * | 2001-03-28 | 2002-10-02 | Rega Inst For Medical Res | Truncating chemokines using dipeptidyl peptidase IV |
| US7553483B2 (en) | 2001-12-17 | 2009-06-30 | Merck Serono Sa | Chemokine mutants acting as chemokine antagonists |
| EP1631680A2 (fr) * | 2003-05-21 | 2006-03-08 | Bayer HealthCare AG | Diagnostics et agents therapeutiques destines a des maladies liees a une dipeptidylpeptidase iv (dpp4) |
| DE102005049637A1 (de) * | 2005-10-14 | 2007-04-26 | Rheinisch-Westfälische Technische Hochschule Aachen | Antagonisten gegen die Interaktion von PF4 und RANTES |
| MX2010001307A (es) | 2007-08-02 | 2010-07-30 | Novimmune Sa | Anticuerpos anti-proteína regulada con la activación, expresada y secretada por los linfocitos t normales y metodos de uso de los mismos. |
| US20130053257A1 (en) * | 2010-02-08 | 2013-02-28 | Paul E. Oran | RANTES Multiplexed Assay, RANTES Variants Related to Disease, and RANTES Variants Related to Enzymatice Activity |
| JP5975886B2 (ja) | 2010-03-11 | 2016-08-23 | ヘルス リサーチ インコーポレイテッドＨｅａｌｔｈ Ｒｅｓｅａｒｃｈ， Ｉｎｃ． | Ｆｃ融合タンパク質を含む、免疫応答を増強するための方法および組成物 |
| TW201718851A (zh) * | 2015-09-18 | 2017-06-01 | 通用醫院公司 | 具有抗化學排斥(anti-fugetactic)性質之經修飾自然殺手細胞及其用途 |
| CN112469430A (zh) | 2018-05-28 | 2021-03-09 | 日内瓦大学 | 抑制大脑炎症的方法 |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
| US11402391B2 (en) | 2020-12-21 | 2022-08-02 | Incelldx, Inc. | Methods of treating a long-hauler subject for chronic COVID-19 by administering a CCR5 or CCL5 antagonist |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0311107A3 (fr) | 1987-10-08 | 1990-04-18 | Stichting REGA V.Z.W. | Fluoro-3'-purine-didéoxy-2',3'-ribosides actifs contre HIV |
| US5739103A (en) * | 1993-11-12 | 1998-04-14 | Dana-Farber Cancer Institute | Chemokine N-terminal deletion mutations |
| PL182786B1 (pl) * | 1994-12-08 | 2002-02-28 | Glaxo Group Ltd | Polipeptyd, sekwencja kwasu nukleinowego, wektor, komórka gospodarza, środek farmaceutyczny, oraz sposób otrzymywania polipeptydu |
| WO1997025427A1 (fr) * | 1996-01-12 | 1997-07-17 | Genetics Institute, Inc. | Beta-chemokine, h1305 (mpc-2) |
| JP2000508527A (ja) * | 1996-03-27 | 2000-07-11 | アイコス コーポレイション | 単球走化性タンパク質―５物質及び方法 |
| FR2748938B1 (fr) * | 1996-05-22 | 1998-07-31 | Pasteur Institut | Utilisation de molecules antagonistes de chemokines pour leur activite antivirale notamment contre un retrovirus de type vih |
| US6168784B1 (en) * | 1997-09-03 | 2001-01-02 | Gryphon Sciences | N-terminal modifications of RANTES and methods of use |
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1997
- 1997-09-29 EP EP97116863A patent/EP0906954A1/fr not_active Withdrawn
- 1997-12-19 EP EP97122471A patent/EP0905240A1/fr not_active Withdrawn
-
1998
- 1998-03-10 EP EP98104216A patent/EP0905241A1/fr not_active Withdrawn
- 1998-09-22 ZA ZA9808676A patent/ZA988676B/xx unknown
- 1998-09-22 ZA ZA9808675A patent/ZA988675B/xx unknown
- 1998-09-28 HU HU0003505A patent/HU226414B1/hu not_active IP Right Cessation
- 1998-09-28 NZ NZ503235A patent/NZ503235A/xx unknown
- 1998-09-28 BR BR9812394-7A patent/BR9812394A/pt not_active Application Discontinuation
- 1998-09-28 EP EP04007579A patent/EP1439231B1/fr not_active Expired - Lifetime
- 1998-09-28 EP EP98951476A patent/EP1019507B1/fr not_active Expired - Lifetime
- 1998-09-28 DE DE69823218T patent/DE69823218T2/de not_active Expired - Lifetime
- 1998-09-28 AU AU97474/98A patent/AU750341B2/en not_active Ceased
- 1998-09-28 WO PCT/EP1998/006143 patent/WO1999016877A1/fr active IP Right Grant
- 1998-09-28 EA EA200000379A patent/EA003940B1/ru not_active IP Right Cessation
- 1998-09-28 NZ NZ516027A patent/NZ516027A/en unknown
- 1998-09-28 UA UA2000042496A patent/UA73080C2/uk unknown
- 1998-09-28 AT AT98947553T patent/ATE264390T1/de active
- 1998-09-28 ES ES04007579T patent/ES2287601T3/es not_active Expired - Lifetime
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- 1998-09-28 BR BR9812565-6A patent/BR9812565A/pt not_active Application Discontinuation
- 1998-09-28 DE DE69838188T patent/DE69838188T2/de not_active Expired - Lifetime
- 1998-09-28 PT PT98947553T patent/PT1021541E/pt unknown
- 1998-09-28 CA CA002304827A patent/CA2304827A1/fr not_active Abandoned
- 1998-09-28 SK SK451-2000A patent/SK286495B6/sk not_active IP Right Cessation
- 1998-09-28 AR ARP980104819A patent/AR013528A1/es active IP Right Grant
- 1998-09-28 ES ES98951476T patent/ES2218860T3/es not_active Expired - Lifetime
- 1998-09-28 PT PT04007579T patent/PT1439231E/pt unknown
- 1998-09-28 JP JP2000513946A patent/JP4230659B2/ja not_active Expired - Fee Related
- 1998-09-28 WO PCT/EP1998/006142 patent/WO1999016876A1/fr active IP Right Grant
- 1998-09-28 DK DK98947553T patent/DK1021541T3/da active
- 1998-09-28 DK DK04007579T patent/DK1439231T3/da active
- 1998-09-28 CZ CZ20001146A patent/CZ299478B6/cs not_active IP Right Cessation
- 1998-09-28 DK DK98951476T patent/DK1019507T3/da active
- 1998-09-28 PL PL339545A patent/PL196427B1/pl not_active IP Right Cessation
- 1998-09-28 CN CNB031492991A patent/CN1233415C/zh not_active Expired - Fee Related
- 1998-09-28 PT PT98951476T patent/PT1019507E/pt unknown
- 1998-09-28 HU HU0003563A patent/HU226468B1/hu not_active IP Right Cessation
- 1998-09-28 AT AT98951476T patent/ATE263242T1/de active
- 1998-09-28 UA UA2000042499A patent/UA73081C2/uk unknown
- 1998-09-28 KR KR1020007003019A patent/KR100560275B1/ko not_active IP Right Cessation
- 1998-09-28 NZ NZ503234A patent/NZ503234A/en unknown
- 1998-09-28 SK SK450-2000A patent/SK286439B6/sk not_active IP Right Cessation
- 1998-09-28 CN CNB988095726A patent/CN1148447C/zh not_active Expired - Fee Related
- 1998-09-28 AR ARP980104820A patent/AR013529A1/es active IP Right Grant
- 1998-09-28 PL PL339559A patent/PL197569B1/pl not_active IP Right Cessation
- 1998-09-28 EE EEP200000152A patent/EE200000152A/xx unknown
- 1998-09-28 JP JP2000513947A patent/JP4233214B2/ja not_active Expired - Fee Related
- 1998-09-28 EE EEP200000151A patent/EE200000151A/xx unknown
- 1998-09-28 CN CNB988095696A patent/CN1145693C/zh not_active Expired - Fee Related
- 1998-09-28 CA CA002305017A patent/CA2305017A1/fr not_active Abandoned
- 1998-09-28 EP EP98947553A patent/EP1021541B1/fr not_active Expired - Lifetime
- 1998-09-28 CZ CZ20001147A patent/CZ299479B6/cs not_active IP Right Cessation
- 1998-09-28 EA EA200000378A patent/EA003942B1/ru not_active IP Right Cessation
- 1998-09-28 DE DE69822856T patent/DE69822856T2/de not_active Expired - Lifetime
- 1998-09-28 AT AT04007579T patent/ATE368742T1/de active
-
2000
- 2000-03-22 BG BG104266A patent/BG64679B1/bg unknown
- 2000-03-22 BG BG104267A patent/BG64757B1/bg unknown
- 2000-03-27 NO NO20001584A patent/NO20001584D0/no not_active Application Discontinuation
- 2000-03-28 NO NO20001609A patent/NO20001609D0/no unknown
- 2000-03-28 US US09/537,859 patent/US6905676B2/en not_active Expired - Fee Related
- 2000-03-28 US US09/537,858 patent/US6977071B2/en not_active Expired - Fee Related
- 2000-03-29 IL IL135351A patent/IL135351A/en not_active IP Right Cessation
- 2000-03-29 IL IL135352A patent/IL135352A/en not_active IP Right Cessation
-
2001
- 2001-04-25 HK HK01102962A patent/HK1032426A1/xx not_active IP Right Cessation
- 2001-04-25 HK HK01102961A patent/HK1032425A1/xx not_active IP Right Cessation
- 2001-04-25 HK HK04105182A patent/HK1062637A1/xx not_active IP Right Cessation
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2005
- 2005-03-07 US US11/072,454 patent/US7326411B2/en not_active Expired - Fee Related
- 2005-05-06 US US11/123,089 patent/US7338653B2/en not_active Expired - Fee Related
- 2005-05-18 US US11/131,221 patent/US20050220790A1/en not_active Abandoned
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2007
- 2007-10-08 CY CY20071101290T patent/CY1110927T1/el unknown
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