EA200000379A1 - Усеченные по амино-концу rantes как антагонисты хемокинов - Google Patents

Усеченные по амино-концу rantes как антагонисты хемокинов

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Publication number
EA200000379A1
EA200000379A1 EA200000379A EA200000379A EA200000379A1 EA 200000379 A1 EA200000379 A1 EA 200000379A1 EA 200000379 A EA200000379 A EA 200000379A EA 200000379 A EA200000379 A EA 200000379A EA 200000379 A1 EA200000379 A1 EA 200000379A1
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EA
Eurasian Patent Office
Prior art keywords
rantes
amino
chemokins
trunked
antagonists
Prior art date
Application number
EA200000379A
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English (en)
Other versions
EA003940B1 (ru
Inventor
Поль Прост
Софи Стрюйф
Йо Вам Дамме
Original Assignee
Апплайд Резеч Системз Арс Холдинг Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8227408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200000379(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Апплайд Резеч Системз Арс Холдинг Н.В. filed Critical Апплайд Резеч Системз Арс Холдинг Н.В.
Publication of EA200000379A1 publication Critical patent/EA200000379A1/ru
Publication of EA003940B1 publication Critical patent/EA003940B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к усеченным по амино-концу RANTES, у которых отсутствуют NH-концевые аминокислоты, соответствующие аминокислотным остаткам 1, 1-2, 1-3 или 1-4 природного RANTES, и которые обладают антагонистической активностью по отношению к хемокинам; а также к кДНК-последовательностям, кодирующим такие RANTES; к их применению для лечения и/или диагностики заболеваний, при которых требуется антагонистическая активность против действия хемокинов; и к фармацевтическим композициям, содержащим указанные RANTES.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000379A 1997-09-29 1998-09-28 Усеченный по амино-концу хемокин rantes и способы его использования EA003940B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP97116863A EP0906954A1 (en) 1997-09-29 1997-09-29 Amino-terminal truncated c-c chemokines as chemokine antagonist
EP97122471A EP0905240A1 (en) 1997-09-29 1997-12-19 Amino-terminally truncated c-c chemokines as chemokine antagonists
EP98104216A EP0905241A1 (en) 1997-09-29 1998-03-10 Amino-terminally truncated c-c chemokines as chemokine antagonists
PCT/EP1998/006143 WO1999016877A1 (en) 1997-09-29 1998-09-28 Amino-terminally truncated rantes as chemokine antagonists

Publications (2)

Publication Number Publication Date
EA200000379A1 true EA200000379A1 (ru) 2000-10-30
EA003940B1 EA003940B1 (ru) 2003-10-30

Family

ID=8227408

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200000378A EA003942B1 (ru) 1997-09-29 1998-09-28 Усеченный по амино-концу моноцитарный хемотаксический белок (mcp-2) и способы его использования
EA200000379A EA003940B1 (ru) 1997-09-29 1998-09-28 Усеченный по амино-концу хемокин rantes и способы его использования

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200000378A EA003942B1 (ru) 1997-09-29 1998-09-28 Усеченный по амино-концу моноцитарный хемотаксический белок (mcp-2) и способы его использования

Country Status (29)

Country Link
US (5) US6977071B2 (ru)
EP (6) EP0906954A1 (ru)
JP (2) JP4233214B2 (ru)
KR (2) KR100542934B1 (ru)
CN (3) CN1233415C (ru)
AR (2) AR013528A1 (ru)
AT (3) ATE263242T1 (ru)
AU (2) AU750341B2 (ru)
BG (2) BG64679B1 (ru)
BR (2) BR9812565A (ru)
CA (2) CA2305017A1 (ru)
CY (1) CY1110927T1 (ru)
CZ (2) CZ299479B6 (ru)
DE (3) DE69822856T2 (ru)
DK (3) DK1021541T3 (ru)
EA (2) EA003942B1 (ru)
EE (2) EE200000152A (ru)
ES (3) ES2287601T3 (ru)
HK (3) HK1062637A1 (ru)
HU (2) HU226414B1 (ru)
IL (2) IL135351A (ru)
NO (2) NO20001584D0 (ru)
NZ (3) NZ516027A (ru)
PL (2) PL196427B1 (ru)
PT (3) PT1439231E (ru)
SK (2) SK286439B6 (ru)
UA (2) UA73081C2 (ru)
WO (2) WO1999016877A1 (ru)
ZA (2) ZA988676B (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067117B1 (en) 1997-09-11 2006-06-27 Cambridge University Technical Services, Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6989435B2 (en) 1997-09-11 2006-01-24 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6534626B1 (en) * 1997-12-01 2003-03-18 The United States Of America As Represented By The Department Of Health & Human Services Chemokine variants
US7238711B1 (en) 1999-03-17 2007-07-03 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
DE60030749T2 (de) * 1999-10-25 2007-09-20 Pharis Biotec Gmbh Prozessiertes menschliches chemokin phc-1
EP1167527A1 (en) * 2000-06-22 2002-01-02 Euroscreen S.A. Processed human chemokines PHC-1 and PHC-2
AU2505601A (en) * 1999-11-15 2001-05-30 Wolf-Georg Forssmann Novel use of hcc-2
CA2316405A1 (en) * 2000-05-26 2001-11-26 Ian Clark-Lewis Modulation of inflammation by protease products
EP1176200A3 (de) 2000-06-20 2005-01-12 Switch Biotech Aktiengesellschaft Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankung oder Wundheilung sowie ihre Verwendung zur Indentifizierung von pharmakologisch aktiven Substanzen
UA77950C2 (en) * 2000-10-04 2007-02-15 Applied Research Systems Use of mutants of cc chemokines for treatment of multiple sclerosis
GB2373785A (en) * 2001-03-28 2002-10-02 Rega Inst For Medical Res Truncating chemokines using dipeptidyl peptidase IV
US7553483B2 (en) 2001-12-17 2009-06-30 Merck Serono Sa Chemokine mutants acting as chemokine antagonists
WO2004104216A2 (en) * 2003-05-21 2004-12-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4)
DE102005049637A1 (de) * 2005-10-14 2007-04-26 Rheinisch-Westfälische Technische Hochschule Aachen Antagonisten gegen die Interaktion von PF4 und RANTES
DK2185719T3 (en) 2007-08-02 2014-02-17 Novimmune Sa ANTI-RANTES ANTIBODIES AND PROCEDURES FOR USE THEREOF
WO2011097567A1 (en) * 2010-02-08 2011-08-11 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Rantes multiplexed assay, rantes variants related to disease, and rantes variants related to enzymatice activity
US9296803B2 (en) 2010-03-11 2016-03-29 Health Research, Inc. Methods and compositions containing Fc fusion proteins for enhancing immune responses
TW201718851A (zh) * 2015-09-18 2017-06-01 通用醫院公司 具有抗化學排斥(anti-fugetactic)性質之經修飾自然殺手細胞及其用途
EP3813869B1 (en) 2018-05-28 2023-10-18 Université de Genève Ccr5 inhibitor for use in treating a neuroinflammatory disorder that involves cerebral inflammation
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
US11402391B2 (en) 2020-12-21 2022-08-02 Incelldx, Inc. Methods of treating a long-hauler subject for chronic COVID-19 by administering a CCR5 or CCL5 antagonist

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01265099A (ja) 1987-10-08 1989-10-23 Stichting Rega Vzw 抗ｈｉｖ活性をもつ３’，−フルオロプリン−２’，３’−ジデオキシリボシド類
US5739103A (en) * 1993-11-12 1998-04-14 Dana-Farber Cancer Institute Chemokine N-terminal deletion mutations
WO1996017935A2 (en) * 1994-12-08 1996-06-13 Glaxo Group Limited Rantes peptide and fragments and compositions comprising it for treatment of inflammation
WO1997025427A1 (en) * 1996-01-12 1997-07-17 Genetics Institute, Inc. Beta-chemokine, h1305 (mcp-2)
WO1997035982A2 (en) * 1996-03-27 1997-10-02 Icos Corporation Monocyte chemotactic protein-5 materials and methods
FR2748938B1 (fr) * 1996-05-22 1998-07-31 Pasteur Institut Utilisation de molecules antagonistes de chemokines pour leur activite antivirale notamment contre un retrovirus de type vih
US6168784B1 (en) * 1997-09-03 2001-01-02 Gryphon Sciences N-terminal modifications of RANTES and methods of use

Also Published As

Publication number Publication date
AR013528A1 (es) 2000-12-27
NZ516027A (en) 2003-05-30
AU750606B2 (en) 2002-07-25
CN1148447C (zh) 2004-05-05
DK1439231T3 (da) 2007-11-05
US20050201977A1 (en) 2005-09-15
JP4233214B2 (ja) 2009-03-04
PT1019507E (pt) 2004-06-30
KR20010024213A (ko) 2001-03-26
HUP0003563A3 (en) 2005-11-28
NZ503235A (en) 2002-08-28
EP1439231A3 (en) 2004-12-22
ES2218860T3 (es) 2004-11-16
HK1032425A1 (en) 2001-07-20
KR20010024214A (ko) 2001-03-26
DE69823218T2 (de) 2004-08-26
US20050164936A1 (en) 2005-07-28
KR100560275B1 (ko) 2006-03-10
ATE263242T1 (de) 2004-04-15
CN1271385A (zh) 2000-10-25
HU226414B1 (en) 2008-11-28
IL135351A (en) 2006-08-20
CN1145693C (zh) 2004-04-14
EP1021541B1 (en) 2004-04-14
CN1490049A (zh) 2004-04-21
DE69838188D1 (de) 2007-09-13
JP4230659B2 (ja) 2009-02-25
US6905676B2 (en) 2005-06-14
PL197569B1 (pl) 2008-04-30
EA003942B1 (ru) 2003-10-30
DK1019507T3 (da) 2004-07-19
AU750341B2 (en) 2002-07-18
SK286495B6 (sk) 2008-11-06
ZA988676B (en) 1999-12-03
HUP0003505A3 (en) 2005-11-28
KR100542934B1 (ko) 2006-01-11
PT1439231E (pt) 2007-08-20
SK286439B6 (sk) 2008-10-07
CA2305017A1 (en) 1999-04-08
EE200000151A (et) 2001-02-15
HK1062637A1 (en) 2004-11-19
DK1021541T3 (da) 2004-08-02
CZ20001146A3 (cs) 2000-09-13
AU9442098A (en) 1999-04-23
SK4502000A3 (en) 2000-09-12
BG104267A (en) 2000-11-30
NZ503234A (en) 2002-06-28
EP1439231A2 (en) 2004-07-21
CZ20001147A3 (cs) 2000-09-13
ZA988675B (en) 1999-11-24
US6977071B2 (en) 2005-12-20
PT1021541E (pt) 2004-07-30
CN1233415C (zh) 2005-12-28
HU226468B1 (en) 2008-12-29
US7326411B2 (en) 2008-02-05
PL339545A1 (en) 2000-12-18
NO20001584L (no) 2000-03-27
EP1019507A1 (en) 2000-07-19
EP1439231B1 (en) 2007-08-01
DE69822856T2 (de) 2004-08-19
UA73080C2 (en) 2005-06-15
EP1021541A1 (en) 2000-07-26
WO1999016877A1 (en) 1999-04-08
EP1019507B1 (en) 2004-03-31
AR013529A1 (es) 2000-12-27
EP0906954A1 (en) 1999-04-07
DE69838188T2 (de) 2007-11-22
BR9812394A (pt) 2000-09-12
IL135352A (en) 2006-08-20
HK1032426A1 (en) 2001-07-20
PL196427B1 (pl) 2008-01-31
UA73081C2 (en) 2005-06-15
NO20001609D0 (no) 2000-03-28
ATE368742T1 (de) 2007-08-15
HUP0003505A2 (hu) 2001-02-28
US20030124677A1 (en) 2003-07-03
SK4512000A3 (en) 2000-09-12
CA2304827A1 (en) 1999-04-08
CN1271386A (zh) 2000-10-25
EA200000378A1 (ru) 2000-10-30
CZ299479B6 (cs) 2008-08-06
NO20001609L (no) 2000-03-28
JP2001518296A (ja) 2001-10-16
US20050220790A1 (en) 2005-10-06
BG64679B1 (bg) 2005-11-30
CY1110927T1 (el) 2015-06-10
JP2001518297A (ja) 2001-10-16
WO1999016876A1 (en) 1999-04-08
BR9812565A (pt) 2000-08-01
ES2215324T3 (es) 2004-10-01
ATE264390T1 (de) 2004-04-15
US20030119148A1 (en) 2003-06-26
EE200000152A (et) 2001-02-15
BG104266A (en) 2000-11-30
ES2287601T3 (es) 2007-12-16
PL339559A1 (en) 2000-12-18
BG64757B1 (bg) 2006-02-28
CZ299478B6 (cs) 2008-08-06
HUP0003563A2 (hu) 2001-02-28
EP0905241A1 (en) 1999-03-31
EP0905240A1 (en) 1999-03-31
US7338653B2 (en) 2008-03-04
DE69823218D1 (de) 2004-05-19
NO20001584D0 (no) 2000-03-27
DE69822856D1 (de) 2004-05-06
EA003940B1 (ru) 2003-10-30
AU9747498A (en) 1999-04-23

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