UA61919C2 - Амінокислотний складний ефір, що містить азол, спосіб його одержання, проміжні сполуки та фармацевтична композиція - Google Patents

Амінокислотний складний ефір, що містить азол, спосіб його одержання, проміжні сполуки та фармацевтична композиція Download PDF

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Publication number
UA61919C2
UA61919C2 UA99020835A UA99020835A UA61919C2 UA 61919 C2 UA61919 C2 UA 61919C2 UA 99020835 A UA99020835 A UA 99020835A UA 99020835 A UA99020835 A UA 99020835A UA 61919 C2 UA61919 C2 UA 61919C2
Authority
UA
Ukraine
Prior art keywords
formula
phenyl
triazol
methylpropyl
compounds
Prior art date
Application number
UA99020835A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Ливен Меерпоел
Ян Хеерес
Роберт Йозеф Марія Хендрікс
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of UA61919C2 publication Critical patent/UA61919C2/uk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
UA99020835A 1997-02-11 1998-03-02 Амінокислотний складний ефір, що містить азол, спосіб його одержання, проміжні сполуки та фармацевтична композиція UA61919C2 (uk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP97200374 1997-02-11
EP97203228 1997-10-15
EP98908064A EP0958289B1 (en) 1997-02-11 1998-02-03 Amino acid ester containing azole antifungals
PCT/EP1998/000646 WO1998034934A1 (en) 1997-02-11 1998-02-03 Amino acid ester containing azole antifungals

Publications (1)

Publication Number Publication Date
UA61919C2 true UA61919C2 (uk) 2003-12-15

Family

ID=26146124

Family Applications (1)

Application Number Title Priority Date Filing Date
UA99020835A UA61919C2 (uk) 1997-02-11 1998-03-02 Амінокислотний складний ефір, що містить азол, спосіб його одержання, проміжні сполуки та фармацевтична композиція

Country Status (31)

Country Link
US (3) US6262052B1 (cs)
EP (1) EP0958289B1 (cs)
JP (1) JP4347911B2 (cs)
KR (1) KR100509171B1 (cs)
CN (1) CN1238353C (cs)
AT (1) ATE270290T1 (cs)
AU (1) AU725302C (cs)
BG (1) BG63872B1 (cs)
BR (1) BR9809744A (cs)
CA (1) CA2262791C (cs)
CZ (1) CZ297197B6 (cs)
DE (1) DE69824834T2 (cs)
DK (1) DK0958289T3 (cs)
EE (1) EE03876B1 (cs)
ES (1) ES2224364T3 (cs)
HU (1) HU227744B1 (cs)
ID (1) ID21755A (cs)
IL (2) IL128513A (cs)
MY (1) MY129537A (cs)
NO (1) NO316668B1 (cs)
NZ (1) NZ334477A (cs)
PL (1) PL191152B1 (cs)
PT (1) PT958289E (cs)
RU (1) RU2197489C2 (cs)
SI (1) SI0958289T1 (cs)
SK (1) SK284910B6 (cs)
TR (1) TR199900584T2 (cs)
TW (1) TW495508B (cs)
UA (1) UA61919C2 (cs)
WO (1) WO1998034934A1 (cs)
ZA (1) ZA981079B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
AU1915500A (en) 1998-11-20 2000-06-13 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
ES2194723T3 (es) * 1999-05-04 2003-12-01 Janssen Pharmaceutica Nv Eteres antifungicos.
AU2002365077A1 (en) * 2001-09-19 2003-06-30 Massachusetts Institute Of Technology Methods and products related to non-viral transfection
ITMI20032020A1 (it) * 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
RU2585760C2 (ru) * 2010-05-19 2016-06-10 Сандоз Аг Способ получения хиральных триазолонов
PT3240773T (pt) 2014-12-30 2020-09-10 Dow Agrosciences Llc Compostos picolinamida com atividade fungicida
BR102019004480B1 (pt) * 2018-03-08 2023-03-28 Dow Agrosciences Llc Picolinamidas como fungicidas
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4791111A (en) * 1985-12-23 1988-12-13 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
US4916134A (en) 1987-03-25 1990-04-10 Janssen Pharmacuetica N.V. 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones
CA1331757C (en) 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
DE69330248T2 (de) 1992-03-18 2002-03-21 Janssen Pharmaceutica N.V., Beerse Itraconazol- und saperconazolstereoisomere
EP0736030B1 (en) * 1993-12-21 2001-08-29 Schering Corporation Tetrahydrofuran antifungals
WO1995019983A1 (en) 1994-01-24 1995-07-27 Janssen Pharmaceutica N.V. Watersoluble azole antifungals
CZ59497A3 (en) * 1995-06-02 1997-08-13 Schering Corp Tetrahydrofuran derivative and pharmaceutical composition containing thereof
WO1997000255A1 (en) * 1995-06-19 1997-01-03 Schering Corporation Tetrahydrofuran antifungals

Also Published As

Publication number Publication date
CN1236366A (zh) 1999-11-24
ID21755A (id) 1999-07-22
EP0958289B1 (en) 2004-06-30
PT958289E (pt) 2004-11-30
SK284910B6 (sk) 2006-02-02
EP0958289A1 (en) 1999-11-24
ATE270290T1 (de) 2004-07-15
IL128513A0 (en) 2000-01-31
RU2197489C2 (ru) 2003-01-27
DE69824834D1 (de) 2004-08-05
SK105999A3 (en) 2000-06-12
AU6620798A (en) 1998-08-26
NZ334477A (en) 2001-05-25
DK0958289T3 (da) 2004-11-01
HU227744B1 (en) 2012-02-28
IL128513A (en) 2002-11-10
CZ283599A3 (cs) 2000-02-16
HUP0001050A2 (hu) 2001-04-28
US6512116B2 (en) 2003-01-28
US20010039281A1 (en) 2001-11-08
NO990484D0 (no) 1999-02-02
EE9900100A (et) 1999-10-15
CA2262791A1 (en) 1998-08-13
PL191152B1 (pl) 2006-03-31
CN1238353C (zh) 2006-01-25
BG63872B1 (bg) 2003-04-30
SI0958289T1 (en) 2004-12-31
IL149285A (en) 2007-08-19
MY129537A (en) 2007-04-30
CZ297197B6 (cs) 2006-09-13
AU725302C (en) 2001-08-23
JP4347911B2 (ja) 2009-10-21
US20030158210A1 (en) 2003-08-21
DE69824834T2 (de) 2005-07-21
ES2224364T3 (es) 2005-03-01
CA2262791C (en) 2008-10-28
KR100509171B1 (ko) 2005-08-22
JP2001508080A (ja) 2001-06-19
PL332008A1 (en) 1999-08-16
HUP0001050A3 (en) 2001-07-30
TR199900584T2 (xx) 1999-10-21
EE03876B1 (et) 2002-10-15
TW495508B (en) 2002-07-21
AU725302B2 (en) 2000-10-12
ZA981079B (en) 1999-08-10
KR20000068526A (ko) 2000-11-25
US6262052B1 (en) 2001-07-17
NO990484L (no) 1999-10-11
US6703506B2 (en) 2004-03-09
WO1998034934A1 (en) 1998-08-13
BR9809744A (pt) 2000-06-20
BG103171A (en) 1999-09-30
NO316668B1 (no) 2004-03-29
IL149285A0 (en) 2002-11-10

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